NFATC3 (nuclear factor of activated T cells 3) - Rat Genome Database

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Gene: NFATC3 (nuclear factor of activated T cells 3) Homo sapiens
Analyze
Symbol: NFATC3
Name: nuclear factor of activated T cells 3
RGD ID: 1318613
HGNC Page HGNC:7777
Description: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of miRNA transcription; negative regulation of vascular associated smooth muscle cell differentiation; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: NF-AT4; NF-AT4c; NF-ATc3; NFAT4; NFATX; nuclear factor of activated T-cells 3; nuclear factor of activated T-cells c3 isoform IE-Xa; nuclear factor of activated T-cells, cytoplasmic 3; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3; T cell transcription factor NFAT4; T-cell transcription factor NFAT4
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381668,085,370 - 68,229,259 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1668,084,751 - 68,229,259 (+)EnsemblGRCh38hg38GRCh38
GRCh371668,119,273 - 68,263,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,676,876 - 66,818,338 (+)NCBINCBI36hg18NCBI36
Celera1652,627,801 - 52,769,327 (+)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1653,992,420 - 54,136,266 (+)NCBIHuRef
CHM1_11669,527,224 - 69,671,199 (+)NCBICHM1_1
T2T-CHM13v2.01673,881,124 - 74,025,006 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP)
alpha-pinene  (EXP)
amphetamine  (ISO)
antimycin A  (EXP)
arecoline  (ISO)
aristolochic acid  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
ATP  (ISO)
benzene  (EXP)
benzo[a]pyrene  (EXP)
bisphenol A  (EXP,ISO)
BQ 123  (EXP)
Calcimycin  (EXP)
cisplatin  (EXP)
copper(II) sulfate  (EXP)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (EXP)
diazinon  (EXP)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
dichloromethane  (ISO)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
ethylbenzene  (ISO)
fenpyroximate  (EXP)
fenthion  (ISO)
gentamycin  (ISO)
glafenine  (ISO)
harmine  (EXP)
heparin  (ISO)
hydrogen peroxide  (ISO)
ionomycin  (ISO)
lithium chloride  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
N-acetyl-L-cysteine  (EXP)
Nonylphenol  (ISO)
ozone  (EXP)
perfluorohexanesulfonic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenylephrine  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
picoxystrobin  (EXP)
piroxicam  (EXP)
platycodin D  (ISO)
rimonabant  (ISO)
SCH 23390  (ISO)
simvastatin  (EXP)
sodium arsenite  (EXP,ISO)
succimer  (ISO)
tacrolimus hydrate  (ISO)
tebufenpyrad  (EXP)
thapsigargin  (ISO)
trichloroethene  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
urethane  (EXP)
valproic acid  (EXP)
vinclozolin  (ISO)
vitamin E  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISA)
cytoplasm  (IDA,IEA)
cytosol  (IDA,IEA,ISO,TAS)
nucleoplasm  (IDA,TAS)
nucleus  (IDA,IEA,ISO)
transcription regulator complex  (IBA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. The pro-hypertrophic basic helix-loop-helix protein p8 is degraded by the ubiquitin/proteasome system in a protein kinase B/Akt- and glycogen synthase kinase-3-dependent manner, whereas endothelin induction of p8 mRNA and renal mesangial cell hypertrophy require NFAT4. Goruppi S and Kyriakis JM, J Biol Chem. 2004 May 14;279(20):20950-8. Epub 2004 Mar 11.
2. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Molkentin JD, etal., Cell. 1998 Apr 17;93(2):215-28.
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91.
Additional References at PubMed
PMID:7739550   PMID:7749981   PMID:7957556   PMID:7999066   PMID:8814265   PMID:9121455   PMID:9143705   PMID:9374467   PMID:9498773   PMID:9630228   PMID:9660947   PMID:9759864  
PMID:10089876   PMID:10493829   PMID:11877454   PMID:11997392   PMID:12370307   PMID:12417987   PMID:12477932   PMID:12482669   PMID:12671993   PMID:12788643   PMID:14702039   PMID:15173172  
PMID:15489334   PMID:16051665   PMID:16260021   PMID:16260608   PMID:16445977   PMID:16690925   PMID:17035332   PMID:17875713   PMID:18029348   PMID:18097055   PMID:18675896   PMID:18676376  
PMID:18815128   PMID:19274049   PMID:19913121   PMID:20237496   PMID:20628086   PMID:21047202   PMID:21642596   PMID:21873635   PMID:22094256   PMID:22593154   PMID:22658674   PMID:22749879  
PMID:22846573   PMID:22977251   PMID:23219532   PMID:23543060   PMID:23853098   PMID:23929433   PMID:24330068   PMID:24582564   PMID:25056061   PMID:25215946   PMID:25422138   PMID:25728138  
PMID:25818645   PMID:26186194   PMID:26374065   PMID:26522984   PMID:26527057   PMID:26638075   PMID:26972000   PMID:27123462   PMID:27697837   PMID:27863227   PMID:28089446   PMID:28125639  
