Asb12 (ankyrin repeat and SOCS box containing 12)

Gene: Asb12 (ankyrin repeat and SOCS box containing 12) Ictidomys tridecemlineatus

Analyze

Symbol:

Asb12

Name:

ankyrin repeat and SOCS box containing 12

RGD ID:

12694409

Description:

ENCODES a protein that exhibits ubiquitin protein ligase activity (ortholog); INVOLVED IN intracellular signal transduction (inferred); protein ubiquitination (inferred); regulation of barbed-end actin filament capping (inferred); ASSOCIATED WITH autistic disorder (ortholog); developmental and epileptic encephalopathy 8 (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred); ubiquitin ligase complex (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

ankyrin repeat and SOCS box protein 12

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	52,681,728 - 52,688,167 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936635	3,447,345 - 3,453,762 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936635	3,447,347 - 3,453,762 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

developmental and epileptic encephalopathy 8 (ISO)

genetic disease (ISO)

osteopathia striata with cranial sclerosis (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (IEA)

protein ubiquitination (IEA)

regulation of barbed-end actin filament capping (IEA)

Cellular Component

cytoplasm (IEA)

nucleus (IEA)

ubiquitin ligase complex (IEA)

Molecular Function

protein binding (ISO)

ubiquitin protein ligase activity (IEA,ISO)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

Asb12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	52,681,728 - 52,688,167 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936635	3,447,345 - 3,453,762 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936635	3,447,347 - 3,453,762 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ASB12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	64,224,194 - 64,230,607 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	64,224,194 - 64,230,607 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	63,444,074 - 63,450,487 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	63,360,801 - 63,362,228 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	63,227,096 - 63,228,524	NCBI
Celera	X	63,790,909 - 63,792,336 (-)	NCBI		Celera
Cytogenetic Map	X	q11.2	NCBI
HuRef	X	57,267,791 - 57,274,235 (-)	NCBI		HuRef
CHM1_1	X	63,336,514 - 63,342,953 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	62,649,469 - 62,655,882 (-)	NCBI		T2T-CHM13v2.0

Asb12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	94,513,125 - 94,601,610 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	94,513,807 - 94,601,593 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	95,469,527 - 95,558,004 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	95,470,201 - 95,557,987 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	92,665,538 - 92,673,468 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	91,672,918 - 91,680,848 (-)	NCBI		MGSCv36	mm8
Celera	X	82,496,210 - 82,504,159 (-)	NCBI		Celera
Cytogenetic Map	X	C3	NCBI
cM Map	X	41.99	NCBI

Asb12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	64,338,223 - 64,487,615 (-)	NCBI		GRCr8
mRatBN7.2	X	60,328,325 - 60,478,031 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	60,328,328 - 60,415,619 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	61,798,577 - 61,886,086 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	65,299,093 - 65,386,606 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	62,878,056 - 62,965,560 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	64,714,337 - 64,800,662 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	64,714,335 - 64,800,435 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	65,613,501 - 65,699,198 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	83,013,812 - 83,102,298 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	60,748,301 - 60,835,640 (-)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

Asb12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955475	4,433,390 - 4,437,337 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955475	4,429,854 - 4,436,633 (+)	NCBI	ChiLan1.0	ChiLan1.0

ASB12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	63,757,167 - 63,759,793 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	63,760,773 - 63,763,399 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	53,348,975 - 53,443,379 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	63,430,743 - 63,524,962 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	63,430,743 - 63,437,181 (-)	Ensembl	panpan1.1		panPan2

ASB12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	49,459,926 - 49,465,761 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	49,462,751 - 49,469,686 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	40,298,160 - 40,300,942 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	49,786,908 - 49,789,690 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	49,783,615 - 49,793,541 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	48,442,339 - 48,445,902 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	49,741,613 - 49,744,395 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	49,195,543 - 49,198,325 (-)	NCBI		UU_Cfam_GSD_1.0

ASB12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	50,877,166 - 50,878,674 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	50,877,158 - 50,883,739 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ASB12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	54,606,229 - 54,619,813 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	54,606,233 - 54,612,632 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666083	1,863,505 - 1,866,180 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Asb12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624898	2,685,887 - 2,693,086 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624898	2,686,067 - 2,692,631 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005335215	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040282409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSSTOT00000025087 ⟹ ENSSTOP00000015485

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936635	3,447,345 - 3,453,762 (+)	Ensembl

RefSeq Acc Id:

XM_005335215 ⟹ XP_005335272

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	52,681,728 - 52,688,167 (+)	NCBI
SpeTri2.0	NW_004936635	3,447,347 - 3,453,762 (+)	NCBI

