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ONTOLOGY REPORT - ANNOTATIONS

Term:hematopoietic stem cell differentiation
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Accession:GO:0060218 term browser browse the term
Definition:The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.
Synonyms:exact_synonym: haematopoietic stem cell differentiation;   haemopoietic stem cell differentiation;   hemopoietic stem cell differentiation


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hematopoietic stem cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:48,537,036...48,561,154 JBrowse link
G BCL2 BCL2 apoptosis regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:9028316) Ensembl
MGI		 PMID:9028316 GO_REF:0000107 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658 		JBrowse link
G CDK6 cyclin dependent kinase 6 acts_upstream_of_or_within ISO (PMID:21508411) MGI PMID:21508411 NCBI chr14:18,178,352...18,413,869
Ensembl chr14:18,188,429...18,419,869 		JBrowse link
G CHD2 chromodomain helicase DNA binding protein 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:19137022) Ensembl
MGI		 PMID:19137022 GO_REF:0000107 NCBI chr 3:47,101,789...47,221,473
Ensembl chr 3:47,105,046...47,221,385 		JBrowse link
G ERCC2 ERCC excision repair 2, TFIIH core complex helicase subunit involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17554309) Ensembl
MGI		 PMID:17554309 GO_REF:0000107 NCBI chr 1:110,173,781...110,191,612
Ensembl chr 1:110,173,715...110,190,125 		JBrowse link
G EXT1 exostosin glycosyltransferase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21148566) Ensembl
MGI		 PMID:21148566 GO_REF:0000107 NCBI chr13:17,172,497...17,457,084
Ensembl chr13:17,172,705...17,456,469 		JBrowse link
G FANCB FA complementation group B acts_upstream_of_or_within ISO (PMID:26658157) MGI PMID:26658157 NCBI chr  X:10,690,826...11,140,838
Ensembl chr  X:11,095,200...11,141,029 		JBrowse link
G FBXO21 F-box protein 21 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:35987460) MGI
Ensembl		 PMID:35987460 GO_REF:0000107 NCBI chr26:13,722,301...13,769,273
Ensembl chr26:13,725,137...13,769,234 		JBrowse link
G HOXB4 homeobox B4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:24,837,572...24,848,600
Ensembl chr 9:24,837,914...24,840,648 		JBrowse link
G LMBR1L limb development membrane protein 1 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:5,475,632...5,488,456
Ensembl chr27:5,475,658...5,487,978 		JBrowse link
G MED1 mediator complex subunit 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16324150) Ensembl
MGI		 PMID:16324150 GO_REF:0000107 NCBI chr 9:22,989,257...23,019,350
Ensembl chr 9:22,989,301...23,019,349 		JBrowse link
G MIR125B-1 microRNA mir-125b-1 acts_upstream_of_or_within ISO (PMID:20660734) MGI PMID:20660734 NCBI chr 5:12,097,672...12,097,732
Ensembl chr 5:12,097,658...12,097,745 		JBrowse link
G MIR125B-2 microRNA mir-125b-2 acts_upstream_of_or_within ISO (PMID:20660734) MGI PMID:20660734 NCBI chr31:13,304,980...13,305,040
Ensembl chr31:13,304,964...13,305,052 		JBrowse link
G MIR126 microRNA mir-126 acts_upstream_of_or_within ISO (PMID:20660734) MGI PMID:20660734 NCBI chr 9:48,879,438...48,879,496
Ensembl chr 9:48,879,432...48,879,504 		JBrowse link
G MIR130A microRNA mir-130a acts_upstream_of_or_within ISO (PMID:20660734) MGI PMID:20660734 NCBI chr18:38,543,618...38,543,679
Ensembl chr18:38,543,618...38,543,681 		JBrowse link
G MIR155 microRNA mir-155 acts_upstream_of_or_within ISO (PMID:20660734) MGI PMID:20660734 NCBI chr31:21,078,768...21,078,828
Ensembl chr31:21,078,758...21,078,833 		JBrowse link
G MIR181C microRNA mir-181c acts_upstream_of_or_within ISO (PMID:20660734) MGI PMID:20660734 NCBI chr20:48,593,343...48,593,403
Ensembl chr20:48,593,325...48,593,421 		JBrowse link
G MIR193B microRNA mir-193b acts_upstream_of_or_within ISO (PMID:20660734) MGI PMID:20660734 NCBI chr 6:28,878,050...28,878,108
Ensembl chr 6:28,878,050...28,878,108 		JBrowse link
G MIR542 microRNA mir-542 acts_upstream_of_or_within ISO (PMID:20660734) MGI PMID:20660734 NCBI chr  X:105,178,359...105,178,417
Ensembl chr  X:105,178,347...105,178,430 		JBrowse link
G MIR99A-1 microRNA mir-99a-1 acts_upstream_of_or_within ISO (PMID:20660734) MGI PMID:20660734 NCBI chr31:13,258,782...13,258,840
Ensembl chr31:13,258,782...13,258,840 		JBrowse link
G MIRLET7E microRNA let-7e acts_upstream_of_or_within ISO (PMID:20660734) MGI PMID:20660734 NCBI chr 1:105,400,740...105,400,806
Ensembl chr 1:105,400,730...105,400,816 		JBrowse link
G MLLT3 MLLT3 super elongation complex subunit involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:39,923,165...40,203,574
Ensembl chr11:39,927,517...40,203,281 		JBrowse link
G SFRP1 secreted frizzled related protein 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr16:24,262,451...24,306,162
Ensembl chr16:24,261,946...24,302,964 		JBrowse link
G SH2B3 SH2B adaptor protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14612394) Ensembl
MGI		 PMID:14612394 GO_REF:0000107 NCBI chr26:9,033,851...9,073,095
