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ONTOLOGY REPORT - ANNOTATIONS

Term:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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Accession:GO:0042771 term browser browse the term
Definition:The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
Synonyms:related_synonym: DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis


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intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AEN apoptosis enhancing nuclease involved_in ISO (PMID:18264133) UniProt PMID:18264133 NCBI chr 3:51,797,251...51,819,385
Ensembl chr 3:51,809,975...51,819,394 		JBrowse link
G ATAD5 ATPase family AAA domain containing 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15983387) Ensembl
MGI		 PMID:15983387 GO_REF:0000107 NCBI chr 9:40,869,778...40,917,976
Ensembl chr 9:40,870,924...40,915,629 		JBrowse link
G BAG6 BAG cochaperone 6 involved_in IEA Ensembl GO_REF:0000107 NCBI chr12:1,126,730...1,141,978
Ensembl chr12:1,126,732...1,137,896 		JBrowse link
G BBC3 BCL2 binding component 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16151013) Ensembl
MGI		 PMID:16151013 GO_REF:0000107 NCBI chr 1:108,742,793...108,750,832
Ensembl chr 1:108,741,713...108,749,946 		JBrowse link
G BCL3 BCL3 transcription coactivator acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:16384933) MGI
Ensembl		 PMID:16384933 GO_REF:0000107 NCBI chr 1:110,620,850...110,628,830
Ensembl chr 1:110,620,827...110,654,771 		JBrowse link
G BRCA2 BRCA2 DNA repair associated acts_upstream_of_or_within ISO (PMID:15735671)
(PMID:17476307)		 MGI PMID:15735671 PMID:17476307 NCBI chr25:7,734,450...7,797,851
Ensembl chr25:7,734,453...7,797,815 		JBrowse link
G CDIP1 cell death inducing p53 target 1 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:17599062) MGI
Ensembl		 PMID:17599062 GO_REF:0000107 NCBI chr 6:36,854,124...36,880,231
Ensembl chr 6:36,854,141...36,880,230 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A acts_upstream_of_or_within ISO (PMID:12952892) MGI PMID:12952892 NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281 		JBrowse link
G CHEK2 checkpoint kinase 2 acts_upstream_of_or_within ISO (PMID:10710310) MGI PMID:10710310 NCBI chr26:22,052,256...22,145,675
Ensembl chr26:21,427,961...22,240,624 		JBrowse link
G DDIT4 DNA damage inducible transcript 4 involved_in ISO (PMID:21896779) UniProt PMID:21896779 NCBI chr 4:22,916,718...22,918,893
Ensembl chr 4:22,916,096...22,964,035 		JBrowse link
G DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:9,982,245...9,994,327
Ensembl chr10:9,980,080...9,991,934 		JBrowse link
G ELL3 elongation factor for RNA polymerase II 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:10,514,633...10,517,963
Ensembl chr30:10,515,045...10,517,880 		JBrowse link
G EP300 E1A binding protein p300 involved_in IEA Ensembl GO_REF:0000107 NCBI chr10:24,076,538...24,156,708
Ensembl chr10:24,077,971...24,156,396 		JBrowse link
G HIPK1 homeodomain interacting protein kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16537918) Ensembl
MGI		 PMID:16537918 GO_REF:0000107 NCBI chr17:51,732,079...51,783,534
Ensembl chr17:51,732,016...51,781,063 		JBrowse link
G HIPK2 homeodomain interacting protein kinase 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:16537918) Ensembl
MGI		 PMID:16537918 GO_REF:0000107 NCBI chr16:9,066,957...9,256,916
Ensembl chr16:9,066,970...9,244,526 		JBrowse link
G LOC488622 myeloid cell nuclear differentiation antigen acts_upstream_of_or_within ISO (PMID:14654789) MGI PMID:14654789 NCBI chr38:22,874,345...22,892,362 JBrowse link
G MSH2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:10097137) Ensembl