PMID:28473536   PMID:28514442   PMID:28627449   PMID:28718761   PMID:28724635   PMID:28986522   PMID:29330284   PMID:29507755   PMID:29509190   PMID:29844126   PMID:30895498   PMID:32653643  
PMID:32667692   PMID:33520407   PMID:33840648   PMID:33961781   PMID:34570211   PMID:34831298   PMID:35140242   PMID:35484132  


Genomics

Comparative Map Data
NFATC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381668,085,370 - 68,229,259 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1668,084,751 - 68,229,259 (+)EnsemblGRCh38hg38GRCh38
GRCh371668,119,273 - 68,263,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361666,676,876 - 66,818,338 (+)NCBINCBI36hg18NCBI36
Celera1652,627,801 - 52,769,327 (+)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1653,992,420 - 54,136,266 (+)NCBIHuRef
CHM1_11669,527,224 - 69,671,199 (+)NCBICHM1_1
T2T-CHM13v2.01673,881,124 - 74,025,006 (+)NCBI
Nfatc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398106,785,450 - 106,857,169 (+)NCBIGRCm39mm39
GRCm39 Ensembl8106,785,472 - 106,857,169 (+)Ensembl
GRCm388106,058,818 - 106,130,537 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8106,058,840 - 106,130,537 (+)EnsemblGRCm38mm10GRCm38
MGSCv378108,583,503 - 108,654,437 (+)NCBIGRCm37mm9NCBIm37
MGSCv368108,949,013 - 109,017,574 (+)NCBImm8
Celera8110,287,705 - 110,358,321 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.08NCBI
Nfatc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21933,960,643 - 34,035,150 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1933,960,852 - 34,035,150 (+)Ensembl
Rnor_6.01938,039,542 - 38,114,003 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1938,039,564 - 38,114,003 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01948,906,285 - 48,980,756 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41935,907,800 - 35,982,095 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11935,912,754 - 35,984,893 (+)NCBI
Celera1933,388,369 - 33,462,475 (+)NCBICelera
Cytogenetic Map19q12NCBI
Nfatc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554848,436,330 - 8,526,680 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554848,433,765 - 8,558,005 (-)NCBIChiLan1.0ChiLan1.0
NFATC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11667,850,860 - 67,998,381 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1667,888,806 - 67,996,274 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01648,456,144 - 48,603,306 (+)NCBIMhudiblu_PPA_v0panPan3
NFATC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1581,294,656 - 81,434,256 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl581,296,214 - 81,434,250 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha581,284,804 - 81,424,209 (-)NCBI
ROS_Cfam_1.0581,729,667 - 81,869,214 (-)NCBI
ROS_Cfam_1.0 Ensembl581,729,671 - 81,869,180 (-)Ensembl
UMICH_Zoey_3.1581,556,378 - 81,695,850 (-)NCBI
UNSW_CanFamBas_1.0581,238,820 - 81,378,048 (-)NCBI
UU_Cfam_GSD_1.0581,880,342 - 82,019,645 (-)NCBI
Nfatc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934941,031,813 - 41,126,709 (-)NCBI
SpeTri2.0NW_00493647518,462,424 - 18,557,832 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFATC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl628,666,549 - 28,806,419 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1628,666,458 - 28,806,432 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2625,836,379 - 25,876,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NFATC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1559,193,139 - 59,346,361 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604721,929,743 - 22,082,004 (-)NCBIVero_WHO_p1.0
Nfatc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474618,085,518 - 18,210,401 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_00462474618,083,051 - 18,210,399 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
SHGC-60786  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,260,652 - 68,260,751UniSTSGRCh37
Build 361666,818,153 - 66,818,252RGDNCBI36
Celera1652,769,154 - 52,769,253RGD
Cytogenetic Map16q22.2UniSTS
HuRef1654,133,756 - 54,133,855UniSTS
GeneMap99-GB4 RH Map16406.99UniSTS
Whitehead-RH Map16306.4UniSTS
NCBI RH Map16508.6UniSTS
SHGC-60580  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,259,877 - 68,260,026UniSTSGRCh37
Build 361666,817,378 - 66,817,527RGDNCBI36
Celera1652,768,379 - 52,768,528RGD
Cytogenetic Map16q22.2UniSTS
HuRef1654,132,981 - 54,133,130UniSTS
GeneMap99-GB4 RH Map16406.22UniSTS
Whitehead-RH Map16306.4UniSTS
NCBI RH Map16508.6UniSTS
RH79943  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,261,446 - 68,261,692UniSTSGRCh37
