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cGMP-mediated signaling - Ontology Report - Rat Genome Database

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ONTOLOGY REPORT - ANNOTATIONS

Term:cGMP-mediated signaling
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Accession:GO:0019934 term browser browse the term
Definition:An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell.
Synonyms:exact_synonym: cGMP-mediated signalling

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cGMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADNP activity dependent neuroprotector homeobox ISO RGD PMID:11438390 RGD:1358228 NCBI chr17:52,316,388...52,350,732
Ensembl chr17:52,317,913...52,332,079 		JBrowse link
G ADORA2B adenosine A2b receptor acts_upstream_of IEA Ensembl GO_REF:0000107 NCBI chr12:59,431,834...59,449,701
Ensembl chr12:59,431,513...59,449,672 		JBrowse link
G AQP1 aquaporin 1 (Colton blood group) involved_in ISS
IEA 		UniProt
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr18:42,063,482...42,076,741
Ensembl chr18:42,063,485...42,076,746 		JBrowse link
G CD36 CD36 molecule involved_in ISO (PMID:17416590) BHF-UCL PMID:17416590 NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105 		JBrowse link
G CGAS cyclic GMP-AMP synthase involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:92,483,253...92,500,376
Ensembl chr 1:92,483,327...92,504,307 		JBrowse link
G EDNRB endothelin receptor type B ISO RGD PMID:17585504 RGD:4892585 NCBI chr11:50,073,300...50,102,879
Ensembl chr11:50,072,554...50,102,884 		JBrowse link
G GUCA2B guanylate cyclase activator 2B ISO RGD PMID:9094754 RGD:731150 NCBI chr 6:169,152,172...169,154,557
Ensembl chr 6:169,152,179...169,154,551 		JBrowse link
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,290...44,518,135 		JBrowse link
G GUCY1A2 guanylate cyclase 1 soluble subunit alpha 2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:62,101,581...62,510,803
Ensembl chr 9:62,101,613...62,499,581 		JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687 		JBrowse link
G GUCY2D guanylate cyclase 2D, retinal ISO RGD PMID:9153227 RGD:1599625 NCBI chr12:53,200,570...53,250,566
Ensembl chr12:53,235,801...53,249,467 		JBrowse link
G GUCY2F guanylate cyclase 2F, retinal ISO RGD PMID:9153227 RGD:1599625 NCBI chr  X:89,557,952...89,653,491 JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B involved_in IEA Ensembl GO_REF:0000107 NCBI chr15:131,844,578...131,860,417
Ensembl chr15:131,844,992...131,859,277 		JBrowse link
G HTR2C 5-hydroxytryptamine receptor 2C involved_in IEA Ensembl GO_REF:0000107 NCBI chr  X:94,053,415...94,313,352
Ensembl chr  X:94,053,456...94,313,355 		JBrowse link
G IRAG1 inositol 1,4,5-triphosphate receptor associated 1 involved_in
acts_upstream_of_or_within 		IBA
IEA 		GO_Central
Ensembl		 GO_REF:0000033 GO_REF:0000107 NCBI chr 2:48,745,375...48,930,885
Ensembl chr 2:48,745,371...48,930,883 		JBrowse link
G LOC100625149 guanylate cyclase soluble subunit beta-2 involved_in IBA GO_Central GO_REF:0000033 NCBI chr11:16,772,313...16,811,787 JBrowse link
G NOS2 nitric oxide synthase 2 ISO RGD PMID:12107056 RGD:625635 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146 		JBrowse link
G NPPA natriuretic peptide A involved_in ISO
IBA 		RGD
GO_Central		 PMID:12217425 GO_REF:0000033 RGD:729410 NCBI chr 6:71,919,557...71,921,345
Ensembl chr 6:71,918,845...71,921,405 		JBrowse link
G NPPB natriuretic peptide B involved_in IBA GO_Central GO_REF:0000033 NCBI chr 6:71,930,374...71,931,843