MGI		 PMID:10097137 GO_REF:0000107 NCBI chr10:49,517,448...49,594,001
Ensembl chr10:49,517,369...49,594,210 		JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:11896600) Ensembl
MGI		 PMID:11896600 GO_REF:0000107 NCBI chr 6:18,222,367...18,224,015
Ensembl chr 6:18,222,515...18,224,014 		JBrowse link
G PHLDA3 pleckstrin homology like domain family A member 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 7:1,438,539...1,440,701 JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 acts_upstream_of_or_within ISO (PMID:10807576) MGI PMID:10807576 NCBI chr 1:16,469,793...16,472,910
Ensembl chr 1:16,469,793...16,472,910 		JBrowse link
G PML PML nuclear body scaffold involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:37,232,337...37,278,434
Ensembl chr30:37,232,306...37,277,741 		JBrowse link
G PPP2R5C protein phosphatase 2 regulatory subunit B'gamma involved_in ISO (PMID:17245430) UniProt PMID:17245430 NCBI chr 8:69,846,311...69,969,409
Ensembl chr 8:69,846,446...69,967,578 		JBrowse link
G PYCARD PYD and CARD domain containing involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:17,049,352...17,051,348
Ensembl chr 6:17,049,705...17,051,240 		JBrowse link
G RPS27L ribosomal protein S27 like involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:27,749,297...27,753,226 JBrowse link
G SHISA5 shisa family member 5 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:12135983) Ensembl
MGI		 PMID:12135983 GO_REF:0000107 NCBI chr20:40,604,183...40,624,607
Ensembl chr20:40,601,626...40,623,601 		JBrowse link
G SIRT1 sirtuin 1 involved_in ISO (PMID:20100829) UniProt PMID:20100829 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279 		JBrowse link
G SNW1 SNW domain containing 1 involved_in ISO (PMID:21460037) UniProt PMID:21460037 NCBI chr 8:50,478,924...50,512,360
Ensembl chr 8:50,479,338...50,512,243 		JBrowse link
G TMEM109 transmembrane protein 109 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20060811) Ensembl
MGI		 PMID:20060811 GO_REF:0000107 NCBI chr18:55,377,331...55,389,810
Ensembl chr18:55,363,698...55,385,587 		JBrowse link
G TOPORS TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:15735665) Ensembl
MGI		 PMID:15735665 GO_REF:0000107 NCBI chr11:49,809,156...49,821,224
Ensembl chr11:49,809,465...49,821,075 		JBrowse link
G TP53 tumor protein p53 acts_upstream_of_or_within
involved_in		 ISO
IEA		 (PMID:14654789), (PMID:14744935)
(PMID:12135983)
(PMID:12952892)
(PMID:15983387)
(PMID:17476307)
(PMID:16777961)
(PMID:16286009)		 MGI
Ensembl		 PMID:12135983 PMID:12952892 PMID:14654789 PMID:14744935 PMID:15983387 More... GO_REF:0000107 NCBI chr 5:32,561,406...32,565,149
Ensembl chr 5:32,560,598...32,574,109 		JBrowse link
G TP63 tumor protein p63 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17122775) Ensembl
MGI		 PMID:17122775 GO_REF:0000107 NCBI chr34:21,766,861...21,985,095
Ensembl chr34:21,766,496...21,983,046 		JBrowse link
G TP73 tumor protein p73 involved_in
acts_upstream_of		 ISO (PMID:18174154), (PMID:19490146)
(PMID:15983387)		 UniProt
MGI		 PMID:15983387 PMID:18174154 PMID:19490146 NCBI chr 5:58,194,385...58,241,159
Ensembl chr 5:58,187,826...58,240,839 		JBrowse link
G USP28 ubiquitin specific peptidase 28 involved_in ISO (PMID:16901786) UniProt PMID:16901786 NCBI chr 5:19,431,313...19,480,709
Ensembl chr 5:19,435,451...19,479,640 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATAD5 ATPase family AAA domain containing 5 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:40,869,778...40,917,976
Ensembl chr 9:40,870,924...40,915,629 		JBrowse link
G BCL2L12 BCL2 like 12 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:20837658) Ensembl