Build 361666,818,947 - 66,819,193RGDNCBI36
Celera1652,769,939 - 52,770,185RGD
Cytogenetic Map16q22.2UniSTS
HuRef1654,134,550 - 54,134,796UniSTS
RH64885  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,261,498 - 68,261,641UniSTSGRCh37
Build 361666,818,999 - 66,819,142RGDNCBI36
Celera1652,769,991 - 52,770,134RGD
Cytogenetic Map16q22.2UniSTS
HuRef1654,134,602 - 54,134,745UniSTS
D16S2915  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,226,801 - 68,226,901UniSTSGRCh37
Build 361666,784,302 - 66,784,402RGDNCBI36
Celera1652,735,234 - 52,735,334RGD
Cytogenetic Map16q22.2UniSTS
HuRef1654,099,972 - 54,100,072UniSTS
RH78919  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,260,546 - 68,260,670UniSTSGRCh37
Build 361666,818,047 - 66,818,171RGDNCBI36
Celera1652,769,048 - 52,769,172RGD
Cytogenetic Map16q22.2UniSTS
HuRef1654,133,650 - 54,133,774UniSTS
GeneMap99-GB4 RH Map16406.66UniSTS
NCBI RH Map16508.6UniSTS
SGC32906  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,263,017 - 68,263,154UniSTSGRCh37
Build 361666,820,518 - 66,820,655RGDNCBI36
Celera1652,771,510 - 52,771,647RGD
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map16q22.1UniSTS
HuRef1654,136,121 - 54,136,258UniSTS
GeneMap99-GB4 RH Map16406.33UniSTS
Whitehead-RH Map16306.4UniSTS
NCBI RH Map16508.6UniSTS
RH16192  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,262,933 - 68,263,109UniSTSGRCh37
Build 361666,820,434 - 66,820,610RGDNCBI36
Celera1652,771,426 - 52,771,602RGD
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map16q22.1UniSTS
HuRef1654,136,037 - 54,136,213UniSTS
GeneMap99-GB4 RH Map16406.22UniSTS
NCBI RH Map16508.6UniSTS
SHGC-58359  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,128,033 - 68,128,233UniSTSGRCh37
Build 361666,685,534 - 66,685,734RGDNCBI36
Celera1652,636,458 - 52,636,658RGD
Cytogenetic Map16q22.2UniSTS
HuRef1654,001,183 - 54,001,383UniSTS
TNG Radiation Hybrid Map1629398.0UniSTS
SHGC-35392  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,260,284 - 68,260,501UniSTSGRCh37
Build 361666,817,785 - 66,818,002RGDNCBI36
Celera1652,768,786 - 52,769,003RGD
Cytogenetic Map16q22.2UniSTS
HuRef1654,133,388 - 54,133,605UniSTS
TNG Radiation Hybrid Map1629437.0UniSTS
Stanford-G3 RH Map162578.0UniSTS
GeneMap99-GB4 RH Map16406.33UniSTS
Whitehead-RH Map16306.4UniSTS
NCBI RH Map16508.6UniSTS
GeneMap99-G3 RH Map163022.0UniSTS
G19908  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,262,910 - 68,263,043UniSTSGRCh37
Build 361666,820,411 - 66,820,544RGDNCBI36
Celera1652,771,403 - 52,771,536RGD
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map16q22.1UniSTS
HuRef1654,136,014 - 54,136,147UniSTS
A002B46  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,262,910 - 68,263,043UniSTSGRCh37
Build 361666,820,411 - 66,820,544RGDNCBI36
Celera1652,771,403 - 52,771,536RGD
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map16q22.1UniSTS
HuRef1654,136,014 - 54,136,147UniSTS
GeneMap99-GB4 RH Map16408.3UniSTS
NCBI RH Map16508.6UniSTS
RH17654  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371668,260,362 - 68,260,522UniSTSGRCh37
Build 361666,817,863 - 66,818,023RGDNCBI36
Celera1652,768,864 - 52,769,024RGD
Cytogenetic Map16q22.2UniSTS
HuRef1654,133,466 - 54,133,626UniSTS
GeneMap99-GB4 RH Map16406.88UniSTS
SHGC-67307  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q22.3UniSTS
Cytogenetic Map20q13.3UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map7p13UniSTS
Cytogenetic Map19q13.32UniSTS
Cytogenetic Map19q13.43UniSTS
Cytogenetic Map3q21.2UniSTS
Cytogenetic Map3p21.3UniSTS
Cytogenetic Map18q11.2UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map7q21.2UniSTS
Cytogenetic Map13q14UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map18pter-p11.3UniSTS
Cytogenetic Map7p22.2UniSTS
Cytogenetic Map8q24.3UniSTS
Cytogenetic Map22q11.21UniSTS
Cytogenetic Map4q13.1UniSTS
Cytogenetic Map6p25UniSTS
Cytogenetic Map13q34UniSTS
Cytogenetic Map8q24.22UniSTS
Cytogenetic Map16q21UniSTS
Cytogenetic Map1p35.2UniSTS
Cytogenetic Map1q25.1UniSTS
Cytogenetic Map12q13.3UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map8q21.1UniSTS
Cytogenetic Map19q13.12UniSTS
Cytogenetic Map1p13.3UniSTS
Cytogenetic Map6q22.31UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map7q34UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map12q24.23UniSTS
Cytogenetic Map9p13.3UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map2q24.2UniSTS
Cytogenetic Map2p25.1-p24.1UniSTS
Cytogenetic Map5q32UniSTS
Cytogenetic Map5q31UniSTS
Cytogenetic Map19q13.4UniSTS
Cytogenetic Map16p13.3UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map1q32.2-q41UniSTS
