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ONTOLOGY REPORT - ANNOTATIONS

Term:T-helper 17 cell lineage commitment
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Accession:GO:0072540 term browser browse the term
Definition:The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 17 cell, a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17.
Synonyms:exact_synonym: T-helper 17 cell fate commitment;   Th17 cell lineage commitment;   Th17 fate commitment


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T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr14:75,522,469...75,546,992
Ensembl chr14:75,522,455...75,546,993 		JBrowse link
G IL6 interleukin 6 involved_in ISS (PMID:27893700) UniProt PMID:27893700 GO_REF:0000024 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IL6R interleukin 6 receptor involved_in IEA
ISS		 (PMID:27893700) Ensembl
UniProt		 PMID:27893700 GO_REF:0000107 NCBI chr 1:154,405,343...154,469,450
Ensembl chr 1:154,405,193...154,469,450 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer involved_in ISS (PMID:27893700) UniProt PMID:27893700 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G IRF4 interferon regulatory factor 4 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 6:391,752...411,443
Ensembl chr 6:391,739...411,443 		JBrowse link
G JAK1 Janus kinase 1 involved_in TAS (PMID:27893700) UniProt PMID:27893700 NCBI chr 1:64,833,229...65,067,746
Ensembl chr 1:64,833,223...65,067,754 		JBrowse link
G LY9 lymphocyte antigen 9 involved_in IDA (PMID:22184727) UniProt PMID:22184727 NCBI chr 1:160,796,174...160,828,255
Ensembl chr 1:160,796,074...160,828,261 		JBrowse link
G OTUD5 OTU deubiquitinase 5 acts_upstream_of_or_within ISO (PMID:25470037) MGI PMID:25470037 NCBI chr  X:48,922,024...48,958,381
Ensembl chr  X:48,922,024...48,958,386 		JBrowse link
G SLAMF6 SLAM family member 6 involved_in IDA
IBA
IEA		 (PMID:22184727) UniProt
GO_Central
TreeGrafter		 PMID:22184727 GO_REF:0000033 GO_REF:0000118 NCBI chr 1:160,485,036...160,523,255
Ensembl chr 1:160,485,030...160,523,262 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 involved_in TAS (PMID:27893700) UniProt PMID:27893700 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOXL3 lysyl oxidase like 3 involved_in IEA
IDA
ISS		 (PMID:28065600) Ensembl
UniProt		 PMID:28065600 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:74,532,258...74,555,702
Ensembl chr 2:74,532,258...74,555,690 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chr 1:173,039,202...173,050,941
Ensembl chr 1:173,039,202...173,050,941 		JBrowse link
positive regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD2 bromodomain containing 2 involved_in IEA
IDA		 (PMID:28262505) Ensembl
UniProt		 PMID:28262505 GO_REF:0000107 NCBI chr 6:32,968,594...32,981,505
Ensembl chr 6:32,968,594...32,981,505 		JBrowse link
G BRD4 bromodomain containing 4 involved_in ISS UniProt GO_REF:0000024 NCBI chr19:15,235,519...15,332,539
Ensembl chr19:15,235,519...15,332,545 		JBrowse link
G EP300 E1A binding protein p300 involved_in IDA (PMID:28262505) UniProt PMID:28262505 NCBI chr22:41,092,592...41,180,077
Ensembl chr22:41,092,510...41,180,077 		JBrowse link
G IL12B interleukin 12B involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL12RB1 interleukin 12 receptor subunit beta 1 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr19:18,058,995...18,098,816
Ensembl chr19:18,058,995...18,098,944 		JBrowse link
G IL23A interleukin 23 subunit alpha involved_in IEA
IBA
ISS		 Ensembl
GO_Central
BHF-UCL		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr12:56,338,884...56,340,410
Ensembl chr12:56,334,174...56,340,410 		JBrowse link
G IL23R interleukin 23 receptor involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:67,138,637...67,265,903
Ensembl chr 1:67,138,907...67,259,979 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase involved_in ISS UniProt GO_REF:0000024 NCBI chr 3:193,593,208...193,697,811
Ensembl chr 3:193,593,144...193,697,811 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19613
    immune system process 3224
      T cell selection 66
        positive T cell selection 51
          CD4-positive or CD8-positive, alpha-beta T cell lineage commitment 34
            CD4-positive, alpha-beta T cell lineage commitment 30
              T-helper cell lineage commitment 27
                T-helper 17 cell lineage commitment 22
                  negative regulation of T-helper 17 cell lineage commitment 3
                  positive regulation of T-helper 17 cell lineage commitment 8
                  regulation of T-helper 17 cell lineage commitment + 11
Path 2
Term Annotations click to browse term
  biological_process 19613
    cellular process 18246
      cellular developmental process 5172
        cell differentiation 5171
          cell development 3453
            hemopoiesis 1167
              leukocyte differentiation 749
                mononuclear cell differentiation 620
                  lymphocyte differentiation 513
                    T cell differentiation 365
                      T cell differentiation involved in immune response 98
                        alpha-beta T cell differentiation involved in immune response 90
                          CD4-positive, alpha-beta T cell differentiation involved in immune response 89
                            T-helper cell differentiation 87
                              T-helper cell lineage commitment 27
                                T-helper 17 cell lineage commitment 22
                                  negative regulation of T-helper 17 cell lineage commitment 3
                                  positive regulation of T-helper 17 cell lineage commitment 8
                                  regulation of T-helper 17 cell lineage commitment + 11
paths to the root