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Gene: Rbm4 (RNA binding motif protein 4) Rattus norvegicus

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Symbol:

Rbm4

Name:

RNA binding motif protein 4

RGD ID:

1306891

Description:

Predicted to enable RNA binding activity and cyclin binding activity. Predicted to be involved in several processes, including IRES-dependent translational initiation of linear mRNA; entrainment of circadian clock by photoperiod; and regulation of translation. Predicted to act upstream of or within several processes, including insulin secretion involved in cellular response to glucose stimulus; regulation of gene expression; and regulation of insulin receptor signaling pathway. Predicted to be located in several cellular components, including cytoplasmic stress granule; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be active in nucleus. Orthologous to human RBM4 (RNA binding motif protein 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; chlorpyrifos.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC293663

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	211,507,845 - 211,516,907 (-)	NCBI		GRCr8
mRatBN7.2	1	202,078,442 - 202,087,506 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	202,085,279 - 202,105,380 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	210,431,563 - 210,440,647 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	217,523,875 - 217,532,939 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	210,214,899 - 210,223,962 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	220,038,403 - 220,049,756 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	220,039,734 - 220,048,966 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	226,903,520 - 226,913,901 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	207,394,470 - 207,403,393 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	207,547,786 - 207,556,823 (-)	NCBI
Celera	1	199,618,949 - 199,628,010 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Aicardi-Goutieres Syndrome 3 (ISO)

intellectual disability (ISO)

myoepithelioma (ISO)

Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

caffeine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (EXP)

cisplatin (ISO)

copper(II) sulfate (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

folic acid (ISO)

FR900359 (ISO)

gentamycin (EXP)

hydralazine (ISO)

hydroxyurea (ISO)

ivermectin (ISO)

ketamine (EXP)

lead diacetate (ISO)

methapyrilene (ISO)

methylmercury chloride (ISO)

monosodium L-glutamate (ISO)

N-methyl-N-nitrosourea (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

quartz (ISO)

quercetin (ISO)

SB 203580 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

testosterone (ISO)

tetrachloromethane (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cap-independent translational initiation (ISO)

circadian regulation of gene expression (ISO)

circadian regulation of translation (ISO)

enteroendocrine cell differentiation (ISO)

entrainment of circadian clock by photoperiod (ISO)

glucose homeostasis (ISO)

insulin secretion involved in cellular response to glucose stimulus (ISO)

IRES-dependent translational initiation of linear mRNA (ISO)

miRNA-mediated gene silencing by inhibition of translation (ISO)

negative regulation of translation (ISO)

negative regulation of translation in response to stress (ISO)

negative regulation of translational initiation (ISO)

pancreas development (ISO)

positive regulation of muscle cell differentiation (ISO)

positive regulation of translation (ISO)

regulation of alternative mRNA splicing, via spliceosome (ISO)

regulation of gene expression (ISO)

regulation of insulin receptor signaling pathway (ISO)

regulation of nucleocytoplasmic transport (ISO)

response to arsenic-containing substance (ISO)

Cellular Component

cytoplasm (ISO)

cytoplasmic stress granule (ISO)

cytosol (ISO)

nuclear speck (ISO)

nucleolus (ISO)

nucleoplasm (ISO)

nucleus (IBA,ISO)

perinuclear region of cytoplasm (ISO)

Molecular Function

cyclin binding (ISO)

miRNA binding (ISO)

mRNA 3'-UTR binding (ISO)

mRNA binding (IBA,ISO)

pre-mRNA binding (ISO)

pre-mRNA intronic binding (ISO)

pre-mRNA intronic pyrimidine-rich binding (ISO)

protein binding (ISO)

RNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:12628928	PMID:15159402	PMID:16260624	PMID:16777844	PMID:16907643	PMID:16934801	PMID:17264215	PMID:17284590	PMID:19561594	PMID:19801630	PMID:21518792
PMID:22658674	PMID:22681889	PMID:23129807

Genomics

Comparative Map Data

Rbm4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	211,507,845 - 211,516,907 (-)	NCBI		GRCr8
mRatBN7.2	1	202,078,442 - 202,087,506 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	202,085,279 - 202,105,380 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	210,431,563 - 210,440,647 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	217,523,875 - 217,532,939 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	210,214,899 - 210,223,962 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	220,038,403 - 220,049,756 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	220,039,734 - 220,048,966 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	226,903,520 - 226,913,901 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	207,394,470 - 207,403,393 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	207,547,786 - 207,556,823 (-)	NCBI
Celera	1	199,618,949 - 199,628,010 (-)	NCBI		Celera
Cytogenetic Map	1	q43	NCBI