Cytogenetic Map17q21.31UniSTS
Cytogenetic Map14q12UniSTS
Cytogenetic Map16q24.3UniSTS
Cytogenetic Map17q24.1UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map16p13UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic MapXp22.3UniSTS
Cytogenetic Map14q11.2UniSTS
Cytogenetic Map6p22.3UniSTS
Cytogenetic Map6p25.2UniSTS
Cytogenetic Map14q22.1UniSTS
Cytogenetic Map1p34.3UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map7p15.3UniSTS
Cytogenetic Map1q25.3UniSTS
Cytogenetic Map15q22.2UniSTS
Cytogenetic Map20q12UniSTS
Cytogenetic Map4p15.32UniSTS
Cytogenetic Map19q13.42UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map6p12.3UniSTS
Cytogenetic Map7q33UniSTS
Cytogenetic Map15q13.2UniSTS
Cytogenetic Map8q22.1UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map22q11.1UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map1p36.13UniSTS
Cytogenetic Map5p13.3UniSTS
Cytogenetic Map2p23.3UniSTS
Cytogenetic Map19q13UniSTS
Cytogenetic Map4q26UniSTS
Cytogenetic Map10q11.23UniSTS
Cytogenetic Map16p13.12UniSTS
Cytogenetic Map17q12UniSTS
Cytogenetic Map16q23.1UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map15q15.3UniSTS
Cytogenetic Map2q35UniSTS
Cytogenetic Map22q13.2UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map5q22.1UniSTS
Cytogenetic Map1p36.12UniSTS
Cytogenetic Map14q32.12UniSTS
Cytogenetic Map12q13UniSTS
Cytogenetic Map11q13.1UniSTS
Cytogenetic Map14q32.31UniSTS
Cytogenetic Map17q21.2UniSTS
Cytogenetic Map11q13.5UniSTS
Cytogenetic Map15q25.2UniSTS
Cytogenetic Map22q12.1UniSTS
Cytogenetic Map7p14.3UniSTS
Cytogenetic Map20q13.33UniSTS
Cytogenetic Map1p36.21UniSTS
TNG Radiation Hybrid Map41213.0UniSTS
G38154  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17q12UniSTS
Cytogenetic Map3q26.1UniSTS
Cytogenetic Map18q21.32UniSTS
Cytogenetic Map17q21.2-q21.3UniSTS
Cytogenetic Map19q13.3UniSTS
Cytogenetic MapXp11.3UniSTS
Cytogenetic Map3q21.2UniSTS
Cytogenetic Map19p13.3UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map16q11.2UniSTS
Cytogenetic Map11q13UniSTS
Cytogenetic Map11q23.3UniSTS
Cytogenetic Map1p36.1UniSTS
Cytogenetic Map20q11.2-q13.2UniSTS
Cytogenetic Map3q13.33UniSTS
Cytogenetic Map19p13.12UniSTS
Cytogenetic Map7q36.3UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map12q24.31UniSTS
Cytogenetic Map7p11.2UniSTS
Cytogenetic Map21q22.3UniSTS
Cytogenetic Map17q11.2UniSTS
Cytogenetic Map3q23UniSTS
Cytogenetic Map16q22.2UniSTS
Cytogenetic Map22q13.1UniSTS
Cytogenetic Map1p34UniSTS
Cytogenetic Map5q11.2UniSTS
Cytogenetic Map7q32.1UniSTS
Cytogenetic Map7q11.23UniSTS
Cytogenetic Map4p15.31UniSTS
Cytogenetic Map20q11.22UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map6q21UniSTS
Cytogenetic Map5q13.2UniSTS
Cytogenetic Map4q32.3UniSTS
Cytogenetic Map3p14.3UniSTS
Cytogenetic Map6p24.3UniSTS
Cytogenetic Map2q37UniSTS
Cytogenetic Map1p32UniSTS
Cytogenetic Map3p21.1UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:6971
Count of miRNA genes:1255
Interacting mature miRNAs:1633
Transcripts:ENST00000329524, ENST00000346183, ENST00000349223, ENST00000379165, ENST00000535127, ENST00000539828, ENST00000549350, ENST00000553077, ENST00000561714, ENST00000562171, ENST00000562926, ENST00000563288, ENST00000563319, ENST00000563796, ENST00000565750, ENST00000566301, ENST00000566893, ENST00000567152, ENST00000568466, ENST00000569766, ENST00000570212, ENST00000575270
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 329 585 225 28 876 33 1781 609 577 101 683 636 6 223 1333 3
Low 2110 2365 1499 595 1072 431 2576 1552 3100 317 777 977 169 1 981 1455 3 2
Below cutoff 41 2 1 3 1 36 57 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_004555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_173165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC020978 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC130462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK057574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX710570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC001050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE350846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU849493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA418693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887606 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887608 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887610 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887615 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU887625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L41067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U85428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U85429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U85430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000329524   ⟹   ENSP00000331324
