CDK6 (cyclin dependent kinase 6) - Rat Genome Database

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Gene: CDK6 (cyclin dependent kinase 6) Canis lupus familiaris
Analyze
Symbol: CDK6
Name: cyclin dependent kinase 6
RGD ID: 12304806
Description: ENCODES a protein that exhibits cyclin binding (ortholog); INVOLVED IN DNA damage response (ortholog); hematopoietic progenitor cell differentiation (ortholog); hematopoietic stem cell differentiation (ortholog); PARTICIPATES IN G1/S transition pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); acute myeloid leukemia (ortholog); anemia (ortholog); FOUND IN cyclin D2-CDK6 complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclin-dependent kinase 6; cyclin-dependent kinase 6-like; LOC106559699
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11418,178,352 - 18,413,869 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1418,188,429 - 18,419,869 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1417,739,051 - 17,984,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01417,990,661 - 18,231,585 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1417,991,832 - 18,228,301 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11418,145,467 - 18,391,128 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01417,862,908 - 18,101,297 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01418,137,407 - 18,377,659 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 11 of 11 rows

  
Object Symbol
Species
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Evidence
With
Reference
Notes
Source
Original Reference(s)
CDK6Dogglioblastoma severityISOCDK6 (Homo sapiens)9068941 RGDPMID:10884881 and REF_RGD_ID:13702095
CDK6Doghigh grade glioma severityISOCDK6 (Homo sapiens)9068941 RGDPMID:22736304 and REF_RGD_ID:13702093
CDK6Doghigh grade glioma  ISOCDK6 (Homo sapiens)9068941DNA:amplification:RGDPMID:9102208 and REF_RGD_ID:13702094
CDK6Doginterstitial cystitis  ISOCdk6 (Rattus norvegicus)9068941protein:increased expression:urinary bladder:RGDPMID:38842512 and REF_RGD_ID:407445927
CDK6Doglung adenocarcinoma  ISOCDK6 (Homo sapiens)9068941protein:increased expression:lungRGDPMID:10574260 and REF_RGD_ID:13464325
CDK6Doglung non-small cell carcinoma  ISOCDK6 (Homo sapiens)9068941 RGDPMID:27874949 and REF_RGD_ID:13464321
CDK6Doglung non-small cell carcinoma treatmentISOCDK6 (Homo sapiens)9068941 RGDPMID:23591808 and REF_RGD_ID:13464324
CDK6Dogmedulloblastoma disease_progressionISOCDK6 (Homo sapiens)9068941 RGDPMID:16314645 and REF_RGD_ID:13702096
CDK6Dognon-functioning pancreatic endocrine tumor  ISOCDK6 (Homo sapiens)9068941associated with multiple endocrine neoplasia type 1 and mRNA:increased expression:islet of Langerhans (human)RGDPMID:29149451 and REF_RGD_ID:13781946
CDK6Dogpancreatic adenocarcinoma treatmentISOCDK6 (Homo sapiens)9068941human cells in a mouse modelRGDPMID:25050737 and REF_RGD_ID:13782144
CDK6Dogpancreatic ductal carcinoma treatmentISOCDK6 (Homo sapiens)9068941human cells in a mouse modelRGDPMID:24389175 and REF_RGD_ID:13782187
1 to 11 of 11 rows
Object Symbol
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Term
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Evidence
With
Reference
Notes
Source
Original Reference(s)
CDK6DogBehcet's disease  ISOCDK6 (Homo sapiens)8554872ClinVar Annotator: match by term: Behcet diseaseClinVar 
CDK6Dogpleomorphic xanthoastrocytoma  ISOCDK6 (Homo sapiens)8554872ClinVar Annotator: match by term: Pleomorphic xanthoastrocytomaClinVarPMID:28299358
CDK6Dogprimary autosomal recessive microcephaly 12  ISOCDK6 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23918663 more ...
1 to 15 of 15 rows
Object Symbol
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Evidence
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Reference
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Source
Original Reference(s)
CDK6Dogacute lymphoblastic leukemia  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:24736461
CDK6Dogacute myeloid leukemia  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18206229
CDK6Doganemia  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:28255017
CDK6Dogatrial fibrillation  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:29892015 and PMID:30061737
CDK6DogBrain Stem Neoplasms  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:24098593
CDK6DogChloracne  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:17101203
CDK6DogChromosome Aberrations  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:24736461
CDK6DogExperimental Mammary Neoplasms  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25221644
CDK6Dogglioblastoma  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20534551
CDK6Doghead and neck squamous cell carcinoma  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:29464035
CDK6Dogmalignant mesothelioma  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:25756049
CDK6Dogmedulloblastoma  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19270706 and PMID:23138228
CDK6Dogrheumatoid arthritis  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:18794853
CDK6DogStroke  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:29531354
CDK6DogTriple Negative Breast Neoplasms  ISOCDK6 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:33727089
1 to 15 of 15 rows
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Original Reference(s)
CDK6Dogprimary autosomal recessive microcephaly 12  ISOCDK6 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 20 of 31 rows

