MECP2 (methyl-CpG binding protein 2) - Rat Genome Database

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Gene: MECP2 (methyl-CpG binding protein 2) Canis lupus familiaris
Analyze
Symbol: MECP2
Name: methyl-CpG binding protein 2
RGD ID: 12154441
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); double-stranded methylated DNA binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); associative learning (ortholog); behavioral fear response (ortholog); PARTICIPATES IN DNA modification pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); Angelman syndrome (ortholog); Animal Disease Models (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methyl CpG binding protein 2 (Rett syndrome); methyl-CpG-binding protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,866,721 - 121,876,088 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,873,218 - 121,932,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,201,895 - 107,204,829 (-)NCBI
ROS_Cfam_1.0X125,014,436 - 125,017,609 (-)NCBI
UMICH_Zoey_3.1X120,783,667 - 120,786,824 (-)NCBI
UNSW_CanFamBas_1.0X123,299,346 - 123,302,280 (-)NCBI
UU_Cfam_GSD_1.0X123,060,405 - 123,063,561 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
Angelman syndrome  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
attention deficit hyperactivity disorder  (ISO)
autistic disorder  (ISO)
bruxism  (ISO)
Cocaine-Related Disorders  (ISO)
Craniofacial Abnormalities  (ISO)
Developmental Disabilities  (ISO)
Developmental Disease  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
epilepsy  (ISO)
Facial Hypertrichosis  (ISO)
Fetal Growth Retardation  (ISO)
focal epilepsy  (ISO)
Gastrointestinal Diseases  (ISO)
Generalized Epilepsy  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
intellectual disability  (ISO)
learning disability  (ISO)
MECP2 duplication syndrome  (ISO)
microcephaly  (ISO)
Micrognathism  (ISO)
Muscle Hypotonia  (ISO)
Myoclonus  (ISO)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
non-syndromic X-linked intellectual disability  (ISO)
periventricular nodular heterotopia  (ISO)
pervasive developmental disorder  (ISO)
Psychomotor Disorders  (ISO)
pulmonary fibrosis  (ISO)
respiratory failure  (ISO)
Rett syndrome  (ISO)
Rett Syndrome, Atypical  (ISO)
Rett Syndrome, Zappella Variant  (ISO)
schizophrenia  (ISO)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
Smith-Magenis syndrome  (ISO)
Splenomegaly  (ISO)
stereotypic movement disorder  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
transient cerebral ischemia  (ISO)
visual epilepsy  (ISO)
X-Linked Intellectual Developmental Disorders  (ISO)
X-linked intellectual disability-psychosis-macroorchidism syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (IEA,ISO)
associative learning  (ISO)
behavioral fear response  (IEA,ISO)
brain development  (ISO)
cardiolipin metabolic process  (IEA,ISO)
catecholamine secretion  (ISO)
cell population proliferation  (ISO)
cellular biogenic amine metabolic process  (IEA,ISO)
cellular response to isoquinoline alkaloid  (ISO)
cellular response to potassium ion  (ISO)
cerebellum development  (IEA,ISO)
cerebral cortex development  (ISO)
chemical synaptic transmission  (ISO)
dendrite development  (IEA,ISO)
excitatory postsynaptic potential  (IEA,ISO)
gene expression  (ISO)
glial cell proliferation  (ISO)
glucocorticoid metabolic process  (IEA,ISO)
glutamine metabolic process  (IEA,ISO)
heart development  (ISO)
heterochromatin assembly  (IEA,ISO)
hippocampus development  (ISO)
histone acetylation  (IEA,ISO)
histone methylation  (IEA,ISO)
inositol metabolic process  (IEA,ISO)
learning  (ISO)
long-term memory  (IEA,ISO)
long-term synaptic potentiation  (IEA,ISO)
lung alveolus development  (ISO)
memory  (ISO)
mitotic spindle organization  (IEA)
multicellular organismal response to stress  (ISO)
negative regulation of angiogenesis  (IEA)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (IEA)
negative regulation of dendrite extension  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of locomotion involved in locomotory behavior  (ISO)
negative regulation of neuron apoptotic process  (IEA,ISO)
negative regulation of primary miRNA processing  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of respiratory gaseous exchange  (ISO)
negative regulation of smooth muscle cell differentiation  (IEA)
negative regulation of transcription by RNA polymerase II  (IBA,IEA,ISO)
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation  (IEA)
negative regulation of transcription, DNA-templated  (ISO)
nervous system process involved in regulation of systemic arterial blood pressure  (IEA,ISO)
neuromuscular process  (ISO)
