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Gene: EP300 (E1A binding protein p300) Canis lupus familiaris

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Symbol:

EP300

Name:

E1A binding protein p300

RGD ID:

12259272

Description:

ENCODES a protein that exhibits acetylation-dependent protein binding (inferred); acetyltransferase activity (inferred); acyltransferase activity (inferred); INVOLVED IN internal peptidyl-lysine acetylation (ortholog); internal protein amino acid acetylation (ortholog); N-terminal peptidyl-lysine acetylation (ortholog); PARTICIPATES IN androgen signaling pathway; cortisol signaling pathway; estrogen signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); adenylosuccinase lyase deficiency (ortholog); Agenesis of Corpus Callosum (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH resveratrol

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

histone acetyltransferase p300

RGD Orthologs

Human

Green Monkey

Alliance Orthologs

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	24,076,538 - 24,156,708 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	24,077,971 - 24,156,396 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	24,010,660 - 24,090,852 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	24,823,553 - 24,904,040 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	24,824,097 - 24,903,879 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	24,539,621 - 24,619,804 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	24,860,221 - 24,940,412 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	25,034,546 - 25,114,749 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
EP300	Dog	Alzheimer's disease		ISO	EP300 (Homo sapiens)	9068941	mRNA:increased expression:temporal cortex (human)	RGD	PMID:23585551 and REF_RGD_ID:7327146
EP300	Dog	breast carcinoma		ISO	EP300 (Homo sapiens)	9068941	protein:increased expression:breast	RGD	PMID:12725419 and REF_RGD_ID:2289908
EP300	Dog	cardiac arrest		ISO	EP300 (Homo sapiens)	9068941	associated with Diabetes Mellitus and mRNA:increased expression:blood (human)	RGD	PMID:19577077 and REF_RGD_ID:2312286
EP300	Dog	cardiomyopathy		ISO	EP300 (Homo sapiens)	9068941	protein:increased expression:heart left ventricle and nucleus (human)	RGD	PMID:20375365 and REF_RGD_ID:7364750
EP300	Dog	clear cell renal cell carcinoma	severity	ISO	EP300 (Homo sapiens)	9068941	mRNA:altered expression:kidney and tumor (human)	RGD	PMID:23029358 and REF_RGD_ID:7296925
EP300	Dog	clear cell renal cell carcinoma		ISO	EP300 (Homo sapiens)	9068941	mRNA and protein:increased expression:kidney	RGD	PMID:28551630 and REF_RGD_ID:15036804
EP300	Dog	congestive heart failure		ISO	EP300 (Homo sapiens)	9068941		RGD	PMID:12724418 and REF_RGD_ID:2312280
EP300	Dog	glomerulonephritis		ISO	EP300 (Homo sapiens)	9068941	protein:increased expression:glomerulus and renal tubule (human)	RGD	PMID:17125594 and REF_RGD_ID:7327154
EP300	Dog	idiopathic pulmonary fibrosis		ISO	EP300 (Homo sapiens)	9068941	mRNA:increased expression:lung (human)	RGD	PMID:30119248 and REF_RGD_ID:151347411
EP300	Dog	Optic Nerve Injuries		ISO	EP300 (Homo sapiens)	9068941	human gene in rat model	RGD	PMID:21705428 and REF_RGD_ID:7349392
EP300	Dog	prostate cancer	disease_progression	ISO	EP300 (Homo sapiens)	9068941		RGD	PMID:14633682 and REF_RGD_ID:2289907

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
EP300	Dog	adenylosuccinase lyase deficiency		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Adenylosuccinate lyase deficiency	ClinVar	PMID:28492532
EP300	Dog	Agenesis of Corpus Callosum		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Corpus callosum and agenesis of	ClinVar	PMID:25741868
EP300	Dog	autosomal dominant cerebellar ataxia		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Autosomal dominant cerebellar ataxia	ClinVar	PMID:28492532 and PMID:35401678
EP300	Dog	CHARGE syndrome		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: CHARGE association	ClinVar	PMID:29300383
EP300	Dog	colon carcinoma		ISO	EP300 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:10700188 and PMID:25741868
EP300	Dog	colorectal cancer		ISO	EP300 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:15706485 more ...
EP300	Dog	colorectal cancer		ISO	EP300 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:15706485 more ...
EP300	Dog	colorectal cancer		ISO	EP300 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:15706485 more ...
EP300	Dog	colorectal cancer		ISO	EP300 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:15706485 more ...
EP300	Dog	colorectal carcinoma		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Colorectal carcinoma	ClinVar	PMID:15706485 more ...
EP300	Dog	common variable immunodeficiency 4		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Immunodeficiency more ...	ClinVar	PMID:28492532
EP300	Dog	congenital muscular dystrophy-dystroglycanopathy type A1		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: WALKER-WARBURG SYNDROME OR MUSCLE-EYE-BRAIN DISEASE and POMT1-RELATED	ClinVar	PMID:25741868
EP300	Dog	congenital myopathy 5		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Salih Myopathy	ClinVar	PMID:25741868
EP300	Dog	developmental and epileptic encephalopathy 18		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Early infantile epileptic encephalopathy 18	ClinVar	PMID:28492532
EP300	Dog	Dwarfism		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Short stature	ClinVar	PMID:25741868
EP300	Dog	genetic disease		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:11331617 more ...
EP300	Dog	hepatoblastoma		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Hepatoblastoma	ClinVar	PMID:28492532
EP300	Dog	hereditary breast ovarian cancer syndrome		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndrome	ClinVar	PMID:25741868
EP300	Dog	Hittner Hirsch Kreh Syndrome		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Hittner Hirsch Kreh syndrome	ClinVar	PMID:29300383
EP300	Dog	intellectual disability		ISO	EP300 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:24728327 more ...
EP300	Dog	Menke-Hennekam Syndrome 2		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Menke-Hennekam syndrome 2	ClinVar	PMID:18414213 more ...
EP300	Dog	microcephaly		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Microcephaly	ClinVar	PMID:25741868
EP300	Dog	Multicystic Dysplastic Kidney		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Multicystic dysplastic kidney	ClinVar	PMID:25741868 more ...
EP300	Dog	Multiple Abnormalities		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Multiple congenital anomalies	ClinVar	PMID:18792986 more ...
EP300	Dog	nephronophthisis-like nephropathy 1		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Nephronophthisis-like nephropathy 1	ClinVar	PMID:28492532
EP300	Dog	Neurodevelopmental Disorders		ISO	EP300 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:25741868
EP300	Dog	Rubinstein-Taybi syndrome		ISO	EP300 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:10700188 more ...
EP300	Dog	Rubinstein-Taybi syndrome		ISO	EP300 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:10700188 more ...
EP300	Dog	Rubinstein-Taybi syndrome		ISO	EP300 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:10700188 more ...
EP300	Dog	Rubinstein-Taybi syndrome		ISO	EP300 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:10700188 more ...
EP300	Dog	Rubinstein-Taybi syndrome		ISO	EP300 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:10700188 more ...
EP300	Dog	Spinocerebellar Ataxias		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Spinocerebellar Ataxia and Dominant	ClinVar	PMID:28492532 and PMID:35401678
EP300	Dog	Thumb Deformity		ISO	EP300 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Thumb deformity	ClinVar	PMID:25741868

