Gnl3l (G protein nucleolar 3 like)

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Gene: Gnl3l (G protein nucleolar 3 like) Rattus norvegicus

Analyze

Symbol:

Gnl3l

Name:

G protein nucleolar 3 like

RGD ID:

1600217

Description:

Predicted to have GTP binding activity. Predicted to be involved in several processes, including negative regulation of protein modification by small protein conjugation or removal; negative regulation of telomere maintenance via telomerase; and positive regulation of protein localization to chromosome, telomeric region. Predicted to localize to cytosol and nucleus. Orthologous to human GNL3L (G protein nucleolar 3 like); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

guanine nucleotide binding protein-like 3 (nucleolar)-like; guanine nucleotide-binding protein-like 3-like protein

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	19,961,277 - 19,994,454 (-)	NCBI
Rnor_6.0 Ensembl	X	20,034,882 - 20,070,578 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	X	20,037,558 - 20,070,505 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	X	20,782,438 - 20,819,550 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	40,301,219 - 40,334,396 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	X	20,218,772 - 20,251,971 (-)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dimethylhydrazine (ISO)

1,4-dichlorobenzene (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

acetamide (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP)

bisphenol F (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

coumestrol (ISO)

dexamethasone (ISO)

diazinon (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

finasteride (EXP)

flutamide (EXP)

folic acid (ISO)

formaldehyde (ISO)

indometacin (ISO)

methapyrilene (EXP)

methyl methanesulfonate (ISO)

nefazodone (EXP)

nickel atom (ISO)

panobinostat (ISO)

paracetamol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sulindac (EXP)

sunitinib (ISO)

testosterone enanthate (ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

trichostatin A (ISO)

triptonide (ISO)

tungsten (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of protein binding (ISO)

negative regulation of protein sumoylation (ISO)

negative regulation of protein ubiquitination (ISO)

negative regulation of telomere maintenance via telomerase (ISO)

positive regulation of protein localization to chromosome, telomeric region (ISO)

positive regulation of protein-containing complex assembly (ISO)

regulation of protein stability (ISO)

Cellular Component

cytosol (IEA,ISO)

nucleolus (IBA,ISO)

nucleoplasm (IEA,ISO)

telomerase holoenzyme complex (ISO)

Molecular Function

GTP binding (IEA)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

ribosome biogenesis pathway (IEA)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Pipeline to import KEGG annotations from KEGG into RGD
3.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:18082603	PMID:19487455	PMID:19946888	PMID:22641345	PMID:22658674	PMID:25931508

Genomics

Comparative Map Data

Gnl3l
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	19,961,277 - 19,994,454 (-)	NCBI
Rnor_6.0 Ensembl	X	20,034,882 - 20,070,578 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	X	20,037,558 - 20,070,505 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	X	20,782,438 - 20,819,550 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	40,301,219 - 40,334,396 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	X	20,218,772 - 20,251,971 (-)	NCBI		Celera
Cytogenetic Map	X	q12	NCBI

GNL3L
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	X	54,530,183 - 54,621,521 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	X	54,530,211 - 54,567,289 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	X	54,530,219 - 54,567,289 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	X	54,556,652 - 54,593,722 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	54,573,369 - 54,608,698 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	X	54,439,762 - 54,474,737	NCBI
Celera	X	58,389,207 - 58,426,283 (+)	NCBI
Cytogenetic Map	X	p11.22	NCBI
HuRef	X	51,606,400 - 51,643,319 (+)	NCBI		HuRef
CHM1_1	X	54,547,228 - 54,584,316 (+)	NCBI		CHM1_1

Gnl3l
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	149,766,129 - 149,800,318 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	X	149,766,137 - 149,800,318 (-)	Ensembl
GRCm38	X	150,983,133 - 151,017,322 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	150,983,141 - 151,017,322 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	147,417,676 - 147,451,865 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	X	146,323,857 - 146,357,964 (-)	NCBI			mm8
Celera	X	133,387,729 - 133,422,241 (+)	NCBI		Celera
Cytogenetic Map	X	F3	NCBI

Gnl3l
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955475	1,792,268 - 1,854,288 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955475	1,792,268 - 1,849,601 (+)	NCBI	ChiLan1.0	ChiLan1.0

GNL3L
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	X	54,966,098 - 55,057,466 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	54,966,121 - 55,002,925 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	X	46,733,431 - 46,825,139 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

GNL3L
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	46,270,162 - 46,296,972 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	46,189,870 - 46,296,966 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	37,662,545 - 37,689,357 (+)	NCBI
ROS_Cfam_1.0	X	46,594,979 - 46,621,792 (+)	NCBI
UMICH_Zoey_3.1	X	46,092,970 - 46,119,783 (+)	NCBI
UNSW_CanFamBas_1.0	X	46,543,140 - 46,569,957 (+)	NCBI
UU_Cfam_GSD_1.0	X	46,610,450 - 46,637,264 (+)	NCBI