Ensembl chr 6:71,930,382...71,932,254 		JBrowse link
G NPPC natriuretic peptide C ISO RGD PMID:14691198 RGD:1601491 NCBI chr15:132,504,669...132,509,688
Ensembl chr15:132,506,474...132,509,673 		JBrowse link
G NPR1 natriuretic peptide receptor 1 ISO RGD PMID:2563900 PMID:12217425 RGD:729265 RGD:729410 NCBI chr 4:95,957,220...95,974,253
Ensembl chr 4:95,957,228...95,973,430 		JBrowse link
G NPR2 natriuretic peptide receptor 2 ISO RGD PMID:14691198 RGD:1601491 NCBI chr 1:236,508,994...236,529,172
Ensembl chr 1:236,508,998...236,529,128 		JBrowse link
G PDE2A phosphodiesterase 2A involved_in ISS
IBA
IEA 		UniProt
GO_Central
Ensembl		 GO_REF:0000024 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:7,136,637...7,227,966
Ensembl chr 9:7,136,644...7,227,964 		JBrowse link
G PDE3A phosphodiesterase 3A involved_in ISS
IEA 		AgBase
Ensembl		 GO_REF:0000024 GO_REF:0000107 NCBI chr 5:52,413,503...52,737,771
Ensembl chr 5:52,409,882...52,738,406 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,558,533...98,793,010 		JBrowse link
negative regulation of cGMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MTNR1B melatonin receptor 1B ISO RGD PMID:18363673 RGD:9588673 NCBI chr 9:25,556,756...25,557,792
Ensembl chr 9:25,545,390...25,558,054 		JBrowse link
G NHERF4 NHERF family PDZ scaffold protein 4 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:46,401,377...46,409,804
Ensembl chr 9:46,401,713...46,406,219 		JBrowse link
G PDE10A phosphodiesterase 10A involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:3,120,418...3,394,236
Ensembl chr 1:2,829,411...3,392,651 		JBrowse link
G PDE11A phosphodiesterase 11A involved_in ISO
IBA 		RGD
GO_Central		 PMID:11502204 GO_REF:0000033 RGD:633590 NCBI chr15:83,366,082...83,784,266
Ensembl chr15:83,365,723...83,757,934 		JBrowse link
G PDE2A phosphodiesterase 2A involved_in IBA GO_Central GO_REF:0000033 NCBI chr 9:7,136,637...7,227,966
Ensembl chr 9:7,136,644...7,227,964 		JBrowse link
G THBS1 thrombospondin 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,784...131,746,115 		JBrowse link
nitric oxide-cGMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTR2 angiotensin II receptor type 2 involved_in ISO (PMID:17000928) BHF-UCL PMID:17000928 NCBI chr  X:95,267,709...95,272,237
Ensembl chr  X:95,269,300...95,270,388 		JBrowse link
G APOE apolipoprotein E involved_in IEA Ensembl GO_REF:0000107 NCBI chr 6:51,373,113...51,375,333
Ensembl chr 6:51,372,292...51,375,330 		JBrowse link
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 acts_upstream_of_negative_effect IEA Ensembl GO_REF:0000107 NCBI chr 9:64,336,354...64,445,669
Ensembl chr 9:64,336,499...64,445,663 		JBrowse link
G CD36 CD36 molecule involved_in ISO (PMID:17416590) BHF-UCL PMID:17416590 NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105 		JBrowse link
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,290...44,518,135 		JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687 		JBrowse link
G INS insulin involved_in IEA Ensembl GO_REF:0000107 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841 		JBrowse link
G KCNC2 potassium voltage-gated channel subfamily C member 2 involved_in ISO PMID:11281123 UniProt PMID:11281123 RGD:10047322 NCBI chr 5:38,326,408...38,535,826
Ensembl chr 5:38,326,414...38,533,110 		JBrowse link
G NOS1 nitric oxide synthase 1 involved_in ISO PMID:19278978 BHF-UCL PMID:19278978 RGD:10047220 NCBI chr14:35,112,898...35,299,297
