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ONTOLOGY REPORT - ANNOTATIONS

Term:extracellular vesicle biogenesis
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Accession:GO:0140112 term browser browse the term
Definition:The assembly and secretion a set of components to form an extracellular vesicule, a membrane-bounded vesicle that is released into the extracellular region. Extracellular vesicles include exosomes, microvesicles and apoptotic bodies, based on the mechanism by which they are released from cells and differentiated based on their size and content.
Synonyms:exact_synonym: extracellular vesicle assembly


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extracellular vesicle biogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arrdc1 arrestin domain containing 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:24,815,364...24,825,347
Ensembl chr 2:24,815,364...24,825,264 		JBrowse link
G Arrdc4 arrestin domain containing 4 involved_in IMP (MGI:5804712|PMID:27462458) UniProt PMID:27462458 MGI:5804712 NCBI chr 7:68,386,742...68,398,986
Ensembl chr 7:68,386,743...68,398,989 		JBrowse link
exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cops5 COP9 signalosome subunit 5 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:10,094,825...10,108,384
Ensembl chr 1:10,094,826...10,108,393 		JBrowse link
G Rab11a RAB11A, member RAS oncogene family involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:64,622,582...64,645,038
Ensembl chr 9:64,622,581...64,645,040 		JBrowse link
G Rab27a RAB27A, member RAS oncogene family involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:72,952,092...73,004,905
Ensembl chr 9:72,952,136...73,004,911 		JBrowse link
G Steap3 STEAP family member 3 acts_upstream_of_or_within IMP (PMID:18617898) MGI PMID:18617898 NCBI chr 1:120,154,137...120,198,810
Ensembl chr 1:120,118,487...120,200,435 		JBrowse link
G Tsg101 tumor susceptibility gene 101 involved_in IMP (MGI:5770036|PMID:25392495) ParkinsonsUK-UCL PMID:25392495 MGI:5770036 NCBI chr 7:46,538,693...46,569,716
Ensembl chr 7:46,538,697...46,569,717 		JBrowse link
extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd34 CD34 antigen involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:194,621,239...194,643,587
Ensembl chr 1:194,621,127...194,643,587 		JBrowse link
extracellular exosome biogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase type 13A2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:140,711,812...140,734,641
Ensembl chr 4:140,714,184...140,734,641 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein involved_in IMP (MGI:5914142|PMID:25686249) UniProt PMID:25686249 MGI:5914142 NCBI chr 9:113,480,812...113,537,457
Ensembl chr 9:113,480,812...113,537,327 		JBrowse link
negative regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp9a ATPase, class II, type 9A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:168,476,358...168,584,290
Ensembl chr 2:168,476,358...168,584,329 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Rab7 RAB7, member RAS oncogene family involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:87,976,088...88,022,252
Ensembl chr 6:87,976,088...88,022,252 		JBrowse link
G Vps4b vacuolar protein sorting 4B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:106,698,518...106,724,455
Ensembl chr 1:106,691,801...106,724,458 		JBrowse link
positive regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp13a2 ATPase type 13A2 involved_in IMP
ISO		 (MGI:5770036|PMID:25392495) ParkinsonsUK-UCL
MGI		 PMID:25392495 GO_REF:0000119 MGI:4834177 MGI:5770036 NCBI chr 4:140,711,812...140,734,641
Ensembl chr 4:140,714,184...140,734,641 		JBrowse link
G Chmp2a charged multivesicular body protein 2A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:12,765,933...12,768,704
Ensembl chr 7:12,765,937...12,768,734 		JBrowse link
G Hgs HGF-regulated tyrosine kinase substrate involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:120,358,431...120,374,810
Ensembl chr11:120,358,461...120,374,805 		JBrowse link
G Myo5b myosin VB involved_in ISO RGD
MGI		 PMID:18984164 GO_REF:0000096 MGI:4417868 RGD:11533643 NCBI chr18:74,575,435...74,905,769
Ensembl chr18:74,574,007...74,904,564 		JBrowse link
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:113,480,812...113,537,457
Ensembl chr 9:113,480,812...113,537,327 		JBrowse link
G Rab7 RAB7, member RAS oncogene family involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 6:87,976,088...88,022,252
Ensembl chr 6:87,976,088...88,022,252 		JBrowse link
G Sdc1 syndecan 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:8,821,396...8,843,716
Ensembl chr12:8,821,323...8,843,715 		JBrowse link
G Sdc4 syndecan 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:164,266,167...164,285,512
Ensembl chr 2:164,266,167...164,285,807 		JBrowse link
G Sdcbp syndecan binding protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:6,365,713...6,396,120
Ensembl chr 4:6,365,650...6,408,423 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3, neutral involved_in ISO MGI GO_REF:0000096 MGI:4417868 NCBI chr 8:106,979,180...107,064,597
Ensembl chr 8:106,979,180...107,064,620 		JBrowse link
G Snf8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:95,925,711...95,938,256
Ensembl chr11:95,925,711...95,938,256 		JBrowse link
G Stam signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:14,078,912...14,152,351
Ensembl chr 2:14,078,909...14,154,445 		JBrowse link
G Tsg101 tumor susceptibility gene 101 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:46,538,693...46,569,716
Ensembl chr 7:46,538,697...46,569,717 		JBrowse link
G Vps4a vacuolar protein sorting 4A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:107,757,901...107,772,392
Ensembl chr 8:107,757,854...107,772,387 		JBrowse link
G Vps4b vacuolar protein sorting 4B involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:106,698,518...106,724,455
Ensembl chr 1:106,691,801...106,724,458 		JBrowse link
positive regulation of extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:113,480,812...113,537,457
Ensembl chr 9:113,480,812...113,537,327 		JBrowse link
G Sdc1 syndecan 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:8,821,396...8,843,716
Ensembl chr12:8,821,323...8,843,715 		JBrowse link
G Sdc4 syndecan 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:164,266,167...164,285,512
Ensembl chr 2:164,266,167...164,285,807 		JBrowse link
G Sdcbp syndecan binding protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:6,365,713...6,396,120
Ensembl chr 4:6,365,650...6,408,423 		JBrowse link
regulation of exosomal secretion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chmp3 charged multivesicular body protein 3 NOT|involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chr 6:71,520,820...71,559,593
Ensembl chr 6:71,520,781...71,559,593 		JBrowse link
G Chmp6 charged multivesicular body protein 6 NOT|involved_in ISO (PMID:22660413) UniProt PMID:22660413 NCBI chr11:119,803,874...119,810,378
Ensembl chr11:119,804,267...119,810,374 		JBrowse link
regulation of extracellular exosome assembly term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdcd6ip programmed cell death 6 interacting protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:113,480,812...113,537,457
Ensembl chr 9:113,480,812...113,537,327 		JBrowse link
G Stam signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:14,078,912...14,152,351
Ensembl chr 2:14,078,909...14,154,445 		JBrowse link
G Tsg101 tumor susceptibility gene 101 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:46,538,693...46,569,716
Ensembl chr 7:46,538,697...46,569,717 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28577
    cellular process 17497
      cellular component organization or biogenesis 6979
        cellular component biogenesis 3451
          extracellular vesicle biogenesis 26
            extracellular exosome biogenesis + 24
            extracellular microvesicle biogenesis 0
paths to the root