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,085,658 - 68,229,259 (+)Ensembl
RefSeq Acc Id: ENST00000346183   ⟹   ENSP00000300659
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,085,370 - 68,229,259 (+)Ensembl
RefSeq Acc Id: ENST00000349223   ⟹   ENSP00000264008
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,085,458 - 68,229,258 (+)Ensembl
RefSeq Acc Id: ENST00000379165
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,085,658 - 68,192,228 (+)Ensembl
RefSeq Acc Id: ENST00000535127
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,088,701 - 68,226,934 (+)Ensembl
RefSeq Acc Id: ENST00000539828   ⟹   ENSP00000445670
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,085,441 - 68,192,210 (+)Ensembl
RefSeq Acc Id: ENST00000549350
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,084,778 - 68,192,212 (+)Ensembl
RefSeq Acc Id: ENST00000553077
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,084,751 - 68,192,212 (+)Ensembl
RefSeq Acc Id: ENST00000561714   ⟹   ENSP00000455113
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,085,366 - 68,167,015 (+)Ensembl
RefSeq Acc Id: ENST00000562171   ⟹   ENSP00000456307
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,085,446 - 68,158,073 (+)Ensembl
RefSeq Acc Id: ENST00000562926   ⟹   ENSP00000456120
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,085,861 - 68,226,934 (+)Ensembl
RefSeq Acc Id: ENST00000563288
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,086,701 - 68,226,934 (+)Ensembl
RefSeq Acc Id: ENST00000563319
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,084,751 - 68,226,934 (+)Ensembl
RefSeq Acc Id: ENST00000563796
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,086,638 - 68,226,934 (+)Ensembl
RefSeq Acc Id: ENST00000565750   ⟹   ENSP00000457441
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,123,030 - 68,138,784 (+)Ensembl
RefSeq Acc Id: ENST00000566301
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,084,778 - 68,226,934 (+)Ensembl
RefSeq Acc Id: ENST00000566893
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,084,839 - 68,167,015 (+)Ensembl
RefSeq Acc Id: ENST00000567152
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,086,638 - 68,226,471 (+)Ensembl
RefSeq Acc Id: ENST00000568466   ⟹   ENSP00000454451
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,085,389 - 68,174,514 (+)Ensembl
RefSeq Acc Id: ENST00000569766
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,084,751 - 68,226,471 (+)Ensembl
RefSeq Acc Id: ENST00000570212   ⟹   ENSP00000456379
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,085,861 - 68,226,471 (+)Ensembl
RefSeq Acc Id: ENST00000575270   ⟹   ENSP00000460533
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1668,085,344 - 68,218,090 (+)Ensembl
RefSeq Acc Id: NM_004555   ⟹   NP_004546
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381668,085,370 - 68,229,259 (+)NCBI
GRCh371668,118,654 - 68,263,162 (+)NCBI
Build 361666,676,876 - 66,818,338 (+)NCBI Archive
HuRef1653,992,420 - 54,136,266 (+)ENTREZGENE
CHM1_11669,527,224 - 69,671,199 (+)NCBI
T2T-CHM13v2.01673,881,124 - 74,025,006 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173163   ⟹   NP_775186
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381668,085,370 - 68,229,259 (+)NCBI
GRCh371668,118,654 - 68,263,162 (+)NCBI
Build 361666,676,876 - 66,818,338 (+)NCBI Archive
HuRef1653,992,420 - 54,136,266 (+)ENTREZGENE
CHM1_11669,527,224 - 69,671,199 (+)NCBI
T2T-CHM13v2.01673,881,124 - 74,025,006 (+)NCBI
Sequence:
RefSeq Acc Id: NM_173165   ⟹   NP_775188
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381668,085,370 - 68,229,259 (+)NCBI
GRCh371668,118,654 - 68,263,162 (+)NCBI
Build 361666,676,876 - 66,818,338 (+)NCBI Archive
HuRef1653,992,420 - 54,136,266 (+)ENTREZGENE
CHM1_11669,527,224 - 69,671,199 (+)NCBI
T2T-CHM13v2.01673,881,124 - 74,025,006 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_004546 (Get FASTA)   NCBI Sequence Viewer  
  NP_775186 (Get FASTA)   NCBI Sequence Viewer  
  NP_775188 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA79174 (Get FASTA)   NCBI Sequence Viewer  
  AAA86308 (Get FASTA)   NCBI Sequence Viewer  
  AAB46595 (Get FASTA)   NCBI Sequence Viewer  
  AAB46596 (Get FASTA)   NCBI Sequence Viewer  
  AAB46597 (Get FASTA)   NCBI Sequence Viewer  
  AAH01050 (Get FASTA)   NCBI Sequence Viewer  