  
Object Symbol
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Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CDK6Dogcell dedifferentiation involved_inIEAInterPro:IPR028788150520179 InterProGO_REF:0000002
CDK6Dogcell dedifferentiation involved_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6DogDNA damage response  ISOCdk6 (Rattus norvegicus)9068941 RGDPMID:19151707 and REF_RGD_ID:10053571
CDK6DogG1/S transition of mitotic cell cycle involved_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6DogG1/S transition of mitotic cell cycle involved_inIBACGD:CAL0000191263 more ...150520179 GO_CentralGO_REF:0000033
CDK6Doggliogenesis involved_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Doghematopoietic progenitor cell differentiation acts_upstream_of_or_withinISOMGI:3833563 and MGI:51415149068941 PMID:21508411MGIPMID:21508411
CDK6Doghematopoietic stem cell differentiation acts_upstream_of_or_withinISOMGI:3833563 and MGI:51415149068941 PMID:21508411MGIPMID:21508411
CDK6Doghemopoiesis involved_inISOCdk6 (Mus musculus)9068941 PMID:15315761BHF-UCLPMID:15315761
CDK6Dognegative regulation of cell cycle involved_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dognegative regulation of cellular senescence involved_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dognegative regulation of epithelial cell proliferation involved_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dognegative regulation of monocyte differentiation involved_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dognegative regulation of myeloid cell differentiation involved_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dognegative regulation of osteoblast differentiation involved_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dognegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOMGI:30539759068941 PMID:25342715MGIPMID:25342715
CDK6DogNotch signaling pathway acts_upstream_of_or_withinISOCdk6 (Mus musculus)9068941 PMID:21508411MGIPMID:21508411
CDK6DogNotch signaling pathway acts_upstream_of_or_withinISOMGI:965499068941 PMID:21508411MGIPMID:21508411
CDK6Dogpositive regulation of cell-matrix adhesion involved_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dogpositive regulation of fibroblast proliferation involved_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
1 to 20 of 31 rows

Cellular Component
1 to 13 of 13 rows

  
Object Symbol
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Reference
Notes
Source
Original Reference(s)
CDK6Dogcentrosome located_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dogcyclin D1-CDK6 complex part_ofIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dogcyclin D2-CDK6 complex part_ofISOCdk6 (Mus musculus)9068941 PMID:7739547MGIPMID:7739547
CDK6Dogcyclin D3-CDK6 complex part_ofIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dogcyclin-dependent protein kinase holoenzyme complex part_ofIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dogcyclin-dependent protein kinase holoenzyme complex part_ofIBAMGI:104772 more ...150520179 GO_CentralGO_REF:0000033
CDK6Dogcytoplasm located_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dogcytoplasm is_active_inIBAPANTHER:PTN000623979 more ...150520179 GO_CentralGO_REF:0000033
CDK6Dogcytosol located_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dognucleoplasm located_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dognucleus located_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dognucleus is_active_inIBAFB:FBgn0015618 more ...150520179 GO_CentralGO_REF:0000033
CDK6Dogruffle located_inIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
1 to 13 of 13 rows

