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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:intrinsic apoptotic signaling pathway by p53 class mediator
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Accession:GO:0072332 term browser browse the term
Definition:The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, and ends when the execution phase of apoptosis is triggered.
Synonyms:exact_synonym: intrinsic apoptotic signaling pathway by signal transduction by p53 class mediator
 related_synonym: signal transduction by p53 class mediator resulting in induction of apoptosis


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intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator acts_upstream_of_or_within ISO (PMID:10479688) RGD PMID:10479688 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bok BCL2 family apoptosis regulator BOK involved_in ISO (PMID:15102863) RGD PMID:15102863 NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476 		JBrowse link
G Casp6 caspase 6 involved_in ISO
IEA
ISS		 (PMID:22858542)
GO_REF:0000107
GO_REF:0000024		 RGD
Ensembl
UniProt		 PMID:22858542 GO_REF:0000024 GO_REF:0000107 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502 		JBrowse link
G Cep63 centrosomal protein 63 acts_upstream_of ISO MGI:98834 (PMID:26158450) RGD PMID:26158450 NCBI chr 8:103,162,639...103,214,177
Ensembl chr 8:103,162,700...103,214,177 		JBrowse link
G Ddx5 DEAD-box helicase 5 involved_in ISO (PMID:15660129) RGD PMID:15660129 NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283 		JBrowse link
G E2f1 E2F transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:11095619)		 Ensembl
RGD		 PMID:11095619 GO_REF:0000107 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G E2f2 E2F transcription factor 2 acts_upstream_of_or_within ISO (PMID:11095619) RGD PMID:11095619 NCBI chr 5:148,399,193...148,422,595
Ensembl chr 5:148,399,642...148,421,217 		JBrowse link
G Eda2r ectodysplasin A2 receptor acts_upstream_of_or_within ISO MGI:98834 (PMID:20434500) RGD PMID:20434500 NCBI chr  X:62,224,763...62,269,333
Ensembl chr  X:62,228,229...62,269,268 		JBrowse link
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit acts_upstream_of_or_within ISO MGI:2183949 (PMID:18545656) RGD PMID:18545656 NCBI chr 1:79,033,342...79,047,102
Ensembl chr 1:79,033,326...79,047,102 		JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase involved_in ISS
IBA
IEA
ISO		 GO_REF:0000024
GO_REF:0000033
GO_REF:0000118
GO_REF:0000107
(PMID:15313915)		 UniProt
GO_Central
TreeGrafter
Ensembl
RGD		 PMID:15313915 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340 		JBrowse link
G Hint1 histidine triad nucleotide binding protein 1 involved_in ISO
ISS		 (PMID:16835243)
GO_REF:0000024		 RGD
UniProt		 PMID:16835243 GO_REF:0000024 NCBI chr10:38,989,516...38,993,259
Ensembl chr 4:92,100,973...92,101,568 		JBrowse link
G Jmy junction mediating and regulatory protein, p53 cofactor involved_in
acts_upstream_of_or_within		 IBA
ISO		 GO_REF:0000033
(PMID:10518217)		 GO_Central
RGD		 PMID:10518217 GO_REF:0000033 NCBI chr 2:24,662,104...24,730,955
Ensembl chr 2:24,668,854...24,731,006 		JBrowse link
G Mybbp1a MYB binding protein 1a involved_in ISO
IEA		 (PMID:21471221)
GO_REF:0000107		 RGD
Ensembl		 PMID:21471221 GO_REF:0000107 NCBI chr10:57,056,897...57,067,258
Ensembl chr10:57,056,874...57,067,255 		JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 involved_in ISO
IEA		 (PMID:22123926)
GO_REF:0000107		 RGD
Ensembl		 PMID:22123926 GO_REF:0000107 NCBI chr10:79,972,550...79,987,074
Ensembl chr10:79,972,556...79,987,085 		JBrowse link
G Perp p53 apoptosis effector related to PMP22 acts_upstream_of_or_within ISO (PMID:10733530) RGD PMID:10733530 NCBI chr 1:13,542,067...13,554,514