MGI		 PMID:20837658 GO_REF:0000107 NCBI chr 1:106,865,346...106,873,329 JBrowse link
G CD44 CD44 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr18:32,735,493...32,826,483
Ensembl chr18:32,737,907...32,827,107 		JBrowse link
G CD74 CD74 molecule involved_in IEA Ensembl GO_REF:0000107 NCBI chr 4:58,689,745...58,698,421
Ensembl chr 4:58,689,752...58,698,151 		JBrowse link
G ELL3 elongation factor for RNA polymerase II 3 involved_in IEA Ensembl GO_REF:0000107 NCBI chr30:10,514,633...10,517,963
Ensembl chr30:10,515,045...10,517,880 		JBrowse link
G KDM1A lysine demethylase 1A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:76,313,742...76,375,716
Ensembl chr 2:76,156,434...76,375,632 		JBrowse link
G MARCHF7 membrane associated ring-CH-type finger 7 involved_in IEA Ensembl GO_REF:0000107 NCBI chr36:5,481,449...5,533,139
Ensembl chr36:5,481,456...5,531,957 		JBrowse link
G MIF macrophage migration inhibitory factor involved_in IEA Ensembl GO_REF:0000107
G MUC1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) BHF-UCL PMID:15710329 NCBI chr 7:42,338,939...42,344,690
Ensembl chr 7:42,340,375...42,344,690 		JBrowse link
G SIRT1 sirtuin 1 involved_in ISO (PMID:11672522) BHF-UCL PMID:11672522 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279 		JBrowse link
G TRIAP1 TP53 regulated inhibitor of apoptosis 1 involved_in ISO (PMID:15735003) BHF-UCL PMID:15735003 NCBI chr26:16,349,513...16,352,805
Ensembl chr26:16,351,044...16,352,773 		JBrowse link
G ZNF385A zinc finger protein 385A involved_in IEA Ensembl GO_REF:0000107 NCBI chr27:928,250...948,275
Ensembl chr27:928,349...947,186 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPL26 ribosomal protein L26 involved_in ISO (PMID:16213212) CAFA PMID:16213212 NCBI chr 5:33,152,114...33,158,237
Ensembl chr 5:33,152,113...33,158,302 		JBrowse link
G STEAP3 STEAP3 metalloreductase acts_upstream_of_or_within ISO (PMID:18617898) MGI PMID:18617898 NCBI chr19:30,745,910...30,795,310
Ensembl chr19:30,747,921...30,795,338 		JBrowse link
G TP73 tumor protein p73 acts_upstream_of_or_within ISO (PMID:15983387) MGI PMID:15983387 NCBI chr 5:58,194,385...58,241,159
Ensembl chr 5:58,187,826...58,240,839 		JBrowse link
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNRNPK heterogeneous nuclear ribonucleoprotein K acts_upstream_of_or_within ISO (PMID:20673990) MGI PMID:20673990 NCBI chr 1:75,499,334...75,511,525
Ensembl chr 1:75,499,393...75,511,425 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17101
    response to stimulus 9113
      cellular response to stimulus 7517
        cellular response to stress 1888
          DNA damage response 798
            intrinsic apoptotic signaling pathway in response to DNA damage 107
              intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 45
                negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 12
                positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3
                regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 16
Path 2
Term Annotations click to browse term
  biological_process 17101
    cellular process 16595
      cell death 2037
        programmed cell death 2037
          apoptotic process 1961
            apoptotic signaling pathway 659
              intrinsic apoptotic signaling pathway 335
                intrinsic apoptotic signaling pathway by p53 class mediator 87
                  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 45
                    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 12
                    positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3
                    regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 16
paths to the root