SFRP1 (secreted frizzled related protein 1) - Rat Genome Database

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Gene: SFRP1 (secreted frizzled related protein 1) Canis lupus familiaris
Analyze
Symbol: SFRP1
Name: secreted frizzled related protein 1
RGD ID: 12322408
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activity (inferred); frizzled binding (inferred); heparin binding (inferred); INVOLVED IN anterior/posterior pattern specification (ortholog); BMP signaling pathway (ortholog); bone trabecula formation (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH Breast Neoplasms (ortholog); Colorectal Neoplasms (ortholog); diastolic heart failure (ortholog); FOUND IN cell surface (inferred); collagen-containing extracellular matrix (inferred); cytosol (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: FrzA; secreted frizzled-related protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11624,262,451 - 24,306,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1624,261,946 - 24,302,964 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1624,766,734 - 24,810,532 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01626,010,215 - 26,053,984 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1626,010,215 - 26,053,974 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11624,382,043 - 24,425,801 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01624,943,898 - 24,987,804 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,995,596 - 25,039,359 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
bone trabecula formation  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cell differentiation  (IEA)
cellular response to BMP stimulus  (IEA)
cellular response to estradiol stimulus  (IEA)
cellular response to estrogen stimulus  (IEA)
cellular response to fibroblast growth factor stimulus  (IEA)
cellular response to growth factor stimulus  (IEA)
cellular response to heparin  (IEA)
cellular response to hypoxia  (IEA)
cellular response to interleukin-1  (IEA)
cellular response to prostaglandin E stimulus  (IEA,ISO)
cellular response to starvation  (IEA)
cellular response to transforming growth factor beta stimulus  (IEA)
cellular response to tumor necrosis factor  (IEA)
cellular response to vitamin D  (IEA)
cellular response to X-ray  (IEA)
convergent extension involved in somitogenesis  (IEA,ISO)
development of primary male sexual characteristics  (IEA,ISO)
digestive tract morphogenesis  (IEA,ISO)
dopaminergic neuron differentiation  (IEA)
dorsal/ventral axis specification  (IEA)
extrinsic apoptotic signaling pathway  (IEA,ISO)
female gonad development  (IEA,ISO)
hematopoietic progenitor cell differentiation  (IEA)
hematopoietic stem cell differentiation  (IEA)
hemopoiesis  (IEA,ISO)
male gonad development  (IEA,ISO)
negative regulation of androgen receptor signaling pathway  (IEA)
negative regulation of apoptotic process  (IEA)
negative regulation of B cell differentiation  (IEA)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of bone remodeling  (IEA)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation  (IEA)
negative regulation of cell growth  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of epithelial cell proliferation  (IEA)
negative regulation of epithelial to mesenchymal transition  (IEA)
negative regulation of fibroblast apoptotic process  (IEA)
negative regulation of fibroblast proliferation  (IEA)
negative regulation of gene expression  (IEA,ISO)
negative regulation of insulin secretion  (IEA)
negative regulation of ossification  (IEA,ISO)
negative regulation of osteoblast differentiation  (IEA,ISO)
negative regulation of osteoblast proliferation  (IEA,ISO)
negative regulation of osteoclast differentiation  (IEA,ISO)
negative regulation of peptidyl-tyrosine phosphorylation  (IEA)
negative regulation of planar cell polarity pathway involved in axis elongation  (IEA,ISO)
negative regulation of Wnt signaling pathway  (IEA,ISO)
neural crest cell fate commitment  (IEA,ISO)
neural tube closure  (IEA,ISO)
neural tube development  (IEA,ISO)
non-canonical Wnt signaling pathway  (IEA)
osteoblast differentiation  (IEA)
osteoclast differentiation  (IEA,ISO)
planar cell polarity pathway involved in axis elongation  (IEA,ISO)
planar cell polarity pathway involved in neural tube closure  (IEA,ISO)
positive regulation of apoptotic process  (IEA)
positive regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of cell growth  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of epithelial cell proliferation  (IEA)
positive regulation of extrinsic apoptotic signaling pathway  (IEA,ISO)
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of fibroblast apoptotic process  (IEA)
positive regulation of non-canonical Wnt signaling pathway  (IEA)
positive regulation of smoothened signaling pathway  (IEA)
positive regulation of Wnt signaling pathway  (IEA)
prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis  (IEA,ISO)
regulation of branching involved in prostate gland morphogenesis  (IEA,ISO)
regulation of cell cycle process  (IEA)
regulation of establishment of planar polarity  (IEA,ISO)
regulation of midbrain dopaminergic neuron differentiation  (IEA)
regulation of neuron projection development  (IEA)
regulation of ossification  (ISO)
response to organic cyclic compound  (IEA)
response to xenobiotic stimulus  (IEA)
somatic stem cell population maintenance  (IEA,ISO)
somitogenesis  (IEA,ISO)
stromal-epithelial cell signaling involved in prostate gland development  (IEA)
ureteric bud development  (IEA)
Wnt signaling pathway  (IEA)
Wnt signaling pathway involved in somitogenesis  (IEA,ISO)
Wnt signaling pathway, planar cell polarity pathway  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202   PMID:30151888  