Ensembl chr 1:13,542,067...13,554,511 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in ISO (PMID:15102863)
(MGI:2679929|PMID:14500851)		 RGD PMID:14500851 PMID:15102863 MGI:2679929 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pml PML nuclear body scaffold acts_upstream_of_or_within ISO (PMID:14992722) RGD PMID:14992722 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Pou4f1 POU class 4 homeobox 1 involved_in IEA
ISO
ISS		 GO_REF:0000107
(MGI:5825431|PMID:17145718)
GO_REF:0000024		 Ensembl
RGD
UniProt		 PMID:17145718 GO_REF:0000024 GO_REF:0000107 MGI:5825431 NCBI chr15:81,253,714...81,260,057
Ensembl chr15:81,257,781...81,259,728 		JBrowse link
G Pou4f2 POU class 4 homeobox 2 involved_in ISS
ISO		 GO_REF:0000024
(MGI:5825431|PMID:17145718)		 UniProt
RGD		 PMID:17145718 GO_REF:0000024 MGI:5825431 NCBI chr19:29,486,686...29,490,327
Ensembl chr19:29,486,686...29,490,327 		JBrowse link
G Ppp1r13b protein phosphatase 1, regulatory subunit 13B involved_in ISO (PMID:11684014) RGD PMID:11684014 NCBI chr 6:130,890,682...130,963,845
Ensembl chr 6:130,890,679...130,963,330 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor acts_upstream_of ISO MGI:3584037 (PMID:15989966) RGD PMID:15989966 NCBI chr10:2,129,949...2,165,381
Ensembl chr10:2,129,978...2,165,663 		JBrowse link
G Rrp8 ribosomal RNA processing 8 involved_in ISO
IEA		 (PMID:21471221)
GO_REF:0000107		 RGD
Ensembl		 PMID:21471221 GO_REF:0000107 NCBI chr 1:160,081,092...160,088,709
Ensembl chr 1:160,084,295...160,089,331 		JBrowse link
G Shisa5 shisa family member 5 acts_upstream_of_or_within ISO (PMID:12135983) RGD PMID:12135983 NCBI chr 8:109,691,504...109,706,411
Ensembl chr 8:109,691,522...109,706,408 		JBrowse link
G Stk11 serine/threonine kinase 11 involved_in ISO
ISS		 (PMID:11430832)
GO_REF:0000024		 RGD
UniProt		 PMID:11430832 GO_REF:0000024 NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 ISO (PMID:12172011), (PMID:16322561), (PMID:17310983)
MGI:2442860 (PMID:12135983), (PMID:16107883), (PMID:20434500)		 RGD PMID:12135983 PMID:12172011 PMID:16107883 PMID:16322561 PMID:17310983 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53bp2 tumor protein p53 binding protein, 2 involved_in ISO (PMID:11684014) RGD PMID:11684014 NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432 		JBrowse link
G Wwox WW domain-containing oxidoreductase acts_upstream_of_or_within ISO MGI:98834 (PMID:11058590) RGD PMID:11058590 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391 		JBrowse link
G Zfp385b zinc finger protein 385B involved_in ISO (PMID:22945289) RGD PMID:22945289 NCBI chr 3:62,355,182...62,640,417
Ensembl chr 3:62,355,196...62,640,510 		JBrowse link
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aen apoptosis enhancing nuclease involved_in ISS
IBA
ISO		 GO_REF:0000024
GO_REF:0000033
(PMID:18264133)		 UniProt
GO_Central
RGD		 PMID:18264133 GO_REF:0000024 GO_REF:0000033 NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523 		JBrowse link
G Atad5 ATPase family, AAA domain containing 5 acts_upstream_of_or_within ISO MGI:1336991|MGI:98834 (PMID:15983387) RGD PMID:15983387 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Bag6 BAG cochaperone 6 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:17403783)		 UniProt
Ensembl
RGD		 PMID:17403783 GO_REF:0000024 GO_REF:0000107 NCBI chr20:3,675,938...3,690,414
Ensembl chr20:3,675,938...3,688,657 		JBrowse link
G Bbc3 Bcl-2 binding component 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2681654 (PMID:16151013)		 Ensembl
RGD		 PMID:16151013 GO_REF:0000107 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509 		JBrowse link
G Bcl3 BCL3, transcription coactivator acts_upstream_of_or_within ISO (PMID:16384933) RGD PMID:16384933 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Brca2 BRCA2, DNA repair associated involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:2429691|MGI:3052655|MGI:98834 (PMID:15735671), (PMID:17476307)		 Ensembl