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
EP300	Dog	adenoid cystic carcinoma		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:23685749
EP300	Dog	Breast Neoplasms		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:26229107
EP300	Dog	Colorectal Neoplasms		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD
EP300	Dog	Craniofacial Abnormalities		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:26921506
EP300	Dog	Endometrial Neoplasms		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:23104009
EP300	Dog	esophagus squamous cell carcinoma		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:17965222 and PMID:25151357
EP300	Dog	lung adenocarcinoma		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:27158780
EP300	Dog	lung small cell carcinoma		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:22941188
EP300	Dog	melanoma		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:23698071
EP300	Dog	obesity		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:26441656
EP300	Dog	squamous cell carcinoma		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:27158780
EP300	Dog	Stevens-Johnson syndrome		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:25811541
EP300	Dog	T-cell non-Hodgkin lymphoma		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:26192917
EP300	Dog	transitional cell carcinoma		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:21822268
EP300	Dog	urinary bladder cancer		ISO	EP300 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:21822268

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
EP300	Dog	colorectal cancer		ISO	EP300 (Homo sapiens)	7240710		OMIM
EP300	Dog	Menke-Hennekam Syndrome 2		ISO	EP300 (Homo sapiens)	7240710		OMIM
EP300	Dog	Rubinstein-Taybi syndrome		ISO	EP300 (Homo sapiens)	7240710		OMIM

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
EP300	Dog	resveratrol	multiple interactions	EXP		6480464	[[Resveratrol promotes the reaction [SIRT1 protein binds to EP300 protein]] which results in decreased activity of EP300 protein] which results in decreased acetylation of RELA protein more ...	CTD	PMID:21239502