RBM4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	66,638,703 - 66,668,380 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	66,638,667 - 66,668,374 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	66,406,174 - 66,435,851 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	66,162,714 - 66,170,516 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	66,162,777 - 66,170,514	NCBI
Celera	11	63,731,742 - 63,740,539 (+)	NCBI		Celera
Cytogenetic Map	11	q13.2	NCBI
HuRef	11	62,734,477 - 62,764,214 (+)	NCBI		HuRef
CHM1_1	11	66,289,814 - 66,319,584 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	66,634,947 - 66,664,627 (+)	NCBI		T2T-CHM13v2.0

Rbm4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	4,834,321 - 4,844,037 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	4,834,321 - 4,843,929 (-)	Ensembl		GRCm39 Ensembl
GRCm38	19	4,784,293 - 4,794,009 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	4,784,293 - 4,793,901 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	4,784,293 - 4,793,877 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	4,784,293 - 4,793,877 (-)	NCBI		MGSCv36	mm8
Celera	19	4,655,503 - 4,665,087 (-)	NCBI		Celera
Cytogenetic Map	19	A	NCBI
cM Map	19	4.11	NCBI

RBM4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	67,864,630 - 67,894,452 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	68,884,652 - 68,953,231 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	61,996,221 - 62,026,007 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	65,319,464 - 65,349,183 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	65,298,404 - 65,349,183 (+)	Ensembl	panpan1.1		panPan2

RBM14
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	5,776,539 - 5,784,337 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	5,776,535 - 5,784,337 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

LOC103221203
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	7,604,440 - 7,638,536 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	104,891,337 - 104,925,391 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	252
Count of miRNA genes:	173
Interacting mature miRNAs:	210
Transcripts:	ENSRNOT00000026611
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	207243873	252243873	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	210980612	255980612	Rat
1354653	Despr9	Despair related QTL 9		0.00019	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	177339686	222339686	Rat
2293673	Bss27	Bone structure and strength QTL 27	18.63	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	1	181059071	226059071	Rat
2293677	Bss41	Bone structure and strength QTL 41	9.38	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	1	181059071	226059071	Rat
1549830	Bss1	Bone structure and strength QTL 1	4.8		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	182039247	227039247	Rat
70163	Bw20	Body weight QTL 20	5.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	183564652	228564652	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
631838	Niddm36	Non-insulin dependent diabetes mellitus QTL 36		0.01	insulin secretion trait (VT:0003564)	calculated pancreatic islet insulin release measurement (CMO:0001217)	1	193964073	238964073	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
2293689	Bss47	Bone structure and strength QTL 47	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	1	181059071	226059071	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	210980612	255980612	Rat
61341	Bp26	Blood pressure QTL 26			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	139442053	223964440	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
2293693	Bss22	Bone structure and strength QTL 22	33.52	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	1	181059071	226059071	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	99645382	221502378	Rat
2300161	Bmd43	Bone mineral density QTL 43	8.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	181059071	226059071	Rat
1300145	Rf7	Renal function QTL 7	2.96		urine creatinine amount (VT:0010540)	urine creatinine level (CMO:0000125)	1	194575422	239575422	Rat
61347	Bp197	Blood pressure QTL 197	4.2		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	1	168063662	213063662	Rat
8655655	Arrd2	Age-related retinal degeneration QTL 2	7.79		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	193400541	238400541	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	200449456	256003563	Rat
631214	Bw61	Body weight QTL61	3.4	0.0001	intramuscular adipose amount (VT:0010044)	intramuscular fat area (CMO:0001162)	1	182535316	227535316	Rat
7771612	Cm80	Cardiac mass QTL 80	8.4		heart left ventricle mass (VT:0007031)	heart left ventricle weight (CMO:0000776)	1	146080545	243492863	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	103779152	223964440	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	210980612	255980612	Rat
2300174	Bmd42	Bone mineral density QTL 42	8.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	bone mineral density (CMO:0001226)	1	181059071	226059071	Rat
737828	Hcas3	Hepatocarcinoma susceptibility QTL 3	4.9		liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	1	153679879	232414077	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
1358886	Bp260	Blood pressure QTL 260	3.67		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	160574007	235238518	Rat
2293654	Bss30	Bone structure and strength QTL 30	32.65	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	1	181059071	226059071	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	210980612	255980612	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	207243873	252243873	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
2300187	Bmd41	Bone mineral density QTL 41	8.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	181059071	226059071	Rat
2314011	Gluco56	Glucose level QTL 56			blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	209203273	254203273	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	202543537	247543537	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	205674651	250674651	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	207243873	252243873	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
634312	Bp143	Blood pressure QTL 143	3	0.0002	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	203300512	229359342	Rat
1358294	Bw37	Body weight QTL 37	5	0.000011	body mass (VT:0001259)	body weight (CMO:0000012)	1	180739993	225739993	Rat
724559	Pancm1	Pancreatic morphology QTL 1	7.1		islet of Langerhans morphology trait (VT:0005215)	pancreatic islet damage composite score (CMO:0001156)	1	191190115	223964326	Rat
2312420	Pur17	Proteinuria QTL 17	7.1	0.0001	urine protein amount (VT:0005160)	urine total protein excretion rate (CMO:0000756)	1	172718770	228180370	Rat
10059600	Bp378	Blood pressure QTL 378	3.08	0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	186298393	231298393	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	188241285	250779312	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	208798288	253798288	Rat
724562	Rends1	Renal damage susceptibility QTL 1		0.05	kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	1	139442053	223964440	Rat
1300168	Bp170	Blood pressure QTL 170	2.76		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	192995199	237995199	Rat
61403	Niddm4	Non-insulin dependent diabetes mellitus QTL 4			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	201464383	246464383	Rat
2292222	Bp307	Blood pressure QTL 307	3.06	0.0014	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	186298393	231298393	Rat
2292220	Bp306	Blood pressure QTL 306	3.47	0.00087	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	186298393	231298393	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	203675682	248675682	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	205674651	250674651	Rat
1600380	Niddm70	Non-insulin dependent diabetes mellitus QTL 70	3.1	0.0008	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	185979875	230979875	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
1582206	Kidm33	Kidney mass QTL 33	6.9		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	197807365	233480676	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	210980612	255980612	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	210980612	255980612	Rat
8655855	Arrd3	Age-related retinal degeneration QTL 3	3.07		lens clarity trait (VT:0001304)	cataract incidence/prevalence measurement (CMO:0001585)	1	193400541	238400541	Rat
634338	Hcar4	Hepatocarcinoma resistance QTL 4	4.6		liver integrity trait (VT:0010547)	liver tumorous lesion number to liver area ratio (CMO:0001210)	1	202851915	223964440	Rat
6480783	Insul19	Insulin level QTL 19	4.33		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	203300512	213659238	Rat
6903303	Scl34	Serum cholesterol QTL 34	2.5	0.0033	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	1	173363824	227535316	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	207099883	252099883	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	210980612	255980612	Rat
2293083	Iddm25	Insulin dependent diabetes mellitus QTL 25	4.18		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	191260175	236260175	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	111949780	228180370	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2325727	Pia41	Pristane induced arthritis QTL 41			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	188241285	233241285	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	210980612	255980612	Rat