RGD		 PMID:15735671 PMID:17476307 GO_REF:0000107 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567 		JBrowse link
G Cdip1 cell death-inducing p53 target 1 acts_upstream_of_or_within
involved_in		 ISO
IBA
IEA		 (PMID:17599062)
GO_REF:0000033
GO_REF:0000107		 RGD
GO_Central
Ensembl		 PMID:17599062 GO_REF:0000033 GO_REF:0000107 NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A acts_upstream_of_or_within ISO MGI:1933751 (PMID:12952892) RGD PMID:12952892 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek2 checkpoint kinase 2 acts_upstream_of_or_within ISO MGI:2386905 (PMID:10710310) RGD PMID:10710310 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 involved_in ISS
ISO
IEA		 GO_REF:0000024
(MGI:5298149|PMID:21896779)
GO_REF:0000107		 UniProt
RGD
Ensembl		 PMID:21896779 GO_REF:0000024 GO_REF:0000107 MGI:5298149 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105 		JBrowse link
G Dyrk2 dual specificity tyrosine phosphorylation regulated kinase 2 involved_in ISO (PMID:17349958) RGD PMID:17349958 NCBI chr 7:54,348,724...54,381,363
Ensembl chr 7:54,349,610...54,380,106 		JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
(PMID:22768269)		 Ensembl
RGD		 PMID:22768269 GO_REF:0000107 NCBI chr 3:108,413,035...108,417,181
Ensembl chr 3:108,410,448...108,417,132 		JBrowse link
G Ep300 E1A binding protein p300 involved_in ISO (PMID:17403783) RGD PMID:17403783 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:1314872|MGI:98834 (PMID:16537918)
GO_REF:0000033
GO_REF:0000118		 Ensembl
RGD
GO_Central
TreeGrafter		 PMID:16537918 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 2:191,248,817...191,299,787
Ensembl chr 2:191,248,817...191,298,902 		JBrowse link
G Hipk2 homeodomain interacting protein kinase 2 acts_upstream_of_or_within ISO MGI:1314872|MGI:98834 (PMID:16537918) RGD PMID:16537918 NCBI chr 4:67,439,327...67,619,223
Ensembl chr 4:67,440,501...67,619,223 		JBrowse link
G Msh2 mutS homolog 2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:98834 (PMID:10097137)		 Ensembl
RGD		 PMID:10097137 GO_REF:0000107 NCBI chr 6:6,813,793...6,872,960
Ensembl chr 6:6,813,795...6,872,938 		JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator acts_upstream_of_or_within ISO MGI:3784016 (PMID:11896600) RGD PMID:11896600 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 involved_in ISO
IBA
ISS		 (PMID:19203586)
GO_REF:0000033
GO_REF:0000024		 RGD
GO_Central
UniProt		 PMID:19203586 GO_REF:0000024 GO_REF:0000033 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:10807576)		 Ensembl
RGD		 PMID:10807576 GO_REF:0000107 NCBI chr18:59,986,020...59,992,434
Ensembl chr18:59,986,017...59,992,429 		JBrowse link
G Pml PML nuclear body scaffold involved_in ISO (MGI:3580934|PMID:15626733) RGD PMID:15626733 MGI:3580934 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971 		JBrowse link
G Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma involved_in ISO (PMID:17245430) RGD PMID:17245430 NCBI chr 6:129,461,689...129,598,344
Ensembl chr 6:129,461,648...129,598,346 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO (PMID:14730312) RGD PMID:14730312 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Rps27l ribosomal protein S27-like involved_in ISO (PMID:17057733), (PMID:18056458) RGD PMID:17057733 PMID:18056458 NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418 		JBrowse link
G Shisa5 shisa family member 5 acts_upstream_of_or_within ISO (PMID:12135983) RGD PMID:12135983 NCBI chr 8:109,691,504...109,706,411
Ensembl chr 8:109,691,522...109,706,408 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO (PMID:20100829) RGD PMID:20100829 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Snw1 SNW domain containing 1 involved_in ISO (PMID:21460037) RGD PMID:21460037 NCBI chr 6:107,095,450...107,119,536