Sequence:

show sequence

ACAGTGGAAAAAGAGGGCCCCTTCTACTCTAGCCCAGGGCAGTAGGGGCTCCCCATGCAGGGTC
CACCAGGGCCCAAGTATATCGAAGAGGCACAGAGGAAGCAACACAGTTCAGTGTGGCCTCAGGC
CGAAGTCTTATCTGGCATGTCTTCCTCCTCATAATGAAAGTAGTCCTGTTACAATCAGCCAAAA
TGAACCTCATGGATATCACCAAGATCTTCTCCCTCCTGCAGCCCGAAAAAGAGGAGGAGGACAC
AAACACTGGGGAAAAACAGGCTCTCAATCAAGCAGTGTATGACAACGACTCCCATACCTTGGAT
CAGCTTCTACGCCAGGAGCGTTACAAACGTTTCATCAATAGCAGGAGTGGCTGGGGTGTTCCTG
GGACACCCTTGCGCTTAGCTGCTTCTTATGGACACTTGAGCTGTGTGCAGGTCCTCCTGGCACA
TGGCGCTGATGTTGACAGTTTGGACGTCAAGGCACAGACACCACTTTTCACTGCCGTCAGTCAT
GGCCATCTGGACTGTGTGCGTGTGCTTTTAGAAGCTGGTGCATGTCCTGGAGGTAGCATCTACA
ACAATTGTTCTCCTGTGCTCACAGCTGCACGTGATGGTGCTATTGCCATCCTGCAAGAGCTCCT
AGGCCATGGTGCAGAGCCCAATGTCAAGGCTAAGCTACCAGTGTGGGCATCAAATATAGCTTCA
TGTTCTGGCCCTCTCTATTTGGCTGCAGTCTATGGACACCTGGACTGTTTCCGCCTGCTTTTGC
TCTATGGGGCAGATCCTGATTACAACTGCACTGACAAGGGCCTACTAGCTCGTGTTCCACGACC
CCGCACCCTCCTTGATATCTGCTTTCACCATAATTGTGCGCCAGAGTATATCCAGCTGTTAATT
GATTTTGGTGCTAATGTCTACCTTCCATCTCTCCCTCTGGACCAGACCTCTCATGATGATAAAG
GTGTTACATTGCTGATACAGGCCCGAGCCACTCCACGGTCACTCCTATCCCAGGCCCGTTTAGT
TATCCGCAGAGCCCTGCGCCAGACCTGCCAGCCACAAGCCATCGACCAGCTGGAAATTCCCCCC
GTGTTGATTAGCTACCTCAAACACCAAACATGATCTTGCAATGTTTCCAGGAACCCATGATGCC
TCCAAAAACCACCTAAGGACCCAGGTAGCTGTAGGGCACAACAACCCACTCAACTGGAGCTGTC
CTCCCATATTATCCTCCATGATTAAATCCTCAGCAAAAAGT

hide sequence

RefSeq Acc Id:

XM_040282409 ⟹ XP_040138343

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	52,684,579 - 52,688,167 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005335272	(Get FASTA)	NCBI Sequence Viewer
	XP_040138343	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000015485.2

RefSeq Acc Id:	XP_005335272 ⟸ XM_005335215
- Peptide Label:	isoform X2
- UniProtKB:	I3MTP0 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKVVLLQSAKMNLMDITKIFSLLQPEKEEEDTNTGEKQALNQAVYDNDSHTLDQLLRQERYKRF INSRSGWGVPGTPLRLAASYGHLSCVQVLLAHGADVDSLDVKAQTPLFTAVSHGHLDCVRVLLE AGACPGGSIYNNCSPVLTAARDGAIAILQELLGHGAEPNVKAKLPVWASNIASCSGPLYLAAVY GHLDCFRLLLLYGADPDYNCTDKGLLARVPRPRTLLDICFHHNCAPEYIQLLIDFGANVYLPSL PLDQTSHDDKGVTLLIQARATPRSLLSQARLVIRRALRQTCQPQAIDQLEIPPVLISYLKHQT hide sequence

RefSeq Acc Id:	XP_040138343 ⟸ XM_040282409
- Peptide Label:	isoform X1
- UniProtKB:	I3MTP0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSSTOP00000015485 ⟸ ENSSTOT00000025087

Protein Domains

SOCS box

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000022386	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000025087.2	UniProtKB/TrEMBL
Gene3D-CATH	1.25.40.20	UniProtKB/TrEMBL
	SOCS box	UniProtKB/TrEMBL
InterPro	Ankyrin_rpt	UniProtKB/TrEMBL
	Ankyrin_rpt-contain_sf	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
	SOCS_box-like_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Asb12	ENTREZGENE
PANTHER	MYOTROPHIN	UniProtKB/TrEMBL
	MYOTROPHIN-RELATED	UniProtKB/TrEMBL
Pfam	Ank	UniProtKB/TrEMBL
	Ank_2	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
PROSITE	ANK_REP_REGION	UniProtKB/TrEMBL
	ANK_REPEAT	UniProtKB/TrEMBL
	SOCS	UniProtKB/TrEMBL
SMART	ANK	UniProtKB/TrEMBL
	SOCS_box	UniProtKB/TrEMBL
Superfamily-SCOP	SSF158235	UniProtKB/TrEMBL
	SSF48403	UniProtKB/TrEMBL
UniProt	I3MTP0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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