EXT1 (exostosin glycosyltransferase 1) - Rat Genome Database

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Gene: EXT1 (exostosin glycosyltransferase 1) Canis lupus familiaris
Analyze
Symbol: EXT1
Name: exostosin glycosyltransferase 1
RGD ID: 12332355
Description: ENCODES a protein that exhibits glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity (ortholog); INVOLVED IN antigen processing and presentation (ortholog); axon guidance (ortholog); basement membrane organization (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); breast cancer (ortholog); FOUND IN catalytic complex (ortholog); Golgi apparatus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: exostoses (multiple) 1; exostosin 1; exostosin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11317,172,497 - 17,457,084 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1317,172,705 - 17,456,469 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1317,173,248 - 17,457,626 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01317,470,129 - 17,750,747 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1317,470,144 - 17,750,070 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11317,205,173 - 17,489,568 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01317,305,318 - 17,589,066 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01317,549,676 - 17,834,137 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antigen processing and presentation  (IEA,ISO)
axon guidance  (IEA,ISO)
basement membrane organization  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
bone growth  (IEA,ISO)
bone morphogenesis  (IEA,ISO)
bone resorption  (IEA,ISO)
brain development  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cartilage development involved in endochondral bone morphogenesis  (IEA,ISO)
cell adhesion  (IEA,ISO)
cell adhesion mediated by integrin  (IEA,ISO)
cell fate commitment  (IEA,ISO)
cell morphogenesis  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell surface receptor signaling pathway  (IEA,ISO)
cellular component organization  (IEA,ISO)
cellular response to BMP stimulus  (IEA,ISO)
cellular response to fibroblast growth factor stimulus  (IEA,ISO)
cellular response to virus  (IEA,ISO)
chondrocyte differentiation  (IEA,ISO)
chondrocyte hypertrophy  (IEA,ISO)
chondrocyte proliferation  (IEA,ISO)
chondroitin sulfate metabolic process  (IEA,ISO)
collagen fibril organization  (IEA,ISO)
cranial skeletal system development  (IEA,ISO)
dendrite self-avoidance  (IEA,ISO)
dendritic cell migration  (IEA,ISO)
developmental growth involved in morphogenesis  (IEA,ISO)
embryonic morphogenesis  (IEA,ISO)
embryonic skeletal joint development  (IEA,ISO)
endochondral bone growth  (IEA,ISO)
endochondral bone morphogenesis  (IEA,ISO)
endochondral ossification  (IEA,ISO)
endoderm development  (IEA,ISO)
epithelial tube branching involved in lung morphogenesis  (IEA,ISO)
epithelium development  (IEA,ISO)
fear response  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IEA,ISO)
fluid transport  (IEA,ISO)
gastrulation  (IEA,ISO)
gene expression  (IEA,ISO)
glandular epithelial cell differentiation  (IEA,ISO)
glomerular basement membrane development  (IEA,ISO)
glycosaminoglycan biosynthetic process  (IEA)
hair cycle process  (IEA,ISO)
hair follicle morphogenesis  (IEA,ISO)
heart contraction  (IEA,ISO)
heart field specification  (IEA,ISO)
hematopoietic progenitor cell differentiation  (IEA,ISO)
hematopoietic stem cell differentiation  (IEA,ISO)
hematopoietic stem cell homeostasis  (IEA,ISO)
hematopoietic stem cell migration to bone marrow  (IEA,ISO)
heparan sulfate proteoglycan biosynthetic process  (IEA,ISO)
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process  (IEA)
heparin biosynthetic process  (IEA,ISO)
heparin metabolic process  (IEA,ISO)
hypersensitivity  (IEA,ISO)
leukocyte tethering or rolling  (IEA,ISO)
limb joint morphogenesis  (IEA,ISO)
lymphocyte adhesion to endothelial cell of high endothelial venule  (IEA,ISO)
lymphocyte migration into lymphoid organs  (IEA,ISO)
mesenchymal cell differentiation involved in bone development  (IEA,ISO)
mesenchyme development  (IEA,ISO)
mesoderm development  (IEA,ISO)
motor behavior  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
multicellular organismal-level water homeostasis  (IEA,ISO)
neural crest cell differentiation  (IEA,ISO)