Markers in Region

BE099273

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	202,086,401 - 202,087,408 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	220,047,862 - 220,048,868	NCBI	Rnor6.0
Rnor_5.0	1	226,978,858 - 226,979,864	UniSTS	Rnor5.0
Rnor_5.0	1	226,912,710 - 226,913,716	UniSTS	Rnor5.0
RGSC_v3.4	1	207,402,307 - 207,403,313	UniSTS	RGSC3.4
Celera	1	199,626,906 - 199,627,912	UniSTS
RH 3.4 Map	1	1557.3	UniSTS
Cytogenetic Map	1	q42-q43	UniSTS

RH128421

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	202,088,459 - 202,088,642 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	220,049,920 - 220,050,102	NCBI	Rnor6.0
Rnor_5.0	1	226,980,916 - 226,981,098	UniSTS	Rnor5.0
Rnor_5.0	1	226,914,768 - 226,914,950	UniSTS	Rnor5.0
RGSC_v3.4	1	207,404,365 - 207,404,547	UniSTS	RGSC3.4
Celera	1	199,628,964 - 199,629,146	UniSTS
RH 3.4 Map	1	1557.3	UniSTS
Cytogenetic Map	1	q42-q43	UniSTS

RH133459

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	202,084,870 - 202,085,089 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	220,046,331 - 220,046,549	NCBI	Rnor6.0
Rnor_5.0	1	226,977,327 - 226,977,545	UniSTS	Rnor5.0
Rnor_5.0	1	226,911,179 - 226,911,397	UniSTS	Rnor5.0
RGSC_v3.4	1	207,400,776 - 207,400,994	UniSTS	RGSC3.4
Celera	1	199,625,375 - 199,625,593	UniSTS
RH 3.4 Map	1	1555.9	UniSTS
Cytogenetic Map	1	q42-q43	UniSTS

