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ONTOLOGY REPORT - ANNOTATIONS


Term:telomerase holoenzyme complex
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Accession:GO:0005697 term browser browse the term
Definition:Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits.


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telomerase holoenzyme complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkc1 dyskerin pseudouridine synthase 1 ISS
ISO
GO_REF:0000024
(PMID:12135483), (PMID:18082603), (PMID:29695869)
UniProt
RGD
PMID:12135483 PMID:18082603 PMID:29695869 GO_REF:0000024 NCBI chr  X:155,844,914...155,862,363
Ensembl chr  X:155,844,857...155,862,475
JBrowse link
G Gar1 GAR1 ribonucleoprotein ISS
ISO
GO_REF:0000024
(PMID:29695869)
UniProt
RGD
PMID:29695869 GO_REF:0000024 NCBI chr 2:235,250,453...235,258,464
Ensembl chr 2:235,250,453...235,257,731
JBrowse link
G Gnl3l G protein nucleolar 3 like ISO (PMID:18082603) RGD PMID:18082603 NCBI chr  X:20,037,558...20,070,505
Ensembl chr  X:20,034,882...20,070,578
JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C ISO (PMID:18082603) RGD PMID:18082603 NCBI chr15:28,486,605...28,517,353
Ensembl chr15:28,486,617...28,517,353
JBrowse link
G Hnrnpu heterogeneous nuclear ribonucleoprotein U IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:18082603)
Ensembl
RGD
PMID:18082603, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr13:96,222,093...96,238,845
Ensembl chr13:96,225,912...96,238,572
JBrowse link
G Lsm11 LSM11, U7 small nuclear RNA associated ISO (PMID:18082603) RGD PMID:18082603 NCBI chr10:31,023,561...31,041,700
Ensembl chr10:31,028,697...31,041,626
JBrowse link
G Nat10 N-acetyltransferase 10 ISO (PMID:18082603) RGD PMID:18082603 NCBI chr 3:93,658,119...93,698,136
Ensembl chr 3:93,658,117...93,698,136
JBrowse link
G Nhp2 NHP2 ribonucleoprotein ISO (PMID:18082603), (PMID:29695869) RGD PMID:18082603 PMID:29695869 NCBI chr10:34,975,701...34,979,082
Ensembl chr10:34,975,708...34,979,082
JBrowse link
G Nop10 NOP10 ribonucleoprotein ISO (PMID:18082603), (PMID:29695869) RGD PMID:18082603 PMID:29695869 NCBI chr 3:103,747,654...103,748,739
Ensembl chr 3:103,747,654...103,748,739
JBrowse link
G Nvl nuclear VCP-like ISO (PMID:22226966) RGD PMID:22226966 NCBI chr13:99,410,026...99,468,783
Ensembl chr13:99,410,026...99,468,778
JBrowse link
G Ptges3 prostaglandin E synthase 3 ISO (PMID:12135483) RGD PMID:12135483 NCBI chr 7:2,479,267...2,497,024
Ensembl chr 7:2,479,311...2,497,013
JBrowse link
G Smg5 SMG5 nonsense mediated mRNA decay factor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 2:187,708,247...187,735,355
Ensembl chr 2:187,708,234...187,735,355
JBrowse link
G Smg6 SMG6 nonsense mediated mRNA decay factor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:61,526,024...61,542,583
NCBI chr10:61,771,912...62,007,030
Ensembl chr10:61,772,449...62,007,030
Ensembl chr10:61,772,449...62,007,030
JBrowse link
G Smg7 SMG7 nonsense mediated mRNA decay factor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr13:70,258,919...70,321,886
Ensembl chr13:70,258,915...70,321,752
JBrowse link
G Snrpb small nuclear ribonucleoprotein polypeptides B and B1 ISO (PMID:18082603) RGD PMID:18082603 NCBI chr 3:122,696,125...122,703,734
Ensembl chr 3:122,695,939...122,703,734
JBrowse link
G Snrpd3 small nuclear ribonucleoprotein D3 polypeptide ISO (PMID:18082603) RGD PMID:18082603 NCBI chr20:14,080,562...14,095,644