Genomics

Comparative Map Data
SFRP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11624,262,451 - 24,306,162 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1624,261,946 - 24,302,964 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1624,766,734 - 24,810,532 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01626,010,215 - 26,053,984 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1626,010,215 - 26,053,974 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11624,382,043 - 24,425,801 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01624,943,898 - 24,987,804 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,995,596 - 25,039,359 (+)NCBIUU_Cfam_GSD_1.0
SFRP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38841,261,962 - 41,309,473 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl841,261,962 - 41,309,473 (-)EnsemblGRCh38hg38GRCh38
GRCh37841,119,481 - 41,166,992 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36841,238,635 - 41,286,137 (-)NCBINCBI36Build 36hg18NCBI36
Build 34841,238,635 - 41,286,137NCBI
Celera840,068,517 - 40,116,053 (-)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef839,647,919 - 39,695,566 (-)NCBIHuRef
CHM1_1841,167,412 - 41,215,102 (-)NCBICHM1_1
T2T-CHM13v2.0841,535,586 - 41,583,179 (-)NCBIT2T-CHM13v2.0
Sfrp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,901,401 - 23,939,648 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,901,518 - 23,939,648 (+)EnsemblGRCm39 Ensembl
GRCm38823,411,383 - 23,449,632 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl823,411,502 - 23,449,632 (+)EnsemblGRCm38mm10GRCm38
MGSCv37824,521,974 - 24,560,104 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36824,877,063 - 24,915,177 (+)NCBIMGSCv36mm8
Celera824,905,624 - 24,944,019 (+)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.48NCBI
Sfrp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81675,278,325 - 75,316,736 (-)NCBIGRCr8
mRatBN7.21668,575,763 - 68,614,180 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1668,575,763 - 68,614,286 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1673,854,196 - 73,892,590 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01677,271,342 - 77,309,732 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01672,520,516 - 72,558,923 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01673,372,007 - 73,410,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1673,372,007 - 73,410,777 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,006,739 - 73,045,509 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,030,458 - 73,067,304 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11673,031,966 - 73,066,892 (-)NCBI
Celera1666,467,691 - 66,505,810 (-)NCBICelera
Cytogenetic Map16q12.5NCBI
Sfrp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555361,663,344 - 1,703,514 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555361,663,721 - 1,702,678 (+)NCBIChiLan1.0ChiLan1.0
SFRP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2759,714,926 - 59,762,921 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1835,432,207 - 35,480,221 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0840,507,027 - 40,555,053 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1837,956,423 - 38,001,865 (-)NCBIpanpan1.1PanPan1.1panPan2
Sfrp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494347,320,083 - 47,364,001 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367851,276,420 - 1,321,017 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367851,276,478 - 1,320,397 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SFRP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1710,436,426 - 10,489,748 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11710,436,414 - 10,489,773 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21711,790,230 - 11,878,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SFRP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1839,243,775 - 39,289,050 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl839,243,780 - 39,288,984 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660522,558,131 - 2,612,751 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sfrp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247802,132,960 - 2,174,508 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247802,133,105 - 2,172,301 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SFRP1
484 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 20 6 6 6 6 3 6
Low 1 5 2 6 5 6 7
Below cutoff 1 8