  ACG55625 (Get FASTA)   NCBI Sequence Viewer  
  ACG55626 (Get FASTA)   NCBI Sequence Viewer  
  ACG55627 (Get FASTA)   NCBI Sequence Viewer  
  ACG55628 (Get FASTA)   NCBI Sequence Viewer  
  ACG55629 (Get FASTA)   NCBI Sequence Viewer  
  ACG55630 (Get FASTA)   NCBI Sequence Viewer  
  ACG55631 (Get FASTA)   NCBI Sequence Viewer  
  ACG55632 (Get FASTA)   NCBI Sequence Viewer  
  ACG55633 (Get FASTA)   NCBI Sequence Viewer  
  ACG55634 (Get FASTA)   NCBI Sequence Viewer  
  ACG55635 (Get FASTA)   NCBI Sequence Viewer  
  ACG55636 (Get FASTA)   NCBI Sequence Viewer  
  ACG55637 (Get FASTA)   NCBI Sequence Viewer  
  ACG55638 (Get FASTA)   NCBI Sequence Viewer  
  ACG55639 (Get FASTA)   NCBI Sequence Viewer  
  ACG55640 (Get FASTA)   NCBI Sequence Viewer  
  ACG55641 (Get FASTA)   NCBI Sequence Viewer  
  ACG55642 (Get FASTA)   NCBI Sequence Viewer  
  ACG55643 (Get FASTA)   NCBI Sequence Viewer  
  ACG55644 (Get FASTA)   NCBI Sequence Viewer  
  ACG55645 (Get FASTA)   NCBI Sequence Viewer  
  BAD93061 (Get FASTA)   NCBI Sequence Viewer  
  BAF83059 (Get FASTA)   NCBI Sequence Viewer  
  CAD88555 (Get FASTA)   NCBI Sequence Viewer  
  EAW83210 (Get FASTA)   NCBI Sequence Viewer  
  EAW83211 (Get FASTA)   NCBI Sequence Viewer  
  EAW83212 (Get FASTA)   NCBI Sequence Viewer  
  EAW83213 (Get FASTA)   NCBI Sequence Viewer  
  Q12968 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_004546   ⟸   NM_004555
- Peptide Label: isoform 2
- UniProtKB: Q12968 (UniProtKB/Swiss-Prot),   B5B2S0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_775186   ⟸   NM_173163
- Peptide Label: isoform 3
- UniProtKB: Q12968 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_775188   ⟸   NM_173165
- Peptide Label: isoform 1
- UniProtKB: Q99842 (UniProtKB/Swiss-Prot),   Q12968 (UniProtKB/Swiss-Prot),   B5B2S1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000300659   ⟸   ENST00000346183
RefSeq Acc Id: ENSP00000456379   ⟸   ENST00000570212
RefSeq Acc Id: ENSP00000264008   ⟸   ENST00000349223
RefSeq Acc Id: ENSP00000455113   ⟸   ENST00000561714
RefSeq Acc Id: ENSP00000460533   ⟸   ENST00000575270
RefSeq Acc Id: ENSP00000456120   ⟸   ENST00000562926
RefSeq Acc Id: ENSP00000456307   ⟸   ENST00000562171
RefSeq Acc Id: ENSP00000331324   ⟸   ENST00000329524
RefSeq Acc Id: ENSP00000445670   ⟸   ENST00000539828
RefSeq Acc Id: ENSP00000457441   ⟸   ENST00000565750
RefSeq Acc Id: ENSP00000454451   ⟸   ENST00000568466
Protein Domains
RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q12968-F1-model_v2 AlphaFold Q12968 1-1075 view protein structure

Promoters
RGD ID:6793315
Promoter ID:HG_KWN:24079
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_173164,   OTTHUMT00000268889,   OTTHUMT00000268890,   OTTHUMT00000268891,   UC002EVL.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361666,675,886 - 66,677,352 (+)MPROMDB
RGD ID:7232627
Promoter ID:EPDNEW_H22059
Type:initiation region
Name:NFATC3_2
Description:nuclear factor of activated T-cells 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H22060  EPDNEW_H22061  EPDNEW_H22062  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381668,084,817 - 68,084,877EPDNEW
RGD ID:7232629
Promoter ID:EPDNEW_H22060
Type:initiation region
Name:NFATC3_1
Description:nuclear factor of activated T-cells 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H22059  EPDNEW_H22061  EPDNEW_H22062  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381668,085,370 - 68,085,430EPDNEW
RGD ID:7232631
Promoter ID:EPDNEW_H22061
Type:initiation region
Name:NFATC3_3
Description:nuclear factor of activated T-cells 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H22059  EPDNEW_H22060  EPDNEW_H22062  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381668,085,615 - 68,085,675EPDNEW
RGD ID:7232635
Promoter ID:EPDNEW_H22062
Type:initiation region
Name:NFATC3_4
Description:nuclear factor of activated T-cells 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H22059  EPDNEW_H22060  EPDNEW_H22061  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381668,086,638 - 68,086,698EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_173165.2(NFATC3):c.1402-13668C>T single nucleotide variant Lung cancer [RCV000100190] Chr16:68144201 [GRCh38]
Chr16:68178104 [GRCh37]
Chr16:16q22.1		 uncertain significance
GRCh38/hg38 16q13-22.2(chr16:56883592-71279975)x3 copy number gain See cases [RCV000052405] Chr16:56883592..71279975 [GRCh38]
Chr16:56917504..71313878 [GRCh37]
Chr16:55475005..69871379 [NCBI36]
Chr16:16q13-22.2		 pathogenic
GRCh38/hg38 16q21-23.1(chr16:58456122-74708723)x3 copy number gain See cases [RCV000052408] Chr16:58456122..74708723 [GRCh38]