Ensembl chr 6:107,095,457...107,119,536 		JBrowse link
G Tmem109 transmembrane protein 109 involved_in
acts_upstream_of_or_within		 IEA
ISO
IBA		 GO_REF:0000107
MGI:4453832 (PMID:20060811)
GO_REF:0000033
GO_REF:0000118		 Ensembl
RGD
GO_Central
TreeGrafter		 PMID:20060811 GO_REF:0000033 GO_REF:0000107 GO_REF:0000118 NCBI chr 1:207,519,628...207,530,245
Ensembl chr 1:207,519,624...207,530,215 		JBrowse link
G Topors TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase acts_upstream_of_or_within ISO (PMID:15735665) RGD PMID:15735665 NCBI chr 5:55,388,033...55,399,937
Ensembl chr 5:55,387,632...55,399,937 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 ISO
IEA		 (MGI:4944151|PMID:20818388), (MGI:5882892|PMID:16213212)
MGI:109337|MGI:1096393|MGI:1336991|MGI:1857263|MGI:1926340|MGI:2442925 (PMID:12135983), (PMID:12952892), (PMID:15983387), (PMID:16286009), (PMID:16777961), (PMID:17476307)
GO_REF:0000107
(PMID:14654789), (PMID:14744935)
(PMID:16213212), (PMID:17403783)		 RGD
Ensembl		 PMID:12135983 PMID:12952892 PMID:14654789 PMID:14744935 PMID:15983387 More... GO_REF:0000107 MGI:4944151 MGI:5882892 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp63 tumor protein p63 acts_upstream_of_or_within ISO MGI:1934269 (PMID:17122775) RGD PMID:17122775 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Tp73 tumor protein p73 involved_in
acts_upstream_of		 ISO (PMID:18174154), (PMID:19490146)
MGI:2442925|MGI:98834 (PMID:15983387)		 RGD PMID:15983387 PMID:18174154 PMID:19490146 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Usp28 ubiquitin specific peptidase 28 involved_in ISO
ISS		 (PMID:16901786)
GO_REF:0000024		 RGD
UniProt		 PMID:16901786 GO_REF:0000024 NCBI chr 8:49,325,766...49,386,229
Ensembl chr 8:49,325,867...49,386,229 		JBrowse link
intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb2 bradykinin receptor B2 involved_in
acts_upstream_of		 IEA
ISO		 GO_REF:0000107
MGI:98834|MGI:99702 (PMID:16571598)		 Ensembl
RGD		 PMID:16571598 GO_REF:0000107 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Armc10 armadillo repeat containing 10 involved_in ISO
IBA		 (PMID:17904127)
GO_REF:0000033		 RGD
GO_Central		 PMID:17904127 GO_REF:0000033 NCBI chr 4:13,399,004...13,414,594
Ensembl chr 4:13,395,207...13,414,548 		JBrowse link
G Cep63 centrosomal protein 63 acts_upstream_of_or_within ISO MGI:98834 (PMID:26158450) RGD PMID:26158450 NCBI chr 8:103,162,639...103,214,177
Ensembl chr 8:103,162,700...103,214,177 		JBrowse link
G Mdm2 MDM2 proto-oncogene involved_in ISO (PMID:17310983) RGD PMID:17310983 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915 		JBrowse link
G Mdm4 MDM4 regulator of p53 involved_in ISO (MGI:2182884|PMID:12101245) RGD PMID:12101245 MGI:2182884 NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226 		JBrowse link
G Mir21 microRNA 21 involved_in ISO (PMID:18829576) RGD PMID:18829576 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO
IEA		 (PMID:23985028)
GO_REF:0000107		 RGD
Ensembl		 PMID:23985028 GO_REF:0000107 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555 		JBrowse link
G Pttg1ip PTTG1 interacting protein acts_upstream_of_or_within ISO (PMID:24506068) RGD PMID:24506068 NCBI chr20:11,030,013...11,047,742
Ensembl chr20:11,030,015...11,047,316 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B acts_upstream_of_or_within ISO MGI:2672883 (PMID:12858174) RGD PMID:12858174 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633 		JBrowse link
G Rrn3 RRN3 homolog, RNA polymerase I transcription factor acts_upstream_of_or_within ISO MGI:3584037 (PMID:15989966) RGD PMID:15989966 NCBI chr10:2,129,949...2,165,381