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
EP300	Dog	animal organ morphogenesis	acts_upstream_of_or_within	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	apoptotic process	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	B cell differentiation	acts_upstream_of_or_within	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	behavioral defense response	involved_in	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	canonical NF-kappaB signal transduction	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	cellular response to L-leucine	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	cellular response to nutrient levels	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	cellular response to UV	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	chromatin remodeling	involved_in	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	chromatin remodeling	involved_in	IEA	GO:0004402	150520179		GOC	GO_REF:0000108
EP300	Dog	circadian rhythm	involved_in	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	face morphogenesis	involved_in	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	fat cell differentiation	involved_in	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	heart development	acts_upstream_of_or_within	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	internal peptidyl-lysine acetylation	involved_in	ISO	EP300 (Homo sapiens)	9068941	PMID:17403783	UniProt	PMID:17403783
EP300	Dog	internal protein amino acid acetylation	involved_in	ISO	EP300 (Homo sapiens)	9068941	PMID:18722353	UniProt	PMID:18722353
EP300	Dog	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	learning or memory	involved_in	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	lung development	acts_upstream_of_or_within	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	megakaryocyte development	acts_upstream_of_or_within	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	multicellular organism growth	involved_in	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	N-terminal peptidyl-lysine acetylation	involved_in	ISO	EP300 (Homo sapiens)	9068941	PMID:12435739	UniProt	PMID:12435739
EP300	Dog	negative regulation of autophagy	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	negative regulation of gluconeogenesis	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	negative regulation of protein oligomerization	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	negative regulation of protein-containing complex assembly	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	negative regulation of transcription by RNA polymerase II	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	peptidyl-lysine butyrylation	involved_in	ISO	EP300 (Homo sapiens)	9068941	PMID:17267393 and PMID:29775581	UniProt	PMID:17267393 and PMID:29775581
EP300	Dog	peptidyl-lysine crotonylation	involved_in	ISO	EP300 (Homo sapiens)	9068941	PMID:25818647	UniProt	PMID:25818647
EP300	Dog	peptidyl-lysine propionylation	involved_in	ISO	EP300 (Homo sapiens)	9068941	PMID:17267393	UniProt	PMID:17267393
EP300	Dog	platelet formation	acts_upstream_of_or_within	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	positive regulation by host of viral transcription	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	positive regulation of DNA-binding transcription factor activity	involved_in	ISO	EP300 (Homo sapiens)	9068941	PMID:25818647	UniProt	PMID:25818647
EP300	Dog	positive regulation of DNA-templated transcription	acts_upstream_of_or_within	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	positive regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	positive regulation of gene expression	acts_upstream_of_or_within	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	positive regulation of neuron projection development	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	positive regulation of protein import into nucleus	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	positive regulation of receptor signaling pathway via JAK-STAT	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	positive regulation of T-helper 17 cell lineage commitment	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	positive regulation of TORC1 signaling	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	positive regulation of TORC2 signaling	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	positive regulation of transcription by RNA polymerase II	involved_in	IEA	ARBA:ARBA00027996	150520179		UniProt	GO_REF:0000117
EP300	Dog	positive regulation of transcription by RNA polymerase II	involved_in	IBA	FB:FBgn0261617 more ...	150520179		GO_Central	GO_REF:0000033
EP300	Dog	positive regulation of transcription by RNA polymerase II	involved_in	IEA	UniProtKB:B2RWS6 more ...	150520179		Ensembl	GO_REF:0000107
EP300	Dog	positive regulation of transforming growth factor beta receptor signaling pathway	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	protein acetylation	involved_in	ISO	EP300 (Homo sapiens)	9068941	PMID:21030595 and PMID:24939902	UniProt	PMID:21030595 and PMID:24939902
EP300	Dog	protein destabilization	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	protein stabilization	involved_in	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	regulation of androgen receptor signaling pathway	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	regulation of DNA-templated transcription	involved_in	IEA	InterPro:IPR003101 more ...	150520179		InterPro	GO_REF:0000002
EP300	Dog	regulation of glycolytic process	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	regulation of mitochondrion organization	involved_in	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	regulation of transcription by RNA polymerase II	acts_upstream_of_or_within	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	regulation of tubulin deacetylation	involved_in	ISO	EP300 (Homo sapiens)	9068941	PMID:18722353	UniProt	PMID:18722353
EP300	Dog	response to estrogen	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	response to hypoxia	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	rhythmic process	involved_in	IEA	UniProtKB-KW:KW-0090	150520179		UniProt	GO_REF:0000043
EP300	Dog	skeletal muscle tissue development	acts_upstream_of_or_within	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	somitogenesis	acts_upstream_of_or_within	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	swimming	involved_in	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	thigmotaxis	involved_in	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	transcription by RNA polymerase II	acts_upstream_of	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	transcription initiation-coupled chromatin remodeling	involved_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
EP300	Dog	chromatin	is_active_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	cytoplasm	located_in	IEA	UniProtKB-SubCell:SL-0086	150520179		UniProt	GO_REF:0000044
EP300	Dog	cytoplasm	is_active_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	cytoplasm	located_in	IEA	UniProtKB-KW:KW-0963	150520179		UniProt	GO_REF:0000043
EP300	Dog	cytosol	located_in	ISO	EP300 (Homo sapiens)	9068941		HPA	GO_REF:0000052
EP300	Dog	cytosol	is_active_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	histone acetyltransferase complex	part_of	IEA	InterPro:IPR014744	150520179		InterPro	GO_REF:0000002
EP300	Dog	histone acetyltransferase complex	part_of	IBA	FB:FBgn0261617 more ...	150520179		GO_Central	GO_REF:0000033
EP300	Dog	histone acetyltransferase complex	part_of	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	nucleoplasm	located_in	IEA	ARBA:ARBA00026290	150520179		UniProt	GO_REF:0000117
EP300	Dog	nucleoplasm	located_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	150520179		UniProt	GO_REF:0000043
EP300	Dog	nucleus	located_in	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	nucleus	located_in	IEA	InterPro:IPR014744	150520179		InterPro	GO_REF:0000002
EP300	Dog	protein-containing complex	part_of	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	transcription regulator complex	part_of	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	transcription regulator complex	part_of	IBA	MGI:1098280 more ...	150520179		GO_Central	GO_REF:0000033

