EP300 (E1A binding protein p300) - Rat Genome Database

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Gene: EP300 (E1A binding protein p300) Canis lupus familiaris
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Symbol: EP300
Name: E1A binding protein p300
RGD ID: 12259272
Description: ENCODES a protein that exhibits acetyltransferase activity (ortholog); acyltransferase activity (ortholog); androgen receptor binding (ortholog); INVOLVED IN apoptotic process (ortholog); cellular response to UV (ortholog); epigenetic maintenance of chromatin in transcription-competent conformation (ortholog); PARTICIPATES IN androgen signaling pathway; cortisol signaling pathway; estrogen signaling pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); Agenesis of Corpus Callosum (ortholog); Alzheimer's disease (ortholog); FOUND IN cytosol (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH resveratrol
Type: protein-coding
RefSeq Status: MODEL
Also known as: histone acetyltransferase p300
RGD Orthologs
Human
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,076,538 - 24,156,708 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,077,971 - 24,156,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1024,010,660 - 24,090,852 (-)NCBI
ROS_Cfam_1.01024,823,553 - 24,904,040 (-)NCBI
UMICH_Zoey_3.11024,539,621 - 24,619,804 (-)NCBI
UNSW_CanFamBas_1.01024,860,221 - 24,940,412 (-)NCBI
UU_Cfam_GSD_1.01025,034,546 - 25,114,749 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
resveratrol  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (ISO)
cellular response to UV  (ISO)
epigenetic maintenance of chromatin in transcription-competent conformation  (ISO)
histone acetylation  (ISO)
histone H2B acetylation  (ISO)
histone H4 acetylation  (ISO)
internal peptidyl-lysine acetylation  (ISO)
internal protein amino acid acetylation  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
macrophage derived foam cell differentiation  (ISO)
N-terminal peptidyl-lysine acetylation  (ISO)
negative regulation of gluconeogenesis  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
peptidyl-lysine acetylation  (ISO)
peptidyl-lysine butyrylation  (ISO)
peptidyl-lysine crotonylation  (ISO)
peptidyl-lysine propionylation  (ISO)
positive regulation by host of viral transcription  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of transforming growth factor beta receptor signaling pathway  (ISO)
protein acetylation  (ISO)
protein destabilization  (ISO)
regulation of androgen receptor signaling pathway  (ISO)
regulation of glycolytic process  (ISO)
regulation of tubulin deacetylation  (ISO)
response to estrogen  (ISO)
response to hypoxia  (ISO)

Cellular Component
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

References

Genomics

Comparative Map Data
EP300
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11024,076,538 - 24,156,708 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1024,077,971 - 24,156,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1024,010,660 - 24,090,852 (-)NCBI
ROS_Cfam_1.01024,823,553 - 24,904,040 (-)NCBI
UMICH_Zoey_3.11024,539,621 - 24,619,804 (-)NCBI
UNSW_CanFamBas_1.01024,860,221 - 24,940,412 (-)NCBI
UU_Cfam_GSD_1.01025,034,546 - 25,114,749 (-)NCBI
EP300
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2241,092,592 - 41,180,077 (+)EnsemblGRCh38hg38GRCh38
GRCh382241,092,592 - 41,180,077 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372241,488,596 - 41,576,081 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,818,553 - 39,906,024 (+)NCBINCBI36hg18NCBI36
Build 342239,813,106 - 39,900,578NCBI
Celera2225,294,977 - 25,382,428 (+)NCBI
Cytogenetic Map22q13.2NCBI
HuRef2224,453,007 - 24,540,433 (+)NCBIHuRef
CHM1_12241,448,337 - 41,535,740 (+)NCBICHM1_1
EP300
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11923,634,132 - 23,726,095 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1923,634,571 - 23,724,979 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666045101,701,940 - 101,792,946 (-)NCBIVero_WHO_p1.0


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 12 2 10 6
Low 6 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_022424377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038488518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038550447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038614413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038638531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038638541 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000099 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000001723   ⟹   ENSCAFP00000001585
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1024,077,971 - 24,156,396 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000065648   ⟹   ENSCAFP00000063662
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1024,077,971 - 24,156,396 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000066651   ⟹   ENSCAFP00000060804
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1024,077,971 - 24,156,396 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000085148   ⟹   ENSCAFP00000049413
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1024,077,971 - 24,156,396 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000086120   ⟹   ENSCAFP00000055921
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1024,077,971 - 24,156,396 (-)Ensembl
RefSeq Acc Id: XM_038488517   ⟹   XP_038344445
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11024,539,621 - 24,619,804 (-)NCBI
RefSeq Acc Id: XM_038488518   ⟹   XP_038344446
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11024,539,621 - 24,619,239 (-)NCBI
RefSeq Acc Id: XM_038550446   ⟹   XP_038406374
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01025,034,546 - 25,114,749 (-)NCBI
RefSeq Acc Id: XM_038550447   ⟹   XP_038406375
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01025,034,546 - 25,114,184 (-)NCBI
RefSeq Acc Id: XM_038614412   ⟹   XP_038470340
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01024,860,221 - 24,940,412 (-)NCBI
RefSeq Acc Id: XM_038614413   ⟹   XP_038470341
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01024,860,221 - 24,939,847 (-)NCBI
RefSeq Acc Id: XM_038638531   ⟹   XP_038494459
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1024,010,660 - 24,090,852 (-)NCBI
RefSeq Acc Id: XM_038638541   ⟹   XP_038494469
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha1024,010,660 - 24,090,287 (-)NCBI
RefSeq Acc Id: XM_038679753   ⟹   XP_038535681
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01024,823,553 - 24,904,040 (-)NCBI
RefSeq Acc Id: XM_038679754   ⟹   XP_038535682
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01024,823,553 - 24,903,475 (-)NCBI
Reference Sequences
RefSeq Acc Id: ENSCAFP00000001585   ⟸   ENSCAFT00000001723
RefSeq Acc Id: ENSCAFP00000060804   ⟸   ENSCAFT00000066651
RefSeq Acc Id: ENSCAFP00000055921   ⟸   ENSCAFT00000086120
RefSeq Acc Id: ENSCAFP00000063662   ⟸   ENSCAFT00000065648
RefSeq Acc Id: ENSCAFP00000049413   ⟸   ENSCAFT00000085148
RefSeq Acc Id: XP_038344445   ⟸   XM_038488517
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038344446   ⟸   XM_038488518
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038470340   ⟸   XM_038614412
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038470341   ⟸   XM_038614413
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038535681   ⟸   XM_038679753
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038535682   ⟸   XM_038679754
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038494459   ⟸   XM_038638531
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038494469   ⟸   XM_038638541
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038406374   ⟸   XM_038550446
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038406375   ⟸   XM_038550447
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000001125 Ensembl
NCBI Gene EP300 ENTREZGENE
VGNC ID VGNC:84862 ENTREZGENE