AA957251

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	202,078,281 - 202,078,472 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	220,039,745 - 220,039,935	NCBI	Rnor6.0
Rnor_5.0	1	226,904,861 - 226,905,051	UniSTS	Rnor5.0
Celera	1	199,618,789 - 199,618,979	UniSTS
RH 3.4 Map	1	1555.9	UniSTS
Cytogenetic Map	1	q42	UniSTS
Cytogenetic Map	1	q42-q43	UniSTS

RH138350

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	202,077,005 - 202,077,236 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	220,038,469 - 220,038,699	NCBI	Rnor6.0
Rnor_5.0	1	226,903,585 - 226,903,815	UniSTS	Rnor5.0
RGSC_v3.4	1	207,393,131 - 207,393,361	UniSTS	RGSC3.4
Celera	1	199,617,513 - 199,617,743	UniSTS
RH 3.4 Map	1	1556.0	UniSTS
Cytogenetic Map	1	q42-q43	UniSTS

BM389926

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	202,085,471 - 202,085,628 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	220,046,932 - 220,047,088	NCBI	Rnor6.0
Rnor_5.0	1	226,977,928 - 226,978,084	UniSTS	Rnor5.0
Rnor_5.0	1	226,911,780 - 226,911,936	UniSTS	Rnor5.0
RGSC_v3.4	1	207,401,377 - 207,401,533	UniSTS	RGSC3.4
Celera	1	199,625,976 - 199,626,132	UniSTS
RH 3.4 Map	1	1557.0	UniSTS
Cytogenetic Map	1	q42-q43	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001170484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760102	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008760104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC126581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC086338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM086093	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000067093 ⟹ ENSRNOP00000059872

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	202,085,279 - 202,087,482 (-)	Ensembl
Rnor_6.0 Ensembl	1	220,039,734 - 220,048,950 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087573 ⟹ ENSRNOP00000072133

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	202,085,310 - 202,105,380 (-)	Ensembl
Rnor_6.0 Ensembl	1	220,039,905 - 220,048,966 (-)	Ensembl

RefSeq Acc Id:

NM_001170484 ⟹ NP_001163955

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	211,507,845 - 211,516,907 (-)	NCBI
mRatBN7.2	1	202,078,442 - 202,087,506 (-)	NCBI
Rnor_6.0	1	220,039,905 - 220,048,966 (-)	NCBI
Rnor_5.0	1	226,903,520 - 226,913,901 (-)	NCBI
Celera	1	199,618,949 - 199,628,010 (-)	NCBI

Sequence:

show sequence

GAGTCACTGCTGTGGCCGCCGCCATTTTAGCGTTTTGTCAGAGCCGTCTACGCTGCGAGGAGGA
GGACCTGCAGATTTCCATGCGGCTGTGTGGAGATGGTGAAACTGTTCATCGGAAATCTGCCCCG
GGAGGCCACAGAGCAGGAGATCCGCTCACTCTTCGAGCAGTACGGGAAGGTGCTGGAATGTGAC
ATCATTAAGAACTATGGCTTTGTGCACATAGAGGACAAGACGGCCGCTGAGGATGCCATACGCA
ACCTGCACCACTACAAACTGCACGGAGTGAACATCAATGTGGAAGCCAGCAAGAATAAGAGCAA
AGCTTCAACCAAATTACATGTGGGCAACATCAGTCCCACTTGTACCAACCAAGAGCTTCGGGCC
AAGTTTGAGGAGTACGGCCCAGTCATCGAATGTGACATCGTGAAAGATTATGCCTTTGTACACA
TGGAGCGGGCAGAAGATGCGGTGGAGGCCATCAGGGGCCTTGACAACACAGAGTTTCAAGGCAA
ACGAATGCACGTGCAGTTGTCCACCAGCCGGCTTAGGACCGCGCCCGGGATGGGAGACCAGAGC
GGCTGCTATCGGTGCGGGAAAGAGGGGCACTGGTCCAAAGAGTGTCCGATAGACCGTTCGGGCC
GTGTGGCAGACTTGACCGAGCAATATAATGAGCAATATGGAGCAGTGCGTACGCCTTACACCAT
GAGTTATGGGGATTCATTGTATTACAACAACACGTACGGAGCGCTCGATGCCTACTACAAGCGC
TGCCGTGCTGCCCGGTCCTATGAGGCAGTGGCAGCTGCAGCTGCCTCTGCATATAATAACTATG
CAGAGCAGACTTTGTCCCAGCTGCCACAAGTCCAGAACACAGCCATGGCCAGTCACCTCACCTC
CACCTCTCTTGATCCCTACAATAGACATCTGTTGCCGCCTTCAGGAGCTGCTGCAGCAGCAGCT
GCTGCTGCTGCTGCTGCTGCTGCTTGTACTGCAGCTTCTACTCCATATTACGGGCGGGATCGGA
GCCCCCTGCGTCGCGCTACAGGCCCAGTTCCCACTGTTGGAGAGGGCTACGGTTACGGGCATGA
CAGTGAGTTGTCCCAAGCTTCAGCAGCTGCTCGGAATTCCCTGTACGACATGGCCCGGTATGAG
CGGGAGCAGTATGCGGATCGGGCGCGGTACTCAGCCTTTTAAAGTTTGAGGTGGGATGTGTGTG
GGCTGAAATTCCGAGCTGCGGTTGTGCATGAGAATACACCCTTCGTGGTACCCCATCTCCGGGA
CGTTCTCGGCTCTGTGCATTCAGTCCCTCAGGAACCATGGACCTTAATTTACCTTGTTAAGTTC
TTTCTCTTTCCTATTCTCTTTCCTGCTCAATTTCCTGTTCTCCTGTTTATTCTTCTGTAACTTC
CCATTCGAGTTCTGTTCTCCCAGCATGCCTCCTATG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001163955	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH86338	(Get FASTA)	NCBI Sequence Viewer
	EDM12417	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000072133.2

