HTR2C (5-hydroxytryptamine receptor 2C) - Rat Genome Database

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Gene: HTR2C (5-hydroxytryptamine receptor 2C) Sus scrofa
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Symbol: HTR2C
Name: 5-hydroxytryptamine receptor 2C
RGD ID: 14254071
Description: ENCODES a protein that exhibits G protein-coupled serotonin receptor activity (ortholog); INVOLVED IN animal organ regeneration (ortholog); behavioral response to nicotine (ortholog); feeding behavior (ortholog); ASSOCIATED WITH anxiety disorder (ortholog); autistic disorder (ortholog); bipolar disorder (ortholog); FOUND IN cell surface (ortholog); external side of plasma membrane (ortholog); INTERACTS WITH mesulergine
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5HTR2C
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX94,053,456 - 94,313,356 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X94,053,415 - 94,313,352 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X108,811,549 - 108,871,722 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2X108,566,657 - 108,733,261 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
mesulergine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
behavioral fear response  (IEA)
behavioral response to nicotine  (ISO)
cellular calcium ion homeostasis  (IEA)
cGMP-mediated signaling  (IEA)
chemical synaptic transmission  (IBA)
feeding behavior  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (IBA)
G protein-coupled serotonin receptor signaling pathway  (IEA)
inositol phosphate-mediated signaling  (ISO)
locomotory behavior  (IEA)
negative regulation of dopamine metabolic process  (ISO)
negative regulation of locomotion  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IBA)
phospholipase C-activating serotonin receptor signaling pathway  (IEA,ISO)
phospholipase D-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of acetylcholine secretion, neurotransmission  (ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of fat cell differentiation  (IEA,ISO)
positive regulation of gamma-aminobutyric acid secretion  (ISO)
positive regulation of phosphatidylinositol biosynthetic process  (IEA)
positive regulation of vasoconstriction  (ISO)
regulation of appetite  (IEA)
regulation of corticotropin-releasing hormone secretion  (IEA)
regulation of nervous system process  (IEA)
regulation of sensory perception of pain  (ISO)
release of sequestered calcium ion into cytosol  (IBA,IEA)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:10617681   PMID:22471812  


Genomics

Comparative Map Data
HTR2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX94,053,456 - 94,313,356 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X94,053,415 - 94,313,352 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X108,811,549 - 108,871,722 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2X108,566,657 - 108,733,261 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HTR2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X114,584,086 - 114,910,061 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX114,584,078 - 114,910,061 (+)EnsemblGRCh38hg38GRCh38
GRCh37X113,818,559 - 114,144,624 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X113,724,807 - 114,050,880 (+)NCBINCBI36hg18NCBI36
Build 34X113,641,530 - 113,967,604NCBI
CeleraX114,253,715 - 114,579,778 (+)NCBI
Cytogenetic MapXq23NCBI
HuRefX103,403,272 - 103,731,741 (+)NCBIHuRef
CHM1_1X113,729,484 - 114,055,500 (+)NCBICHM1_1
T2T-CHM13v2.0X112,992,593 - 113,318,748 (+)NCBI
Htr2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X145,745,509 - 145,980,273 (+)NCBIGRCm39mm39
GRCm39 EnsemblX145,745,509 - 145,980,273 (+)Ensembl
GRCm38X146,962,464 - 147,197,277 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX146,962,513 - 147,197,277 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X143,397,056 - 143,631,820 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X142,208,881 - 142,443,644 (+)NCBImm8
CeleraX130,902,904 - 131,136,225 (+)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX68.46NCBI
