TTLL12 (tubulin tyrosine ligase like 12) - Rat Genome Database

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Gene: TTLL12 (tubulin tyrosine ligase like 12) Canis lupus familiaris
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Symbol: TTLL12
Name: tubulin tyrosine ligase like 12
RGD ID: 12379637
Description: ENCODES a protein that exhibits histone H4K20 trimethyltransferase activity (ortholog); tubulin-tyrosine ligase activity (ortholog); INVOLVED IN negative regulation of type I interferon-mediated signaling pathway (inferred); protein modification process (inferred); regulation of mitotic cell cycle (inferred); ASSOCIATED WITH Developmental Delay with Variable Intellectual Impairment and Behavioral Abnormalities (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); plasma membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tubulin tyrosine ligase-like family, member 12; tubulin--tyrosine ligase-like protein 12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11022,367,590 - 22,385,167 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1022,367,367 - 22,386,617 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1022,304,290 - 22,321,864 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01023,112,096 - 23,129,643 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1023,111,562 - 23,129,625 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11022,831,432 - 22,848,971 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01023,150,355 - 23,167,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01023,326,241 - 23,343,803 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
plasma membrane  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
TTLL12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11022,367,590 - 22,385,167 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1022,367,367 - 22,386,617 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1022,304,290 - 22,321,864 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01023,112,096 - 23,129,643 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1023,111,562 - 23,129,625 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11022,831,432 - 22,848,971 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01023,150,355 - 23,167,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01023,326,241 - 23,343,803 (+)NCBIUU_Cfam_GSD_1.0
TTLL12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382243,166,622 - 43,187,134 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2243,166,622 - 43,187,134 (-)EnsemblGRCh38hg38GRCh38
GRCh372243,562,628 - 43,583,140 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362241,892,572 - 41,913,051 (-)NCBINCBI36Build 36hg18NCBI36
Celera2227,473,015 - 27,493,525 (-)NCBICelera
Cytogenetic Map22q13.2NCBI
HuRef2226,520,840 - 26,541,320 (-)NCBIHuRef
CHM1_12243,521,891 - 43,542,376 (-)NCBICHM1_1
T2T-CHM13v2.02243,647,474 - 43,667,938 (-)NCBIT2T-CHM13v2.0
Ttll12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391583,459,295 - 83,479,358 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1583,459,291 - 83,479,358 (-)EnsemblGRCm39 Ensembl
GRCm381583,575,094 - 83,595,157 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1583,575,090 - 83,595,157 (-)EnsemblGRCm38mm10GRCm38
MGSCv371583,405,524 - 83,425,587 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361583,403,576 - 83,422,878 (-)NCBIMGSCv36mm8
Celera1585,701,912 - 85,721,975 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1539.4NCBI
Ttll12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87116,612,609 - 116,631,244 (-)NCBIGRCr8
mRatBN7.27114,731,890 - 114,751,237 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7114,731,892 - 114,751,356 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7116,479,632 - 116,498,238 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07118,705,346 - 118,723,851 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07118,674,816 - 118,693,321 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07124,472,758 - 124,491,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7124,472,758 - 124,491,004 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07124,461,238 - 124,479,484 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47121,601,492 - 121,620,937 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17121,634,544 - 121,655,280 (-)NCBI
Celera7111,043,936 - 111,062,464 (-)NCBICelera
Cytogenetic Map7q34NCBI
Ttll12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541328,316,936 - 28,333,508 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541328,316,936 - 28,333,423 (-)NCBIChiLan1.0ChiLan1.0
TTLL12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22352,977,557 - 53,009,632 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12255,669,517 - 55,702,553 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02224,038,128 - 24,070,135 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12242,248,276 - 42,270,232 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2242,249,660 - 42,271,318 (-)Ensemblpanpan1.1panPan2
