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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of actin filament polymerization
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Accession:GO:0030837 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
Comment:Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin depolymerization ; GO:0030835').
Synonyms:exact_synonym: down regulation of actin filament polymerization;   downregulation of actin filament polymerization;   negative regulation of actin polymerization
 narrow_synonym: inhibition of actin filament polymerization
 broad_synonym: negative regulation of actin polymerization and/or depolymerization

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negative regulation of actin filament polymerization term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Add1 adducin 1 ISO RGD PMID:8675693 RGD:7174724 NCBI chrNW_004936477:20,695,109...20,766,053
Ensembl chrNW_004936477:20,691,951...20,766,152 		JBrowse link
G Arfgef1 ADP ribosylation factor guanine nucleotide exchange factor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936496:6,807,388...6,914,960
Ensembl chrNW_004936496:6,807,403...6,914,987 		JBrowse link
G Bbs4 Bardet-Biedl syndrome 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23716571) Ensembl
MGI		 PMID:23716571 GO_REF:0000107 NCBI chrNW_004936471:31,962,500...32,019,516
Ensembl chrNW_004936471:31,962,336...32,020,712 		JBrowse link
G Capn1 calpain 1 ISO RGD PMID:25653381 RGD:13792590 NCBI chrNW_004936599:4,178,963...4,201,037
Ensembl chrNW_004936599:4,178,901...4,201,052 		JBrowse link
G Cyrib CYFIP related Rac1 interactor B involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936470:18,665,898...18,803,864
Ensembl chrNW_004936470:18,721,037...18,804,065 		JBrowse link
G Fhod3 formin homology 2 domain containing 3 acts_upstream_of_or_within ISO (PMID:19706596) MGI PMID:19706596 NCBI chrNW_004936517:8,614,384...9,044,894
Ensembl chrNW_004936517:8,614,867...9,044,894 		JBrowse link
G Hip1r huntingtin interacting protein 1 related involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936558:1,778,862...1,804,071
Ensembl chrNW_004936558:1,778,888...1,791,610 		JBrowse link
G Kank1 KN motif and ankyrin repeat domains 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17996375) MGI
TreeGrafter
InterPro
Ensembl		 PMID:17996375 GO_REF:0000002 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936503:4,125,302...4,255,880
Ensembl chrNW_004936503:4,122,204...4,246,680 		JBrowse link
G Kank2 KN motif and ankyrin repeat domains 2 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936659:1,320,169...1,340,137
Ensembl chrNW_004936659:1,321,980...1,337,746 		JBrowse link
G Kank3 KN motif and ankyrin repeat domains 3 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936588:5,155,833...5,168,656
Ensembl chrNW_004936588:5,156,095...5,164,627 		JBrowse link
G LOC101961439 twinfilin-2 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936529:3,538,813...3,555,562
Ensembl chrNW_004936529:3,538,862...3,555,593 		JBrowse link
G LOC101967251 profilin-2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,992,508...1,993,271 JBrowse link
G Mkks MKKS centrosomal shuttling protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23716571) Ensembl
MGI		 PMID:23716571 GO_REF:0000107 NCBI chrNW_004936485:9,089,118...9,114,396
Ensembl chrNW_004936485:9,088,963...9,115,175 		JBrowse link
G Myadm myeloid associated differentiation marker involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936994:78,989...83,536
Ensembl chrNW_004936994:80,439...83,536 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 ISO RGD PMID:17662049 RGD:7240703 NCBI chrNW_004936541:4,873,459...4,919,787
Ensembl chrNW_004936541:4,873,182...4,937,500 		JBrowse link
G Pfn1 profilin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936677:2,762,971...2,766,038
Ensembl chrNW_004936677:2,762,971...2,766,149 		JBrowse link
G Pfn2 profilin 2 involved_in IEA Ensembl GO_REF:0000107
G Prkcd protein kinase C delta involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:3,892,625...3,923,467
Ensembl chrNW_004936473:3,892,366...3,923,515 		JBrowse link
G Slit2 slit guidance ligand 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936477:8,111,212...8,448,567
Ensembl chrNW_004936477:8,109,228...8,446,653 		JBrowse link
G Ssh1 slingshot protein phosphatase 1 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936769:665,146...721,131
Ensembl chrNW_004936769:669,793...697,893 		JBrowse link