neuron projection development  (IEA,ISO)
olfactory bulb development  (IEA,ISO)
optic nerve development  (IEA,ISO)
ossification  (IEA)
ossification involved in bone maturation  (IEA,ISO)
perichondral bone morphogenesis  (IEA,ISO)
podocyte differentiation  (IEA,ISO)
polysaccharide biosynthetic process  (IEA)
protein catabolic process  (IEA,ISO)
protein glycosylation  (IEA)
protein-containing complex assembly  (IEA,ISO)
proteoglycan biosynthetic process  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
response to growth factor  (IEA,ISO)
response to heparin  (IEA,ISO)
response to leukemia inhibitory factor  (IEA,ISO)
response to light intensity  (IEA,ISO)
response to virus  (IEA,ISO)
sebaceous gland development  (IEA,ISO)
smoothened signaling pathway  (IEA,ISO)
smoothened signaling pathway involved in lung development  (IEA,ISO)
social behavior  (IEA,ISO)
sodium ion homeostasis  (IEA,ISO)
stem cell division  (IEA,ISO)
stomach development  (IEA,ISO)
sulfation  (IEA,ISO)
sweat gland development  (IEA,ISO)
synaptic transmission, glutamatergic  (IEA,ISO)
tight junction organization  (IEA,ISO)
vacuole organization  (IEA,ISO)
vasodilation  (IEA,ISO)
vocalization behavior  (IEA,ISO)
wound healing  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EXT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11317,172,497 - 17,457,084 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1317,172,705 - 17,456,469 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1317,173,248 - 17,457,626 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01317,470,129 - 17,750,747 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1317,470,144 - 17,750,070 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11317,205,173 - 17,489,568 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01317,305,318 - 17,589,066 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01317,549,676 - 17,834,137 (-)NCBIUU_Cfam_GSD_1.0
EXT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388117,794,490 - 118,111,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl8117,794,490 - 118,111,826 (-)EnsemblGRCh38hg38GRCh38
GRCh378118,806,729 - 119,124,065 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368118,880,783 - 119,193,239 (-)NCBINCBI36Build 36hg18NCBI36
Build 348118,880,786 - 119,193,239NCBI
Celera8115,000,160 - 115,312,582 (-)NCBICelera
Cytogenetic Map8q24.11NCBI
HuRef8114,138,448 - 114,450,830 (-)NCBIHuRef
CHM1_18118,852,044 - 119,165,143 (-)NCBICHM1_1
T2T-CHM13v2.08118,922,893 - 119,240,285 (-)NCBIT2T-CHM13v2.0
Ext1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391552,931,657 - 53,209,579 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1552,927,434 - 53,209,555 (-)EnsemblGRCm39 Ensembl
GRCm381553,068,261 - 53,346,183 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1553,064,038 - 53,346,159 (-)EnsemblGRCm38mm10GRCm38
MGSCv371552,899,816 - 53,177,738 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361552,898,622 - 53,176,027 (-)NCBIMGSCv36mm8
Celera1554,621,498 - 54,903,011 (-)NCBICelera
Cytogenetic Map15CNCBI
cM Map1520.0NCBI
Ext1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8786,265,651 - 86,544,488 (-)NCBIGRCr8
mRatBN7.2784,375,769 - 84,654,625 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl784,375,784 - 84,655,357 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx786,286,761 - 86,565,626 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0788,487,951 - 88,766,801 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0788,293,436 - 88,572,286 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0792,605,008 - 92,881,392 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl792,605,728 - 92,882,068 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0793,245,551 - 93,521,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4789,392,837 - 89,671,523 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera781,215,848 - 81,493,311 (-)NCBICelera
Cytogenetic Map7q31NCBI
Ext1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541723,798,393 - 24,067,100 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541723,798,044 - 24,067,759 (-)NCBIChiLan1.0ChiLan1.0
