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ONTOLOGY REPORT - ANNOTATIONS

Term:negative regulation of CD4-positive, alpha-beta T cell differentiation
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Accession:GO:0043371 term browser browse the term
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation.
Comment:Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'.
Synonyms:exact_synonym: down regulation of CD4-positive, alpha beta T cell differentiation;   downregulation of CD4-positive, alpha beta T cell differentiation;   negative regulation of CD4-positive T lymphocyte differentiation;   negative regulation of CD4-positive T-cell differentiation;   negative regulation of CD4-positive, alpha beta T lymphocyte differentiation
 narrow_synonym: inhibition of CD4-positive, alpha beta T cell differentiation
 related_synonym: negative regulation of CD4-positive, alpha beta T cell development


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negative regulation of CD4-positive, alpha-beta T cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CBFB core-binding factor subunit beta involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr16:67,029,149...67,101,058
Ensembl chr16:67,028,984...67,101,058 		JBrowse link
G HMGB1 high mobility group box 1 involved_in IDA (PMID:22473704) UniProt PMID:22473704 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G RUNX1 RUNX family transcription factor 1 involved_in ISS UniProt GO_REF:0000024 NCBI chr21:34,787,801...35,049,302
Ensembl chr21:34,787,801...36,004,667 		JBrowse link
G RUNX3 RUNX family transcription factor 3 involved_in ISS UniProt GO_REF:0000024 NCBI chr 1:24,899,511...24,965,138
Ensembl chr 1:24,899,511...24,965,121 		JBrowse link
negative regulation of T-helper 1 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,268,498...2,270,588
Ensembl chr11:2,268,498...2,270,588 		JBrowse link
G IL4R interleukin 4 receptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr16:27,313,756...27,364,778
Ensembl chr16:27,313,668...27,364,778 		JBrowse link
G JAK3 Janus kinase 3 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr19:17,824,782...17,847,982
Ensembl chr19:17,824,780...17,848,071 		JBrowse link
G TNFSF4 TNF superfamily member 4 involved_in ISS BHF-UCL GO_REF:0000024 NCBI chr 1:173,172,870...173,450,733
Ensembl chr 1:173,162,645...173,477,583 		JBrowse link
negative regulation of T-helper 17 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,268,498...2,270,588
Ensembl chr11:2,268,498...2,270,588 		JBrowse link
G FOXP3 forkhead box P3 involved_in IMP (PMID:23169781) UniProt PMID:23169781 NCBI chr  X:49,250,438...49,264,710
Ensembl chr  X:49,250,438...49,264,800 		JBrowse link
G IL2 interleukin 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL4 interleukin 4 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:18792410) TreeGrafter
MGI		 PMID:18792410 GO_REF:0000118 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G PF4 platelet factor 4 ISO RGD PMID:24986443 RGD:329901907 NCBI chr 4:73,980,811...73,982,124
Ensembl chr 4:73,980,811...73,982,027 		JBrowse link
G RC3H1 ring finger and CCCH-type domains 1 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:173,931,084...174,022,357
Ensembl chr 1:173,931,084...174,022,357 		JBrowse link
G RC3H2 ring finger and CCCH-type domains 2 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 9:122,844,556...122,905,359
Ensembl chr 9:122,844,556...122,905,359 		JBrowse link
G SMAD7 SMAD family member 7 involved_in IEA
ISS		 Ensembl
BHF-UCL		 GO_REF:0000024 GO_REF:0000107 NCBI chr18:48,919,853...48,950,965
Ensembl chr18:48,919,853...48,950,965 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in ISS
IEA		 UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122 		JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:23034280) Ensembl
MGI		 PMID:23034280 GO_REF:0000107 NCBI chr 1:155,001,750...155,018,523
Ensembl chr 1:155,002,630...155,018,523 		JBrowse link
G ZC3H12A zinc finger CCCH-type containing 12A involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:37,474,580...37,484,377