Ensembl chr20:14,080,565...14,095,181
JBrowse link
G Snrpe small nuclear ribonucleoprotein polypeptide E ISO (PMID:18082603) RGD PMID:18082603 NCBI chr13:50,252,707...50,258,951
Ensembl chr 8:129,371,556...129,371,973
JBrowse link
G Tep1 telomerase associated protein 1 IDA
IBA
ISO
IEA
PMID:9118230
PMID:21873635
(MGI:85699|PMID:9020079)
(PMID:12135483)
GO_REF:0000107
RGD
Ensembl
PMID:9020079 PMID:12135483, PMID:9118230, PMID:21873635 GO_REF:0000107 MGI:85699, RGD:1299082, RGD:13792537 NCBI chr15:27,751,186...27,798,839
Ensembl chr15:27,751,180...27,798,839
JBrowse link
G Terc telomerase RNA component ISO MGI:1857930 (MGI:1097832|PMID:9335332) RGD PMID:9335332 MGI:1097832 NCBI chr 2:116,432,723...116,433,110
Ensembl chr 2:116,432,691...116,433,110
JBrowse link
G Tert telomerase reverse transcriptase ISS
ISO
GO_REF:0000024
RNAcentral:URS00004A7003_9606 (PMID:12135483), (PMID:18082603), (PMID:19701182), (PMID:29695869)
UniProt
RGD
PMID:12135483 PMID:18082603 PMID:19701182 PMID:29695869 GO_REF:0000024 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Wrap53 WD repeat containing, antisense to TP53 ISS
ISO
GO_REF:0000024
(PMID:19179534), (PMID:26170453), (PMID:29695869), (PMID:29804836)
UniProt
RGD
PMID:19179534 PMID:26170453 PMID:29695869 PMID:29804836 GO_REF:0000024 NCBI chr10:56,169,024...56,185,800
Ensembl chr10:56,169,025...56,185,857
JBrowse link
box H/ACA telomerase RNP complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dkc1 dyskerin pseudouridine synthase 1 ISO (PMID:18082603) RGD PMID:18082603 NCBI chr  X:155,844,914...155,862,363
Ensembl chr  X:155,844,857...155,862,475
JBrowse link
G Gar1 GAR1 ribonucleoprotein ISO (PMID:10757788) RGD PMID:10757788 NCBI chr 2:235,250,453...235,258,464
Ensembl chr 2:235,250,453...235,257,731
JBrowse link
G Nhp2 NHP2 ribonucleoprotein ISO (PMID:18082603) RGD PMID:18082603 NCBI chr10:34,975,701...34,979,082
Ensembl chr10:34,975,708...34,979,082
JBrowse link
G Nop10 NOP10 ribonucleoprotein ISO
IBA
(PMID:18082603)
PMID:21873635
RGD PMID:18082603, PMID:21873635 RGD:13792537 NCBI chr 3:103,747,654...103,748,739
Ensembl chr 3:103,747,654...103,748,739
JBrowse link
telomerase catalytic core complex term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tert telomerase reverse transcriptase ISO
IBA
RNAcentral:URS00004A7003_9606 (PMID:11313459), (PMID:16507993), (PMID:17940095), (PMID:18082603), (PMID:19701182), (PMID:9398860), (PMID:9443919)
PMID:21873635
(MGI:3588604|PMID:16037417)
RGD PMID:9398860 PMID:9443919 PMID:11313459 PMID:16037417 PMID:16507993 PMID:17940095 PMID:18082603 PMID:19701182, PMID:21873635 MGI:3588604, RGD:13792537 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20615
    protein-containing complex 6107
      nuclear protein-containing complex 1237
        telomerase holoenzyme complex 21
          box H/ACA telomerase RNP complex 4
          telomerase catalytic core complex 1
Path 2
Term Annotations click to browse term
  cellular_component 20615
    cellular anatomical entity 20304
      organelle 13278
        membrane-bounded organelle 11263
          intracellular membrane-bounded organelle 10518
            nucleus 6987
              nuclear protein-containing complex 1237
                telomerase holoenzyme complex 21
                  box H/ACA telomerase RNP complex 4
                  telomerase catalytic core complex 1
paths to the root