Ensembl chr26:9,005,281...9,070,204 		JBrowse link
G SP7 Sp7 transcription factor involved_in ISO (PMID:18932205) BHF-UCL PMID:18932205 NCBI chr27:1,878,612...1,887,063
Ensembl chr27:1,880,424...1,887,679 		JBrowse link
G SRF serum response factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20709909) Ensembl
MGI		 PMID:20709909 GO_REF:0000107 NCBI chr12:11,664,441...11,673,846
Ensembl chr12:11,664,527...11,671,533 		JBrowse link
G TAL1 TAL bHLH transcription factor 1, erythroid differentiation factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:14726374)
(PMID:15677556)		 Ensembl
MGI		 PMID:14726374 PMID:15677556 GO_REF:0000107 NCBI chr15:13,446,752...13,462,038
Ensembl chr15:13,449,481...13,462,047 		JBrowse link
G TP53 tumor protein p53 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109 		JBrowse link
G UFL1 UFM1 specific ligase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:54,988,200...55,023,414
Ensembl chr12:54,988,264...55,021,626 		JBrowse link
G XRCC5 X-ray repair cross complementing 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17554309) Ensembl
MGI		 PMID:17554309 GO_REF:0000107 NCBI chr37:23,095,769...23,185,680
Ensembl chr37:23,095,754...23,185,586 		JBrowse link
G ZFP36 ZFP36 ring finger protein involved_in
acts_upstream_of		 IEA
ISO		 (PMID:11588035) Ensembl
MGI		 PMID:11588035 GO_REF:0000107 NCBI chr 1:113,815,972...113,818,093
Ensembl chr 1:113,816,273...113,818,065 		JBrowse link
negative regulation of hematopoietic stem cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA9 heat shock protein family A (Hsp70) member 9 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr11:26,122,917...26,142,458
Ensembl chr11:26,121,499...26,142,434 		JBrowse link
G LOC100683370 thymosin beta-4 involved_in ISO (PMID:7694679) UniProt PMID:7694679 NCBI chr 1:21,127,694...21,128,346 JBrowse link
G N4BP2L2 NEDD4 binding protein 2 like 2 involved_in ISO (PMID:19506020) UniProt PMID:19506020 NCBI chr25:7,622,032...7,694,396
Ensembl chr25:7,623,670...7,694,398 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524 		JBrowse link
G TCF15 transcription factor 15 involved_in IEA Ensembl GO_REF:0000107 NCBI chr24:20,274,113...20,281,081
Ensembl chr24:20,274,050...20,280,270 		JBrowse link
G ZFP36 ZFP36 ring finger protein involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11588035) Ensembl
MGI		 PMID:11588035 GO_REF:0000107 NCBI chr 1:113,815,972...113,818,093
Ensembl chr 1:113,816,273...113,818,065 		JBrowse link
positive regulation of hematopoietic stem cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXC1 forkhead box C1 involved_in ISO (PMID:24590069) UniProt PMID:24590069
regulation of hematopoietic stem cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDK6 cyclin dependent kinase 6 acts_upstream_of_or_within ISO (PMID:25342715) MGI PMID:25342715 NCBI chr14:18,178,352...18,413,869
Ensembl chr14:18,188,429...18,419,869 		JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:29,494,641...29,537,933
Ensembl chr17:29,496,128...29,537,933 		JBrowse link
G KAT5 lysine acetyltransferase 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:51,499,615...51,507,434
Ensembl chr18:51,499,938...51,576,699 		JBrowse link
G PRKDC protein kinase, DNA-activated, catalytic subunit involved_in ISS UniProt GO_REF:0000024 NCBI chr29:24,904...243,926
Ensembl chr29:35,007...243,895 		JBrowse link
G PUS7 pseudouridine synthase 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:14,882,276...14,939,070
Ensembl chr18:14,878,034...14,938,537 		JBrowse link
G SETD1A SET domain containing 1A, histone lysine methyltransferase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:17,224,107...17,246,527
Ensembl chr 6:17,224,694...17,245,870 		JBrowse link
G YTHDF2 YTH N6-methyladenosine RNA binding protein F2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:71,760,232...71,791,420
Ensembl chr 2:71,760,312...71,792,527 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 22103
    cellular process 21633
      cellular developmental process 4646
        cell differentiation 4645
          hematopoietic progenitor cell differentiation 180
            hematopoietic stem cell differentiation 43
              negative regulation of hematopoietic stem cell differentiation 6
              positive regulation of hematopoietic stem cell differentiation 1
              regulation of hematopoietic stem cell differentiation + 14
Path 2
Term Annotations click to browse term
  biological_process 22103
    developmental process 6888
      cellular developmental process 4646
        cell differentiation 4645
          cell development 3280
            hemopoiesis 1058
              hematopoietic progenitor cell differentiation 180
                hematopoietic stem cell differentiation 43
                  negative regulation of hematopoietic stem cell differentiation 6
                  positive regulation of hematopoietic stem cell differentiation 1
                  regulation of hematopoietic stem cell differentiation + 14
paths to the root