Carmil2 (capping protein regulator and myosin 1 linker 2)

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Gene: Carmil2 (capping protein regulator and myosin 1 linker 2) Ictidomys tridecemlineatus

Analyze

Symbol:

Carmil2

Name:

capping protein regulator and myosin 1 linker 2

RGD ID:

12646778

Description:

ENCODES a protein that exhibits phospholipid binding (inferred); protein-containing complex binding (inferred); INVOLVED IN establishment of protein localization (ortholog); homeostasis of number of cells (ortholog); positive regulation of interferon-gamma production (ortholog); ASSOCIATED WITH autosomal dominant dyskeratosis congenita 6 (ortholog); chromosome 16q22 deletion syndrome (ortholog); combined immunodeficiency (ortholog); FOUND IN cell-cell junction (ortholog); F-actin capping protein complex (ortholog); immunological synapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

capping protein, Arp2/3 and myosin-I linker protein 2; LOW QUALITY PROTEIN: capping protein, Arp2/3 and myosin-I linker protein 2; LOW QUALITY PROTEIN: leucine-rich repeat-containing protein 16C

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	41,539,934 - 41,553,241 (-)	NCBI
SpeTri2.0	NW_004936475	18,036,233 - 18,049,144 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant dyskeratosis congenita 6 (ISO)

chromosome 16q22 deletion syndrome (ISO)

combined immunodeficiency (ISO)

combined T cell and B cell immunodeficiency (ISO)

immunodeficiency 58 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin filament network formation (IEA)

cell migration (IEA)

establishment of protein localization (ISO)

establishment or maintenance of cell polarity (IEA)

establishment or maintenance of monopolar cell polarity (IEA)

homeostasis of number of cells (ISO)

maintenance of cell polarity (IEA)

negative regulation of barbed-end actin filament capping (IEA)

positive regulation of cell migration (IEA)

positive regulation of extracellular matrix disassembly (IEA)

positive regulation of interferon-gamma production (ISO)

positive regulation of interleukin-2 production (ISO)

positive regulation of lamellipodium assembly (IEA)

positive regulation of lamellipodium organization (IEA)

positive regulation of regulatory T cell differentiation (ISO)

positive regulation of ruffle assembly (IEA)

positive regulation of T cell proliferation (ISO)

T cell receptor signaling pathway (ISO)

thymus development (ISO)

wound healing, spreading of cells (IEA)

Cellular Component

actin cytoskeleton (IEA)

cell leading edge (IEA)

cell-cell junction (ISO)

cellular anatomical entity (IEA)

cytoplasm (IEA)

F-actin capping protein complex (ISO)

immunological synapse (ISO)

intermediate filament cytoskeleton (IEA)

lamellipodium (IEA)

macropinosome (IEA)

plasma membrane (IEA)

ruffle (IEA)

Molecular Function

phospholipid binding (IEA)

protein binding (ISO)

protein-containing complex binding (IEA)

References

Genomics

Comparative Map Data

Carmil2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	41,539,934 - 41,553,241 (-)	NCBI
SpeTri2.0	NW_004936475	18,036,233 - 18,049,144 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CARMIL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	67,645,144 - 67,657,569 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	16	67,644,988 - 67,657,569 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	67,679,047 - 67,691,472 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	66,236,531 - 66,248,973 (+)	NCBI	NCBI36		hg18	NCBI36
Celera	16	52,187,520 - 52,199,962 (+)	NCBI
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	53,551,938 - 53,564,384 (+)	NCBI		HuRef
CHM1_1	16	69,086,723 - 69,099,185 (+)	NCBI		CHM1_1

Carmil2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	106,412,642 - 106,424,827 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	8	106,412,906 - 106,424,819 (+)	Ensembl
GRCm38	8	105,686,010 - 105,698,195 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	105,686,274 - 105,698,187 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	108,214,806 - 108,222,065 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	108,580,035 - 108,587,294 (+)	NCBI			mm8
Celera	8	109,915,749 - 109,923,083 (+)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI

