RGD Reference Report - Protective effect of infliximab on ischemia/reperfusion-induced damage in rat kidney. - Rat Genome Database

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Protective effect of infliximab on ischemia/reperfusion-induced damage in rat kidney.

Authors: Tasdemir, C  Tasdemir, S  Vardi, N  Ates, B  Parlakpinar, H  Kati, B  Karaaslan, MG  Acet, A 
Citation: Tasdemir C, etal., Ren Fail. 2012;34(9):1144-9. doi: 10.3109/0886022X.2012.717490. Epub 2012 Sep 6.
RGD ID: 6909167
Pubmed: PMID:22950848   (View Abstract at PubMed)
DOI: DOI:10.3109/0886022X.2012.717490   (Journal Full-text)

OBJECTIVE: To investigate the protective effect of infliximab on ischemia-reperfusion (I/R) injury of the rat kidney. METHODS: Twenty-eight male Wistar albino rats were divided into four groups: sham-operated, I/R, I/R with infliximab administered before ischemia [I/R + infliximab (bi)], and I/R with infliximab administered before reperfusion [I/R + infliximab (br)]. After a right nephrectomy to produce damage, the left renal vessels were occluded for 60 min, followed by 24-h reperfusion in rats. Changes in the rat kidney were observed by measuring the tissue levels of malondialdehyde (MDA), myeloperoxidase (MPO), glutathione (GSH), and superoxide dismutase (SOD) and by evaluating hematoxylin-eosin (H&E)-stained and periodic acid-Schiff (PAS) sections. RESULTS: The MDA and MPO levels in the I/R group were significantly higher than in the other groups (p < 0.05), and the SOD and GSH levels in the I/R + infliximab (bi) and I/R + infliximab (br) groups were significantly higher than in the I/R group (p < 0.05). However, histological examination revealed that the I/R + infliximab (bi) group and the I/R + infliximab (br) group had significantly fewer tubular changes and interstitial inflammatory cell infiltration than the I/R group. CONCLUSION: These results show that infliximab may protect against I/R injury in the rat I/R model.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MPOHumanKidney Reperfusion Injury  ISOMpo (Rattus norvegicus)protein:increased activity:kidneyRGD 
MpoMouseKidney Reperfusion Injury  ISOMpo (Rattus norvegicus)protein:increased activity:kidneyRGD 
MpoRatKidney Reperfusion Injury  IEP protein:increased activity:kidneyRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mpo  (myeloperoxidase)

Genes (Mus musculus)
Mpo  (myeloperoxidase)

Genes (Homo sapiens)
MPO  (myeloperoxidase)


Additional Information