neuromuscular process controlling posture  (ISO)
neuron differentiation  (ISO)
neuron maturation  (IEA,ISO)
neuron projection development  (ISO)
Notch signaling pathway  (ISO)
olfactory bulb development  (ISO)
oligodendrocyte development  (ISO)
oligodendrocyte differentiation  (ISO)
phosphatidylcholine metabolic process  (IEA,ISO)
positive regulation of anterograde dense core granule transport  (ISO)
positive regulation of branching morphogenesis of a nerve  (ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of dendrite extension  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of DNA methylation  (IEA)
positive regulation of G2/M transition of mitotic cell cycle  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of histone H3-K9 trimethylation  (IEA)
positive regulation of microtubule nucleation  (IEA)
positive regulation of retrograde dense core granule transport  (ISO)
positive regulation of synaptic plasticity  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
post-embryonic development  (IEA,ISO)
principal sensory nucleus of trigeminal nerve development  (ISO)
proprioception  (IEA,ISO)
protein localization  (IEA,ISO)
regulation of action potential firing threshold  (ISO)
regulation of DNA methylation  (ISO)
regulation of gene expression  (ISO)
regulation of gene expression by genomic imprinting  (IEA,ISO)
regulation of gene expression, epigenetic  (ISO)
regulation of histone H3-K9 methylation  (ISO)
regulation of respiratory gaseous exchange by nervous system process  (IEA,ISO)
regulation of synapse organization  (ISO)
regulation of synaptic plasticity  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
respiratory gaseous exchange by respiratory system  (IEA,ISO)
response to cocaine  (ISO)
response to estradiol  (ISO)
response to hypoxia  (IEA,ISO)
response to ionizing radiation  (ISO)
response to lead ion  (ISO)
response to organic cyclic compound  (ISO)
response to other organism  (IEA,ISO)
sensory perception of pain  (IEA,ISO)
social behavior  (IEA,ISO)
spinal cord development  (ISO)
startle response  (IEA,ISO)
striatum development  (ISO)
synapse assembly  (IEA,ISO)
thalamus development  (ISO)
trans-synaptic signaling by BDNF  (ISO)
triglyceride metabolic process  (ISO)
ventricular system development  (IEA,ISO)
visual learning  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
MECP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,866,721 - 121,876,088 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,873,218 - 121,932,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,201,895 - 107,204,829 (-)NCBI
ROS_Cfam_1.0X125,014,436 - 125,017,609 (-)NCBI
UMICH_Zoey_3.1X120,783,667 - 120,786,824 (-)NCBI
UNSW_CanFamBas_1.0X123,299,346 - 123,302,280 (-)NCBI
UU_Cfam_GSD_1.0X123,060,405 - 123,063,561 (-)NCBI
MECP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,021,573 - 154,097,717 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX154,021,573 - 154,137,103 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,287,024 - 153,363,174 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,940,458 - 153,016,323 (-)NCBINCBI36hg18NCBI36
Build 34X152,808,110 - 152,883,976NCBI
CeleraX153,520,969 - 153,596,868 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,928,231 - 142,007,659 (-)NCBIHuRef
CHM1_1X153,161,670 - 153,237,718 (-)NCBICHM1_1
T2T-CHM13v2.0X152,295,254 - 152,371,375 (-)NCBI
Mecp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,070,198 - 73,129,296 (-)NCBIGRCm39mm39
GRCm39 EnsemblX73,070,198 - 73,178,969 (-)Ensembl
GRCm38X74,026,592 - 74,085,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,026,592 - 74,135,363 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,272,160 - 71,330,975 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X70,279,550 - 70,338,313 (-)NCBImm8
CeleraX65,279,211 - 65,338,021 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.63NCBI
Mecp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,781,177 - 151,844,687 (-)NCBImRatBN7.2
mRatBN7.2 EnsemblX151,789,930 - 151,844,689 (-)Ensembl
Rnor_6.0X156,650,389 - 156,713,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,655,960 - 156,705,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,390,961 - 152,461,647 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,980,599 - 160,035,260 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X160,055,071 - 160,104,134 (-)NCBI
Celera1136,055,782 - 136,105,104 (+)NCBICelera
Cytogenetic MapXq37NCBI
Mecp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580679,109 - 735,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955580674,014 - 737,586 (-)NCBIChiLan1.0ChiLan1.0