Carmil2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	33,571,255 - 33,586,783 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	19	33,574,257 - 33,586,965 (+)	Ensembl
Rnor_6.0	19	37,652,383 - 37,665,333 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	37,652,969 - 37,668,019 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	48,519,170 - 48,532,037 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	35,515,397 - 35,530,595 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	19	33,001,781 - 33,014,730 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

Carmil2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955484	9,025,460 - 9,037,580 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955484	9,025,409 - 9,037,942 (-)	NCBI	ChiLan1.0	ChiLan1.0

CARMIL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	16	67,378,283 - 67,390,760 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	67,378,353 - 67,390,709 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	16	47,989,040 - 48,001,455 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

CARMIL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	81,792,683 - 81,804,274 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	81,792,155 - 81,804,152 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	81,782,441 - 81,794,868 (-)	NCBI
ROS_Cfam_1.0	5	82,227,854 - 82,240,296 (-)	NCBI
ROS_Cfam_1.0 Ensembl	5	82,227,874 - 82,239,343 (-)	Ensembl
UMICH_Zoey_3.1	5	82,054,178 - 82,066,594 (-)	NCBI
UNSW_CanFamBas_1.0	5	81,735,709 - 81,748,107 (-)	NCBI
UU_Cfam_GSD_1.0	5	82,378,251 - 82,390,674 (-)	NCBI

CARMIL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	28,264,320 - 28,279,703 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	28,265,130 - 28,277,649 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	25,490,372 - 25,498,577 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CARMIL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	59,787,069 - 59,801,615 (-)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	5	59,787,120 - 59,801,122 (-)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666047	22,540,823 - 22,553,913 (-)	NCBI	Vero_WHO_p1.0

Carmil2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624746	18,692,179 - 18,704,952 (-)	NCBI	HetGla_female_1.0		hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_021721661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040278886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040278887	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040278888	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040278889	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

XM_040278886 ⟹ XP_040134820

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	41,539,934 - 41,553,240 (-)	NCBI

RefSeq Acc Id:

XM_040278887 ⟹ XP_040134821

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	41,539,934 - 41,553,240 (-)	NCBI

RefSeq Acc Id:

XM_040278888 ⟹ XP_040134822

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	41,539,934 - 41,553,240 (-)	NCBI

RefSeq Acc Id:

XM_040278889 ⟹ XP_040134823

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	41,539,934 - 41,553,241 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_040134820	(Get FASTA)	NCBI Sequence Viewer
	XP_040134821	(Get FASTA)	NCBI Sequence Viewer
	XP_040134822	(Get FASTA)	NCBI Sequence Viewer
	XP_040134823	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_040134823 ⟸ XM_040278889
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_040134821 ⟸ XM_040278887
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_040134822 ⟸ XM_040278888
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_040134820 ⟸ XM_040278886
- Peptide Label:	isoform X1

Protein Domains

Carm_PH CARMIL_C

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000016451	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSSTOP00000014727	UniProtKB/TrEMBL
	ENSSTOP00000025703	UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000016455	UniProtKB/TrEMBL
	ENSSTOT00000040806	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
	3.80.10.10	UniProtKB/TrEMBL
InterPro	CARMIL2	UniProtKB/TrEMBL
	CARMIL_C	UniProtKB/TrEMBL
	CARMIL_PH	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/TrEMBL
	PH-like_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Carmil2	ENTREZGENE
PANTHER	PTHR24112:SF32	UniProtKB/TrEMBL
Pfam	Carm_PH	UniProtKB/TrEMBL
	CARMIL_C	UniProtKB/TrEMBL
	LRR_6	UniProtKB/TrEMBL
UniProt	A0A287CWP8_ICTTR	UniProtKB/TrEMBL
	I3MRK3_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM