RGD Reference Report - The oxidation induced by anti-MPO antibodies triggers fibrosis in microscopic polyangiitis. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

The oxidation induced by anti-MPO antibodies triggers fibrosis in microscopic polyangiitis.

Authors: Guilpain, P  Chereau, C  Goulvestre, C  Servettaz, A  Montani, D  Tamas, N  Pagnoux, C  Hachulla, E  Weill, B  Guillevin, L  Mouthon, L  Batteux, F 
Citation: Guilpain P, etal., Eur Respir J. 2010 Nov 11.
RGD ID: 5130969
Pubmed: PMID:21071471   (View Abstract at PubMed)
DOI: DOI:10.1183/09031936.00148409   (Journal Full-text)

Lung fibrosis is considered as a severe manifestation of microscopic polyangiitis (MPA). Antimyeloperoxidase (MPO) antibodies in MPA patients' sera can activate MPO and lead to the production of reactive oxygen species (ROS). While high levels of ROS are cytotoxic, low levels can induce fibroblast proliferation. Therefore, we hypothesized that the oxidative stress induced by anti-MPO antibodies could contribute to lung fibrosis. Twenty-one MPA patients (42 sera) were enrolled in the study, including six patients (19 sera) with lung fibrosis. Serum advanced oxidation protein products (AOPP), MPO-induced hypochlorous acid (HOCl), and serum-induced fibroblast proliferation were assayed. AOPP levels, MPO-induced HOCl production and serum-induced fibroblast proliferation were higher in patients than in healthy controls (P<0.0001, P=0.0001 and P=0.0005, respectively). Increased HOCl production was associated with active disease (P=0.002). Serum AOPP levels and serum-induced fibroblast proliferation were higher in patients with active MPA and lung fibrosis (P<0.0001). Significant linear relationship between fibroblast proliferation, AOPP levels and HOCl production was observed only in patients with lung fibrosis. The oxidative stress, in particular the production of HOCl through the interaction of MPO with anti-MPO antibodies, could trigger the fibrotic process observed in MPA.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MPOHumanvasculitis  IMP microscopic polyangiitisRGD 
MpoMousevasculitis  ISOMPO (Homo sapiens)microscopic polyangiitisRGD 
MpoRatvasculitis  ISOMPO (Homo sapiens)microscopic polyangiitisRGD 

Objects Annotated

Genes (Rattus norvegicus)
Mpo  (myeloperoxidase)

Genes (Mus musculus)
Mpo  (myeloperoxidase)

Genes (Homo sapiens)
MPO  (myeloperoxidase)


Additional Information