Ensembl chr 1:37,474,580...37,484,377 		JBrowse link
negative regulation of T-helper 17 cell lineage commitment term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOXL3 lysyl oxidase like 3 involved_in IEA
ISS
IDA		 (PMID:28065600) Ensembl
UniProt		 PMID:28065600 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:74,532,258...74,555,702
Ensembl chr 2:74,532,258...74,555,690 		JBrowse link
G TBX21 T-box transcription factor 21 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122 		JBrowse link
G TNFSF18 TNF superfamily member 18 involved_in ISO (MGI:5551556|PMID:24107315) UniProt PMID:24107315 MGI:5551556 NCBI chr 1:173,039,202...173,050,941
Ensembl chr 1:173,039,202...173,050,941 		JBrowse link
negative regulation of T-helper 2 cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ANXA1 annexin A1 involved_in IDA
IEA		 (PMID:17008549) UniProt
TreeGrafter		 PMID:17008549 GO_REF:0000118 NCBI chr 9:73,151,865...73,170,393
Ensembl chr 9:73,151,865...73,170,393 		JBrowse link
G ASCL2 achaete-scute family bHLH transcription factor 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr11:2,268,498...2,270,588
Ensembl chr11:2,268,498...2,270,588 		JBrowse link
G BCL6 BCL6 transcription repressor involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12594267) Ensembl
MGI		 PMID:12594267 GO_REF:0000107 NCBI chr 3:187,721,377...187,745,468
Ensembl chr 3:187,721,377...187,745,725 		JBrowse link
G HLX H2.0 like homeobox involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16424184) Ensembl
MGI		 PMID:16424184 GO_REF:0000107 NCBI chr 1:220,879,443...220,885,059
Ensembl chr 1:220,879,431...220,885,059 		JBrowse link
G SOCS5 suppressor of cytokine signaling 5 involved_in IEA
ISS		 Ensembl
UniProt		 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:46,698,937...46,763,129
Ensembl chr 2:46,698,952...46,780,245 		JBrowse link
G ZNF271P zinc finger protein 271, pseudogene acts_upstream_of_or_within ISO (PMID:19783676) MGI PMID:19783676 NCBI chr18:35,290,272...35,310,766
Ensembl chr18:35,290,276...35,328,390
Ensembl chr18:35,290,276...35,328,390 		JBrowse link
negative regulation of T-helper cell differentiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RC3H1 ring finger and CCCH-type domains 1 involved_in
acts_upstream_of_or_within		 ISS
ISO
IEA		 (PMID:15917799) BHF-UCL
MGI
Ensembl		 PMID:15917799 GO_REF:0000024 GO_REF:0000107 NCBI chr 1:173,931,084...174,022,357
Ensembl chr 1:173,931,084...174,022,357 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19613
    immune system process 3224
      leukocyte activation 1137
        lymphocyte activation 931
          T cell activation 666
            alpha-beta T cell activation 221
              CD4-positive, alpha-beta T cell activation 145
                CD4-positive, alpha-beta T cell differentiation 112
                  negative regulation of CD4-positive, alpha-beta T cell differentiation 25
                    negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 0
                    negative regulation of T-helper cell differentiation + 21
Path 2
Term Annotations click to browse term
  biological_process 19613
    cellular process 18246
      cellular developmental process 5172
        cell differentiation 5171
          cell development 3453
            hemopoiesis 1167
              leukocyte differentiation 749
                mononuclear cell differentiation 620
                  lymphocyte differentiation 513
                    T cell differentiation 365
                      alpha-beta T cell differentiation 151
                        CD4-positive, alpha-beta T cell differentiation 112
                          regulation of CD4-positive, alpha-beta T cell differentiation 68
                            negative regulation of CD4-positive, alpha-beta T cell differentiation 25
                              negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation + 0
                              negative regulation of T-helper cell differentiation + 21
paths to the root