Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

ONTOLOGY REPORT - ANNOTATIONS

Term:interleukin-1-mediated signaling pathway
go back to main search page
Accession:GO:0070498 term browser browse the term
Definition:The series of molecular signals initiated by interleukin-1 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: IL-1-mediated signaling pathway;   interleukin-1-mediated signalling pathway
 narrow_synonym: IL-1 alpha-mediated signaling pathway;   IL-1 beta-mediated signaling pathway;   interleukin-1 alpha-mediated signaling pathway;   interleukin-1 beta-mediated signaling pathway


show annotations for term's descendants           Sort by:
interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGR1 early growth response 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575 		JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:23,359,551...23,419,114
Ensembl chr16:23,359,813...23,419,075 		JBrowse link
G IL1B interleukin 1 beta involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL1R1 interleukin 1 receptor type 1 involved_in ISO
IEA		 RGD
TreeGrafter
Ensembl
GOC		 PMID:20967881 GO_REF:0000107 GO_REF:0000108 GO_REF:0000118 RGD:5130945 NCBI chr10:40,825,986...40,897,898
Ensembl chr10:40,827,377...40,897,596 		JBrowse link
G IL1RAP interleukin 1 receptor accessory protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr34:22,547,422...22,628,628
Ensembl chr34:22,546,899...22,623,544 		JBrowse link
G IRAK1 interleukin 1 receptor associated kinase 1 NOT|involved_in
acts_upstream_of_or_within		 ISO
IEA		 (PMID:11397809)
(PMID:12054681)		 UniProt
MGI
Ensembl		 PMID:11397809 PMID:12054681 GO_REF:0000107 NCBI chr  X:121,853,340...121,862,582
Ensembl chr  X:121,819,432...121,862,576 		JBrowse link
G IRAK2 interleukin 1 receptor associated kinase 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr20:8,133,987...8,197,009
Ensembl chr20:8,134,970...8,196,910 		JBrowse link
G IRAK3 interleukin 1 receptor associated kinase 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12054681) Ensembl
MGI
TreeGrafter		 PMID:12054681 GO_REF:0000107 GO_REF:0000118 NCBI chr10:8,683,541...8,730,757
Ensembl chr10:8,684,242...8,729,268 		JBrowse link
G IRAK4 interleukin 1 receptor associated kinase 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:10,313,782...10,340,652
Ensembl chr27:10,314,187...10,340,682 		JBrowse link
G MAP3K7 mitogen-activated protein kinase kinase kinase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:49,669,849...49,740,039
Ensembl chr12:49,672,389...49,739,850 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 involved_in ISO (PMID:20018936) BHF-UCL PMID:20018936 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor involved_in IEA Ensembl GO_REF:0000107 NCBI chr23:7,901,578...7,905,274
Ensembl chr23:7,901,250...7,904,534 		JBrowse link
G NFKBIA NFKB inhibitor alpha involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433 		JBrowse link
G PLCB1 phospholipase C beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:13,337,285...13,996,218
Ensembl chr24:13,322,296...13,995,539 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
G RPS6KA4 ribosomal protein S6 kinase A4 involved_in ISO (PMID:20018936) BHF-UCL PMID:20018936 NCBI chr18:52,708,849...52,720,561
Ensembl chr18:52,708,838...52,736,728 		JBrowse link
G RPS6KA5 ribosomal protein S6 kinase A5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:61,801,185...61,962,846
Ensembl chr 8:61,802,812...61,973,259 		JBrowse link
G ST18 ST18 C2H2C-type zinc finger transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:3,971,851...4,266,642
Ensembl chr29:3,974,157...4,080,067 		JBrowse link
G TIRAP TIR domain containing adaptor protein NOT|involved_in ISO (MGI:2149909|PMID:11544529) BHF-UCL PMID:11544529 MGI:2149909 NCBI chr 5:8,222,217...8,237,595
Ensembl chr 5:8,221,794...8,226,074 		JBrowse link
G TNIP2 TNFAIP3 interacting protein 2 involved_in ISO (MGI:3656197|PMID:16633345) UniProt PMID:16633345 MGI:3656197 NCBI chr 3:61,511,676...61,535,480 JBrowse link
G TOLLIP toll interacting protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:45,559,385...45,578,467
Ensembl chr18:45,560,681...45,578,449 		JBrowse link
G TRAF6 TNF receptor associated factor 6 involved_in ISO
IEA		 RGD
Ensembl		 PMID:20967881 GO_REF:0000107 RGD:5130945 NCBI chr18:31,674,242...31,689,160
Ensembl chr18:31,675,391...31,688,641 		JBrowse link
negative regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1R2 interleukin 1 receptor type 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23395675) Ensembl
MGI		 PMID:23395675 GO_REF:0000107 NCBI chr10:40,967,532...41,003,659
Ensembl chr10:40,896,669...41,034,113 		JBrowse link
G IL1RN interleukin 1 receptor antagonist involved_in IEA
IBA		 TreeGrafter
GO_Central		 GO_REF:0000033 GO_REF:0000118 NCBI chr17:37,236,690...37,250,424
Ensembl chr17:37,212,751...37,249,329 		JBrowse link
G IL6 interleukin 6 involved_in ISO (MGI:5795829|PMID:11159963) BHF-UCL PMID:11159963 MGI:5795829 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G MIR21 microRNA mir-21 acts_upstream_of_or_within ISO (PMID:25327529) BHF-UCL PMID:25327529 NCBI chr 9:34,340,550...34,340,609
Ensembl chr 9:34,340,533...34,340,624 		JBrowse link
G MIR27A microRNA mir-27a involved_in ISO (PMID:25327529) BHF-UCL PMID:25327529 NCBI chr20:48,620,556...48,620,615
Ensembl chr20:48,620,556...48,620,615 		JBrowse link
G OTUD4 OTU deubiquitinase 4 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr15:43,816,656...43,861,813
Ensembl chr15:43,818,196...43,861,784 		JBrowse link
positive regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1R1 interleukin 1 receptor type 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23395675) Ensembl
MGI		 PMID:23395675 GO_REF:0000107 NCBI chr10:40,825,986...40,897,898
Ensembl chr10:40,827,377...40,897,596 		JBrowse link
regulation of interleukin-1-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VRK2 VRK serine/threonine kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:58,432,144...58,544,189
Ensembl chr10:58,431,978...58,544,189 		JBrowse link
G ZBP1 Z-DNA binding protein 1 involved_in ISO (MGI:6394181|PMID:31630209) UniProt PMID:31630209 MGI:6394181 NCBI chr24:42,583,674...42,589,857
Ensembl chr24:42,584,083...42,589,753 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17925
    cellular process 16910
      signal transduction 6317
        cell surface receptor signaling pathway 2807
          cytokine-mediated signaling pathway 493
            interleukin-1-mediated signaling pathway 30
              negative regulation of interleukin-1-mediated signaling pathway 6
              positive regulation of interleukin-1-mediated signaling pathway 1
              regulation of interleukin-1-mediated signaling pathway + 9
Path 2
Term Annotations click to browse term
  biological_process 17925
    response to stimulus 9451
      response to chemical 5158
        response to peptide 1239
          response to cytokine 1215
            cellular response to cytokine stimulus 1079
              cytokine-mediated signaling pathway 493
                interleukin-1-mediated signaling pathway 30
                  negative regulation of interleukin-1-mediated signaling pathway 6
                  positive regulation of interleukin-1-mediated signaling pathway 1
                  regulation of interleukin-1-mediated signaling pathway + 9
paths to the root