SRF (serum response factor) - Rat Genome Database

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Gene: SRF (serum response factor) Canis lupus familiaris
Analyze
Symbol: SRF
Name: serum response factor
RGD ID: 12436018
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament organization (ortholog); associative learning (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH Cardiomegaly (ortholog); cardiomyopathy (ortholog); Cardiovascular Abnormalities (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: serum response factor (c-fos serum response element-binding transcription factor)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,664,441 - 11,673,846 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,664,527 - 11,671,533 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1211,691,502 - 11,700,834 (+)NCBI
ROS_Cfam_1.01212,146,868 - 12,156,424 (+)NCBI
UMICH_Zoey_3.11211,674,421 - 11,683,753 (+)NCBI
UNSW_CanFamBas_1.01211,758,840 - 11,768,172 (+)NCBI
UU_Cfam_GSD_1.01211,853,634 - 11,862,966 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament organization  (ISO)
associative learning  (IEA,ISO)
bicellular tight junction assembly  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
bronchus cartilage development  (IEA,ISO)
cardiac myofibril assembly  (IEA,ISO)
cardiac vascular smooth muscle cell differentiation  (IEA,ISO)
cell migration involved in sprouting angiogenesis  (IEA,ISO)
cell-cell adhesion  (ISO)
cell-matrix adhesion  (IEA,ISO)
cellular response to glucose stimulus  (ISO)
cellular senescence  (IEA)
contractile actin filament bundle assembly  (ISO)
developmental growth  (IEA,ISO)
dorsal aorta morphogenesis  (IEA,ISO)
epithelial cell-cell adhesion  (IEA,ISO)
epithelial structure maintenance  (IEA,ISO)
erythrocyte development  (IEA,ISO)
eyelid development in camera-type eye  (IEA,ISO)
face development  (IEA,ISO)
forebrain development  (ISO)
gastrulation  (ISO)
heart development  (ISO)
heart looping  (IEA,ISO)
heart trabecula formation  (IEA,ISO)
hematopoietic stem cell differentiation  (IEA,ISO)
hippocampus development  (IEA,ISO)
in utero embryonic development  (ISO)
leukocyte differentiation  (ISO)
long-term memory  (ISO)
long-term synaptic depression  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
lung smooth muscle development  (IEA,ISO)
megakaryocyte development  (IEA,ISO)
mesoderm formation  (IEA,ISO)
morphogenesis of an epithelial sheet  (IEA,ISO)
muscle cell cellular homeostasis  (IEA,ISO)
negative regulation of amyloid-beta clearance  (IEA)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of pri-miRNA transcription by RNA polymerase II  (IEA)
neuron migration  (IEA,ISO)
neuron projection development  (IEA,ISO)
platelet activation  (IEA,ISO)
platelet formation  (IEA,ISO)
positive regulation of axon extension  (IEA,ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of filopodium assembly  (IEA,ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IEA)
positive regulation of smooth muscle contraction  (IEA)
positive regulation of transcription by glucose  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA,ISO)
positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  (IEA)
positive regulation of transcription initiation from RNA polymerase II promoter  (IEA)
positive regulation of transcription via serum response element binding  (IEA)
positive regulation of transcription, DNA-templated  (ISO)
positive thymic T cell selection  (IEA,ISO)
primitive streak formation  (IEA,ISO)
regulation of cell adhesion  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
regulation of transcription, DNA-templated  (ISO)
regulation of water loss via skin  (IEA,ISO)
response to cytokine  (IEA)
response to hormone  (IEA)
response to hypoxia  (IEA)
sarcomere organization  (IEA,ISO)
skin morphogenesis  (IEA,ISO)
stress fiber assembly  (IEA,ISO)
tangential migration from the subventricular zone to the olfactory bulb  (IEA,ISO)
thymus development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
trachea cartilage development  (IEA,ISO)
trophectodermal cell differentiation  (IEA,ISO)

Cellular Component
chromatin  (IEA)
cytoplasm  (IEA)
nucleus  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16690609  


