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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of translational initiation
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Accession:GO:0045947 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate or extent of translational initiation.
Synonyms:exact_synonym: down regulation of translational initiation;   downregulation of translational initiation
 narrow_synonym: inhibition of translational initiation


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negative regulation of translational initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ago2 argonaute RISC catalytic component 2 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000104
(PMID:17524464), (PMID:19801630)		 UniProt
RGD		 PMID:17524464 PMID:19801630 GO_REF:0000024 GO_REF:0000104 NCBI chr 7:105,018,202...105,105,118
Ensembl chr 7:105,029,120...105,104,974 		JBrowse link
G Bank1 B-cell scaffold protein with ankyrin repeats 1 acts_upstream_of_or_within ISO MGI:3686872 (PMID:24227780) RGD PMID:24227780 NCBI chr 2:224,530,475...224,800,420
Ensembl chr 2:224,530,475...224,800,405 		JBrowse link
G C5h8orf88 similar to human chromosome 8 open reading frame 88 involved_in IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 5:28,330,167...28,355,691
Ensembl chr 5:28,330,206...28,357,152 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISS
ISO		 GO_REF:0000024
(PMID:16601681)		 UniProt
RGD		 PMID:16601681 GO_REF:0000024 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630 		JBrowse link
G Eif4e2 eukaryotic translation initiation factor 4E family member 2 involved_in ISO (PMID:32726578), (PMID:35878012) RGD PMID:32726578 PMID:35878012 NCBI chr 9:87,886,126...87,914,470
Ensembl chr 9:87,878,085...87,914,482 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 involved_in
acts_upstream_of_or_within		 IMP
ISO
IEA
IBA		 (PMID:22578813)
GO_REF:0000117
GO_REF:0000033
(PMID:16142217)		 RGD
UniProt
GO_Central		 PMID:16142217 PMID:22578813 PMID:11865047 GO_REF:0000033 GO_REF:0000117, RGD:1625627 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Eif4ebp2 eukaryotic translation initiation factor 4E binding protein 2 involved_in ISO
IBA		 (PMID:30765518)
(PMID:16237163), (PMID:20347422), (PMID:23172145)
GO_REF:0000033		 RGD
GO_Central		 PMID:16237163 PMID:20347422 PMID:23172145 PMID:30765518 GO_REF:0000033 NCBI chr20:29,379,444...29,400,110
Ensembl chr20:29,382,668...29,399,946 		JBrowse link
G Eif4ebp3 eukaryotic translation initiation factor 4E binding protein 3 involved_in IEA GO_REF:0000117 UniProt GO_REF:0000117 NCBI chr18:28,263,089...28,268,033
Ensembl chr18:28,162,311...28,268,024 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:18805096)		 UniProt
RGD		 PMID:18805096 GO_REF:0000024 NCBI chr  X:147,240,239...147,278,057
Ensembl chr  X:147,240,301...147,278,050 		JBrowse link
G Gigyf2 GRB10 interacting GYF protein 2 involved_in ISO (PMID:32726578), (PMID:35878012) RGD PMID:32726578 PMID:35878012 NCBI chr 9:88,001,212...88,127,040
Ensembl chr 9:88,001,301...88,125,715 		JBrowse link
G Larp1 La ribonucleoprotein 1, translational regulator involved_in ISO (PMID:28379136) RGD PMID:28379136 NCBI chr10:42,191,378...42,246,361
Ensembl chr10:42,191,325...42,243,371 		JBrowse link
G Paip2 poly(A) binding protein interacting protein 2 involved_in ISO
IEA		 (PMID:11172725)
GO_REF:0000002		 RGD
InterPro		 PMID:11172725 GO_REF:0000002 NCBI chr18:27,199,762...27,218,359
Ensembl chr18:27,199,796...27,214,863 		JBrowse link
G Paip2b poly(A) binding protein interacting protein 2B involved_in ISO (PMID:16804161) RGD PMID:16804161 NCBI chr 4:116,292,001...116,323,387
Ensembl chr 4:116,292,020...116,323,379 		JBrowse link
G Rbm4 RNA binding motif protein 4 involved_in ISO (PMID:19801630) RGD PMID:19801630 NCBI chr 1:202,078,442...202,087,506
Ensembl chr 1:202,085,279...202,105,380 		JBrowse link
G Scrib scribble planar cell polarity protein involved_in ISO (PMID:34535749) RGD PMID:34535749 NCBI chr 7:107,759,343...107,782,364
Ensembl chr 7:107,759,343...107,782,331 		JBrowse link
G Tpr translocated promoter region, nuclear basket protein involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:21613532)		 UniProt
Ensembl
RGD		 PMID:21613532 GO_REF:0000024 GO_REF:0000107 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496 		JBrowse link
G Zfp598 zinc finger protein 598 involved_in ISO (PMID:28065601) RGD PMID:28065601 NCBI chr10:13,694,224...13,706,235
Ensembl chr10:13,694,286...13,706,233 		JBrowse link
negative regulation of formation of translation preinitiation complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl13a ribosomal protein L13A involved_in ISO
ISS		 (PMID:17218275)
GO_REF:0000024		 RGD
UniProt		 PMID:17218275 GO_REF:0000024 NCBI chr 1:95,609,374...95,612,557
Ensembl chr 1:95,609,370...95,620,463 		JBrowse link
negative regulation of translation in response to oxidative stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pml PML nuclear body scaffold involved_in ISO (PMID:16915281) RGD PMID:16915281 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
negative regulation of translational initiation in response to stress term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 involved_in ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 involved_in ISO
IBA		 (PMID:12176355)
GO_REF:0000033		 RGD
GO_Central		 PMID:12176355 GO_REF:0000033 NCBI chr 3:105,356,261...105,441,630
Ensembl chr 3:105,356,261...105,441,630 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha involved_in ISS
ISO		 GO_REF:0000024
(PMID:12176355)		 UniProt
RGD		 PMID:12176355 GO_REF:0000024 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    cellular process 19150
      metabolic process 11950
        translational initiation 133
          negative regulation of translational initiation 21
            negative regulation of cytoplasmic translational initiation + 1
            negative regulation of formation of translation initiation ternary complex 0
            negative regulation of mitochondrial translational initiation 0
            negative regulation of translational initiation by iron 0
            negative regulation of translational initiation in response to stress + 4
Path 2
Term Annotations click to browse term
  biological_process 20069
    biological regulation 13555
      regulation of biological process 13132
        regulation of cellular process 12767
          regulation of metabolic process 6743
            regulation of biosynthetic process 5507
              regulation of macromolecule biosynthetic process 5306
                regulation of gene expression 5186
                  post-transcriptional regulation of gene expression 773
                    regulation of translation 492
                      regulation of translational initiation 75
                        negative regulation of translational initiation 21
                          negative regulation of cytoplasmic translational initiation + 1
                          negative regulation of formation of translation initiation ternary complex 0
                          negative regulation of mitochondrial translational initiation 0
                          negative regulation of translational initiation by iron 0
                          negative regulation of translational initiation in response to stress + 4
paths to the root