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ONTOLOGY REPORT - ANNOTATIONS

Term:regulation of type I interferon-mediated signaling pathway
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Accession:GO:0060338 term browser browse the term
Definition:Any process that modulates the rate, frequency or extent of a type I interferon-mediated signaling pathway.
Synonyms:exact_synonym: regulation of type I interferon-mediated signalling pathway


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regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDC37 cell division cycle 37, HSP90 cochaperone acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16280321) MGI
Ensembl		 PMID:16280321 GO_REF:0000107 NCBI chr20:50,727,702...50,738,197
Ensembl chr20:50,727,749...50,736,269 		JBrowse link
negative regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADAR adenosine deaminase RNA specific involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19060901) Ensembl
MGI		 PMID:19060901 GO_REF:0000107 NCBI chr 7:42,762,021...42,785,192
Ensembl chr 7:42,748,136...42,782,999 		JBrowse link
G CACTIN cactin, spliceosome C complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:55,803,494...55,817,467
Ensembl chr20:55,803,530...55,816,549 		JBrowse link
G CNOT7 CCR4-NOT transcription complex subunit 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:40,554,214...40,571,841
Ensembl chr16:40,555,565...40,571,720 		JBrowse link
G DCST1 DC-STAMP domain containing 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:42,443,787...42,457,361
Ensembl chr 7:42,428,113...42,457,062 		JBrowse link
G EIF4E2 eukaryotic translation initiation factor 4E family member 2 involved_in ISO (PMID:35878012) UniProt PMID:35878012 NCBI chr25:44,192,037...44,203,401
Ensembl chr25:44,192,038...44,214,631 		JBrowse link
G GIGYF2 GRB10 interacting GYF protein 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr25:44,317,540...44,453,761
Ensembl chr25:44,317,517...44,452,064 		JBrowse link
G ISG15 ISG15 ubiquitin like modifier involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:56,230,879...56,237,354
Ensembl chr 5:56,236,318...56,404,695 		JBrowse link
G MAVS mitochondrial antiviral signaling protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:17,510,209...17,529,286
Ensembl chr24:17,512,761...17,523,807 		JBrowse link
G METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:18,528,755...18,546,303
Ensembl chr15:18,528,772...18,546,531 		JBrowse link
G MIR21 microRNA mir-21 involved_in ISO (PMID:23633945) BHF-UCL PMID:23633945 NCBI chr 9:34,340,550...34,340,609
Ensembl chr 9:34,340,533...34,340,624 		JBrowse link
G MMP12 matrix metallopeptidase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:28,918,626...28,933,404
Ensembl chr 5:28,918,594...28,933,309 		JBrowse link
G MUL1 mitochondrial E3 ubiquitin protein ligase 1 involved_in ISO (PMID:23399697) UniProt PMID:23399697 NCBI chr 2:78,394,013...78,402,032
Ensembl chr 2:78,394,040...78,425,482 		JBrowse link
G NLRC5 NLR family CARD domain containing 5 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:59,279,535...59,359,327
Ensembl chr 2:59,280,390...59,338,931 		JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:10,385,393...10,396,734
Ensembl chr26:10,385,447...10,396,733 		JBrowse link
G OAS3 2'-5'-oligoadenylate synthetase 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr26:10,404,548...10,423,039
Ensembl chr26:10,404,414...10,423,039 		JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:78,160,564...78,252,382
Ensembl chr 7:78,160,589...78,252,719 		JBrowse link
G SAMHD1 SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:25,623,997...25,676,336
Ensembl chr24:25,626,134...25,680,902 		JBrowse link
G SMIM30 small integral membrane protein 30 involved_in ISO (PMID:37656786) UniProt PMID:37656786 NCBI chr14:52,594,889...52,596,902
Ensembl chr14:52,595,562...52,595,741 		JBrowse link
G STAT2 signal transducer and activator of transcription 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:641,543...660,882
Ensembl chr10:642,718...658,546 		JBrowse link
G TREX1 three prime repair exonuclease 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18724932) Ensembl
MGI		 PMID:18724932 GO_REF:0000107 NCBI chr20:40,624,845...40,626,840
Ensembl chr20:40,624,891...40,626,906 		JBrowse link
G TTLL12 tubulin tyrosine ligase like 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:22,367,590...22,385,167
Ensembl chr10:22,367,367...22,386,617 		JBrowse link
G USP18 ubiquitin specific peptidase 18 involved_in ISO (PMID:28165510) UniProt PMID:28165510 NCBI chr27:45,739,845...45,814,668 JBrowse link
G YTHDF2 YTH N6-methyladenosine RNA binding protein F2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:71,760,232...71,791,420
Ensembl chr 2:71,760,312...71,792,527 		JBrowse link
G YTHDF3 YTH N6-methyladenosine RNA binding protein F3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr29:13,239,900...13,280,035
Ensembl chr29:13,239,966...13,277,051 		JBrowse link
positive regulation of type I interferon-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FADD Fas associated via death domain involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:48,087,447...48,094,497 JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon involved_in IEA Ensembl GO_REF:0000107 NCBI chr38:2,747,303...2,772,574
Ensembl chr38:2,747,297...2,772,587 		JBrowse link
G IRF3 interferon regulatory factor 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17618271) Ensembl
MGI		 PMID:17618271 GO_REF:0000107 NCBI chr 1:106,875,016...106,879,065
Ensembl chr 1:106,875,118...106,879,065 		JBrowse link
G IRF7 interferon regulatory factor 7 acts_upstream_of_or_within ISO (PMID:17618271) MGI PMID:17618271
G LSM14A LSM14A mRNA processing body assembly factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:22745163) Ensembl
MGI		 PMID:22745163 GO_REF:0000107 NCBI chr 1:118,061,854...118,117,493
Ensembl chr 1:118,063,512...118,117,478 		JBrowse link
G MAVS mitochondrial antiviral signaling protein involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:17,510,209...17,529,286
Ensembl chr24:17,512,761...17,523,807 		JBrowse link
G MMP12 matrix metallopeptidase 12 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:28,918,626...28,933,404
Ensembl chr 5:28,918,594...28,933,309 		JBrowse link
G NLRC5 NLR family CARD domain containing 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:59,279,535...59,359,327
Ensembl chr 2:59,280,390...59,338,931 		JBrowse link
G RBM47 RNA binding motif protein 47 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:71,985,725...72,135,271
Ensembl chr 3:71,985,831...72,132,918 		JBrowse link
G RNF185 ring finger protein 185 involved_in ISO (PMID:28273161) UniProt PMID:28273161 NCBI chr26:24,146,172...24,177,747
Ensembl chr26:24,146,005...24,240,653 		JBrowse link
G STING1 stimulator of interferon response cGAMP interactor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:34,783,947...34,792,204
Ensembl chr 2:34,784,232...34,789,072 		JBrowse link
G TBK1 TANK binding kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:7,169,664...7,208,890
Ensembl chr10:7,168,007...7,208,899 		JBrowse link
G TRIM41 tripartite motif containing 41 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:414,725...426,074
Ensembl chr11:415,764...425,656 		JBrowse link
G TRIM56 tripartite motif containing 56 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:8,744,970...8,752,896
Ensembl chr 6:8,749,438...8,751,753 		JBrowse link
G TRIM6 tripartite motif containing 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr21:28,595,887...28,611,562
Ensembl chr21:28,595,448...28,611,124 		JBrowse link
G UBE2K ubiquitin conjugating enzyme E2 K involved_in IEA Ensembl GO_REF:0000107 NCBI chr 3:72,713,035...72,780,199
Ensembl chr 3:72,717,236...72,780,210 		JBrowse link
G USP27X ubiquitin specific peptidase 27 X-linked involved_in ISO (PMID:31534008) UniProt PMID:31534008 NCBI chr  X:42,645,534...42,648,801 JBrowse link
G WNT5A Wnt family member 5A involved_in IEA Ensembl GO_REF:0000107 NCBI chr20:34,756,430...34,790,937
Ensembl chr20:34,769,930...34,786,673 		JBrowse link
G ZBP1 Z-DNA binding protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17618271) InterPro
TreeGrafter
MGI		 PMID:17618271 GO_REF:0000002 GO_REF:0000118 NCBI chr24:42,583,674...42,589,857
Ensembl chr24:42,584,083...42,589,753 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17924
    cellular process 16926
      signal transduction 6329
        regulation of signal transduction 3170
          regulation of cytokine-mediated signaling pathway 166
            regulation of type I interferon-mediated signaling pathway 41
              negative regulation of type I interferon-mediated signaling pathway 24
              positive regulation of type I interferon-mediated signaling pathway 19
Path 2
Term Annotations click to browse term
  biological_process 17924
    response to stimulus 9455
      response to biotic stimulus 1724
        response to external biotic stimulus 1681
          response to other organism 1678
            defense response to other organism 1147
              defense response to symbiont 1023
                innate immune response 833
                  response to type I interferon 73
                    cellular response to type I interferon 67
                      type I interferon-mediated signaling pathway 64
                        regulation of type I interferon-mediated signaling pathway 41
                          negative regulation of type I interferon-mediated signaling pathway 24
                          positive regulation of type I interferon-mediated signaling pathway 19
paths to the root