Genomics

Comparative Map Data
SRF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,664,441 - 11,673,846 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,664,527 - 11,671,533 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1211,691,502 - 11,700,834 (+)NCBI
ROS_Cfam_1.01212,146,868 - 12,156,424 (+)NCBI
UMICH_Zoey_3.11211,674,421 - 11,683,753 (+)NCBI
UNSW_CanFamBas_1.01211,758,840 - 11,768,172 (+)NCBI
UU_Cfam_GSD_1.01211,853,634 - 11,862,966 (+)NCBI
SRF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl643,171,269 - 43,181,506 (+)EnsemblGRCh38hg38GRCh38
GRCh38643,171,269 - 43,181,506 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37643,139,007 - 43,149,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,246,898 - 43,257,222 (+)NCBINCBI36hg18NCBI36
Build 34643,247,014 - 43,257,221NCBI
Celera644,691,142 - 44,701,465 (+)NCBI
Cytogenetic Map6p21.1NCBI
HuRef642,855,575 - 42,865,934 (+)NCBIHuRef
CHM1_1643,141,808 - 43,152,132 (+)NCBICHM1_1
Srf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,857,764 - 46,869,194 (-)NCBIGRCm39mm39
GRCm39 Ensembl1746,859,255 - 46,867,101 (-)Ensembl
GRCm381746,546,838 - 46,558,267 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,548,329 - 46,556,175 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,683,788 - 46,693,111 (-)NCBIGRCm37mm9NCBIm37
MGSCv361746,010,028 - 46,019,351 (-)NCBImm8
Celera1749,982,837 - 49,992,041 (-)NCBICelera
Cytogenetic Map17CNCBI
Srf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2914,426,453 - 14,435,734 (+)NCBImRatBN7.2
Rnor_6.0 Ensembl916,737,642 - 16,747,225 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0916,737,637 - 16,747,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0915,642,584 - 15,652,178 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.499,788,378 - 9,797,639 (+)NCBIRGSC3.4rn4RGSC3.4
Celera912,173,971 - 12,183,234 (+)NCBICelera
Cytogenetic Map9q12NCBI
Srf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,098,968 - 9,107,057 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,100,546 - 9,109,305 (+)NCBIChiLan1.0ChiLan1.0
SRF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1644,057,192 - 44,066,768 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl644,057,192 - 44,066,768 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0642,763,099 - 42,773,332 (+)NCBIMhudiblu_PPA_v0panPan3
Srf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,170,709 - 47,180,262 (+)NCBI
SpeTri2.0NW_00493647616,779,941 - 16,789,499 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,213,063 - 38,222,140 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,213,300 - 38,223,686 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,712,387 - 43,724,048 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11728,983,161 - 28,993,465 (-)NCBI
ChlSab1.1 Ensembl1728,983,002 - 28,992,995 (-)Ensembl
Vero_WHO_p1.0NW_02366604443,231,123 - 43,241,353 (+)NCBI
Srf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475416,371,995 - 16,381,287 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 5 16 6 6 4 12 10 5
Low 1 6 6 6 2 8 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000002887   ⟹   ENSCAFP00000002675
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1211,664,527 - 11,671,533 (+)Ensembl
RefSeq Acc Id: XM_038491870   ⟹   XP_038347798
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11211,674,421 - 11,683,753 (+)NCBI
RefSeq Acc Id: XM_038554128   ⟹   XP_038410056
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01211,853,634 - 11,862,966 (+)NCBI
RefSeq Acc Id: XM_038617989   ⟹   XP_038473917
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01211,758,840 - 11,768,172 (+)NCBI
RefSeq Acc Id: XM_038683589   ⟹   XP_038539517
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01212,146,868 - 12,156,424 (+)NCBI
RefSeq Acc Id: XM_847209   ⟹   XP_852302
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11211,664,441 - 11,673,846 (+)NCBI
Dog10K_Boxer_Tasha1211,691,502 - 11,700,834 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038347798 (Get FASTA)   NCBI Sequence Viewer  
  XP_038410056 (Get FASTA)   NCBI Sequence Viewer  
  XP_038473917 (Get FASTA)   NCBI Sequence Viewer  
  XP_038539517 (Get FASTA)   NCBI Sequence Viewer  
  XP_852302 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_852302   ⟸   XM_847209
- UniProtKB: F1PH12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000002675   ⟸   ENSCAFT00000002887
RefSeq Acc Id: XP_038347798   ⟸   XM_038491870
RefSeq Acc Id: XP_038473917   ⟸   XM_038617989
RefSeq Acc Id: XP_038539517   ⟸   XM_038683589
RefSeq Acc Id: XP_038410056   ⟸   XM_038554128
Protein Domains
MADS-box

Promoters
RGD ID:13685435
Promoter ID:EPDNEW_C3503
Type:single initiation site
Name:SRF_1
Description:serum response factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11211,664,794 - 11,664,854EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001829 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000002675 ENTREZGENE
NCBI Gene SRF ENTREZGENE
UniProt F1PH12 ENTREZGENE
VGNC ID VGNC:46799 ENTREZGENE