Gnl3l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	39,084,141 - 39,117,404 (+)	NCBI
SpeTri2.0	NW_004936751	1,423,822 - 1,457,257 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GNL3L
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	47,256,334 - 47,284,520 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	47,256,467 - 47,284,520 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	53,113,296 - 53,141,321 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GNL3L
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	50,650,512 - 50,684,835 (+)	NCBI
ChlSab1.1 Ensembl	X	50,666,794 - 50,684,649 (+)	Ensembl

Gnl3l
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624909	2,401,242 - 2,524,409 (+)	NCBI

Position Markers

RH140481

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	X	20,035,125 - 20,035,263	NCBI	Rnor6.0
Rnor_5.0	X	20,782,682 - 20,782,820	UniSTS	Rnor5.0
RGSC_v3.4	X	40,298,786 - 40,298,924	UniSTS	RGSC3.4
Celera	X	20,216,339 - 20,216,477	UniSTS
Cytogenetic Map	X	q14-q21	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
731181	Uae27	Urinary albumin excretion QTL 27	2.7	0.0059	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	X	1	44092703	Rat
634325	Bw13	Body weight QTL 13	0		body mass (VT:0001259)	body weight (CMO:0000012)	X	1662453	21592783	Rat
70165	Bp64	Blood pressure QTL 64	5.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	X	1662609	33443848	Rat
631204	Gluco15	Glucose level QTL 15		0.001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	X	1838166	24331837	Rat
1298071	Edpm12	Estrogen-dependent pituitary mass QTL 12	3.2		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	X	4282140	49282140	Rat
631666	Iddm5	Insulin dependent diabetes mellitus QTL 5			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	5954078	50954078	Rat
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	15688119	127888215	Rat
71116	Niddm16	Non-insulin dependent diabetes mellitus QTL 16	7.81		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	X	18153352	63153352	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	51
Count of miRNA genes:	45
Interacting mature miRNAs:	47
Transcripts:	ENSRNOT00000003397
Prediction methods:	Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	10	74	35	34	11	8
Low								1			7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001081958	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CA505625	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CA512184	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB544748	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB783942	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB801341	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223839	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000003397 ⟹ ENSRNOP00000003397

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	20,034,882 - 20,070,578 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093602 ⟹ ENSRNOP00000076269

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	X	20,037,557 - 20,070,537 (-)	Ensembl

RefSeq Acc Id:

NM_001081958 ⟹ NP_001075427

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	19,961,277 - 19,994,454 (-)	NCBI
Rnor_6.0	X	20,037,558 - 20,070,505 (-)	NCBI
Rnor_5.0	X	20,782,438 - 20,819,550 (-)	NCBI
RGSC_v3.4	X	40,301,219 - 40,334,396 (-)	RGD
Celera	X	20,218,772 - 20,251,971 (-)	RGD

Sequence:

show sequence

CCCTGCCGGAAGTGTAGGAAGAAGCGGGCACATTTGAACATCTCTTTTCGAGCTTCTCTGATCA
TCATGATGAAGCTTAGACACAAAAACAAAAAACCAGGTAAAGGTTCTAAAGGCTGTAAGAAGCC
CGCAAGGCAAAATGGGAAGAAAGTAACGTCCAGACCATCATCTGCTCCCCAGATTGTTCATGGC
AATGACCATGCCAGTCGGGAGGCCGAATTAAAGAAGAAAAGGGTTGAAGAGATGAGGGAGAAGC
AGCAGGTTGCTCGGGAGCAAGAGAGACAAAGACACAGGACCATGGAGAGCTATTGTCAGGATGT
CCTGAAACGTCAGCAGGAGTTTGAACAAAAGGAAGAAGTTTTGCAGGAATTAAATATGTTTCCT
CAGTTGGATGATGAGGCCACAAGGAAGGCCTATTATAAGGAATTCCGGAAGGTGGTAGAGTACT
CTGATGTGATTCTGGAAGTCCTAGATGCTAGAGACCCATTGGGCTGCCGGTGTTTCCAGATGGA
GGAGACTGTCCTTCGTGCAGAAGGCAACAAGAAGCTGGTCTTGGTCTTGAATAAGATAGACCTG
GTTCCCAAGGAGATTGTGGAAAAGTGGCTGGAATACCTTCGCAATGAACTGCCGACTGTGGCTT
TCAAGGCCAGCACACAGCATCATCAGGTCAAAAACTTGACTCGGTGTAAAGTTCCAGTGGACCA
GGCCTCTGAGTCACTGTTGAAAAGCAAAGCCTGCTTTGGAGCTGAAAACCTCATGAGGGTCCTG
GGGAACTACTGTCGTCTGGGGGAAATACGTGGCCACATTCGTGTGGGTGTTGTAGGCCTTCCCA
ATGTGGGGAAGAGCAGTCTGATCAATAGCCTGAAGCGCAGCCGTGCGTGTAGTGTGGGAGCTGT
TCCTGGTGTCACAAAATTCATGCAGGAGGTCTACCTAGACAAGTTTATCAGGCTGCTGGATGCA
CCAGGCATTGTCGCAGGACCCAATTCAGAGGTGGGCACCATCCTGCGTAATTGCATCCATGTGC
AGAAGCTGGCAGACCCTGTGACCCCGGTGGAGACCATCCTTCAGCGCTGCAACCTGGAGGAGAT
TTCCAACTATTATGGTGTGTCTGGATTCCAGACTACTGAGCACTTTCTGACTGCAGTGGCCCAT
CGTTTGGGAAAGAAGAAGAAGGGAGGTGTCTATAGTCAAGAACAGGCTGCCAAAGCTGTGCTGG
CTGACTGGGTGAGTGGGAAGATCAGCTTCTATACGCCACCACCGCCCACTCACACTCTGCCCAC
CCATCTCAGTGCTGAGATTGTTAAGGAGATGACTGAGGTCTTTGATATAGAAGACACTGAGCAG
GCCAATGAAGATACCATGGAATGCTTAGCCGTGGGAGAATCCGATGAGCTGTTGGGTGACATGG
ACCCCCAAGAAATGGAGGTCAGGTGGCTCCATTCTCCACTGGTGAAAATAGCAGATGCCATTGA
AAATAAAACCACCGTGTATAAGATTGGAAATCTCACTGGGTATTGTACCAAACCAAACCGTCAT
CAGATGGGGTGGCCTAAACGCAATGTGGACCACCATTGCCCCCAAAATAACCGTGTAGTGGAAG
TCAGTTCAGTGGACCGCCGCCCGATGTTGCAGAGGATCCTGGAGACAGACCCACTTCAACAAGG
CCAGGCACTGGCATCTGCCTTGAAGAATAAGAAAAAATTGCAGAAGCGTTCAGATAAAATCGCC
ACTAAGTTGTCTGACTCCATGATGTCTATGCTTGACCTCTCTGGCAATTCTGATGACTGTGCTG
ATGACTGAGCAGCTGACC

