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ONTOLOGY REPORT - ANNOTATIONS

Term:T-helper 2 cell differentiation
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Accession:GO:0045064 term browser browse the term
Definition:The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:related_synonym: T-helper 2 cell development


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T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BATF basic leucine zipper ATF-like transcription factor involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr14:75,522,469...75,546,992
Ensembl chr14:75,522,455...75,546,993 		JBrowse link
G BCL3 BCL3 transcription coactivator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16081776) Ensembl
MGI		 PMID:16081776 GO_REF:0000107 NCBI chr19:44,747,705...44,760,044
Ensembl chr19:44,747,705...44,760,044 		JBrowse link
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of		 IEA
ISO		 (PMID:12594267) Ensembl
MGI		 PMID:12594267 GO_REF:0000107 NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725 		JBrowse link
G GATA3 GATA binding protein 3 involved_in
acts_upstream_of_or_within		 IEA
ISO
IDA		 (PMID:20706986)
(PMID:20484083)		 Ensembl
MGI
UniProt		 PMID:20484083 PMID:20706986 GO_REF:0000107 NCBI chr10:8,045,333...8,075,198
Ensembl chr10:8,045,378...8,075,198 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr 1:220,879,443...220,885,059
Ensembl chr 1:220,879,431...220,885,059 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20706986) TreeGrafter
MGI		 PMID:20706986 GO_REF:0000118 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL4R interleukin 4 receptor involved_in
acts_upstream_of		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr16:27,313,756...27,364,778
Ensembl chr16:27,313,668...27,364,778 		JBrowse link
G IL6 interleukin 6 acts_upstream_of ISO (PMID:12594267) MGI PMID:12594267 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G KMT2A lysine methyltransferase 2A involved_in IDA (PMID:20484083) UniProt PMID:20484083 NCBI chr11:118,436,492...118,526,832
Ensembl chr11:118,436,456...118,526,832 		JBrowse link
G MEN1 menin 1 involved_in IDA (PMID:20484083) UniProt PMID:20484083 NCBI chr11:64,803,516...64,811,294
Ensembl chr11:64,803,510...64,811,294 		JBrowse link
G MYB MYB proto-oncogene, transcription factor involved_in IMP (PMID:20484083) UniProt PMID:20484083 NCBI chr 6:135,181,308...135,219,172
Ensembl chr 6:135,181,308...135,219,173 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IDA
IEA		 (PMID:17008549) UniProt
TreeGrafter		 PMID:17008549 GO_REF:0000118 NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393 		JBrowse link
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,268,498...2,270,588
Ensembl chr11:2,268,498...2,270,588 		JBrowse link
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12594267) Ensembl
MGI		 PMID:12594267 GO_REF:0000107 NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr 1:220,879,443...220,885,059
Ensembl chr 1:220,879,431...220,885,059 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:46,698,937...46,763,129
Ensembl chr 2:46,698,952...46,780,245 		JBrowse link
G ZNF271P zinc finger protein 271, pseudogene acts_upstream_of_or_within ISO (PMID:19783676) MGI PMID:19783676 NCBI chr18:35,290,272...35,310,766
Ensembl chr18:35,290,276...35,328,390
Ensembl chr18:35,290,276...35,328,390 		JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD86 CD86 molecule involved_in NAS (PMID:9915850) UniProt PMID:9915850 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139 		JBrowse link
G IL18 interleukin 18 involved_in ISS
IEA		 BHF-UCL
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL4R interleukin 4 receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr16:27,313,756...27,364,778
Ensembl chr16:27,313,668...27,364,778 		JBrowse link
G IL6 interleukin 6 acts_upstream_of_or_within ISO (PMID:12594267) MGI PMID:12594267 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,332,331...247,449,108 		JBrowse link
G PRKCZ protein kinase C zeta involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:2,048,504...2,185,395
Ensembl chr 1:2,050,411...2,185,395 		JBrowse link
G RARA retinoic acid receptor alpha involved_in IDA (PMID:18416830) BHF-UCL PMID:18416830 NCBI chr17:40,309,180...40,357,643
Ensembl chr17:40,309,180...40,357,643 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:173,172,870...173,450,733
Ensembl chr 1:173,162,645...173,477,583 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19612
    response to stimulus 10176
      immune response 2288
        type 2 immune response 46
          T-helper 2 cell differentiation 21
            T-helper 2 cell lineage commitment 0
            negative regulation of T-helper 2 cell differentiation 6
            positive regulation of T-helper 2 cell differentiation 8
            regulation of T-helper 2 cell differentiation + 14
Path 2
Term Annotations click to browse term
  biological_process 19612
    cellular process 18244
      cellular developmental process 5172
        cell differentiation 5171
          cell development 3453
            hemopoiesis 1167
              leukocyte differentiation 749
                mononuclear cell differentiation 620
                  lymphocyte differentiation 513
                    T cell differentiation 365
                      T cell differentiation involved in immune response 98
                        alpha-beta T cell differentiation involved in immune response 90
                          CD4-positive, alpha-beta T cell differentiation involved in immune response 89
                            T-helper cell differentiation 87
                              T-helper 2 cell differentiation 21
                                T-helper 2 cell lineage commitment 0
                                negative regulation of T-helper 2 cell differentiation 6
                                positive regulation of T-helper 2 cell differentiation 8
                                regulation of T-helper 2 cell differentiation + 14
paths to the root