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
EP300	Dog	acetylation-dependent protein binding	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	acetyltransferase activity	enables	IEA	UniProtKB:B2RWS6 more ...	150520179		Ensembl	GO_REF:0000107
EP300	Dog	acyltransferase activity	enables	IEA	UniProtKB-KW:KW-0012	150520179		UniProt	GO_REF:0000043
EP300	Dog	acyltransferase activity	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	beta-catenin binding	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	chromatin binding	enables	IEA	UniProtKB:B2RWS6 more ...	150520179		Ensembl	GO_REF:0000107
EP300	Dog	chromatin DNA binding	enables	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	chromatin DNA binding	enables	IBA	MGI:1276116 more ...	150520179		GO_Central	GO_REF:0000033
EP300	Dog	damaged DNA binding	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	DNA binding	enables	IEA	UniProtKB:B2RWS6 more ...	150520179		Ensembl	GO_REF:0000107
EP300	Dog	DNA-binding transcription factor binding	enables	IEA	ARBA:ARBA00026336	150520179		UniProt	GO_REF:0000117
EP300	Dog	DNA-binding transcription factor binding	enables	IEA	UniProtKB:B2RWS6 more ...	150520179		Ensembl	GO_REF:0000107
EP300	Dog	histone acetyltransferase activity	enables	IEA	InterPro:IPR013178 more ...	150520179		InterPro	GO_REF:0000002
EP300	Dog	histone acetyltransferase activity	enables	IBA	FB:FBgn0261617 more ...	150520179		GO_Central	GO_REF:0000033
EP300	Dog	histone acetyltransferase activity	enables	IEA	UniProtKB:B2RWS6 more ...	150520179		Ensembl	GO_REF:0000107
EP300	Dog	histone acetyltransferase activity	enables	IEA	ARBA:ARBA00026967	150520179		UniProt	GO_REF:0000117
EP300	Dog	histone butyryltransferase activity	enables	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	histone crotonyltransferase activity	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	histone H2B acetyltransferase activity	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	histone H3 acetyltransferase activity	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	histone H3K122 acetyltransferase activity	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	histone H3K18 acetyltransferase activity	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	histone H3K27 acetyltransferase activity	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	histone H4 acetyltransferase activity	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	histone lactyltransferase (CoA-dependent) activity	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	L-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	metal ion binding	enables	IEA	UniProtKB-KW:KW-0479	150520179		UniProt	GO_REF:0000043
EP300	Dog	NF-kappaB binding	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	nuclear androgen receptor binding	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	nuclear receptor binding	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	p53 binding	enables	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	peptide butyryltransferase activity	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	pre-mRNA intronic binding	enables	IEA	UniProtKB:B2RWS6 and ensembl:ENSMUSP00000066789	150520179		Ensembl	GO_REF:0000107
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q9UL17	9068941	PMID:17075044	IntAct	PMID:17075044
EP300	Dog	protein binding	enables	ISO	UniProtKB:P19838-PRO_0000030311 and UniProtKB:Q04206	9068941	PMID:23811396	ARUK-UCL	PMID:23811396
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q913V3-PRO_0000278754	9068941	PMID:15380363	AgBase	PMID:15380363
EP300	Dog	protein binding	enables	ISO	UniProtKB:P03070 and UniProtKB:P04637	9068941	PMID:16611888	IntAct	PMID:16611888
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q00613 and UniProtKB:Q99LG4	9068941	PMID:18451878	UniProt	PMID:18451878
EP300	Dog	protein binding	enables	ISO	UniProtKB:P05549 and UniProtKB:Q99967	9068941	PMID:12586840	IntAct	PMID:12586840
EP300	Dog	protein binding	enables	ISO	UniProtKB:O00327 more ...	9068941	PMID:14645221	UniProt	PMID:14645221
EP300	Dog	protein binding	enables	ISO	UniProtKB:P11473	9068941	PMID:20089040	IntAct	PMID:20089040
EP300	Dog	protein binding	enables	ISO	UniProtKB:P04637 and UniProtKB:Q9QXM1	9068941	PMID:10518217	IntAct	PMID:10518217
EP300	Dog	protein binding	enables	ISO	UniProtKB:P03255	9068941	PMID:1331501	IntAct	PMID:1331501
EP300	Dog	protein binding	enables	ISO	UniProtKB:P35637 and UniProtKB:Q01844	9068941	PMID:18509338	IntAct	PMID:18509338
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q16665	9068941	PMID:15261140 more ...	IntAct	PMID:15261140 more ...
EP300	Dog	protein binding	enables	ISO	UniProtKB:P97769 and UniProtKB:Q99966	9068941	PMID:10722728	UniProt	PMID:10722728
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q99966	9068941	PMID:16864582	UniProt	PMID:16864582
EP300	Dog	protein binding	enables	ISO	UniProtKB:P27695 and UniProtKB:P67809	9068941	PMID:20856196	IntAct	PMID:20856196
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q13625 more ...	9068941	PMID:21513714	IntAct	PMID:21513714
EP300	Dog	protein binding	enables	ISO	UniProtKB:P03255 and UniProtKB:P03255-2	9068941	PMID:12743606	IntAct	PMID:12743606
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q8WXX7	9068941	PMID:25519132 and PMID:34637754	IntAct	PMID:25519132 and PMID:34637754
EP300	Dog	protein binding	enables	ISO	UniProtKB:P27695	9068941	PMID:20808282	IntAct	PMID:20808282
EP300	Dog	protein binding	enables	ISO	UniProtKB:P04637 and UniProtKB:Q06945	9068941	PMID:19234109	UniProt	PMID:19234109
EP300	Dog	protein binding	enables	ISO	UniProtKB:P35222 and UniProtKB:Q99966	9068941	PMID:15843474	UniProt	PMID:15843474
EP300	Dog	protein binding	enables	ISO	UniProtKB:P15923 and UniProtKB:Q13562	9068941	PMID:14752053	UniProt	PMID:14752053
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q16665 and UniProtKB:Q99967	9068941	PMID:9887100	UniProt	PMID:9887100
EP300	Dog	protein binding	enables	ISO	UniProtKB:P03122 more ...	9068941	PMID:12368347	IntAct	PMID:12368347
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q8WYH8 and UniProtKB:Q9UNL4	9068941	PMID:12750254	UniProt	PMID:12750254
EP300	Dog	protein binding	enables	ISO	UniProtKB:P03255 more ...	9068941	PMID:10330164	IntAct	PMID:10330164
EP300	Dog	protein binding	enables	ISO	UniProtKB:P56524 and UniProtKB:Q9UQL6	9068941	PMID:24413532	UniProt	PMID:24413532
EP300	Dog	protein binding	enables	ISO	UniProtKB:P11473 and UniProtKB:Q01844	9068941	PMID:21988832	IntAct	PMID:21988832
EP300	Dog	protein binding	enables	ISO	UniProtKB:P03255-2	9068941	PMID:9881977	IntAct	PMID:9881977
EP300	Dog	protein binding	enables	ISO	UniProtKB:P04637	9068941	PMID:14759370 more ...	IntAct	PMID:14759370 more ...
EP300	Dog	protein binding	enables	ISO	UniProtKB:P05549 and UniProtKB:Q99967-1	9068941	PMID:12586840	UniProt	PMID:12586840