Ensembl chr10:2,129,978...2,165,663 		JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 involved_in ISO (MGI:5553386|PMID:24523556) RGD PMID:24523556 MGI:5553386 NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atad5 ATPase family, AAA domain containing 5 involved_in ISO (MGI:3584078|PMID:15983387) RGD PMID:15983387 MGI:3584078 NCBI chr10:65,070,682...65,118,489
Ensembl chr10:65,070,689...65,117,845 		JBrowse link
G Bcl2l12 Bcl2 like 12 acts_upstream_of_or_within ISO (PMID:20837658) RGD PMID:20837658 NCBI chr 1:95,472,272...95,480,991
Ensembl chr 1:95,472,272...95,480,991 		JBrowse link
G Cd44 CD44 molecule involved_in ISO
IEA		 (PMID:17045821)
GO_REF:0000107
(MGI:3690285|PMID:17045821)		 RGD
Ensembl		 PMID:17045821 GO_REF:0000107 MGI:3690285 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620 		JBrowse link
G Cd74 CD74 molecule involved_in ISO
IBA
IEA
ISS		 (PMID:17045821)
GO_REF:0000033
GO_REF:0000107
GO_REF:0000024
(MGI:3690285|PMID:17045821)		 RGD
GO_Central
Ensembl
BHF-UCL		 PMID:17045821 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 MGI:3690285 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003 		JBrowse link
G Ell3 elongation factor for RNA polymerase II 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:22768269)		 Ensembl
RGD		 PMID:22768269 GO_REF:0000107 NCBI chr 3:108,413,035...108,417,181
Ensembl chr 3:108,410,448...108,417,132 		JBrowse link
G Kdm1a lysine demethylase 1A involved_in ISO (PMID:17805299) RGD PMID:17805299 NCBI chr 5:148,782,976...148,838,319
Ensembl chr 5:148,782,976...148,838,319 		JBrowse link
G Marchf7 membrane associated ring-CH-type finger 7 involved_in ISS
IEA
ISO		 GO_REF:0000024
GO_REF:0000107
(PMID:29295817)		 UniProt
Ensembl
RGD		 PMID:29295817 GO_REF:0000024 GO_REF:0000107 NCBI chr 3:44,680,229...44,720,172
Ensembl chr 3:44,681,632...44,720,168 		JBrowse link
G Mif macrophage migration inhibitory factor involved_in ISO (PMID:17045821) RGD PMID:17045821 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504 		JBrowse link
G Muc1 mucin 1, cell surface associated involved_in ISO (PMID:15710329) RGD PMID:15710329 NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733 		JBrowse link
G Sirt1 sirtuin 1 involved_in ISO
IEA		 (MGI:2152474|PMID:11672522)
GO_REF:0000107		 RGD
Ensembl		 PMID:11672522 GO_REF:0000107 MGI:2152474 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 involved_in ISO (PMID:15735003) RGD PMID:15735003 NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042 		JBrowse link
G Zfp385a zinc finger protein 385A involved_in ISO (PMID:17719541) RGD PMID:17719541 NCBI chr 7:134,448,914...134,475,548
Ensembl chr 7:134,448,921...134,475,548 		JBrowse link
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdkrb2 bradykinin receptor B2 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:98834|MGI:99702 (PMID:16571598)		 Ensembl
RGD		 PMID:16571598 GO_REF:0000107 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif5a eukaryotic translation initiation factor 5A involved_in ISO (PMID:15371445) RGD PMID:15371445 NCBI chr10:54,640,104...54,644,845
Ensembl chr10:54,640,024...54,644,656 		JBrowse link
G Mir186 microRNA 186 acts_upstream_of ISO (PMID:27714074) RGD PMID:27714074 NCBI chr 2:246,582,806...246,582,891
Ensembl chr 2:246,582,806...246,582,891 		JBrowse link
G Msx1 msh homeobox 1 involved_in ISO (PMID:15705871) RGD PMID:15705871 NCBI chr14:72,961,036...72,964,970
Ensembl chr14:72,961,148...72,964,966 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor involved_in ISO (PMID:10962037) RGD PMID:10962037 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Rps7 ribosomal protein S7 involved_in ISO (PMID:17310983) RGD PMID:17310983 NCBI chr 6:45,266,200...45,271,064
Ensembl chr 6:45,223,980...45,271,145 		JBrowse link