Sequence


RefSeq Acc Id: ENSCAFT00000009243   ⟹   ENSCAFP00000008577
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1624,262,098 - 24,302,964 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000045729   ⟹   ENSCAFP00000037572
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1624,261,946 - 24,302,964 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845015374   ⟹   ENSCAFP00845011939
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1626,010,215 - 26,053,974 (+)Ensembl
RefSeq Acc Id: XM_003639564   ⟹   XP_003639612
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11624,262,451 - 24,306,162 (+)NCBI
Dog10K_Boxer_Tasha1624,766,734 - 24,810,532 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038497519   ⟹   XP_038353447
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11624,382,043 - 24,425,801 (+)NCBI
RefSeq Acc Id: XM_038559971   ⟹   XP_038415899
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01624,995,596 - 25,039,359 (+)NCBI
RefSeq Acc Id: XM_038624008   ⟹   XP_038479936
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01624,943,898 - 24,987,804 (+)NCBI
RefSeq Acc Id: XM_038689771   ⟹   XP_038545699
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01626,010,215 - 26,053,984 (+)NCBI
RefSeq Acc Id: XP_003639612   ⟸   XM_003639564
- UniProtKB: A0A8C0JP54 (UniProtKB/TrEMBL),   A0A8C0QEZ7 (UniProtKB/TrEMBL),   A0A8I3N6M9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000037572   ⟸   ENSCAFT00000045729
RefSeq Acc Id: ENSCAFP00000008577   ⟸   ENSCAFT00000009243
RefSeq Acc Id: XP_038353447   ⟸   XM_038497519
RefSeq Acc Id: XP_038479936   ⟸   XM_038624008
RefSeq Acc Id: XP_038545699   ⟸   XM_038689771
- UniProtKB: A0A8C0JP54 (UniProtKB/TrEMBL),   A0A8C0QEZ7 (UniProtKB/TrEMBL),   A0A8I3N6M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415899   ⟸   XM_038559971
- UniProtKB: A0A8C0JP54 (UniProtKB/TrEMBL),   A0A8C0QEZ7 (UniProtKB/TrEMBL),   A0A8I3N6M9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845011939   ⟸   ENSCAFT00845015374
Protein Domains
FZ   NTR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005737 Ensembl
  ENSCAFG00000057560 UniProtKB/TrEMBL
  ENSCAFG00030017408 UniProtKB/TrEMBL
  ENSCAFG00040007003 UniProtKB/TrEMBL
  ENSCAFG00845008758 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000094986.1 UniProtKB/TrEMBL
  ENSCAFT00030032049.1 UniProtKB/TrEMBL
  ENSCAFT00040012970.1 UniProtKB/TrEMBL
  ENSCAFT00845015374 ENTREZGENE
  ENSCAFT00845015374.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.2000.10 UniProtKB/TrEMBL
  2.40.50.120 UniProtKB/TrEMBL
InterPro Frizzled/SFRP UniProtKB/TrEMBL
  Frizzled_dom UniProtKB/TrEMBL
  Frizzled_dom_sf UniProtKB/TrEMBL
  Netrin_domain UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/TrEMBL
  SFRP1_CRD UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
NCBI Gene SFRP1 ENTREZGENE
PANTHER PTHR11309 UniProtKB/TrEMBL
  PTHR11309:SF87 UniProtKB/TrEMBL
Pfam NTR UniProtKB/TrEMBL
  PF01392 UniProtKB/TrEMBL
PROSITE NTR UniProtKB/TrEMBL
  PS50038 UniProtKB/TrEMBL
SMART C345C UniProtKB/TrEMBL
  FRI UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/TrEMBL
  SSF63501 UniProtKB/TrEMBL
UniProt A0A8C0JP54 ENTREZGENE
  A0A8C0QEZ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N6M9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:46080 ENTREZGENE