Mecp2 (methyl-CpG binding protein 2) - Rat Genome Database

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Gene: Mecp2 (methyl-CpG binding protein 2) Chinchilla lanigera
Analyze
Symbol: Mecp2
Name: methyl-CpG binding protein 2
RGD ID: 8964415
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); DNA binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); associative learning (ortholog); behavioral fear response (ortholog); PARTICIPATES IN DNA modification pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); Angelman syndrome (ortholog); Animal Disease Models (ortholog); FOUND IN centrosome (ortholog); chromatin (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: methyl CpG binding protein 2; methyl CpG binding protein 2 (Rett syndrome); methyl-CpG-binding protein 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580679,109 - 735,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955580674,014 - 737,586 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
Angelman syndrome  (ISO)
Animal Disease Models  (ISO)
anxiety disorder  (ISO)
attention deficit hyperactivity disorder  (ISO)
autistic disorder  (ISO)
bruxism  (ISO)
Cocaine-Related Disorders  (ISO)
Craniofacial Abnormalities  (ISO)
Developmental Disabilities  (ISO)
Developmental Disease  (ISO)
Emery-Dreifuss muscular dystrophy  (ISO)
epilepsy  (ISO)
Facial Hypertrichosis  (ISO)
Fetal Growth Retardation  (ISO)
focal epilepsy  (ISO)
Gastrointestinal Diseases  (ISO)
Generalized Epilepsy  (ISO)
genetic disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
Hyperalgesia  (ISO)
immunodeficiency 33  (ISO)
intellectual disability  (ISO)
learning disability  (ISO)
MECP2 duplication syndrome  (ISO)
microcephaly  (ISO)
Micrognathism  (ISO)
Muscle Hypotonia  (ISO)
Myoclonus  (ISO)
Nervous System Malformations  (ISO)
Neurodevelopmental Disorders  (ISO)
non-syndromic X-linked intellectual disability  (ISO)
periventricular nodular heterotopia  (ISO)
pervasive developmental disorder  (ISO)
Psychomotor Disorders  (ISO)
pulmonary fibrosis  (ISO)
respiratory failure  (ISO)
Rett syndrome  (ISO)
Rett Syndrome, Atypical  (ISO)
Rett Syndrome, Zappella Variant  (ISO)
schizophrenia  (ISO)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
Smith-Magenis syndrome  (ISO)
Splenomegaly  (ISO)
stereotypic movement disorder  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
transient cerebral ischemia  (ISO)
visual epilepsy  (ISO)
X-Linked Intellectual Developmental Disorders  (ISO)
X-linked intellectual disability-psychosis-macroorchidism syndrome  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adult locomotory behavior  (ISO)
associative learning  (ISO)
behavioral fear response  (ISO)
brain development  (ISO)
cardiolipin metabolic process  (ISO)
catecholamine secretion  (ISO)
cell population proliferation  (ISO)
cellular biogenic amine metabolic process  (ISO)
cellular response to isoquinoline alkaloid  (ISO)
cellular response to potassium ion  (ISO)
cerebellum development  (ISO)
cerebral cortex development  (ISO)
chemical synaptic transmission  (ISO)
dendrite development  (ISO)
epigenetic regulation of gene expression  (ISO)
excitatory postsynaptic potential  (ISO)
gene expression  (ISO)
glial cell proliferation  (ISO)
glucocorticoid metabolic process  (ISO)
glutamine metabolic process  (ISO)
heart development  (ISO)
heterochromatin formation  (ISO)
hippocampus development  (ISO)
histone acetylation  (ISO)
histone methylation  (ISO)
inositol metabolic process  (ISO)
learning  (ISO)
long-term memory  (ISO)
long-term synaptic potentiation  (ISO)
lung alveolus development  (ISO)
memory  (ISO)
mitotic spindle organization  (ISO)
multicellular organismal response to stress  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of astrocyte differentiation  (ISO)
negative regulation of blood vessel endothelial cell migration  (ISO)
negative regulation of dendrite extension  (ISO)
negative regulation of dendritic spine development  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of locomotion involved in locomotory behavior  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of primary miRNA processing  (ISO)
