YTHDF2 (YTH N6-methyladenosine RNA binding protein F2) - Rat Genome Database

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Gene: YTHDF2 (YTH N6-methyladenosine RNA binding protein F2) Canis lupus familiaris
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Symbol: YTHDF2
Name: YTH N6-methyladenosine RNA binding protein F2
RGD ID: 12281787
Description: ENCODES a protein that exhibits C5-methylcytidine-containing RNA reader activity (inferred); N6-methyladenosine-containing RNA reader activity (inferred); RNA binding (inferred); INVOLVED IN positive regulation of translational initiation (ortholog); ASSOCIATED WITH hepatocellular carcinoma (ortholog); FOUND IN centriolar satellite (inferred); cytoplasm (inferred); cytoplasmic ribonucleoprotein granule (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: YTH domain family, member 2; YTH domain-containing family protein 2; YTH N6-methyladenosine RNA binding protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,760,232 - 71,791,420 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,760,312 - 71,792,527 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,336,008 - 68,368,586 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,319,158 - 72,351,686 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,319,154 - 72,351,626 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,147,969 - 69,180,375 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,155,530 - 70,188,135 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,153,556 - 71,186,141 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
YTHDF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,760,232 - 71,791,420 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,760,312 - 71,792,527 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,336,008 - 68,368,586 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,319,158 - 72,351,686 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,319,154 - 72,351,626 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,147,969 - 69,180,375 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,155,530 - 70,188,135 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,153,556 - 71,186,141 (-)NCBIUU_Cfam_GSD_1.0
YTHDF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,736,624 - 28,769,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,736,621 - 28,769,775 (+)EnsemblGRCh38hg38GRCh38
GRCh37129,063,136 - 29,096,287 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,935,723 - 28,968,874 (+)NCBINCBI36Build 36hg18NCBI36
Build 34128,884,098 - 28,916,902NCBI
Celera127,459,395 - 27,492,550 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef127,315,797 - 27,348,923 (+)NCBIHuRef
CHM1_1129,178,454 - 29,211,612 (+)NCBICHM1_1
T2T-CHM13v2.0128,578,615 - 28,611,771 (+)NCBIT2T-CHM13v2.0
Ythdf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394131,912,227 - 131,939,567 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4131,912,223 - 131,939,614 (-)EnsemblGRCm39 Ensembl
GRCm384132,184,916 - 132,212,256 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,184,912 - 132,212,303 (-)EnsemblGRCm38mm10GRCm38
MGSCv374131,740,831 - 131,768,171 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,458,133 - 131,484,332 (-)NCBIMGSCv36mm8
Celera4130,346,178 - 130,373,501 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map464.92NCBI
Ythdf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,665,467 - 149,693,127 (-)NCBIGRCr8
mRatBN7.25144,381,426 - 144,407,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,381,431 - 144,408,144 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,080,642 - 147,105,456 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05148,850,486 - 148,875,300 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05148,839,793 - 148,864,300 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,364,490 - 150,390,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,365,101 - 150,390,099 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,037,607 - 154,063,041 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,063,958 - 151,089,250 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,073,989 - 151,099,406 (-)NCBI
Celera5142,815,747 - 142,839,776 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ythdf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554527,783,398 - 7,815,468 (+)NCBIChiLan1.0ChiLan1.0
YTHDF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21198,072,609 - 198,107,749 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,191,694 - 197,225,390 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,007,592 - 28,041,179 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,038,751 - 29,070,533 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,038,831 - 29,070,533 (+)Ensemblpanpan1.1panPan2
Ythdf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,966,462 - 47,003,229 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,791,073 - 12,827,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,791,121 - 12,827,122 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YTHDF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,716,759 - 85,747,375 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,717,147 - 85,756,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,553,445 - 79,583,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YTHDF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,041,657 - 104,078,705 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,040,679 - 104,078,484 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603312,443,353 - 12,479,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ythdf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476412,533,257 - 12,567,514 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476412,533,317 - 12,567,514 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in YTHDF2