hide sequence

Protein Sequences


Protein RefSeqs	NP_001075427	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001075427 ⟸ NM_001081958

- Sequence:

show sequence

MMKLRHKNKKPGKGSKGCKKPARQNGKKVTSRPSSAPQIVHGNDHASREAELKKKRVEEMREKQ
QVAREQERQRHRTMESYCQDVLKRQQEFEQKEEVLQELNMFPQLDDEATRKAYYKEFRKVVEYS
DVILEVLDARDPLGCRCFQMEETVLRAEGNKKLVLVLNKIDLVPKEIVEKWLEYLRNELPTVAF
KASTQHHQVKNLTRCKVPVDQASESLLKSKACFGAENLMRVLGNYCRLGEIRGHIRVGVVGLPN
VGKSSLINSLKRSRACSVGAVPGVTKFMQEVYLDKFIRLLDAPGIVAGPNSEVGTILRNCIHVQ
KLADPVTPVETILQRCNLEEISNYYGVSGFQTTEHFLTAVAHRLGKKKKGGVYSQEQAAKAVLA
DWVSGKISFYTPPPPTHTLPTHLSAEIVKEMTEVFDIEDTEQANEDTMECLAVGESDELLGDMD
PQEMEVRWLHSPLVKIADAIENKTTVYKIGNLTGYCTKPNRHQMGWPKRNVDHHCPQNNRVVEV
SSVDRRPMLQRILETDPLQQGQALASALKNKKKLQKRSDKIATKLSDSMMSMLDLSGNSDDCAD
D

hide sequence

RefSeq Acc Id:

ENSRNOP00000076269 ⟸ ENSRNOT00000093602

RefSeq Acc Id:

ENSRNOP00000003397 ⟸ ENSRNOT00000003397

Protein Domains

CP-type G

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701763

Promoter ID:

EPDNEW_R12287

Type:

initiation region

Name:

Gnl3l_1

Description:

G protein nucleolar 3 like

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	20,070,557 - 20,070,617	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1600217	AgrOrtholog
Ensembl Genes	ENSRNOG00000002509	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000003397	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000076269	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000003397	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000093602	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1580.10	UniProtKB/TrEMBL
InterPro	G_CP_dom	UniProtKB/TrEMBL
	GTP-bd_ortho_bundle	UniProtKB/TrEMBL
	GTP1_OBG	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
NCBI Gene	100034253	ENTREZGENE
Pfam	MMR_HSR1	UniProtKB/TrEMBL
PhenoGen	Gnl3l	PhenoGen
PRINTS	GTP1OBG	UniProtKB/TrEMBL
PROSITE	G_CP	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52540	UniProtKB/TrEMBL
UniProt	D3ZMZ9_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-15	Gnl3l	G protein nucleolar 3 like	Gnl3l	guanine nucleotide binding protein-like 3 (nucleolar)-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-03-03	Gnl3l	guanine nucleotide binding protein-like 3 (nucleolar)-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)