Molecular Function
1 to 20 of 44 rows

  
Object Symbol
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Reference
Notes
Source
Original Reference(s)
CDK6DogATP binding enablesIEAInterPro:IPR000719 and InterPro:IPR017441150520179 InterProGO_REF:0000002
CDK6DogATP binding enablesIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6DogATP binding enablesIEAUniProtKB-KW:KW-0067150520179 UniProtGO_REF:0000043
CDK6DogATP binding enablesIEAUniRule:UR001503341150520179 UniProtGO_REF:0000104
CDK6Dogcyclin binding  ISOCcnd3 (Rattus norvegicus)9068941 RGDPMID:15809057 and REF_RGD_ID:1582338
CDK6Dogcyclin binding enablesIBAFB:FBgn0016131 more ...150520179 GO_CentralGO_REF:0000033
CDK6Dogcyclin binding enablesIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dogcyclin binding  ISOCcnd2 (Rattus norvegicus)9068941 RGDPMID:15809057 and REF_RGD_ID:1582338
CDK6Dogcyclin-dependent protein serine/threonine kinase activity enablesIEAInterPro:IPR028788150520179 InterProGO_REF:0000002
CDK6Dogcyclin-dependent protein serine/threonine kinase activity enablesIBACGD:CAL0000191263 more ...150520179 GO_CentralGO_REF:0000033
CDK6Dogcyclin-dependent protein serine/threonine kinase activity enablesIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6DogFBXO family protein binding enablesIEAUniProtKB:Q00534 and ensembl:ENSP00000397087150520179 EnsemblGO_REF:0000107
CDK6Dogkinase activity enablesIEAUniProtKB-KW:KW-0418150520179 UniProtGO_REF:0000043
CDK6Dognucleotide binding enablesIEAUniProtKB-KW:KW-0547150520179 UniProtGO_REF:0000043
CDK6Dognucleotide binding enablesIEAUniRule:UR001503341150520179 UniProtGO_REF:0000104
CDK6Dogprotein binding enablesISOUniProtKB:P082389068941 PMID:22939624IntActPMID:22939624
CDK6Dogprotein binding enablesISOPR:P30280 and PR:Q3U7U39068941 PMID:21652635MGIPMID:21652635
CDK6Dogprotein binding enablesISOUniProtKB:P302829068941 PMID:23079656IntActPMID:23079656
CDK6Dogprotein binding enablesISOUniProtKB:O890889068941 PMID:7651726MGIPMID:7651726
CDK6Dogprotein binding enablesISOPR:Q9Z1L39068941 PMID:21135503MGIPMID:21135503
1 to 20 of 44 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
CDK6DogG1/S transition pathway  ISOCDK6 (Homo sapiens)9068941 RGDPMID:10919634 more ...
PMID:22301074   PMID:30032202  



CDK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11418,178,352 - 18,413,869 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1418,188,429 - 18,419,869 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1417,739,051 - 17,984,302 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01417,990,661 - 18,231,585 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1417,991,832 - 18,228,301 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11418,145,467 - 18,391,128 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01417,862,908 - 18,101,297 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01418,137,407 - 18,377,659 (-)NCBIUU_Cfam_GSD_1.0
CDK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38792,604,921 - 92,836,573 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl792,604,921 - 92,836,573 (-)EnsemblGRCh38hg38GRCh38
GRCh37792,234,235 - 92,465,887 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36792,072,171 - 92,301,148 (-)NCBINCBI36Build 36hg18NCBI36
Build 34791,878,887 - 92,107,863NCBI
Celera786,938,762 - 87,170,471 (-)NCBICelera
Cytogenetic Map7q21.2NCBI
HuRef786,843,599 - 87,075,188 (-)NCBIHuRef
CHM1_1792,164,273 - 92,395,977 (-)NCBICHM1_1
T2T-CHM13v2.0793,846,868 - 94,078,562 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2791,563,451 - 91,795,159 (-)NCBI
Cdk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3953,391,004 - 3,581,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl53,391,485 - 3,581,008 (+)EnsemblGRCm39 Ensembl
GRCm3853,341,004 - 3,531,008 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl53,341,485 - 3,531,008 (+)EnsemblGRCm38mm10GRCm38
MGSCv3753,344,312 - 3,522,225 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3653,350,318 - 3,528,231 (+)NCBIMGSCv36mm8
Celera53,279,311 - 3,457,786 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map52.04NCBI
Cdk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8431,592,384 - 31,784,732 (-)NCBIGRCr8
mRatBN7.2430,637,650 - 30,829,688 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl430,646,460 - 30,829,634 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx435,619,211 - 35,799,521 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0431,545,296 - 31,725,618 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0429,941,333 - 30,121,666 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0427,781,728 - 27,969,653 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl427,785,647 - 27,966,398 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0427,685,042 - 27,872,388 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4427,362,656 - 27,618,006 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1427,471,179 - 27,635,330 (-)NCBI
Celera426,070,823 - 26,248,747 (-)NCBICelera
Cytogenetic Map4q13NCBI
Cdk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554329,521,794 - 9,726,417 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554329,521,794 - 9,727,772 (-)NCBIChiLan1.0ChiLan1.0
CDK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26110,490,882 - 110,725,552 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17158,755,524 - 158,990,195 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0784,603,419 - 84,835,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1798,198,740 - 98,430,305 (-)NCBIpanpan1.1PanPan1.1panPan2
Cdk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511831,562,931 - 31,777,533 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368031,024,779 - 1,227,516 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368031,025,047 - 1,229,396 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl972,518,101 - 72,764,129 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1972,510,858 - 72,765,631 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2979,239,881 - 79,316,977 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CDK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12156,167,731 - 56,403,976 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2156,170,450 - 56,393,808 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604247,876,694 - 48,113,340 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cdk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624809349,404 - 579,599 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624809349,453 - 588,986 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in CDK6
2057 total Variants



adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10


1 to 30 of 31 rows
RefSeq Transcripts XM_022427346 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038436151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038436153 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038436155 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038436158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038436160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038494534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038556826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038620761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686444 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038686447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000156 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 31 rows

Ensembl Acc Id: ENSCAFT00000003170   ⟹   ENSCAFP00000002945
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1418,188,429 - 18,419,869 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845023565   ⟹   ENSCAFP00845018501
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1417,991,832 - 18,228,301 (-)Ensembl
RefSeq Acc Id: XM_038436151   ⟹   XP_038292079
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1417,739,051 - 17,982,635 (-)NCBI
RefSeq Acc Id: XM_038436153   ⟹   XP_038292081
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1417,739,051 - 17,984,302 (-)NCBI
RefSeq Acc Id: XM_038436155   ⟹   XP_038292083
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1417,739,051 - 17,982,910 (-)NCBI
RefSeq Acc Id: XM_038436158   ⟹   XP_038292086
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1417,739,051 - 17,982,635 (-)NCBI
RefSeq Acc Id: XM_038436160   ⟹   XP_038292088
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1417,739,051 - 17,982,641 (-)NCBI
RefSeq Acc Id: XM_038494530   ⟹   XP_038350458
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11418,145,467 - 18,389,461 (-)NCBI
RefSeq Acc Id: XM_038494531   ⟹   XP_038350459
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11418,145,467 - 18,391,128 (-)NCBI
RefSeq Acc Id: XM_038494532   ⟹   XP_038350460
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11418,145,467 - 18,389,736 (-)NCBI
RefSeq Acc Id: XM_038494533   ⟹   XP_038350461
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11418,145,467 - 18,389,461 (-)NCBI
RefSeq Acc Id: XM_038494534   ⟹   XP_038350462
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11418,145,467 - 18,389,467 (-)NCBI
RefSeq Acc Id: XM_038556822   ⟹   XP_038412750
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01418,137,407 - 18,375,992 (-)NCBI
RefSeq Acc Id: XM_038556823   ⟹   XP_038412751
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01418,137,407 - 18,377,659 (-)NCBI
RefSeq Acc Id: XM_038556824   ⟹   XP_038412752
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01418,137,407 - 18,376,267 (-)NCBI
RefSeq Acc Id: XM_038556825   ⟹   XP_038412753
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01418,137,407 - 18,375,992 (-)NCBI
RefSeq Acc Id: XM_038556826   ⟹   XP_038412754
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01418,137,407 - 18,375,998 (-)NCBI
RefSeq Acc Id: XM_038620756   ⟹   XP_038476684
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01417,862,908 - 18,099,630 (-)NCBI
RefSeq Acc Id: XM_038620757   ⟹   XP_038476685
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01417,862,908 - 18,101,297 (-)NCBI
RefSeq Acc Id: XM_038620758   ⟹   XP_038476686
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01417,862,908 - 18,099,905 (-)NCBI
RefSeq Acc Id: XM_038620760   ⟹   XP_038476688
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01417,862,908 - 18,099,630 (-)NCBI
RefSeq Acc Id: XM_038620761   ⟹   XP_038476689
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01417,862,908 - 18,099,636 (-)NCBI