265 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014110064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022412457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038462150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038462151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038470511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038531354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038595580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659654 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038659655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000018565   ⟹   ENSCAFP00000017196
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl271,775,101 - 71,788,204 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000035288   ⟹   ENSCAFP00000030532
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl271,760,312 - 71,792,527 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845016859   ⟹   ENSCAFP00845013117
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl272,319,154 - 72,351,626 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845016881   ⟹   ENSCAFP00845013134
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl272,334,967 - 72,351,626 (-)Ensembl
RefSeq Acc Id: XM_038462150   ⟹   XP_038318078
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha268,336,008 - 68,368,581 (-)NCBI
RefSeq Acc Id: XM_038462151   ⟹   XP_038318079
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha268,336,008 - 68,368,586 (-)NCBI
RefSeq Acc Id: XM_038470510   ⟹   XP_038326438
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1269,147,969 - 69,180,370 (-)NCBI
RefSeq Acc Id: XM_038470511   ⟹   XP_038326439
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1269,147,969 - 69,180,375 (-)NCBI
RefSeq Acc Id: XM_038531353   ⟹   XP_038387281
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0271,153,556 - 71,186,136 (-)NCBI
RefSeq Acc Id: XM_038531354   ⟹   XP_038387282
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0271,153,556 - 71,186,141 (-)NCBI
RefSeq Acc Id: XM_038595579   ⟹   XP_038451507
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0270,155,530 - 70,188,131 (-)NCBI
RefSeq Acc Id: XM_038595580   ⟹   XP_038451508
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0270,155,530 - 70,188,135 (-)NCBI
RefSeq Acc Id: XM_038659654   ⟹   XP_038515582
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0272,319,158 - 72,351,681 (-)NCBI
RefSeq Acc Id: XM_038659655   ⟹   XP_038515583
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0272,319,158 - 72,351,686 (-)NCBI
Ensembl Acc Id: ENSCAFP00000030532   ⟸   ENSCAFT00000035288
Ensembl Acc Id: ENSCAFP00000017196   ⟸   ENSCAFT00000018565
RefSeq Acc Id: XP_038326439   ⟸   XM_038470511
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038326438   ⟸   XM_038470510
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038451508   ⟸   XM_038595580
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038451507   ⟸   XM_038595579
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038515583   ⟸   XM_038659655
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RW07 (UniProtKB/TrEMBL),   A0A8I3NCD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038515582   ⟸   XM_038659654
- Peptide Label: isoform X1
- UniProtKB: A0A8C0RW05 (UniProtKB/TrEMBL),   A0A8I3NEE9 (UniProtKB/TrEMBL),   A0A8C0RW07 (UniProtKB/TrEMBL),   A0A8I3NCD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038318079   ⟸   XM_038462151
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RW07 (UniProtKB/TrEMBL),   A0A8I3NCD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038318078   ⟸   XM_038462150
- Peptide Label: isoform X1
- UniProtKB: A0A8C0RW05 (UniProtKB/TrEMBL),   A0A8I3NEE9 (UniProtKB/TrEMBL),   A0A8C0RW07 (UniProtKB/TrEMBL),   A0A8I3NCD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387282   ⟸   XM_038531354
- Peptide Label: isoform X2
- UniProtKB: A0A8C0RW07 (UniProtKB/TrEMBL),   A0A8I3NCD4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038387281   ⟸   XM_038531353
- Peptide Label: isoform X1
- UniProtKB: A0A8C0RW05 (UniProtKB/TrEMBL),   A0A8C0RW07 (UniProtKB/TrEMBL),   A0A8I3NCD4 (UniProtKB/TrEMBL),   A0A8I3NEE9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845013134   ⟸   ENSCAFT00845016881
Ensembl Acc Id: ENSCAFP00845013117   ⟸   ENSCAFT00845016859
Protein Domains
YTH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000011700 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030008559 UniProtKB/TrEMBL
  ENSCAFG00040002345 UniProtKB/TrEMBL
  ENSCAFG00845009574 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000018565.5 UniProtKB/TrEMBL
  ENSCAFT00000035288.4 UniProtKB/TrEMBL
  ENSCAFT00030015746.1 UniProtKB/TrEMBL
  ENSCAFT00030015786.1 UniProtKB/TrEMBL
  ENSCAFT00040004450.1 UniProtKB/TrEMBL
  ENSCAFT00040004465.1 UniProtKB/TrEMBL
  ENSCAFT00845016859 ENTREZGENE
  ENSCAFT00845016859.1 UniProtKB/TrEMBL
  ENSCAFT00845016881.1 UniProtKB/TrEMBL
Gene3D-CATH ph1033 like domains UniProtKB/TrEMBL
InterPro YTH_domain UniProtKB/TrEMBL
  YTH_prot UniProtKB/TrEMBL
NCBI Gene YTHDF2 ENTREZGENE
PANTHER PTHR12357 UniProtKB/TrEMBL
  YTH DOMAIN-CONTAINING FAMILY PROTEIN 2 UniProtKB/TrEMBL
Pfam YTH UniProtKB/TrEMBL
PROSITE YTH UniProtKB/TrEMBL
UniProt A0A8C0RW05 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0RW07 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NCD4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NEE9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:48506 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-01-30 YTHDF2  YTH N6-methyladenosine RNA binding protein F2  YTHDF2  YTH N6-methyladenosine RNA binding protein 2  Symbol and/or name change 19259463 PROVISIONAL