Htr2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X110,640,777 - 110,870,288 (+)NCBImRatBN7.2
mRatBN7.2 EnsemblX110,641,153 - 110,870,287 (+)Ensembl
Rnor_6.0X118,084,520 - 118,318,040 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX118,084,890 - 118,318,039 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X118,226,113 - 118,460,830 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X31,012,921 - 31,244,127 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X31,069,048 - 31,185,684 (-)NCBI
CeleraX109,958,913 - 110,179,824 (+)NCBICelera
Cytogenetic MapXq34NCBI
Htr2c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955490910,415 - 1,126,373 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955490912,615 - 1,126,347 (-)NCBIChiLan1.0ChiLan1.0
HTR2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X114,169,823 - 114,503,179 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX114,199,485 - 114,503,201 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X103,673,172 - 103,999,133 (+)NCBIMhudiblu_PPA_v0panPan3
HTR2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X87,342,800 - 87,641,224 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX87,342,792 - 87,638,579 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX73,595,073 - 73,759,737 (+)NCBI
ROS_Cfam_1.0X89,055,367 - 89,357,473 (+)NCBI
ROS_Cfam_1.0 EnsemblX89,055,355 - 89,357,011 (+)Ensembl
UMICH_Zoey_3.1X86,633,342 - 86,797,977 (+)NCBI
UNSW_CanFamBas_1.0X88,307,583 - 88,472,268 (+)NCBI
UU_Cfam_GSD_1.0X88,140,047 - 88,305,373 (+)NCBI
Htr2c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X86,426,392 - 86,655,882 (+)NCBI
SpeTri2.0NW_0049364991,002,083 - 1,109,446 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HTR2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X102,190,355 - 102,499,928 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX102,325,731 - 102,497,278 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606527,537,759 - 27,837,340 (+)NCBIVero_WHO_p1.0
Htr2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249401,040,911 - 1,157,057 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046249401,040,744 - 1,299,266 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system nervous system
High
Medium 2
Low 16
Below cutoff 1 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000035084   ⟹   ENSSSCP00000030956
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX94,053,456 - 94,313,356 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000082136   ⟹   ENSSSCP00000059742
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX94,194,750 - 94,313,356 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000083553   ⟹   ENSSSCP00000060594
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX94,053,671 - 94,311,904 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000089036   ⟹   ENSSSCP00000070015
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 EnsemblX94,053,456 - 94,262,442 (+)Ensembl
RefSeq Acc Id: NM_001286590   ⟹   NP_001273519
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X94,053,447 - 94,310,944 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021079477   ⟹   XP_020935136
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1X94,053,415 - 94,313,352 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001273519 (Get FASTA)   NCBI Sequence Viewer  
  XP_020935136 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF25829 (Get FASTA)   NCBI Sequence Viewer  
  CBX88672 (Get FASTA)   NCBI Sequence Viewer  
  CBX88673 (Get FASTA)   NCBI Sequence Viewer  
  CBY77919 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020935136   ⟸   XM_021079477
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001273519   ⟸   NM_001286590
- UniProtKB: G7ZKZ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000030956   ⟸   ENSSSCT00000035084
RefSeq Acc Id: ENSSSCP00000060594   ⟸   ENSSSCT00000083553
RefSeq Acc Id: ENSSSCP00000070015   ⟸   ENSSSCT00000089036
RefSeq Acc Id: ENSSSCP00000059742   ⟸   ENSSSCT00000082136