G Ssh2 slingshot protein phosphatase 2 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936538:5,735,806...5,990,480
Ensembl chrNW_004936538:5,735,797...5,990,546 		JBrowse link
G Ssh3 slingshot protein phosphatase 3 involved_in IEA InterPro
TreeGrafter		 GO_REF:0000002 GO_REF:0000118 NCBI chrNW_004936599:2,414,128...2,422,183
Ensembl chrNW_004936599:2,414,090...2,422,361 		JBrowse link
G Tlr2 toll like receptor 2 involved_in ISO (MGI:5307186|PMID:22198949) ARUK-UCL PMID:22198949 MGI:5307186 NCBI chrNW_004936576:522,234...531,660
Ensembl chrNW_004936576:527,434...529,788 		JBrowse link
G Twf1 twinfilin actin binding protein 1 involved_in IEA InterPro
Ensembl		 GO_REF:0000002 GO_REF:0000107 NCBI chrNW_004936512:2,280,266...2,293,101
Ensembl chrNW_004936512:2,280,064...2,293,117 		JBrowse link
actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avil advillin involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936646:1,930,447...1,952,069
Ensembl chrNW_004936646:1,930,656...1,948,991 		JBrowse link
G Capza1 capping actin protein of muscle Z-line subunit alpha 1 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936690:1,184,644...1,223,732 JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936589:2,194,332...2,234,547
Ensembl chrNW_004936589:2,194,332...2,234,653 		JBrowse link
G Capza3 capping actin protein of muscle Z-line subunit alpha 3 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936548:7,520,125...7,521,192
Ensembl chrNW_004936548:7,520,142...7,521,041 		JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936474:5,594,193...5,656,665
Ensembl chrNW_004936474:5,594,152...5,709,315 		JBrowse link
G Gsn gelsolin involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000043 GO_REF:0000107 NCBI chrNW_004936487:9,749,755...9,802,787
Ensembl chrNW_004936487:9,764,944...9,802,841 		JBrowse link
G LOC101975760 F-actin-capping protein subunit alpha-1-like involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004937099:167,936...179,340 JBrowse link
G Myh9 myosin heavy chain 9 NOT|involved_in ISO (MGI:5619440|PMID:23325791) UniProt PMID:23325791 MGI:5619440 NCBI chrNW_004936492:4,384,215...4,466,229
Ensembl chrNW_004936492:4,384,215...4,466,262 		JBrowse link
G Rdx radixin involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936612:3,992,542...4,060,598
Ensembl chrNW_004936612:3,992,542...4,040,315 		JBrowse link
G Scin scinderin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936795:418,874...495,990
Ensembl chrNW_004936795:418,436...495,936 		JBrowse link
G Spta1 spectrin alpha, erythrocytic 1 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936740:1,686,218...1,759,083
Ensembl chrNW_004936740:1,686,218...1,759,078 		JBrowse link
G Sptan1 spectrin alpha, non-erythrocytic 1 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936487:16,071,043...16,142,662
Ensembl chrNW_004936487:16,070,996...16,142,662 		JBrowse link
G Sptb spectrin beta, erythrocytic involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chrNW_004936495:8,415,950...8,540,590
Ensembl chrNW_004936495:8,415,912...8,486,039 		JBrowse link
G Sptbn1 spectrin beta, non-erythrocytic 1 involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chrNW_004936491:920,830...1,108,374
Ensembl chrNW_004936491:956,986...1,108,640 		JBrowse link
G Sptbn2 spectrin beta, non-erythrocytic 2 involved_in IEA UniProt GO_REF:0000043 GO_REF:0000104 NCBI chrNW_004936599:2,890,404...2,928,502
Ensembl chrNW_004936599:2,890,817...2,928,499 		JBrowse link
G Sptbn4 spectrin beta, non-erythrocytic 4 involved_in IEA UniProt GO_REF:0000043 NCBI chrNW_004936661:2,831,132...2,903,619
Ensembl chrNW_004936661:2,827,572...2,903,655 		JBrowse link
G Tpm1 tropomyosin 1 ISO RGD PMID:15779917 RGD:1600523 NCBI chrNW_004936471:23,643,645...23,670,775
Ensembl chrNW_004936471:23,643,613...23,670,775 		JBrowse link
G Vil1 villin 1 involved_in IEA Ensembl
UniProt		 GO_REF:0000043 GO_REF:0000107 NCBI chrNW_004936569:914,511...938,481
Ensembl chrNW_004936569:914,512...938,608 		JBrowse link
barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Add1 adducin 1 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936477:20,695,109...20,766,053
Ensembl chrNW_004936477:20,691,951...20,766,152 		JBrowse link
G Add2 adducin 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936491:14,856,764...14,971,161
Ensembl chrNW_004936491:14,862,531...14,971,329 		JBrowse link
G Add3 adducin 3 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936486:928,956...1,042,168
Ensembl chrNW_004936486:928,522...1,043,084 		JBrowse link