Chr16:58490026..74742621 [GRCh37]
Chr16:57047527..73300122 [NCBI36]
Chr16:16q21-23.1		 pathogenic
GRCh38/hg38 16q21-24.3(chr16:65313395-90081985)x3 copy number gain See cases [RCV000052421] Chr16:65313395..90081985 [GRCh38]
Chr16:65347298..90148393 [GRCh37]
Chr16:63904799..88675894 [NCBI36]
Chr16:16q21-24.3		 pathogenic
GRCh38/hg38 16q21-22.1(chr16:63318997-70555249)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053334]|See cases [RCV000053334] Chr16:63318997..70555249 [GRCh38]
Chr16:63352901..70589152 [GRCh37]
Chr16:61910402..69146653 [NCBI36]
Chr16:16q21-22.1		 pathogenic
GRCh38/hg38 16q21-24.1(chr16:62925929-84585795)x3 copy number gain See cases [RCV000135863] Chr16:62925929..84585795 [GRCh38]
Chr16:62959833..84619401 [GRCh37]
Chr16:61517334..83176902 [NCBI36]
Chr16:16q21-24.1		 pathogenic
GRCh38/hg38 16q21-24.3(chr16:65511483-90096995)x3 copy number gain See cases [RCV000139426] Chr16:65511483..90096995 [GRCh38]
Chr16:65545386..90163403 [GRCh37]
Chr16:64102887..88690904 [NCBI36]
Chr16:16q21-24.3		 pathogenic
GRCh38/hg38 16q21-24.3(chr16:64389378-90081985)x3 copy number gain See cases [RCV000142578] Chr16:64389378..90081985 [GRCh38]
Chr16:64423281..90148393 [GRCh37]
Chr16:62980782..88675894 [NCBI36]
Chr16:16q21-24.3		 pathogenic|likely pathogenic
GRCh38/hg38 16q12.2-24.3(chr16:52899183-90088654)x3 copy number gain See cases [RCV000143425] Chr16:52899183..90088654 [GRCh38]
Chr16:52933095..90155062 [GRCh37]
Chr16:51490596..88682563 [NCBI36]
Chr16:16q12.2-24.3		 pathogenic
GRCh38/hg38 16q12.1-22.1(chr16:49685521-68401712)x3 copy number gain See cases [RCV000143752] Chr16:49685521..68401712 [GRCh38]
Chr16:49719432..68435615 [GRCh37]
Chr16:48276933..66993116 [NCBI36]
Chr16:16q12.1-22.1		 pathogenic
GRCh38/hg38 16q21-23.3(chr16:65957829-83611443)x3 copy number gain See cases [RCV000143742] Chr16:65957829..83611443 [GRCh38]
Chr16:65991732..83645048 [GRCh37]
Chr16:64549233..82202549 [NCBI36]
Chr16:16q21-23.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46615804-90142285)x1 copy number loss Ductal breast carcinoma [RCV000207138] Chr16:46615804..90142285 [GRCh37]
Chr16:16q11.2-24.3		 uncertain significance
GRCh37/hg19 16q12.2-22.2(chr16:55359026-70884455)x1 copy number loss Ductal breast carcinoma [RCV000207067] Chr16:55359026..70884455 [GRCh37]
Chr16:16q12.2-22.2		 likely pathogenic|uncertain significance
Single allele complex Ductal breast carcinoma [RCV000207314] Chr16:56368689..90141355 [GRCh37]
Chr16:16q12.2-24.3		 uncertain significance
GRCh37/hg19 16q22.1(chr16:67654566-68404073)x1 copy number loss See cases [RCV000449234] Chr16:67654566..68404073 [GRCh37]
Chr16:16q22.1		 likely pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46464488-90155062)x3 copy number gain See cases [RCV000446110] Chr16:46464488..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:69193-90274381)x3 copy number gain See cases [RCV000446684] Chr16:69193..90274381 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.2-q24.3(chr16:9273328-89548493)x3 copy number gain See cases [RCV000511622] Chr16:9273328..89548493 [GRCh37]
Chr16:16p13.2-q24.3		 uncertain significance
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062)x3 copy number gain See cases [RCV000512138] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:85881-90155062) copy number gain See cases [RCV000511296] Chr16:85881..90155062 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16q11.2-24.3(chr16:46455960-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626435] Chr16:46455960..90354753 [GRCh37]
Chr16:16q11.2-24.3		 drug response
GRCh37/hg19 16q11.2-24.3(chr16:46497599-90354753)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626429] Chr16:46497599..90354753 [GRCh37]
Chr16:16q11.2-24.3		 drug response
GRCh37/hg19 16q13-24.3(chr16:57051473-89797669)x3 copy number gain See cases [RCV000512511] Chr16:57051473..89797669 [GRCh37]
Chr16:16q13-24.3		 pathogenic
NM_173165.3(NFATC3):c.1922G>A (p.Arg641Gln) single nucleotide variant Keratoconus [RCV000678670] Chr16:68181481 [GRCh38]
Chr16:68215384 [GRCh37]
Chr16:16q22.1		 uncertain significance
GRCh37/hg19 16q12.2-22.2(chr16:54416050-72453266)x3 copy number gain not provided [RCV000683820] Chr16:54416050..72453266 [GRCh37]
Chr16:16q12.2-22.2		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90163275)x3 copy number gain not provided [RCV000738917] Chr16:88165..90163275 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:88165-90274695)x3 copy number gain not provided [RCV000738918] Chr16:88165..90274695 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