EP300	Dog	protein binding	enables	ISO	UniProtKB:P06790	9068941	PMID:10702269	IntAct	PMID:10702269
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q99LG4 and UniProtKB:Q9QXM1	9068941	PMID:11511361	UniProt	PMID:11511361
EP300	Dog	protein binding	enables	ISO	EP300 (Homo sapiens)	9068941	PMID:17150957 and PMID:26983400	UniProt	PMID:17150957 and PMID:26983400
EP300	Dog	protein binding	enables	ISO	UniProtKB:P20265	9068941	PMID:11029584	IntAct	PMID:11029584
EP300	Dog	protein binding	enables	ISO	UniProtKB:O00571	9068941	PMID:28128295	UniProt	PMID:28128295
EP300	Dog	protein binding	enables	ISO	UniProtKB:P46379	9068941	PMID:17403783	UniProt	PMID:17403783
EP300	Dog	protein binding	enables	ISO	UniProtKB:P12004	9068941	PMID:24939902	UniProt	PMID:24939902
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q9NXW9	9068941	PMID:23145062	IntAct	PMID:23145062
EP300	Dog	protein binding	enables	ISO	UniProtKB:P15923-2	9068941	PMID:12435739	UniProt	PMID:12435739
EP300	Dog	protein binding	enables	ISO	UniProtKB:P12980	9068941	PMID:18160048	UniProt	PMID:18160048
EP300	Dog	protein binding	enables	ISO	UniProtKB:P55209	9068941	PMID:11940655	IntAct	PMID:11940655
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q9BZS1	9068941	PMID:16652169	UniProt	PMID:16652169
EP300	Dog	protein binding	enables	ISO	UniProtKB:O60356 and UniProtKB:P04637	9068941	PMID:18690848	UniProt	PMID:18690848
EP300	Dog	protein binding	enables	ISO	UniProtKB:K4P3M7	9068941	PMID:16760386	IntAct	PMID:16760386
EP300	Dog	protein binding	enables	ISO	UniProtKB:P42226	9068941	PMID:23461825	IntAct	PMID:23461825
EP300	Dog	protein binding	enables	ISO	UniProtKB:P10914	9068941	PMID:15509808	UniProt	PMID:15509808
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q6ZSB9	9068941	PMID:25245946	UniProt	PMID:25245946
EP300	Dog	protein binding	enables	ISO	UniProtKB:P03259	9068941	PMID:10049825 and PMID:9018065	IntAct	PMID:10049825 and PMID:9018065
EP300	Dog	protein binding	enables	ISO	UniProtKB:P39748	9068941	PMID:11430825	UniProt	PMID:11430825
EP300	Dog	protein binding	enables	ISO	UniProtKB:P61201	9068941	PMID:23441852	IntAct	PMID:23441852
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q9NPI1	9068941	PMID:20228809	IntAct	PMID:20228809
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q92831	9068941	PMID:8684459	IntAct	PMID:8684459
EP300	Dog	protein binding	enables	ISO	UniProtKB:P35638	9068941	PMID:17872950	UniProt	PMID:17872950
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q12778	9068941	PMID:15890677	UniProt	PMID:15890677
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q00839	9068941	PMID:11909954	UniProt	PMID:11909954
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q91XJ0	9068941	PMID:14716005	UniProt	PMID:14716005
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q9H2X6	9068941	PMID:16917507	IntAct	PMID:16917507
EP300	Dog	protein binding	enables	ISO	UniProtKB:P51530	9068941	PMID:20019387	UniProt	PMID:20019387
EP300	Dog	protein binding	enables	ISO	UniProtKB:P56279	9068941	PMID:19064921	IntAct	PMID:19064921
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q8IXJ6	9068941	PMID:18722353	UniProt	PMID:18722353
EP300	Dog	protein binding	enables	ISO	UniProtKB:O60934	9068941	PMID:21108945	IntAct	PMID:21108945
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q15650	9068941	PMID:25219498	UniProt	PMID:25219498
EP300	Dog	protein binding	enables	ISO	UniProtKB:O15350	9068941	PMID:19218448	IntAct	PMID:19218448
EP300	Dog	protein binding	enables	ISO	UniProtKB:O95863	9068941	PMID:25314079	IntAct	PMID:25314079
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q9UIH9	9068941	PMID:23999430	UniProt	PMID:23999430
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q8C8B0	9068941	PMID:12929931	UniProt	PMID:12929931
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q9Y6B2	9068941	PMID:11073990	UniProt	PMID:11073990
EP300	Dog	protein binding	enables	ISO	UniProtKB:P24941	9068941	PMID:23455922 more ...	IntAct	PMID:23455922 more ...
EP300	Dog	protein binding	enables	ISO	UniProtKB:P78545	9068941	PMID:15075319	UniProt	PMID:15075319
EP300	Dog	protein binding	enables	ISO	UniProtKB:P04608	9068941	PMID:9811832	IntAct	PMID:9811832
EP300	Dog	protein binding	enables	ISO	UniProtKB:P84022	9068941	PMID:15588252	UniProt	PMID:15588252
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q13309	9068941	PMID:22770219	IntAct	PMID:22770219
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q13761	9068941	PMID:24229708	IntAct	PMID:24229708
EP300	Dog	protein binding	enables	ISO	UniProtKB:P03372	9068941	PMID:11581164	UniProt	PMID:11581164
EP300	Dog	protein binding	enables	ISO	UniProtKB:P16220-1	9068941	PMID:17476304	IntAct	PMID:17476304
EP300	Dog	protein binding	enables	ISO	UniProtKB:P17844	9068941	PMID:12527917	IntAct	PMID:12527917
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q9UBL3	9068941	PMID:23870121	IntAct	PMID:23870121
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q96EB6	9068941	PMID:15632193 more ...	IntAct	PMID:15632193 more ...
EP300	Dog	protein binding	enables	ISO	UniProtKB:O60356	9068941	PMID:11940591	UniProt	PMID:11940591
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q61221	9068941	PMID:20609350	IntAct	PMID:20609350
EP300	Dog	protein binding	enables	ISO	UniProtKB:Q8X834	9068941	PMID:27018634	AgBase	PMID:27018634
EP300	Dog	protein propionyltransferase activity	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	protein-lysine-acetyltransferase activity	enables	IEA	UniProtKB:B2RWS6 more ...	150520179		Ensembl	GO_REF:0000107
EP300	Dog	RNA polymerase II-specific DNA-binding transcription factor binding	enables	IEA	UniProtKB:B2RWS6 more ...	150520179		Ensembl	GO_REF:0000107
EP300	Dog	STAT family protein binding	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	transcription coactivator activity	enables	IEA	InterPro:IPR014744	150520179		InterPro	GO_REF:0000002
EP300	Dog	transcription coactivator activity	enables	IBA	FB:FBgn0261617 more ...	150520179		GO_Central	GO_REF:0000033
EP300	Dog	transcription coactivator activity	enables	IEA	UniProtKB:B2RWS6 more ...	150520179		Ensembl	GO_REF:0000107
EP300	Dog	transcription coactivator binding	enables	IEA	UniProtKB:B2RWS6 more ...	150520179		Ensembl	GO_REF:0000107
EP300	Dog	transcription coregulator activity	enables	IEA	InterPro:IPR003101 and InterPro:IPR036529	150520179		InterPro	GO_REF:0000002
EP300	Dog	transcription coregulator binding	enables	IEA	UniProtKB:Q09472 and ensembl:ENSP00000263253	150520179		Ensembl	GO_REF:0000107
EP300	Dog	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	150520179		UniProt	GO_REF:0000043
EP300	Dog	zinc ion binding	enables	IEA	InterPro:IPR000433	150520179		InterPro	GO_REF:0000002
EP300	Dog	zinc ion binding	enables	IEA	UniProtKB-KW:KW-0863	150520179		UniProt	GO_REF:0000043

