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ONTOLOGY REPORT - ANNOTATIONS

Term:positive thymic T cell selection
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Accession:GO:0045059 term browser browse the term
Definition:The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death.
Synonyms:exact_synonym: positive thymic T lymphocyte selection


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positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD1D CD1d molecule acts_upstream_of_or_within ISO (PMID:9133426) MGI PMID:9133426 NCBI chr 1:158,178,030...158,186,427
Ensembl chr 1:158,178,030...158,186,427 		JBrowse link
G CD3D CD3 delta subunit of T-cell receptor complex involved_in ISS
IEA
IBA		 UniProt
TreeGrafter
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr11:118,338,954...118,342,705
Ensembl chr11:118,339,075...118,342,705 		JBrowse link
G CD3E CD3 epsilon subunit of T-cell receptor complex involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:118,304,730...118,316,173
Ensembl chr11:118,304,730...118,316,175 		JBrowse link
G CD3G CD3 gamma subunit of T-cell receptor complex involved_in IBA
IEA		 GO_Central
TreeGrafter		 GO_REF:0000033 GO_REF:0000118 NCBI chr11:118,344,344...118,355,161
Ensembl chr11:118,344,344...118,355,161 		JBrowse link
G CD74 CD74 molecule involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:7679955), (PMID:8598040)
(PMID:9432982)		 Ensembl
MGI		 PMID:7679955 PMID:8598040 PMID:9432982 GO_REF:0000107 NCBI chr 5:150,401,639...150,412,910
Ensembl chr 5:150,401,637...150,412,969 		JBrowse link
G DOCK2 dedicator of cytokinesis 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12871644) Ensembl
MGI		 PMID:12871644 GO_REF:0000107 NCBI chr 5:169,637,275...170,083,382
Ensembl chr 5:169,637,268...170,083,382 		JBrowse link
G HLA-DMA major histocompatibility complex, class II, DM alpha acts_upstream_of_or_within ISO (PMID:8598041), (PMID:9432982)
(PMID:8638109)
(PMID:8598040)		 MGI PMID:8598040 PMID:8598041 PMID:8638109 PMID:9432982 NCBI chr 6:32,948,618...32,953,097
Ensembl chr 6:32,948,613...32,969,094 		JBrowse link
G ITPKB inositol-trisphosphate 3-kinase B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15064401) Ensembl
MGI		 PMID:15064401 GO_REF:0000107 NCBI chr 1:226,631,690...226,739,282
Ensembl chr 1:226,631,690...226,739,323 		JBrowse link
G NFATC3 nuclear factor of activated T cells 3 involved_in ISS UniProt GO_REF:0000024 NCBI chr16:68,085,370...68,229,259
Ensembl chr16:68,084,751...68,229,259 		JBrowse link
G PTPRC protein tyrosine phosphatase receptor type C involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:8666928) Ensembl
MGI		 PMID:8666928 GO_REF:0000107 NCBI chr 1:198,638,713...198,757,476
Ensembl chr 1:198,638,457...198,757,476 		JBrowse link
G SHH sonic hedgehog signaling molecule involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 7:155,799,980...155,812,463
Ensembl chr 7:155,799,980...155,812,463 		JBrowse link
G SRF serum response factor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21098124) Ensembl
MGI		 PMID:21098124 GO_REF:0000107 NCBI chr 6:43,171,269...43,181,506
Ensembl chr 6:43,171,269...43,181,506 		JBrowse link
G STK11 serine/threonine kinase 11 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:21487392) Ensembl
MGI		 PMID:21487392 GO_REF:0000107 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431 		JBrowse link
G ZAP70 zeta chain of T cell receptor associated protein kinase 70 acts_upstream_of_or_within
involved_in		 IDA
IEA		 (PMID:7630421) MGI
Ensembl		 PMID:7630421 GO_REF:0000107 NCBI chr 2:97,713,576...97,756,364
Ensembl chr 2:97,713,576...97,739,862 		JBrowse link
negative regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTPN2 protein tyrosine phosphatase non-receptor type 2 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr18:12,785,478...12,884,237
Ensembl chr18:12,785,478...12,929,643 		JBrowse link
regulation of positive thymic T cell selection term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FOXN1 forkhead box N1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr17:28,506,348...28,538,900
Ensembl chr17:28,506,243...28,538,900 		JBrowse link
G TOX thymocyte selection associated high mobility group box involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 8:58,805,412...59,119,147
Ensembl chr 8:58,805,412...59,119,147 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19613
    immune system process 3224
      T cell selection 66
        positive T cell selection 51
          positive thymic T cell selection 17
            negative regulation of positive thymic T cell selection 1
            positive regulation of positive thymic T cell selection 0
            regulation of positive thymic T cell selection + 3
Path 2
Term Annotations click to browse term
  biological_process 19613
    cellular process 18246
      cellular developmental process 5172
        cell differentiation 5171
          cell development 3453
            hemopoiesis 1167
              leukocyte differentiation 749
                mononuclear cell differentiation 620
                  lymphocyte differentiation 513
                    T cell differentiation 365
                      T cell selection 66
                        positive T cell selection 51
                          positive thymic T cell selection 17
                            negative regulation of positive thymic T cell selection 1
                            positive regulation of positive thymic T cell selection 0
                            regulation of positive thymic T cell selection + 3
paths to the root