Ensembl chr14:35,113,184...35,295,944 		JBrowse link
G THBS1 thrombospondin 1 acts_upstream_of_negative_effect IEA Ensembl GO_REF:0000107 NCBI chr 1:131,728,781...131,746,098
Ensembl chr 1:131,728,784...131,746,115 		JBrowse link
positive regulation of cGMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADORA2B adenosine A2b receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr12:59,431,834...59,449,701
Ensembl chr12:59,431,513...59,449,672 		JBrowse link
G GUCA1A guanylate cyclase activator 1A ISO RGD PMID:12545196 RGD:1599357 NCBI chr 7:37,282,630...37,296,713
Ensembl chr 7:37,282,700...37,296,717 		JBrowse link
G LOC100523457 olfactory guanylyl cyclase GC-D-like involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:10,833,010...10,867,824 JBrowse link
G NPPA natriuretic peptide A ISO RGD PMID:7552344 PMID:12608696 RGD:1626242 RGD:1626243 NCBI chr 6:71,919,557...71,921,345
Ensembl chr 6:71,918,845...71,921,405 		JBrowse link
G NPPB natriuretic peptide B ISO RGD PMID:7552344 RGD:1626243 NCBI chr 6:71,930,374...71,931,843
Ensembl chr 6:71,930,382...71,932,254 		JBrowse link
G NPPC natriuretic peptide C ISO RGD PMID:12746286 RGD:1580115 NCBI chr15:132,504,669...132,509,688
Ensembl chr15:132,506,474...132,509,673 		JBrowse link
G NPR1 natriuretic peptide receptor 1 ISO RGD PMID:7552344 RGD:1626243 NCBI chr 4:95,957,220...95,974,253
Ensembl chr 4:95,957,228...95,973,430 		JBrowse link
G NPR2 natriuretic peptide receptor 2 ISO RGD PMID:7552344 RGD:1626243 NCBI chr 1:236,508,994...236,529,172
Ensembl chr 1:236,508,998...236,529,128 		JBrowse link
G RUNDC3A RUN domain containing 3A involved_in ISO
IBA 		atrial natriuretic factor-mediated RGD
GO_Central		 PMID:11071862 GO_REF:0000033 RGD:1299631 NCBI chr12:18,920,365...18,929,766
Ensembl chr12:18,920,370...18,930,223 		JBrowse link
positive regulation of nitric oxide-cGMP mediated signal transduction term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KDR kinase insert domain receptor acts_upstream_of_or_within IEA Ensembl GO_REF:0000107 NCBI chr 8:41,809,116...41,856,379
Ensembl chr 8:41,809,122...41,856,336 		JBrowse link
regulation of cGMP-mediated signaling term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PDE2A phosphodiesterase 2A involved_in IEA Ensembl GO_REF:0000107 NCBI chr 9:7,136,637...7,227,966
Ensembl chr 9:7,136,644...7,227,964 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18944
    cellular process 18486
      signal transduction 7030
        intracellular signal transduction 3068
          intracellular signaling cassette 1992
            cGMP-mediated signaling 40
              negative regulation of cGMP-mediated signaling + 6
              nitric oxide-cGMP-mediated signaling + 11
              positive regulation of cGMP-mediated signaling + 10
              regulation of cGMP-mediated signaling + 16
Path 2
Term Annotations click to browse term
  biological_process 18944
    biological regulation 13005
      regulation of biological process 12624
        signaling 7571
          signal transduction 7030
            intracellular signal transduction 3068
              intracellular signaling cassette 1992
                cGMP-mediated signaling 40
                  negative regulation of cGMP-mediated signaling + 6
                  nitric oxide-cGMP-mediated signaling + 11
                  positive regulation of cGMP-mediated signaling + 10
                  regulation of cGMP-mediated signaling + 16
paths to the root