RefSeq Acc Id:

NP_001163955 ⟸ NM_001170484

- UniProtKB:

A6HYZ0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVKLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVN
INVEASKNKSKASTKLHVGNISPTCTNQELRAKFEEYGPVIECDIVKDYAFVHMERAEDAVEAI
RGLDNTEFQGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPIDRSGRVADLTEQYNE
QYGAVRTPYTMSYGDSLYYNNTYGALDAYYKRCRAARSYEAVAAAAASAYNNYAEQTLSQLPQV
QNTAMASHLTSTSLDPYNRHLLPPSGAAAAAAAAAAAAAACTAASTPYYGRDRSPLRRATGPVP
TVGEGYGYGHDSELSQASAAARNSLYDMARYEREQYADRARYSAF

hide sequence

Ensembl Acc Id:

ENSRNOP00000059872 ⟸ ENSRNOT00000067093

Ensembl Acc Id:

ENSRNOP00000072133 ⟸ ENSRNOT00000087573

Protein Domains

CCHC-type RRM

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690632

Promoter ID:

EPDNEW_R1154

Type:

initiation region

Name:

Rbm4_1

Description:

RNA binding motif protein 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	220,048,927 - 220,048,987	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1306891	AgrOrtholog
BioCyc Gene	G2FUF-56735	BioCyc
Ensembl Genes	ENSRNOG00000050741	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000087573.2	UniProtKB/TrEMBL
Gene3D-CATH	3.30.70.330	UniProtKB/TrEMBL
	Zinc finger, CCHC-type	UniProtKB/TrEMBL
InterPro	Euk_RNA-bind_prot	UniProtKB/TrEMBL
	Nucleotide-bd_a/b_plait_sf	UniProtKB/TrEMBL
	RBD_domain_sf	UniProtKB/TrEMBL
	RBM4_RRM1	UniProtKB/TrEMBL
	RBM4_RRM2	UniProtKB/TrEMBL
	RRM_dom	UniProtKB/TrEMBL
	Znf_CCHC	UniProtKB/TrEMBL
KEGG Report	rno:293663	UniProtKB/TrEMBL
NCBI Gene	293663	ENTREZGENE
PANTHER	HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN M-RELATED	UniProtKB/TrEMBL
	OS02G0815200 PROTEIN	UniProtKB/TrEMBL
Pfam	RRM_1	UniProtKB/TrEMBL
	zf-CCHC	UniProtKB/TrEMBL
PhenoGen	Rbm4	PhenoGen
PROSITE	RRM	UniProtKB/TrEMBL
	ZF_CCHC	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000050741	RatGTEx
SMART	RRM	UniProtKB/TrEMBL
	ZnF_C2HC	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54928	UniProtKB/TrEMBL
UniProt	A6HYZ0	ENTREZGENE, UniProtKB/TrEMBL
	D4A1W5_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Rbm4	RNA binding motif protein 4	Rbm4_predicted	RNA binding motif protein 4 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Rbm4_predicted	RNA binding motif protein 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar