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ONTOLOGY REPORT - ANNOTATIONS


Term:telomerase holoenzyme complex
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Accession:GO:0005697 term browser browse the term
Definition:Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.



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telomerase holoenzyme complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acd ACD, shelterin complex subunit and telomerase recruitment factor part_of IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr19:33,586,739...33,589,481
Ensembl chr19:33,586,745...33,589,461
JBrowse link
G Dkc1 dyskerin pseudouridine synthase 1 part_of ISO
ISS
(PMID:12135483), (PMID:18082603), (PMID:29695869)
GO_REF:0000024
RGD
UniProt
PMID:12135483 PMID:18082603 PMID:29695869 GO_REF:0000024
G Gar1 GAR1 ribonucleoprotein part_of ISO
ISS
(PMID:29695869)
GO_REF:0000024
RGD
UniProt
PMID:29695869 GO_REF:0000024 NCBI chr 2:218,375,231...218,382,509
Ensembl chr 2:218,375,353...218,382,524
JBrowse link
G Gnl3l G protein nucleolar 3 like part_of ISO (PMID:18082603) RGD PMID:18082603 NCBI chr  X:19,961,277...19,994,454
Ensembl chr  X:19,958,603...19,994,508
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C part_of ISO (PMID:18082603) RGD PMID:18082603 NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U part_of IBA
ISO
IEA
PMID:21873635
(PMID:18082603)
GO_REF:0000107
RGD
Ensembl
PMID:18082603 PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr13:90,069,058...90,086,905
Ensembl chr13:90,074,181...90,086,588
JBrowse link
G Lsm11 LSM11, U7 small nuclear RNA associated part_of ISO (PMID:18082603) RGD PMID:18082603 NCBI chr10:30,367,841...30,385,956
Ensembl chr10:30,370,727...30,385,944
JBrowse link
G Nat10 N-acetyltransferase 10 part_of ISO (PMID:18082603) RGD PMID:18082603 NCBI chr 3:90,111,643...90,151,644
Ensembl chr 3:90,111,645...90,149,927
JBrowse link
G Nhp2 NHP2 ribonucleoprotein part_of ISO (PMID:18082603), (PMID:29695869) RGD PMID:18082603 PMID:29695869 NCBI chr10:35,877,015...35,880,409
Ensembl chr10:35,877,054...35,882,545
JBrowse link
G Nop10 NOP10 ribonucleoprotein part_of ISO (PMID:18082603), (PMID:29695869) RGD PMID:18082603 PMID:29695869 NCBI chr 3:99,066,857...99,067,942
Ensembl chr 3:99,066,857...99,067,942
JBrowse link
G Nvl nuclear VCP-like part_of ISO (PMID:22226966) RGD PMID:22226966 NCBI chr13:92,851,023...92,906,749
Ensembl chr13:92,853,650...92,906,049
JBrowse link
G Ptges3 prostaglandin E synthase 3 part_of ISO (PMID:12135483) RGD PMID:12135483 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084
JBrowse link
G Smg5 SMG5 nonsense mediated mRNA decay factor part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:173,804,987...173,832,102
Ensembl chr 2:173,805,019...173,832,102
JBrowse link
G Smg6 SMG6 nonsense mediated mRNA decay factor part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:59,786,258...60,014,395
Ensembl chr10:59,786,258...60,014,395
JBrowse link
G Smg7 SMG7 nonsense mediated mRNA decay factor part_of IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:64,986,145...65,050,698
Ensembl chr13:64,987,434...65,050,582
JBrowse link
G Snrpb small nuclear ribonucleoprotein polypeptides B and B1 part_of ISO (PMID:18082603) RGD PMID:18082603 NCBI chr 3:117,369,816...117,379,344
Ensembl chr 3:117,370,100...117,379,339
JBrowse link
G Snrpd3 small nuclear ribonucleoprotein D3 polypeptide part_of ISO (PMID:18082603) RGD PMID:18082603 NCBI chr20:13,130,112...13,145,947
Ensembl chr20:13,130,119...13,145,978
JBrowse link
G Snrpe small nuclear ribonucleoprotein polypeptide E part_of ISO (PMID:18082603) RGD PMID:18082603 NCBI chr13:45,050,986...45,057,231
Ensembl chr13:45,050,986...45,057,310
JBrowse link
G Tep1 telomerase associated protein 1 part_of IEA
IBA
ISO
IDA
GO_REF:0000107
PMID:21873635
(PMID:12135483)
PMID:9118230
(MGI:85699|PMID:9020079)
Ensembl
RGD
PMID:9020079 PMID:12135483 PMID:21873635 PMID:9118230 GO_REF:0000107 MGI:85699, RGD:13792537, RGD:1299082 NCBI chr15:24,045,876...24,093,526
Ensembl chr15:24,045,878...24,093,526
JBrowse link
G Terc telomerase RNA component part_of ISO MGI:1857930 (MGI:1097832|PMID:9335332)
UniProtKB:O14746 (PMID:19701182)
RGD PMID:9335332 PMID:19701182 MGI:1097832 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Tert telomerase reverse transcriptase part_of ISO
ISS
RNAcentral:URS00004A7003_9606 (PMID:12135483), (PMID:18082603), (PMID:19701182), (PMID:29695869)
GO_REF:0000024
RGD
UniProt
PMID:12135483 PMID:18082603 PMID:19701182 PMID:29695869 GO_REF:0000024 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link
G Wrap53 WD repeat containing, antisense to TP53 part_of ISO
ISS
(PMID:19179534), (PMID:26170453), (PMID:29695869), (PMID:29804836)
GO_REF:0000024
RGD
UniProt
PMID:19179534 PMID:26170453 PMID:29695869 PMID:29804836 GO_REF:0000024 NCBI chr10:54,282,092...54,299,908
Ensembl chr10:54,282,105...54,298,929
JBrowse link
box H/ACA telomerase RNP complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkc1 dyskerin pseudouridine synthase 1 part_of ISO (PMID:18082603) RGD PMID:18082603
G Gar1 GAR1 ribonucleoprotein part_of ISO (PMID:10757788) RGD PMID:10757788 NCBI chr 2:218,375,231...218,382,509
Ensembl chr 2:218,375,353...218,382,524
JBrowse link
G Nhp2 NHP2 ribonucleoprotein part_of ISO (PMID:18082603) RGD PMID:18082603 NCBI chr10:35,877,015...35,880,409
Ensembl chr10:35,877,054...35,882,545
JBrowse link
G Nop10 NOP10 ribonucleoprotein part_of IBA
ISO
PMID:21873635
(PMID:18082603)
RGD PMID:18082603 PMID:21873635 RGD:13792537 NCBI chr 3:99,066,857...99,067,942
Ensembl chr 3:99,066,857...99,067,942
JBrowse link
G Terc telomerase RNA component part_of ISO (PMID:10757788), (PMID:18082603) RGD PMID:10757788 PMID:18082603 NCBI chr 2:112,815,654...112,816,041 JBrowse link
telomerase catalytic core complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Terc telomerase RNA component part_of ISO (PMID:11313459), (PMID:18082603), (PMID:19701182), (PMID:9398860), (PMID:9443919) RGD PMID:9398860 PMID:9443919 PMID:11313459 PMID:18082603 PMID:19701182 NCBI chr 2:112,815,654...112,816,041 JBrowse link
G Tert telomerase reverse transcriptase part_of ISO
IBA
RNAcentral:URS00004A7003_9606 (PMID:11313459), (PMID:16507993), (PMID:17940095), (PMID:18082603), (PMID:19701182), (PMID:9398860), (PMID:9443919)
PMID:21873635
(MGI:3588604|PMID:16037417)
RGD PMID:9398860 PMID:9443919 PMID:11313459 PMID:16037417 PMID:16507993 More... MGI:3588604, RGD:13792537 NCBI chr 1:29,637,213...29,659,509
Ensembl chr 1:29,637,506...29,659,561
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20630
    protein-containing complex 6398
      catalytic complex 1809
        telomerase holoenzyme complex 22
          box H/ACA telomerase RNP complex 5
          telomerase catalytic core complex 2
Path 2
Term Annotations click to browse term
  cellular_component 20630
    cellular anatomical entity 20384
      organelle 13567
        membrane-bounded organelle 12079
          intracellular membrane-bounded organelle 11574
            nucleus 7235
              nuclear protein-containing complex 1348
                telomerase holoenzyme complex 22
                  box H/ACA telomerase RNP complex 5
                  telomerase catalytic core complex 2
paths to the root