GRCh37/hg19 16p13.3-q24.3(chr16:61451-90294632)x3 copy number gain not provided [RCV000738915] Chr16:61451..90294632 [GRCh37]
Chr16:16p13.3-q24.3		 pathogenic
NM_173165.3(NFATC3):c.412C>T (p.Arg138Trp) single nucleotide variant not provided [RCV000970792] Chr16:68122295 [GRCh38]
Chr16:68156198 [GRCh37]
Chr16:16q22.1		 benign
GRCh37/hg19 16q22.1(chr16:67132790-68166320) copy number loss not provided [RCV000767617] Chr16:67132790..68166320 [GRCh37]
Chr16:16q22.1		 pathogenic
GRCh37/hg19 16q21-24.3(chr16:61524229-90155062)x3 copy number gain not provided [RCV001249359] Chr16:61524229..90155062 [GRCh37]
Chr16:16q21-24.3		 not provided
NM_173165.3(NFATC3):c.816G>A (p.Gly272=) single nucleotide variant not provided [RCV000963685] Chr16:68122699 [GRCh38]
Chr16:68156602 [GRCh37]
Chr16:16q22.1		 benign
NM_173165.3(NFATC3):c.2733A>C (p.Gln911His) single nucleotide variant not provided [RCV000879140] Chr16:68191402 [GRCh38]
Chr16:68225305 [GRCh37]
Chr16:16q22.1		 likely benign
NM_173165.3(NFATC3):c.2829A>G (p.Pro943=) single nucleotide variant not provided [RCV000970793] Chr16:68191498 [GRCh38]
Chr16:68225401 [GRCh37]
Chr16:16q22.1		 benign
GRCh37/hg19 16q21-22.1(chr16:65669673-70180183)x1 copy number loss not provided [RCV001006797] Chr16:65669673..70180183 [GRCh37]
Chr16:16q21-22.1		 pathogenic
GRCh37/hg19 16q22.1(chr16:67765964-68246270)x1 copy number loss not provided [RCV001259860] Chr16:67765964..68246270 [GRCh37]
Chr16:16q22.1		 uncertain significance
NC_000016.9:g.(?_66545871)_(72146396_?)dup duplication Dyskeratosis congenita, autosomal dominant 6 [RCV001900384]|Immunodeficiency [RCV001900385]|not provided [RCV001900386] Chr16:66545871..72146396 [GRCh37]
Chr16:16q21-22.2		 uncertain significance
GRCh37/hg19 16q11.2-24.3(chr16:46503968-90155062)x3 copy number gain not provided [RCV002221458] Chr16:46503968..90155062 [GRCh37]
Chr16:16q11.2-24.3		 pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7777 AgrOrtholog
COSMIC NFATC3 COSMIC
Ensembl Genes ENSG00000072736 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000264008 ENTREZGENE
  ENSP00000264008.6 UniProtKB/Swiss-Prot
  ENSP00000300659 ENTREZGENE
  ENSP00000300659.5 UniProtKB/Swiss-Prot
  ENSP00000331324 ENTREZGENE
  ENSP00000331324.4 UniProtKB/Swiss-Prot
  ENSP00000445670.2 UniProtKB/TrEMBL
  ENSP00000454451.2 UniProtKB/TrEMBL
  ENSP00000455113.1 UniProtKB/TrEMBL
  ENSP00000456120.1 UniProtKB/TrEMBL
  ENSP00000456307.1 UniProtKB/TrEMBL
  ENSP00000456379.1 UniProtKB/TrEMBL
  ENSP00000457441.2 UniProtKB/TrEMBL
  ENSP00000460533.1 UniProtKB/TrEMBL
Ensembl Transcript ENST00000329524 ENTREZGENE
  ENST00000329524.8 UniProtKB/Swiss-Prot
  ENST00000346183 ENTREZGENE
  ENST00000346183.8 UniProtKB/Swiss-Prot
  ENST00000349223 ENTREZGENE
  ENST00000349223.9 UniProtKB/Swiss-Prot
  ENST00000539828.6 UniProtKB/TrEMBL
  ENST00000561714.5 UniProtKB/TrEMBL
  ENST00000562171.1 UniProtKB/TrEMBL
  ENST00000562926.5 UniProtKB/TrEMBL
  ENST00000565750.2 UniProtKB/TrEMBL
  ENST00000568466.6 UniProtKB/TrEMBL
  ENST00000570212.5 UniProtKB/TrEMBL
  ENST00000575270.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000072736 GTEx
HGNC ID HGNC:7777 ENTREZGENE
Human Proteome Map NFATC3 Human Proteome Map
InterPro Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NFAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4775 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 4775 ENTREZGENE
OMIM 602698 OMIM
PANTHER PTHR12533 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam RHD_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA247 PharmGKB
PRINTS NUCFACTORATC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE REL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B5B2S0 ENTREZGENE, UniProtKB/TrEMBL
  B5B2S1 ENTREZGENE, UniProtKB/TrEMBL
  B5B2S2_HUMAN UniProtKB/TrEMBL
  B5B2S3_HUMAN UniProtKB/TrEMBL
  B5B2S4_HUMAN UniProtKB/TrEMBL
  B5B2S5_HUMAN UniProtKB/TrEMBL
  F8VPH9_HUMAN UniProtKB/TrEMBL
  H3BR83_HUMAN UniProtKB/TrEMBL
  H3BRM3_HUMAN UniProtKB/TrEMBL
  H3BRS1_HUMAN UniProtKB/TrEMBL
  H3BU30_HUMAN UniProtKB/TrEMBL
  I3L3K7_HUMAN UniProtKB/TrEMBL
  NFAC3_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q99842 ENTREZGENE
UniProt Secondary O75211 UniProtKB/Swiss-Prot
  Q14516 UniProtKB/Swiss-Prot
  Q99840 UniProtKB/Swiss-Prot
  Q99841 UniProtKB/Swiss-Prot
  Q99842 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-12-19 NFATC3  nuclear factor of activated T cells 3    nuclear factor of activated T-cells 3  Symbol and/or name change 5135510 APPROVED
2016-03-28 NFATC3  nuclear factor of activated T-cells 3    nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3  Symbol and/or name change 5135510 APPROVED