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ONTOLOGY REPORT - ANNOTATIONS

Term:midbrain-hindbrain boundary development
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Accession:GO:0030917 term browser browse the term
Definition:The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.
Synonyms:exact_synonym: MHB development;   isthmic organizer development;   isthmomesencephalic boundary development;   isthmus development;   midbrain-hindbrain orgainizer development


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midbrain-hindbrain boundary development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G En1 engrailed homeobox 1 acts_upstream_of_or_within ISO MGI:1857163 (PMID:15607945) RGD PMID:15607945 NCBI chr13:31,750,892...31,756,477
Ensembl chr13:31,751,545...31,755,943 		JBrowse link
G Fgf8 fibroblast growth factor 8 acts_upstream_of_or_within ISO MGI:2150347 (PMID:17601531) RGD PMID:17601531 NCBI chr 1:254,533,504...254,539,605
Ensembl chr 1:244,584,652...244,590,359 		JBrowse link
G Gbx2 gastrulation brain homeobox 2 acts_upstream_of_or_within ISO MGI:1857634 (PMID:16651541) RGD PMID:16651541 NCBI chr 9:97,957,304...97,959,883
Ensembl chr 9:90,509,633...90,512,212 		JBrowse link
G Lrp6 LDL receptor related protein 6 acts_upstream_of_or_within ISO MGI:2156191 (PMID:11029008), (PMID:19795512) RGD PMID:11029008 PMID:19795512 NCBI chr 4:168,997,937...169,131,716
Ensembl chr 4:167,270,353...167,400,497 		JBrowse link
G Wnt1 Wnt family member 1 acts_upstream_of_or_within ISO MGI:1857490 (PMID:2205396) RGD PMID:2205396 NCBI chr 7:131,817,558...131,821,605
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
midbrain-hindbrain boundary initiation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ssbp3 single stranded DNA binding protein 3 involved_in IEA
ISO		 GO_REF:0000107
(PMID:15857913)		 Ensembl
RGD		 PMID:15857913 GO_REF:0000107 NCBI chr 5:121,691,370...121,828,035
Ensembl chr 5:121,691,393...121,827,992 		JBrowse link
midbrain-hindbrain boundary maturation during brain development term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Wnt1 Wnt family member 1 acts_upstream_of_or_within ISO MGI:1856382 (PMID:8555108) RGD PMID:8555108 NCBI chr 7:131,817,558...131,821,605
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
midbrain-hindbrain boundary morphogenesis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gbx2 gastrulation brain homeobox 2 acts_upstream_of_or_within ISO MGI:1857634 (PMID:16651541) RGD PMID:16651541 NCBI chr 9:97,957,304...97,959,883
Ensembl chr 9:90,509,633...90,512,212 		JBrowse link
G Hes1 hes family bHLH transcription factor 1 involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000107
MGI:104877 (PMID:11500373)		 Ensembl
RGD		 PMID:11500373 GO_REF:0000107 NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192 		JBrowse link
G Hes3 hes family bHLH transcription factor 3 acts_upstream_of_or_within ISO MGI:104853 (PMID:11522634) RGD PMID:11522634 NCBI chr 5:162,793,611...162,799,578
Ensembl chr 5:162,794,367...162,796,261 		JBrowse link
G Kdm2b lysine demethylase 2B involved_in ISO (PMID:21220025) RGD PMID:21220025 NCBI chr12:39,224,422...39,362,126
Ensembl chr12:33,574,657...33,701,355 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20553
    developmental process 7140
      anatomical structure development 6638
        midbrain-hindbrain boundary development 9
          midbrain-hindbrain boundary initiation 1
          midbrain-hindbrain boundary maturation + 1
          midbrain-hindbrain boundary morphogenesis + 4
Path 2
Term Annotations click to browse term
  biological_process 20553
    developmental process 7140
      anatomical structure development 6638
        multicellular organism development 5350
          embryo development 1377
            embryo development ending in birth or egg hatching 902
              chordate embryonic development 885
                neural tube development 194
                  neural tube patterning 44
                    rostrocaudal neural tube patterning 14
                      midbrain-hindbrain boundary development 9
                        midbrain-hindbrain boundary initiation 1
                        midbrain-hindbrain boundary maturation + 1
                        midbrain-hindbrain boundary morphogenesis + 4
paths to the root