RefSeq Acc Id: XM_038686443   ⟹   XP_038542371
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01417,990,661 - 18,229,918 (-)NCBI
RefSeq Acc Id: XM_038686444   ⟹   XP_038542372
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01417,990,661 - 18,231,585 (-)NCBI
RefSeq Acc Id: XM_038686445   ⟹   XP_038542373
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01417,990,661 - 18,230,193 (-)NCBI
RefSeq Acc Id: XM_038686446   ⟹   XP_038542374
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01417,990,661 - 18,229,918 (-)NCBI
RefSeq Acc Id: XM_038686447   ⟹   XP_038542375
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01417,990,661 - 18,229,924 (-)NCBI
1 to 30 of 30 rows
Protein RefSeqs XP_038292079 (Get FASTA)   NCBI Sequence Viewer  
  XP_038292081 (Get FASTA)   NCBI Sequence Viewer  
  XP_038292083 (Get FASTA)   NCBI Sequence Viewer  
  XP_038292086 (Get FASTA)   NCBI Sequence Viewer  
  XP_038292088 (Get FASTA)   NCBI Sequence Viewer  
  XP_038350458 (Get FASTA)   NCBI Sequence Viewer  
  XP_038350459 (Get FASTA)   NCBI Sequence Viewer  
  XP_038350460 (Get FASTA)   NCBI Sequence Viewer  
  XP_038350461 (Get FASTA)   NCBI Sequence Viewer  
  XP_038350462 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412750 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412751 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412752 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412753 (Get FASTA)   NCBI Sequence Viewer  
  XP_038412754 (Get FASTA)   NCBI Sequence Viewer  
  XP_038476684 (Get FASTA)   NCBI Sequence Viewer  
  XP_038476685 (Get FASTA)   NCBI Sequence Viewer  
  XP_038476686 (Get FASTA)   NCBI Sequence Viewer  
  XP_038476688 (Get FASTA)   NCBI Sequence Viewer  
  XP_038476689 (Get FASTA)   NCBI Sequence Viewer  
  XP_038542371 (Get FASTA)   NCBI Sequence Viewer  
  XP_038542372 (Get FASTA)   NCBI Sequence Viewer  
  XP_038542373 (Get FASTA)   NCBI Sequence Viewer  
  XP_038542374 (Get FASTA)   NCBI Sequence Viewer  
  XP_038542375 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000002945.4
  ENSCAFP00030022617.1
  ENSCAFP00040033205.1
  ENSCAFP00845018501
  ENSCAFP00845018501.1
1 to 30 of 30 rows
1 to 5 of 27 rows
1 to 5 of 27 rows
Ensembl Acc Id: ENSCAFP00000002945   ⟸   ENSCAFT00000003170
RefSeq Acc Id: XP_038350459   ⟸   XM_038494531
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038350460   ⟸   XM_038494532
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038350462   ⟸   XM_038494534
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038350461   ⟸   XM_038494533
- Peptide Label: isoform X1
Protein kinase

RGD ID:13685747
Promoter ID:EPDNEW_C3815
Type:multiple initiation site
Name:CDK6_1
Description:cyclin dependent kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11418,419,922 - 18,419,982EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCAFG00000001998 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013977 UniProtKB/TrEMBL
  ENSCAFG00040020595 UniProtKB/TrEMBL
  ENSCAFG00845013226 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000003170.5 UniProtKB/TrEMBL
  ENSCAFT00030025893.1 UniProtKB/TrEMBL
  ENSCAFT00040038091.1 UniProtKB/TrEMBL
  ENSCAFT00845023565 ENTREZGENE
  ENSCAFT00845023565.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CDK UniProtKB/TrEMBL
  CDK6 UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene CDK6 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 6 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C0TA97 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3RZY6 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:54756 ENTREZGENE
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-14 CDK6  cyclin dependent kinase 6  LOC106559699  cyclin-dependent kinase 6-like  Data merged from RGD:12154535 737654 PROVISIONAL