YTHDF2 (YTH N6-methyladenosine RNA binding protein F2) - Rat Genome Database

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Gene: YTHDF2 (YTH N6-methyladenosine RNA binding protein F2) Chlorocebus sabaeus
Analyze
Symbol: YTHDF2
Name: YTH N6-methyladenosine RNA binding protein F2
RGD ID: 18460485
Description: ENCODES a protein that exhibits C5-methylcytidine-containing RNA reader activity (ortholog); INVOLVED IN gamete generation (ortholog); hematopoietic stem cell proliferation (ortholog); mRNA catabolic process (ortholog); ASSOCIATED WITH genetic disease (ortholog); hepatocellular carcinoma (ortholog); FOUND IN centriolar satellite (ortholog); cytoplasmic ribonucleoprotein granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: YTH domain-containing family protein 2; YTH N6-methyladenosine RNA binding protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,041,657 - 104,078,705 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,040,679 - 104,078,484 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603312,443,353 - 12,479,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
YTHDF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.120104,041,657 - 104,078,705 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl20104,040,679 - 104,078,484 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603312,443,353 - 12,479,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
YTHDF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38128,736,624 - 28,769,775 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl128,736,621 - 28,769,775 (+)EnsemblGRCh38hg38GRCh38
GRCh37129,063,136 - 29,096,287 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36128,935,723 - 28,968,874 (+)NCBINCBI36Build 36hg18NCBI36
Build 34128,884,098 - 28,916,902NCBI
Celera127,459,395 - 27,492,550 (+)NCBICelera
Cytogenetic Map1p35.3NCBI
HuRef127,315,797 - 27,348,923 (+)NCBIHuRef
CHM1_1129,178,454 - 29,211,612 (+)NCBICHM1_1
T2T-CHM13v2.0128,578,615 - 28,611,771 (+)NCBIT2T-CHM13v2.0
Ythdf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394131,912,227 - 131,939,567 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4131,912,223 - 131,939,614 (-)EnsemblGRCm39 Ensembl
GRCm384132,184,916 - 132,212,256 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4132,184,912 - 132,212,303 (-)EnsemblGRCm38mm10GRCm38
MGSCv374131,740,831 - 131,768,171 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364131,458,133 - 131,484,332 (-)NCBIMGSCv36mm8
Celera4130,346,178 - 130,373,501 (-)NCBICelera
Cytogenetic Map4D2.3NCBI
cM Map464.92NCBI
Ythdf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85149,665,467 - 149,693,127 (-)NCBIGRCr8
mRatBN7.25144,381,426 - 144,407,126 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5144,381,431 - 144,408,144 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5147,080,642 - 147,105,456 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05148,850,486 - 148,875,300 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05148,839,793 - 148,864,300 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05150,364,490 - 150,390,173 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5150,365,101 - 150,390,099 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05154,037,607 - 154,063,041 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45151,063,958 - 151,089,250 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15151,073,989 - 151,099,406 (-)NCBI
Celera5142,815,747 - 142,839,776 (-)NCBICelera
Cytogenetic Map5q36NCBI
Ythdf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554527,783,398 - 7,815,468 (+)NCBIChiLan1.0ChiLan1.0
YTHDF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21198,072,609 - 198,107,749 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11197,191,694 - 197,225,390 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0128,007,592 - 28,041,179 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1129,038,751 - 29,070,533 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl129,038,831 - 29,070,533 (+)Ensemblpanpan1.1panPan2
YTHDF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1271,760,232 - 71,791,420 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl271,760,312 - 71,792,527 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,336,008 - 68,368,586 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,319,158 - 72,351,686 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,319,154 - 72,351,626 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,147,969 - 69,180,375 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0270,155,530 - 70,188,135 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0271,153,556 - 71,186,141 (-)NCBIUU_Cfam_GSD_1.0
Ythdf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505846,966,462 - 47,003,229 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647412,791,073 - 12,827,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647412,791,121 - 12,827,122 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YTHDF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl685,716,983 - 85,726,473 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1685,717,147 - 85,756,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2679,553,445 - 79,583,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Ythdf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476412,533,257 - 12,567,514 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476412,533,317 - 12,567,514 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 9 49
Low 11 11
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007979750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000017515   ⟹   ENSCSAP00000016994
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl20104,040,679 - 104,078,484 (-)Ensembl
RefSeq Acc Id: XM_007979750   ⟹   XP_007977941
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.120104,041,657 - 104,078,705 (-)NCBI
Vero_WHO_p1.0NW_02366603312,443,353 - 12,479,983 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007977941 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000016994
  ENSCSAP00000016994.1
Reference Protein Sequences
RefSeq Acc Id: XP_007977941   ⟸   XM_007979750
- UniProtKB: A0A0D9S805 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000016994   ⟸   ENSCSAT00000017515


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000001018 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000017515.1 UniProtKB/TrEMBL
Gene3D-CATH ph1033 like domains UniProtKB/TrEMBL
InterPro YTH_domain UniProtKB/TrEMBL
  YTH_prot UniProtKB/TrEMBL
KEGG Report csab:103225249 UniProtKB/TrEMBL
NCBI Gene YTHDF2 ENTREZGENE
PANTHER PTHR12357 UniProtKB/TrEMBL
  YTH DOMAIN-CONTAINING FAMILY PROTEIN 2 UniProtKB/TrEMBL
Pfam YTH UniProtKB/TrEMBL
PROSITE YTH UniProtKB/TrEMBL
UniProt A0A0D9S805 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-01-31 YTHDF2  YTH N6-methyladenosine RNA binding protein F2  YTHDF2  YTH N6-methyladenosine RNA binding protein 2  Symbol and/or name change 5135510 APPROVED