EXT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27135,221,067 - 135,535,535 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan18110,736,618 - 111,051,056 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v08114,489,325 - 114,803,763 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.18117,011,571 - 117,325,464 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8117,011,919 - 117,324,851 (-)Ensemblpanpan1.1panPan2
Ext1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530320,877,114 - 21,140,365 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647028,303,828 - 28,566,118 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647028,303,213 - 28,566,470 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl420,645,610 - 20,935,540 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1420,645,002 - 20,935,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2421,837,627 - 22,128,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EXT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18112,435,733 - 112,751,301 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603927,547,084 - 27,862,637 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ext1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476316,126,938 - 16,392,804 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476316,126,582 - 16,393,476 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in EXT1
3755 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 3 22 6 6 6 6 12 8 10 6
Low 2 6
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000001302   ⟹   ENSCAFP00000001194
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1317,172,705 - 17,456,469 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845026025   ⟹   ENSCAFP00845020519
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1317,470,144 - 17,750,070 (-)Ensembl
RefSeq Acc Id: XM_038493115   ⟹   XP_038349043
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11317,205,173 - 17,489,568 (-)NCBI
RefSeq Acc Id: XM_038555385   ⟹   XP_038411313
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01317,549,676 - 17,834,137 (-)NCBI
RefSeq Acc Id: XM_038619282   ⟹   XP_038475210
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01317,305,318 - 17,589,066 (-)NCBI
RefSeq Acc Id: XM_038684897   ⟹   XP_038540825
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01317,470,129 - 17,750,747 (-)NCBI
RefSeq Acc Id: XM_539145   ⟹   XP_539145
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11317,172,497 - 17,457,084 (-)NCBI
Dog10K_Boxer_Tasha1317,173,248 - 17,457,626 (-)NCBI
Sequence:
RefSeq Acc Id: XP_539145   ⟸   XM_539145
- Peptide Label: isoform X5
- UniProtKB: A0A8C0SS15 (UniProtKB/TrEMBL),   A0A8C0M7H6 (UniProtKB/TrEMBL),   A0A8P0N408 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000001194   ⟸   ENSCAFT00000001302
RefSeq Acc Id: XP_038349043   ⟸   XM_038493115
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038475210   ⟸   XM_038619282
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038540825   ⟸   XM_038684897
- Peptide Label: isoform X1
- UniProtKB: A0A8C0SS15 (UniProtKB/TrEMBL),   A0A8I3NIH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038411313   ⟸   XM_038555385
- Peptide Label: isoform X4
- UniProtKB: A0A8C0M7H6 (UniProtKB/TrEMBL),   A0A8C0SS15 (UniProtKB/TrEMBL),   A0A8P0N408 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845020519   ⟸   ENSCAFT00845026025

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000831 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004621 UniProtKB/TrEMBL
  ENSCAFG00040015348 UniProtKB/TrEMBL
  ENSCAFG00845014539 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000001302.5 UniProtKB/TrEMBL
  ENSCAFT00030008542.1 UniProtKB/TrEMBL
  ENSCAFT00040028411.1 UniProtKB/TrEMBL
  ENSCAFT00845026025 ENTREZGENE
  ENSCAFT00845026025.1 UniProtKB/TrEMBL
InterPro Exostosin UniProtKB/TrEMBL
  Exostosin_GT47 UniProtKB/TrEMBL
  GT64 UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/TrEMBL
KEGG Report cfa:482024 UniProtKB/TrEMBL
NCBI Gene EXT1 ENTREZGENE
PANTHER ACETYLGLUCOSAMINYLTRANSFERASE UniProtKB/TrEMBL
  ACETYLGLUCOSAMINYLTRANSFERASE UniProtKB/TrEMBL
Pfam Exostosin UniProtKB/TrEMBL
  Glyco_transf_64 UniProtKB/TrEMBL
Superfamily-SCOP SSF53448 UniProtKB/TrEMBL
UniProt A0A8C0M7H6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SS15 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NIH3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0N408 ENTREZGENE
UniProt Secondary A0A8P0N408 UniProtKB/TrEMBL
VGNC ID VGNC:40531 ENTREZGENE