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
EP300	Dog	androgen signaling pathway		ISO	EP300 (Homo sapiens)	9068941		RGD	PMID:17163421 and REF_RGD_ID:2326123
EP300	Dog	cortisol signaling pathway		ISO	EP300 (Homo sapiens)	9068941		RGD	PMID:11306337 and REF_RGD_ID:5147892
EP300	Dog	estrogen signaling pathway		ISO	EP300 (Homo sapiens)	9068941		RGD	PMID:16394250 and REF_RGD_ID:5128512
EP300	Dog	histone modification pathway		ISO	EP300 (Homo sapiens)	9068941		RGD	PMID:21151613 and REF_RGD_ID:9104959
EP300	Dog	hypoxia inducible factor pathway		ISO	EP300 (Homo sapiens)	9068941		RGD	PMID:19364912 more ...

Imported Annotations - PID (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
EP300	Dog	forkhead class A signaling pathway		ISO	EP300 (Homo sapiens)	9068941		PID	PID:200226
EP300	Dog	hypoxia inducible factor pathway		ISO	EP300 (Homo sapiens)	9068941		PID	PID:200036 and PID:200202
EP300	Dog	Notch signaling pathway		ISO	EP300 (Homo sapiens)	9068941		PID	PID:200015
EP300	Dog	p53 signaling pathway		ISO	EP300 (Homo sapiens)	9068941		PID	PID:200206
EP300	Dog	type II interferon signaling pathway		ISO	EP300 (Homo sapiens)	9068941		PID	PID:200129

PMID:22301074	PMID:30032202

EP300
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	24,076,538 - 24,156,708 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	24,077,971 - 24,156,396 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	24,010,660 - 24,090,852 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	24,823,553 - 24,904,040 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	24,824,097 - 24,903,879 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	24,539,621 - 24,619,804 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	24,860,221 - 24,940,412 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	25,034,546 - 25,114,749 (-)	NCBI		UU_Cfam_GSD_1.0