MECP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,458,248 - 153,527,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,465,204 - 153,527,854 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X143,571,864 - 143,647,192 (-)NCBIMhudiblu_PPA_v0panPan3
Mecp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,165,167 - 119,228,780 (-)NCBI
SpeTri2.0NW_004936809902,938 - 967,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MECP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,735,656 - 124,789,110 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,735,523 - 124,789,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,295,001 - 142,349,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MECP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,445,028 - 128,519,892 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,453,577 - 128,455,785 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606566,318,831 - 66,395,535 (-)NCBIVero_WHO_p1.0
Mecp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946628,284 - 685,246 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624946620,581 - 685,339 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 17 1 6 1 6 1 12 10 6
Low 1 5 5 5 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000030916   ⟹   ENSCAFP00000028750
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX121,873,218 - 121,932,994 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000043990   ⟹   ENSCAFP00000039713
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX121,873,218 - 121,932,994 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000065701   ⟹   ENSCAFP00000053080
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX121,874,120 - 121,932,994 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000076107   ⟹   ENSCAFP00000050653
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX121,873,218 - 121,932,994 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000077751   ⟹   ENSCAFP00000056846
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX121,873,218 - 121,924,603 (-)Ensembl
RefSeq Acc Id: XM_022416327   ⟹   XP_022272035
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X121,866,721 - 121,876,088 (-)NCBI
Dog10K_Boxer_TashaX107,201,895 - 107,204,829 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038451269   ⟹   XP_038307197
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X125,014,436 - 125,017,609 (-)NCBI
RefSeq Acc Id: XM_038451270   ⟹   XP_038307198
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X125,014,436 - 125,017,345 (-)NCBI
RefSeq Acc Id: XM_038464246   ⟹   XP_038320174
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_TashaX107,201,895 - 107,204,565 (-)NCBI
RefSeq Acc Id: XM_038524738   ⟹   XP_038380666
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X120,783,667 - 120,786,824 (-)NCBI
RefSeq Acc Id: XM_038524740   ⟹   XP_038380668
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X120,783,667 - 120,786,560 (-)NCBI
RefSeq Acc Id: XM_038588701   ⟹   XP_038444629
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X123,060,405 - 123,063,561 (-)NCBI
RefSeq Acc Id: XM_038588702   ⟹   XP_038444630
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X123,060,405 - 123,063,297 (-)NCBI
RefSeq Acc Id: XM_038653221   ⟹   XP_038509149
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X123,299,346 - 123,302,280 (-)NCBI
RefSeq Acc Id: XM_038653222   ⟹   XP_038509150
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X123,299,346 - 123,302,016 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_022272035   ⟸   XM_022416327
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSCAFP00000028750   ⟸   ENSCAFT00000030916
RefSeq Acc Id: ENSCAFP00000039713   ⟸   ENSCAFT00000043990
RefSeq Acc Id: ENSCAFP00000056846   ⟸   ENSCAFT00000077751
RefSeq Acc Id: ENSCAFP00000050653   ⟸   ENSCAFT00000076107
RefSeq Acc Id: ENSCAFP00000053080   ⟸   ENSCAFT00000065701
RefSeq Acc Id: XP_038380666   ⟸   XM_038524738
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038380668   ⟸   XM_038524740
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038509149   ⟸   XM_038653221
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038509150   ⟸   XM_038653222
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038307197   ⟸   XM_038451269
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038307198   ⟸   XM_038451270
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038320174   ⟸   XM_038464246
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038444629   ⟸   XM_038588701
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038444630   ⟸   XM_038588702
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019440 Ensembl
NCBI Gene MECP2 ENTREZGENE
VGNC ID VGNC:43115 ENTREZGENE