negative regulation of protein binding  (ISO)
negative regulation of respiratory gaseous exchange  (ISO)
negative regulation of smooth muscle cell differentiation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation  (ISO)
nervous system process involved in regulation of systemic arterial blood pressure  (ISO)
neuromuscular process  (ISO)
neuromuscular process controlling posture  (ISO)
neuron differentiation  (ISO)
neuron maturation  (ISO)
neuron projection development  (ISO)
Notch signaling pathway  (ISO)
olfactory bulb development  (ISO)
oligodendrocyte development  (ISO)
oligodendrocyte differentiation  (ISO)
phosphatidylcholine metabolic process  (ISO)
positive regulation of anterograde dense core granule transport  (ISO)
positive regulation of branching morphogenesis of a nerve  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of dendrite extension  (ISO)
positive regulation of dendritic spine development  (ISO)
positive regulation of DNA methylation  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of histone H3-K9 trimethylation  (ISO)
positive regulation of microtubule nucleation  (ISO)
positive regulation of retrograde dense core granule transport  (ISO)
positive regulation of synaptic plasticity  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
post-embryonic development  (ISO)
principal sensory nucleus of trigeminal nerve development  (ISO)
proprioception  (ISO)
protein localization  (ISO)
regulation of action potential firing threshold  (ISO)
regulation of DNA methylation  (ISO)
regulation of gene expression  (ISO)
regulation of gene expression by genomic imprinting  (ISO)
regulation of histone H3-K9 methylation  (ISO)
regulation of respiratory gaseous exchange by nervous system process  (ISO)
regulation of synapse organization  (ISO)
regulation of synaptic plasticity  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
respiratory gaseous exchange by respiratory system  (ISO)
response to cocaine  (ISO)
response to estradiol  (ISO)
response to hypoxia  (ISO)
response to ionizing radiation  (ISO)
response to lead ion  (ISO)
response to organic cyclic compound  (ISO)
response to other organism  (ISO)
sensory perception of pain  (ISO)
social behavior  (ISO)
spinal cord development  (ISO)
startle response  (ISO)
striatum development  (ISO)
synapse assembly  (ISO)
thalamus development  (ISO)
trans-synaptic signaling by BDNF  (ISO)
triglyceride metabolic process  (ISO)
ventricular system development  (ISO)
visual learning  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data
Mecp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580679,109 - 735,288 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955580674,014 - 737,586 (-)NCBIChiLan1.0ChiLan1.0
MECP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,021,573 - 154,097,717 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX154,021,573 - 154,137,103 (-)EnsemblGRCh38hg38GRCh38
GRCh37X153,287,024 - 153,363,174 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,940,458 - 153,016,323 (-)NCBINCBI36hg18NCBI36
Build 34X152,808,110 - 152,883,976NCBI
CeleraX153,520,969 - 153,596,868 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,928,231 - 142,007,659 (-)NCBIHuRef
CHM1_1X153,161,670 - 153,237,718 (-)NCBICHM1_1
T2T-CHM13v2.0X152,295,254 - 152,371,375 (-)NCBI
Mecp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,070,198 - 73,129,296 (-)NCBIGRCm39mm39
GRCm39 EnsemblX73,070,198 - 73,178,969 (-)Ensembl
GRCm38X74,026,592 - 74,085,690 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,026,592 - 74,135,363 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,272,160 - 71,330,975 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X70,279,550 - 70,338,313 (-)NCBImm8
CeleraX65,279,211 - 65,338,021 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.63NCBI
Mecp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,781,177 - 151,844,687 (-)NCBImRatBN7.2
mRatBN7.2 EnsemblX151,789,930 - 151,844,689 (-)Ensembl
Rnor_6.0X156,650,389 - 156,713,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,655,960 - 156,705,233 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,390,961 - 152,461,647 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,980,599 - 160,035,260 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X160,055,071 - 160,104,134 (-)NCBI
Celera1136,055,782 - 136,105,104 (+)NCBICelera
Cytogenetic MapXq37NCBI
MECP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,458,248 - 153,527,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,465,204 - 153,527,854 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X143,571,864 - 143,647,192 (-)NCBIMhudiblu_PPA_v0panPan3
MECP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,866,721 - 121,876,088 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,873,218 - 121,932,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX107,201,895 - 107,204,829 (-)NCBI
ROS_Cfam_1.0X125,014,436 - 125,017,609 (-)NCBI
UMICH_Zoey_3.1X120,783,667 - 120,786,824 (-)NCBI
UNSW_CanFamBas_1.0X123,299,346 - 123,302,280 (-)NCBI
UU_Cfam_GSD_1.0X123,060,405 - 123,063,561 (-)NCBI
Mecp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,165,167 - 119,228,780 (-)NCBI
SpeTri2.0NW_004936809902,938 - 967,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MECP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,735,656 - 124,738,659 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,735,523 - 124,789,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,295,001 - 142,349,438 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MECP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,445,028 - 128,519,892 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,453,577 - 128,455,785 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606566,318,831 - 66,395,535 (-)NCBIVero_WHO_p1.0
Mecp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624946628,284 - 685,246 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624946620,581 - 685,339 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000002326   ⟹   ENSCLAP00000002277
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955580679,109 - 734,982 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000002327   ⟹   ENSCLAP00000002278
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955580679,109 - 730,168 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000002328   ⟹   ENSCLAP00000002279
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_004955580679,987 - 735,288 (-)Ensembl
RefSeq Acc Id: XM_013509691   ⟹   XP_013365145
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_004955580674,014 - 737,586 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013365145 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_013365145   ⟸   XM_013509691
- Sequence:
RefSeq Acc Id: ENSCLAP00000002279   ⟸   ENSCLAT00000002328
RefSeq Acc Id: ENSCLAP00000002278   ⟸   ENSCLAT00000002327
RefSeq Acc Id: ENSCLAP00000002277   ⟸   ENSCLAT00000002326
Protein Domains
MBD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001648 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000002277 ENTREZGENE
  ENSCLAP00000002277.1 UniProtKB/TrEMBL
  ENSCLAP00000002278.1 UniProtKB/TrEMBL
  ENSCLAP00000002279.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000002326 ENTREZGENE
  ENSCLAT00000002326.1 UniProtKB/TrEMBL
  ENSCLAT00000002327.1 UniProtKB/TrEMBL
  ENSCLAT00000002328.1 UniProtKB/TrEMBL
InterPro DNA-bd_dom_sf UniProtKB/TrEMBL
  Me_CpG-bd_MeCP2 UniProtKB/TrEMBL
  MeCP2/MBD4 UniProtKB/TrEMBL
  Methyl_CpG_DNA-bd UniProtKB/TrEMBL
NCBI Gene Mecp2 ENTREZGENE
PANTHER PTHR15074 UniProtKB/TrEMBL
Pfam MBD UniProtKB/TrEMBL
PIRSF Methyl_CpG_bd_MeCP2 UniProtKB/TrEMBL
PROSITE MBD UniProtKB/TrEMBL
SMART MBD UniProtKB/TrEMBL
Superfamily-SCOP SSF54171 UniProtKB/TrEMBL
UniProt A0A8C2UM80_CHILA UniProtKB/TrEMBL
  A0A8C2YJ15_CHILA UniProtKB/TrEMBL
  A0A8C2YJ18_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Mecp2  methyl-CpG binding protein 2    methyl CpG binding protein 2  Symbol and/or name change 5135510 APPROVED
2015-08-25 Mecp2  methyl CpG binding protein 2    methyl CpG binding protein 2 (Rett syndrome)  Symbol and/or name change 5135510 APPROVED