EP300
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	41,092,592 - 41,180,077 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	41,092,510 - 41,180,077 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	41,488,596 - 41,576,081 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	39,818,553 - 39,906,024 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	39,813,106 - 39,900,578	NCBI
Celera	22	25,294,977 - 25,382,428 (+)	NCBI		Celera
Cytogenetic Map	22	q13.2	NCBI
HuRef	22	24,453,007 - 24,540,433 (+)	NCBI		HuRef
CHM1_1	22	41,448,337 - 41,535,740 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	41,567,504 - 41,655,012 (+)	NCBI		T2T-CHM13v2.0

EP300
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	23,634,132 - 23,726,095 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	23,634,571 - 23,724,979 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	101,701,940 - 101,792,946 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants in EP300
551 total Variants

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

adipose tissue	alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	reproductive system	respiratory system
6	5	5	23	22	16	6	6	6	6	33	22	12	14	10


RefSeq Transcripts	XM_022424377	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038488517	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038488518	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038550446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038550447	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038614412	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038614413	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038638531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038638541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038679753	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038679754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCAFT00000001723 ⟹ ENSCAFP00000001585

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	24,077,971 - 24,156,396 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000065648 ⟹ ENSCAFP00000063662

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	24,077,971 - 24,156,396 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000066651 ⟹ ENSCAFP00000060804

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	24,077,971 - 24,156,396 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000085148 ⟹ ENSCAFP00000049413

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	24,077,971 - 24,156,396 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00000086120 ⟹ ENSCAFP00000055921

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	24,077,971 - 24,156,396 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845032551 ⟹ ENSCAFP00845025456

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	24,824,097 - 24,903,879 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845032802 ⟹ ENSCAFP00845025673

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	24,824,097 - 24,903,879 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845033035 ⟹ ENSCAFP00845025855

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	24,824,097 - 24,903,879 (-)	Ensembl

Ensembl Acc Id:

ENSCAFT00845033258 ⟹ ENSCAFP00845026037

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	24,824,097 - 24,903,879 (-)	Ensembl

RefSeq Acc Id:

XM_038488517 ⟹ XP_038344445

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	10	24,539,621 - 24,619,804 (-)	NCBI

RefSeq Acc Id:

XM_038488518 ⟹ XP_038344446

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	10	24,539,621 - 24,619,239 (-)	NCBI

RefSeq Acc Id:

XM_038550446 ⟹ XP_038406374

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	10	25,034,546 - 25,114,749 (-)	NCBI

RefSeq Acc Id:

XM_038550447 ⟹ XP_038406375

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	10	25,034,546 - 25,114,184 (-)	NCBI

RefSeq Acc Id:

XM_038614412 ⟹ XP_038470340

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	10	24,860,221 - 24,940,412 (-)	NCBI

RefSeq Acc Id:

XM_038614413 ⟹ XP_038470341

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	10	24,860,221 - 24,939,847 (-)	NCBI

RefSeq Acc Id:

XM_038638531 ⟹ XP_038494459

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	10	24,010,660 - 24,090,852 (-)	NCBI

RefSeq Acc Id:

XM_038638541 ⟹ XP_038494469

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
Dog10K_Boxer_Tasha	10	24,010,660 - 24,090,287 (-)	NCBI

RefSeq Acc Id:

XM_038679753 ⟹ XP_038535681

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	24,823,553 - 24,904,040 (-)	NCBI

RefSeq Acc Id:

XM_038679754 ⟹ XP_038535682

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	24,823,553 - 24,903,475 (-)	NCBI


Protein RefSeqs	XP_038344445	(Get FASTA)	NCBI Sequence Viewer
	XP_038344446	(Get FASTA)	NCBI Sequence Viewer
	XP_038406374	(Get FASTA)	NCBI Sequence Viewer
	XP_038406375	(Get FASTA)	NCBI Sequence Viewer
	XP_038470340	(Get FASTA)	NCBI Sequence Viewer
	XP_038470341	(Get FASTA)	NCBI Sequence Viewer
	XP_038494459	(Get FASTA)	NCBI Sequence Viewer
	XP_038494469	(Get FASTA)	NCBI Sequence Viewer
	XP_038535681	(Get FASTA)	NCBI Sequence Viewer
	XP_038535682	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000001585.7
	ENSCAFP00000049413.2
	ENSCAFP00000055921.2
	ENSCAFP00000063662.2
	ENSCAFP00030035185.1
	ENSCAFP00030035356.1
	ENSCAFP00030035526.1
	ENSCAFP00030035658.1
	ENSCAFP00030035795.1
	ENSCAFP00040029906.1
	ENSCAFP00040030058.1
	ENSCAFP00040030206.1
	ENSCAFP00040030375.1
	ENSCAFP00040030553.1
	ENSCAFP00845025456
	ENSCAFP00845025456.1
	ENSCAFP00845025673.1
	ENSCAFP00845025855.1
	ENSCAFP00845026037
	ENSCAFP00845026037.1

Ensembl Acc Id:

ENSCAFP00000001585 ⟸ ENSCAFT00000001723

Ensembl Acc Id:

ENSCAFP00000060804 ⟸ ENSCAFT00000066651

Ensembl Acc Id:

ENSCAFP00000055921 ⟸ ENSCAFT00000086120

Ensembl Acc Id:

ENSCAFP00000063662 ⟸ ENSCAFT00000065648

Ensembl Acc Id:

