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Gene: CD3E (CD3e molecule) Homo sapiens
Symbol: CD3E
Name: CD3e molecule
Description: Exhibits SH3 domain binding activity; identical protein binding activity; and protein heterodimerization activity. Involved in negative regulation of gene expression; positive regulation of T cell proliferation; and positive regulation of gene expression. Localizes to T cell receptor complex and external side of plasma membrane. Implicated in primary immunodeficiency disease. Biomarker of severe acute respiratory syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD3-epsilon; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); FLJ18683; IMD18; T-cell antigen receptor complex, epsilon subunit of T3; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 epsilon chain; T3E; TCRE
Mus musculus (house mouse) : Cd3e (CD3 antigen, epsilon polypeptide)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cd3e (CD3e molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd3e (CD3e molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD3E (CD3e molecule)
Canis lupus familiaris (dog) : CD3E (CD3e molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd3e (CD3e molecule)
Sus scrofa (pig) : CD3E (CD3e molecule)
Chlorocebus sabaeus (African green monkey) : CD3E (CD3e molecule)
Heterocephalus glaber (naked mole-rat) : Cd3e (CD3e molecule)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl11118,304,730 - 118,316,175 (+)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl11118,304,545 - 118,316,175 (+)EnsemblGRCh38hg38GRCh38
GRCh3811118,304,730 - 118,316,173 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711118,175,295 - 118,186,890 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611117,680,662 - 117,692,100 (+)NCBINCBI36hg18NCBI36
Build 3411117,680,661 - 117,692,099NCBI
Celera11115,333,175 - 115,344,768 (+)NCBI
Cytogenetic Map11q23.3NCBI
HuRef11114,108,889 - 114,120,482 (+)NCBIHuRef
CHM1_111118,061,293 - 118,072,876 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CD3E
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1319442
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.