G Sh3glb1 SH3 domain -containing GRB2-like endophilin B1 involved_in ISO (MGI:5553386|PMID:24523556) RGD PMID:24523556 MGI:5553386 NCBI chr 2:233,750,838...233,784,817
Ensembl chr 2:233,750,838...233,784,784 		JBrowse link
G Ubb ubiquitin B acts_upstream_of_or_within ISO (PMID:17571083) RGD PMID:17571083 NCBI chr10:47,247,630...47,249,335
Ensembl chr10:47,245,637...47,249,333 		JBrowse link
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rpl26 ribosomal protein L26 involved_in ISO (PMID:16213212)
(MGI:5882892|PMID:16213212)		 RGD PMID:16213212 MGI:5882892 NCBI chr10:53,610,836...53,613,966
Ensembl chr10:53,610,421...53,613,966 		JBrowse link
G Steap3 STEAP3 metalloreductase acts_upstream_of_or_within ISO MGI:4398911 (PMID:18617898) RGD PMID:18617898 NCBI chr13:31,351,954...31,397,344
Ensembl chr13:31,351,954...31,396,519 		JBrowse link
G Tp73 tumor protein p73 acts_upstream_of_or_within ISO MGI:2442925|MGI:98834 (PMID:15983387) RGD PMID:15983387 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
regulation of intrinsic apoptotic signaling pathway by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ankrd2 ankyrin repeat domain 2 acts_upstream_of_or_within ISO (PMID:18302940) RGD PMID:18302940 NCBI chr 1:240,847,111...240,856,563
Ensembl chr 1:240,847,072...240,856,566 		JBrowse link
G Tp53 tumor protein p53 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:17571083)		 Ensembl
RGD		 PMID:17571083 GO_REF:0000107 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hnrnpk heterogeneous nuclear ribonucleoprotein K involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:20673990)		 Ensembl
RGD		 PMID:20673990 GO_REF:0000107 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997 		JBrowse link
G LOC100359916 heterogeneous nuclear ribonucleoprotein K-like involved_in IEA GO_REF:0000107 Ensembl GO_REF:0000107 NCBI chr 5:58,668,326...58,670,222
Ensembl chr 5:58,668,327...58,670,220 		JBrowse link
regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tifab TIFA inhibitor acts_upstream_of_or_within ISO (PMID:32101751) RGD PMID:32101751 NCBI chr17:8,433,406...8,436,541
Ensembl chr17:8,431,635...8,436,592 		JBrowse link
G Usp15 ubiquitin specific peptidase 15 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
(PMID:32101751)		 Ensembl
RGD		 PMID:32101751 GO_REF:0000107 NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20292
    cellular process 18769
      signal transduction 7163
        intracellular signal transduction 2818
          intrinsic apoptotic signaling pathway 341
            intrinsic apoptotic signaling pathway by p53 class mediator 87
              intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 45
              intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + 3
              negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 23
              positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 10
              regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 38
Path 2
Term Annotations click to browse term
  biological_process 20292
    biological regulation 13633
      regulation of biological process 13220
        signaling 7729
          signal transduction 7163
            intracellular signal transduction 2818
              intrinsic apoptotic signaling pathway 341
                intrinsic apoptotic signaling pathway by p53 class mediator 87
                  intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator + 45
                  intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator + 3
                  negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 23
                  positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 10
                  regulation of intrinsic apoptotic signaling pathway by p53 class mediator + 38
paths to the root