ENSCAFP00000049413 ⟸ ENSCAFT00000085148

Protein Domains

Bromo CBP/p300-type HAT KIX TAZ-type ZZ-type

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000001125	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030021720	UniProtKB/TrEMBL
	ENSCAFG00040018233	UniProtKB/TrEMBL
	ENSCAFG00845018383	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000001723.7	UniProtKB/TrEMBL
	ENSCAFT00000065648.2	UniProtKB/TrEMBL
	ENSCAFT00000085148.2	UniProtKB/TrEMBL
	ENSCAFT00000086120.2	UniProtKB/TrEMBL
	ENSCAFT00030040311.1	UniProtKB/TrEMBL
	ENSCAFT00030040502.1	UniProtKB/TrEMBL
	ENSCAFT00030040703.1	UniProtKB/TrEMBL
	ENSCAFT00030040860.1	UniProtKB/TrEMBL
	ENSCAFT00030041025.1	UniProtKB/TrEMBL
	ENSCAFT00040034349.1	UniProtKB/TrEMBL
	ENSCAFT00040034526.1	UniProtKB/TrEMBL
	ENSCAFT00040034693.1	UniProtKB/TrEMBL
	ENSCAFT00040034885.1	UniProtKB/TrEMBL
	ENSCAFT00040035094.1	UniProtKB/TrEMBL
	ENSCAFT00845032551	ENTREZGENE
	ENSCAFT00845032551.1	UniProtKB/TrEMBL
	ENSCAFT00845032802.1	UniProtKB/TrEMBL
	ENSCAFT00845033035.1	UniProtKB/TrEMBL
	ENSCAFT00845033258	ENTREZGENE
	ENSCAFT00845033258.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.1630.10	UniProtKB/TrEMBL
	1.10.246.20	UniProtKB/TrEMBL
	1.20.1020.10	UniProtKB/TrEMBL
	1.20.920.10	UniProtKB/TrEMBL
	2.10.110.40	UniProtKB/TrEMBL
	3.30.40.10	UniProtKB/TrEMBL
	3.30.60.90	UniProtKB/TrEMBL
InterPro	Bromodomain	UniProtKB/TrEMBL
	Bromodomain-like_sf	UniProtKB/TrEMBL
	Bromodomain_CS	UniProtKB/TrEMBL
	CBP_P300_HAT	UniProtKB/TrEMBL
	Histone_AcTrfase_Rtt109/CBP	UniProtKB/TrEMBL
	KIX_dom	UniProtKB/TrEMBL
	KIX_dom_sf	UniProtKB/TrEMBL
	Nuc_rcpt_coact	UniProtKB/TrEMBL
	Nuc_rcpt_coact_CREBbp	UniProtKB/TrEMBL
	Nuc_rcpt_coact_CREBbp_sf	UniProtKB/TrEMBL
	RING_CBP-p300	UniProtKB/TrEMBL
	RING_CBP-p300_sf	UniProtKB/TrEMBL
	TAZ_dom_sf	UniProtKB/TrEMBL
	Znf_RING/FYVE/PHD	UniProtKB/TrEMBL
	Znf_TAZ	UniProtKB/TrEMBL
	Znf_ZZ	UniProtKB/TrEMBL
	Znf_ZZ_sf	UniProtKB/TrEMBL
NCBI Gene	EP300	ENTREZGENE
PANTHER	HISTONE ACETYLTRANSFERASE P300	UniProtKB/TrEMBL
	PTHR13808	UniProtKB/TrEMBL
Pfam	Bromodomain	UniProtKB/TrEMBL
	Creb_binding	UniProtKB/TrEMBL
	DUF902	UniProtKB/TrEMBL
	HAT_KAT11	UniProtKB/TrEMBL
	KIX	UniProtKB/TrEMBL
	PF00569	UniProtKB/TrEMBL
	zf-TAZ	UniProtKB/TrEMBL
PRINTS	BROMODOMAIN	UniProtKB/TrEMBL
	PRICHEXTENSN	UniProtKB/TrEMBL
PROSITE	BROMODOMAIN_1	UniProtKB/TrEMBL
	BROMODOMAIN_2	UniProtKB/TrEMBL
	CBP_P300_HAT	UniProtKB/TrEMBL
	KIX	UniProtKB/TrEMBL
	ZF_TAZ	UniProtKB/TrEMBL
	ZF_ZZ_1	UniProtKB/TrEMBL
	ZF_ZZ_2	UniProtKB/TrEMBL
SMART	BROMO	UniProtKB/TrEMBL
	KAT11	UniProtKB/TrEMBL
	ZnF_TAZ	UniProtKB/TrEMBL
	ZnF_ZZ	UniProtKB/TrEMBL
Superfamily-SCOP	RING/U-box	UniProtKB/TrEMBL
	SSF47040	UniProtKB/TrEMBL
	SSF47370	UniProtKB/TrEMBL
	SSF57933	UniProtKB/TrEMBL
	SSF69125	UniProtKB/TrEMBL
UniProt	A0A8C0P5S4_CANLF	UniProtKB/TrEMBL
	A0A8C0P7Y1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0PBA2_CANLF	UniProtKB/TrEMBL
	A0A8C0PEI4_CANLF	UniProtKB/TrEMBL
	A0A8C0PIR7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0T1V5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0T224	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0T3Z8_CANLF	UniProtKB/TrEMBL
	A0A8C0T765_CANLF	UniProtKB/TrEMBL
	A0A8C0Z1R5_CANLF	UniProtKB/TrEMBL
	A0A8I3NW07_CANLF	UniProtKB/TrEMBL
	A0A8I3P1J8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3P304_CANLF	UniProtKB/TrEMBL
	A0A8I3P730	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:84862	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - PID (archival)