Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:type 2 immune response
go back to main search page
Accession:GO:0042092 term browser browse the term
Definition:An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects.
Synonyms:narrow_synonym: T-helper 2 type immune response;   Th2 immune response



show annotations for term's descendants           Sort by:
 
type 2 immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl6 BCL6, transcription repressor involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:2158438 (MGI:892135|PMID:9171827)
RGD PMID:9171827 PMID:21873635 MGI:892135, RGD:13792537 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Bcl6b BCL6B, transcription repressor involved_in IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974
JBrowse link
G Stard7 StAR-related lipid transfer domain containing 7 acts_upstream_of_or_within ISO MGI:4433666 (MGI:5906122|PMID:25980009) RGD PMID:25980009 MGI:5906122 NCBI chr 3:114,487,163...114,515,825
Ensembl chr 3:114,485,600...114,515,813
JBrowse link
G Traf3ip2 Traf3 interacting protein 2 involved_in ISO MGI:3510784 (MGI:5301483|PMID:21856933) RGD PMID:21856933 MGI:5301483 NCBI chr20:43,011,405...43,054,654
Ensembl chr20:43,011,450...43,054,667
JBrowse link
negative regulation of T-helper 2 cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 involved_in ISO (MGI:5908339|PMID:19360123) RGD PMID:19360123 MGI:5908339 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Ifnb1 interferon beta 1 involved_in ISO (PMID:20554961) RGD PMID:20554961 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Tbx21 T-box transcription factor 21 involved_in ISO (MGI:1354779|PMID:10761931), (MGI:5543347|PMID:23616576) RGD PMID:10761931 PMID:23616576 MGI:1354779 MGI:5543347 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831
JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Anxa1 annexin A1 involved_in ISS
IBA
ISO
GO_REF:0000024
PMID:21873635
(PMID:17008549)
UniProt
RGD
PMID:17008549 PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:96559 (MGI:2450484|PMID:12594267) RGD PMID:12594267 MGI:2450484 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Hlx H2.0-like homeobox acts_upstream_of_or_within ISO MGI:105367|MGI:2182089 (MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:3761239 NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750
JBrowse link
G Socs5 suppressor of cytokine signaling 5 involved_in ISO (MGI:3687909|PMID:12242343) RGD PMID:12242343 MGI:3687909 NCBI chr 6:7,481,039...7,512,644
Ensembl chr 6:7,481,095...7,514,834
JBrowse link
G Zfp35 zinc finger protein 35 acts_upstream_of_or_within ISO MGI:4398896 (MGI:4366385|PMID:19783676) RGD PMID:19783676 MGI:4366385 NCBI chr18:15,268,852...15,284,334
Ensembl chr18:15,268,814...15,285,088
JBrowse link
negative regulation of type 2 immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg2 arginase 2 involved_in IEA
ISO
GO_REF:0000107
(MGI:5810834|PMID:27214549)
Ensembl
RGD
PMID:27214549 GO_REF:0000107 MGI:5810834 NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
JBrowse link
G Bcl6 BCL6, transcription repressor acts_upstream_of_or_within ISO MGI:103034 (MGI:1342381|PMID:10438949) RGD PMID:10438949 MGI:1342381 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:3699670|PMID:14662900)
BHF-UCL
RGD
PMID:14662900 GO_REF:0000024 MGI:3699670 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Ifnl1 interferon, lambda 1 involved_in ISO (PMID:19346497) RGD PMID:19346497 NCBI chr 1:83,798,651...83,800,297 JBrowse link
G Il27ra interleukin 27 receptor subunit alpha acts_upstream_of_or_within ISO MGI:3525439 (MGI:1926579|PMID:11057672) RGD PMID:11057672 MGI:1926579 NCBI chr19:24,109,698...24,121,977
Ensembl chr19:24,109,972...24,121,938
JBrowse link
G Ndfip1 Nedd4 family interacting protein 1 acts_upstream_of_or_within ISO MGI:3695433 (MGI:3694584|PMID:17137798) RGD PMID:17137798 MGI:3694584 NCBI chr18:30,265,808...30,316,068
Ensembl chr18:30,250,613...30,322,311
JBrowse link
G Stat6 signal transducer and activator of transcription 6 acts_upstream_of_or_within ISO MGI:107187 (MGI:1342381|PMID:10438949) RGD PMID:10438949 MGI:1342381 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Zfp35 zinc finger protein 35 acts_upstream_of_or_within ISO MGI:4398896 (MGI:4366385|PMID:19783676) RGD PMID:19783676 MGI:4366385 NCBI chr18:15,268,852...15,284,334
Ensembl chr18:15,268,814...15,285,088
JBrowse link
positive regulation of T-helper 2 cell cytokine production term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd81 Cd81 molecule involved_in ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000107
(MGI:1926561|PMID:11046035)
(PMID:8766544)
UniProt
Ensembl
RGD
PMID:8766544 PMID:11046035 GO_REF:0000024 GO_REF:0000107 MGI:1926561 NCBI chr 1:198,235,861...198,251,660
Ensembl chr 1:198,241,484...198,251,660
JBrowse link
G Dennd1b DENN domain containing 1B involved_in ISO (PMID:26774822)
(MGI:5751612|PMID:26774822)
RGD PMID:26774822 MGI:5751612 NCBI chr13:50,545,324...50,772,922