Ttll12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049455,966,837 - 5,983,407 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936718996,000 - 1,010,342 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936718996,758 - 1,013,372 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TTLL12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl55,701,583 - 5,720,724 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.155,687,895 - 5,719,003 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.253,124,019 - 3,141,730 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TTLL12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11925,693,844 - 25,714,386 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1925,692,610 - 25,714,342 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604599,724,252 - 99,744,802 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ttll12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247525,796,958 - 5,813,075 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247525,796,935 - 5,813,078 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TTLL12
272 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 17 1 6 1 6 12 10 6
Low 5 5 5 5 6 8
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000001412   ⟹   ENSCAFP00000001298
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1022,367,367 - 22,384,509 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000075050   ⟹   ENSCAFP00000065882
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1022,367,367 - 22,386,617 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000083964   ⟹   ENSCAFP00000045807
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1022,367,367 - 22,386,617 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089077   ⟹   ENSCAFP00000060803
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1022,367,367 - 22,386,617 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000093814   ⟹   ENSCAFP00000044792
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1022,367,367 - 22,386,617 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845025083   ⟹   ENSCAFP00845019735
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1023,111,562 - 23,129,625 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845025135   ⟹   ENSCAFP00845019767
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1023,111,562 - 23,129,625 (+)Ensembl
RefSeq Acc Id: XM_038488381   ⟹   XP_038344309
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11022,831,432 - 22,848,971 (+)NCBI
RefSeq Acc Id: XM_038550294   ⟹   XP_038406222
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01023,326,241 - 23,343,803 (+)NCBI
RefSeq Acc Id: XM_038614274   ⟹   XP_038470202
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01023,150,355 - 23,167,934 (+)NCBI
RefSeq Acc Id: XM_038679614   ⟹   XP_038535542
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01023,112,096 - 23,129,643 (+)NCBI
RefSeq Acc Id: XM_531703   ⟹   XP_531703
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11022,367,590 - 22,385,167 (+)NCBI
Dog10K_Boxer_Tasha1022,304,290 - 22,321,864 (+)NCBI
Sequence:
RefSeq Acc Id: XP_531703   ⟸   XM_531703
- UniProtKB: A0A8C0M6L6 (UniProtKB/TrEMBL),   A0A8P0N456 (UniProtKB/TrEMBL),   A0A8C0MBU5 (UniProtKB/TrEMBL),   A0A8P0SY41 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000044792   ⟸   ENSCAFT00000093814
RefSeq Acc Id: ENSCAFP00000001298   ⟸   ENSCAFT00000001412
RefSeq Acc Id: ENSCAFP00000045807   ⟸   ENSCAFT00000083964
RefSeq Acc Id: ENSCAFP00000060803   ⟸   ENSCAFT00000089077
RefSeq Acc Id: ENSCAFP00000065882   ⟸   ENSCAFT00000075050
RefSeq Acc Id: XP_038344309   ⟸   XM_038488381
RefSeq Acc Id: XP_038470202   ⟸   XM_038614274
RefSeq Acc Id: XP_038535542   ⟸   XM_038679614
- UniProtKB: A0A8C0M6L6 (UniProtKB/TrEMBL),   A0A8P0N456 (UniProtKB/TrEMBL),   A0A8C0MBU5 (UniProtKB/TrEMBL),   A0A8P0SY41 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038406222   ⟸   XM_038550294
- UniProtKB: A0A8C0M6L6 (UniProtKB/TrEMBL),   A0A8C0MBU5 (UniProtKB/TrEMBL),   A0A8P0N456 (UniProtKB/TrEMBL),   A0A8P0SY41 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845019767   ⟸   ENSCAFT00845025135
RefSeq Acc Id: ENSCAFP00845019735   ⟸   ENSCAFT00845025083

Promoters
RGD ID:13684933
Promoter ID:EPDNEW_C3002
Type:single initiation site
Name:TTLL12_1
Description:tubulin tyrosine ligase like 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11022,367,410 - 22,367,470EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000909 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004311 UniProtKB/TrEMBL
  ENSCAFG00845014024 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001412.5 UniProtKB/TrEMBL
  ENSCAFT00000093814.2 UniProtKB/TrEMBL
  ENSCAFT00030007943.1 UniProtKB/TrEMBL
  ENSCAFT00030008048.1 UniProtKB/TrEMBL
  ENSCAFT00030008121.1 UniProtKB/TrEMBL
  ENSCAFT00845025083.1 UniProtKB/TrEMBL
  ENSCAFT00845025135.1 UniProtKB/TrEMBL
Gene3D-CATH ATP-grasp fold, B domain UniProtKB/TrEMBL
InterPro TTL/TTLL_fam UniProtKB/TrEMBL
  TTLL12 UniProtKB/TrEMBL
KEGG Report cfa:474474 UniProtKB/TrEMBL
NCBI Gene TTLL12 ENTREZGENE
PANTHER PTHR46088 UniProtKB/TrEMBL
  TUBULIN--TYROSINE LIGASE-LIKE PROTEIN 12 UniProtKB/TrEMBL
Pfam TTL UniProtKB/TrEMBL
PROSITE TTL UniProtKB/TrEMBL
UniProt A0A8C0M693_CANLF UniProtKB/TrEMBL
  A0A8C0M6L6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0MBU5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NI92_CANLF UniProtKB/TrEMBL
  A0A8I3S0J8_CANLF UniProtKB/TrEMBL
  A0A8P0N456 ENTREZGENE
  A0A8P0SY41 ENTREZGENE
UniProt Secondary A0A8P0N456 UniProtKB/TrEMBL
  A0A8P0SY41 UniProtKB/TrEMBL
VGNC ID VGNC:47975 ENTREZGENE