G Avil advillin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936646:1,930,447...1,952,069
Ensembl chrNW_004936646:1,930,656...1,948,991 		JBrowse link
G Capg capping actin protein, gelsolin like involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936712:1,793,666...1,803,621
Ensembl chrNW_004936712:1,793,480...1,806,602 		JBrowse link
G Capza1 capping actin protein of muscle Z-line subunit alpha 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17656356) UniProt
MGI
TreeGrafter
InterPro		 PMID:17656356 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004936690:1,184,644...1,223,732 JBrowse link
G Capza2 capping actin protein of muscle Z-line subunit alpha 2 involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004936589:2,194,332...2,234,547
Ensembl chrNW_004936589:2,194,332...2,234,653 		JBrowse link
G Capza3 capping actin protein of muscle Z-line subunit alpha 3 involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004936548:7,520,125...7,521,192
Ensembl chrNW_004936548:7,520,142...7,521,041 		JBrowse link
G Capzb capping actin protein of muscle Z-line subunit beta involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004936474:5,594,193...5,656,665
Ensembl chrNW_004936474:5,594,152...5,709,315 		JBrowse link
G Dbnl drebrin like NOT|acts_upstream_of_or_within ISO (PMID:10637315) MGI PMID:10637315 NCBI chrNW_004936478:19,007,630...19,021,068
Ensembl chrNW_004936478:19,007,672...19,020,361 		JBrowse link
G Eps8 EGFR pathway substrate 8, signaling adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936587:1,785,721...1,951,474
Ensembl chrNW_004936587:1,785,303...1,951,332 		JBrowse link
G Flii FLII actin remodeling protein involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936741:1,784,802...1,796,176
Ensembl chrNW_004936741:1,783,589...1,796,168 		JBrowse link
G Gsn gelsolin involved_in IEA UniProt
TreeGrafter		 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004936487:9,749,755...9,802,787
Ensembl chrNW_004936487:9,764,944...9,802,841 		JBrowse link
G LOC101961439 twinfilin-2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936529:3,538,813...3,555,562
Ensembl chrNW_004936529:3,538,862...3,555,593 		JBrowse link
G LOC101975760 F-actin-capping protein subunit alpha-1-like involved_in IEA InterPro
TreeGrafter
UniProt		 GO_REF:0000002 GO_REF:0000104 GO_REF:0000118 NCBI chrNW_004937099:167,936...179,340 JBrowse link
G Rdx radixin ISO RGD PMID:2500445 RGD:8693627 NCBI chrNW_004936612:3,992,542...4,060,598
Ensembl chrNW_004936612:3,992,542...4,040,315 		JBrowse link
G Scin scinderin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936795:418,874...495,990
Ensembl chrNW_004936795:418,436...495,936 		JBrowse link
G Svil supervillin involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936613:4,391,928...4,540,125
Ensembl chrNW_004936613:4,404,711...4,542,890 		JBrowse link
G Twf1 twinfilin actin binding protein 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936512:2,280,266...2,293,101
Ensembl chrNW_004936512:2,280,064...2,293,117 		JBrowse link
G Vil1 villin 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936569:914,511...938,481
Ensembl chrNW_004936569:914,512...938,608 		JBrowse link
negative regulation of barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Carmil1 capping protein regulator and myosin 1 linker 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936671:1,404,595...1,632,916
Ensembl chrNW_004936671:1,404,589...1,633,328 		JBrowse link
G Carmil2 capping protein regulator and myosin 1 linker 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936475:18,036,233...18,049,144
Ensembl chrNW_004936475:18,035,994...18,049,129 		JBrowse link
G Cracd capping protein inhibiting regulator of actin dynamics involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936482:18,309,078...18,557,335 JBrowse link
pointed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lmod1 leiomodin 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936567:2,557,090...2,598,069
Ensembl chrNW_004936567:2,557,080...2,596,818 		JBrowse link
G Lmod2 leiomodin 2 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936605:1,829,187...1,838,385
Ensembl chrNW_004936605:1,830,405...1,838,400 		JBrowse link
G Lmod3 leiomodin 3 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936603:1,510,330...1,520,741
Ensembl chrNW_004936603:1,510,330...1,520,911 		JBrowse link
G Tmod1 tropomodulin 1 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936524:6,347,089...6,403,996