Ensembl chr13:50,545,836...50,770,601
JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO (MGI:3046385|PMID:15087456) RGD PMID:15087456 MGI:3046385 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Il4 interleukin 4 involved_in ISO (PMID:20554961) RGD PMID:20554961 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 involved_in ISO (MGI:5795829|PMID:11159963) RGD PMID:11159963 MGI:5795829 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:5689221 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Prkcz protein kinase C, zeta involved_in ISS
ISO
GO_REF:0000024
(MGI:3584076|PMID:15987782)
UniProt
RGD
PMID:15987782 GO_REF:0000024 MGI:3584076 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:3844206|PMID:19047684)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:19047684 GO_REF:0000024 GO_REF:0000107 MGI:3844206 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 involved_in IEA
ISO
GO_REF:0000107
(MGI:5009207|PMID:9973465)
Ensembl
RGD
PMID:9973465 GO_REF:0000107 MGI:5009207 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329
JBrowse link
positive regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il18 interleukin 18 involved_in IEA
ISO
GO_REF:0000107
(MGI:3608083|PMID:12829194)
Ensembl
RGD
PMID:12829194 GO_REF:0000107 MGI:3608083 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il4r interleukin 4 receptor acts_upstream_of_or_within ISO MGI:96109 (MGI:3761239|PMID:16424184) RGD PMID:16424184 MGI:3761239 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il6 interleukin 6 acts_upstream_of_or_within ISO (MGI:2450484|PMID:12594267) RGD PMID:12594267 MGI:2450484 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:5689221 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Prkcz protein kinase C, zeta involved_in ISS
ISO
GO_REF:0000024
(MGI:3584076|PMID:15987782)
UniProt
RGD
PMID:15987782 GO_REF:0000024 MGI:3584076 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Rara retinoic acid receptor, alpha involved_in ISO (PMID:18416830) RGD PMID:18416830 NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:4943387|PMID:18354165) RGD PMID:18354165 MGI:4943387 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
positive regulation of type 2 immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd74 CD74 molecule involved_in IBA
ISO
PMID:21873635
(MGI:2158514|PMID:11823488)
RGD PMID:11823488 PMID:21873635 MGI:2158514, RGD:13792537 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 acts_upstream_of_or_within ISO MGI:3505776 (MGI:3789443|PMID:18436652) RGD PMID:18436652 MGI:3789443 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Il33 interleukin 33 involved_in
acts_upstream_of_or_within
IEA
ISO
GO_REF:0000107
UniProtKB:P08226 (MGI:3775141|PMID:18268038)
(MGI:5543337|PMID:23630360)
Ensembl
RGD
PMID:18268038 PMID:23630360 GO_REF:0000107 MGI:3775141 MGI:5543337 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 involved_in ISO (MGI:5689221|PMID:26098997) RGD PMID:26098997 MGI:5689221 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 involved_in ISO (PMID:21172192) RGD PMID:21172192 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Tnfsf4 TNF superfamily member 4 involved_in ISO (MGI:3763508|PMID:12496423), (MGI:4355816|PMID:17785785), (MGI:4943387|PMID:18354165) RGD PMID:12496423 PMID:17785785 PMID:18354165 MGI:3763508 MGI:4355816 MGI:4943387 NCBI chr13:73,723,329...73,746,809
Ensembl chr13:73,723,329...73,746,788
JBrowse link
regulation of type 2 immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ecm1 extracellular matrix protein 1 acts_upstream_of_or_within ISO MGI:4940879 (MGI:4887510|PMID:21217760) RGD PMID:21217760 MGI:4887510 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
JBrowse link
T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Batf basic leucine zipper ATF-like transcription factor involved_in ISS
ISO
GO_REF:0000024
(MGI:4456325|PMID:20421391), (MGI:5004732|PMID:21572431)
UniProt
RGD
PMID:20421391 PMID:21572431 GO_REF:0000024 MGI:4456325 MGI:5004732 NCBI chr 6:105,353,715...105,376,051
Ensembl chr 6:105,353,715...105,376,051
JBrowse link
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO MGI:2158443 (MGI:3621346|PMID:16081776) RGD PMID:16081776 MGI:3621346 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Gata3 GATA binding protein 3 acts_upstream_of_or_within ISO (MGI:4838368|PMID:20706986) RGD PMID:20706986 MGI:4838368 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Il4 interleukin 4 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:4838368|PMID:20706986)
RGD PMID:20706986 PMID:21873635 MGI:4838368, RGD:13792537 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19497
    response to stimulus 10416
      immune response 1785
        type 2 immune response 37
          T-helper 2 cell cytokine production + 12
          T-helper 2 cell differentiation + 16
          negative regulation of type 2 immune response + 14
          positive regulation of type 2 immune response + 17
          regulation of type 2 immune response + 32
paths to the root