Ensembl chrNW_004936524:6,326,400...6,403,057 		JBrowse link
G Tmod2 tropomodulin 2 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936471:13,602,769...13,636,258
Ensembl chrNW_004936471:13,602,732...13,729,228 		JBrowse link
G Tmod3 tropomodulin 3 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936471:13,652,532...13,729,311
Ensembl chrNW_004936471:13,602,732...13,729,228 		JBrowse link
G Tmod4 tropomodulin 4 involved_in IEA InterPro GO_REF:0000002 NCBI chrNW_004936580:1,375,184...1,380,423
Ensembl chrNW_004936580:1,375,173...1,380,423 		JBrowse link
positive regulation of barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpc2 actin related protein 2/3 complex subunit 2 ISO RGD PMID:15252126 RGD:2306210 NCBI chrNW_004936569:758,358...786,995
Ensembl chrNW_004936569:758,199...786,760 		JBrowse link
G Cfl1 cofilin 1 ISO RGD PMID:23704350 RGD:11570555 NCBI chrNW_004936599:3,678,724...3,682,314
Ensembl chrNW_004936599:3,677,804...3,682,307 		JBrowse link
regulation of barbed-end actin filament capping term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd16 ankyrin repeat domain 16 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936484:8,690,183...8,700,705
Ensembl chrNW_004936484:8,690,090...8,701,499 		JBrowse link
G Asb10 ankyrin repeat and SOCS box containing 10 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936527:6,589,105...6,598,591
Ensembl chrNW_004936527:6,589,021...6,598,591 		JBrowse link
G Asb12 ankyrin repeat and SOCS box containing 12 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936635:3,447,347...3,453,762
Ensembl chrNW_004936635:3,447,345...3,453,762 		JBrowse link
G Asb16 ankyrin repeat and SOCS box containing 16 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936541:638,266...646,463
Ensembl chrNW_004936541:638,319...646,167 		JBrowse link
G Mtpn myotrophin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936592:644,618...679,615
Ensembl chrNW_004936592:644,430...679,800 		JBrowse link
sequestering of actin monomers term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsn gelsolin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936487:9,749,755...9,802,787
Ensembl chrNW_004936487:9,764,944...9,802,841 		JBrowse link
G LOC101961439 twinfilin-2 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936529:3,538,813...3,555,562
Ensembl chrNW_004936529:3,538,862...3,555,593 		JBrowse link
G Pfn4 profilin family member 4 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936493:7,888,211...7,891,273
Ensembl chrNW_004936493:7,888,968...7,892,000 		JBrowse link
G Scin scinderin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936795:418,874...495,990
Ensembl chrNW_004936795:418,436...495,936 		JBrowse link
G Tmsb10 thymosin beta 10 involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936650:3,686,995...3,688,047 JBrowse link
G Tmsb15b thymosin beta 15B involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936499:10,315,198...10,318,382 JBrowse link
G Tmsb4x thymosin beta 4 X-linked involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936470:2,668,525...2,670,611
Ensembl chrNW_004936470:2,668,016...2,670,770 		JBrowse link
G Twf1 twinfilin actin binding protein 1 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936512:2,280,266...2,293,101
Ensembl chrNW_004936512:2,280,064...2,293,117 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15975
    cellular process 15075
      negative regulation of cellular process 4821
        negative regulation of cellular component organization 764
          negative regulation of supramolecular fiber organization 180
            negative regulation of actin filament polymerization 70
              actin filament capping + 45
              sequestering of actin monomers 8
Path 2
Term Annotations click to browse term
  biological_process 15975
    cellular process 15075
      cellular component organization or biogenesis 6485
        cellular component organization 6273
          organelle organization 3510
            cytoskeleton organization 1468
              actin cytoskeleton organization 717
                actin filament organization 463
                  actin polymerization or depolymerization 206
                    regulation of actin polymerization or depolymerization 164
                      regulation of actin filament polymerization 144
                        negative regulation of actin filament polymerization 70
                          actin filament capping + 45
                          sequestering of actin monomers 8
paths to the root