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000012593 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00005002397 UniProtKB/TrEMBL
  ENSSSCG00015011058 UniProtKB/TrEMBL
  ENSSSCG00025013428 UniProtKB/TrEMBL
  ENSSSCG00030066874 UniProtKB/TrEMBL
  ENSSSCG00035031841 UniProtKB/TrEMBL
  ENSSSCG00040003381 UniProtKB/TrEMBL
  ENSSSCG00045014037 UniProtKB/TrEMBL
  ENSSSCG00050040341 UniProtKB/TrEMBL
  ENSSSCG00055016907 UniProtKB/TrEMBL
  ENSSSCG00060043231 UniProtKB/TrEMBL
  ENSSSCG00065040499 UniProtKB/TrEMBL
  ENSSSCG00070029006 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000030956 UniProtKB/TrEMBL
  ENSSSCP00000059742 UniProtKB/TrEMBL
  ENSSSCP00000060594 UniProtKB/TrEMBL
  ENSSSCP00000070015 UniProtKB/TrEMBL
  ENSSSCP00005002096 UniProtKB/TrEMBL
  ENSSSCP00015005684 UniProtKB/TrEMBL
  ENSSSCP00015005703 UniProtKB/TrEMBL
  ENSSSCP00015005723 UniProtKB/TrEMBL
  ENSSSCP00015005743 UniProtKB/TrEMBL
  ENSSSCP00025007160 UniProtKB/TrEMBL
  ENSSSCP00025007174 UniProtKB/TrEMBL
  ENSSSCP00025007192 UniProtKB/TrEMBL
  ENSSSCP00025007216 UniProtKB/TrEMBL
  ENSSSCP00030043068 UniProtKB/TrEMBL
  ENSSSCP00030043080 UniProtKB/TrEMBL
  ENSSSCP00030043092 UniProtKB/TrEMBL
  ENSSSCP00030043111 UniProtKB/TrEMBL
  ENSSSCP00035016878 UniProtKB/TrEMBL
  ENSSSCP00040001350 UniProtKB/TrEMBL
  ENSSSCP00040001357 UniProtKB/TrEMBL
  ENSSSCP00040001363 UniProtKB/TrEMBL
  ENSSSCP00040001369 UniProtKB/TrEMBL
  ENSSSCP00045016493 UniProtKB/TrEMBL
  ENSSSCP00045016513 UniProtKB/TrEMBL
  ENSSSCP00050023031 UniProtKB/TrEMBL
  ENSSSCP00050023036 UniProtKB/TrEMBL
  ENSSSCP00050023040 UniProtKB/TrEMBL
  ENSSSCP00050023043 UniProtKB/TrEMBL
  ENSSSCP00055026717 UniProtKB/TrEMBL
  ENSSSCP00060025118 UniProtKB/TrEMBL
  ENSSSCP00060025126 UniProtKB/TrEMBL
  ENSSSCP00060025127 UniProtKB/TrEMBL
  ENSSSCP00065024057 UniProtKB/TrEMBL
  ENSSSCP00065024059 UniProtKB/TrEMBL
  ENSSSCP00065024064 UniProtKB/TrEMBL
  ENSSSCP00070049467 UniProtKB/TrEMBL
  ENSSSCP00070049468 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000035084 UniProtKB/TrEMBL
  ENSSSCT00000082136 UniProtKB/TrEMBL
  ENSSSCT00000083553 UniProtKB/TrEMBL
  ENSSSCT00000089036 UniProtKB/TrEMBL
  ENSSSCT00005003603 UniProtKB/TrEMBL
  ENSSSCT00015014645 UniProtKB/TrEMBL
  ENSSSCT00015014692 UniProtKB/TrEMBL
  ENSSSCT00015014737 UniProtKB/TrEMBL
  ENSSSCT00015014790 UniProtKB/TrEMBL
  ENSSSCT00025017865 UniProtKB/TrEMBL
  ENSSSCT00025017893 UniProtKB/TrEMBL
  ENSSSCT00025017926 UniProtKB/TrEMBL
  ENSSSCT00025017967 UniProtKB/TrEMBL
  ENSSSCT00030093521 UniProtKB/TrEMBL
  ENSSSCT00030093548 UniProtKB/TrEMBL
  ENSSSCT00030093577 UniProtKB/TrEMBL
  ENSSSCT00030093607 UniProtKB/TrEMBL
  ENSSSCT00035042190 UniProtKB/TrEMBL
  ENSSSCT00040004277 UniProtKB/TrEMBL
  ENSSSCT00040004289 UniProtKB/TrEMBL
  ENSSSCT00040004302 UniProtKB/TrEMBL
  ENSSSCT00040004312 UniProtKB/TrEMBL
  ENSSSCT00045023917 UniProtKB/TrEMBL
  ENSSSCT00045023941 UniProtKB/TrEMBL
  ENSSSCT00050054558 UniProtKB/TrEMBL
  ENSSSCT00050054566 UniProtKB/TrEMBL
  ENSSSCT00050054572 UniProtKB/TrEMBL
  ENSSSCT00050054575 UniProtKB/TrEMBL
  ENSSSCT00055033584 UniProtKB/TrEMBL
  ENSSSCT00060058641 UniProtKB/TrEMBL
  ENSSSCT00060058660 UniProtKB/TrEMBL
  ENSSSCT00060058661 UniProtKB/TrEMBL
  ENSSSCT00065055369 UniProtKB/TrEMBL
  ENSSSCT00065055373 UniProtKB/TrEMBL
  ENSSSCT00065055382 UniProtKB/TrEMBL
  ENSSSCT00070058176 UniProtKB/TrEMBL
  ENSSSCT00070058177 UniProtKB/TrEMBL
InterPro 5HT2C_rcpt UniProtKB/TrEMBL
  5HT_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report ssc:100524920 UniProtKB/TrEMBL
NCBI Gene HTR2C ENTREZGENE
PANTHER PTHR24247:SF32 UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS 5HT2CRECEPTR UniProtKB/TrEMBL
  5HTRECEPTOR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/TrEMBL
UniProt A0A4X1VZZ6_PIG UniProtKB/TrEMBL
  A0A4X1W4R8_PIG UniProtKB/TrEMBL
  A0A5G2Q8Z2_PIG UniProtKB/TrEMBL
  A0A5G2R0W3_PIG UniProtKB/TrEMBL
  A0A8D0HP79_PIG UniProtKB/TrEMBL
  A0A8D1BIG6_PIG UniProtKB/TrEMBL
  A0A8D1YRI6_PIG UniProtKB/TrEMBL
  G7ZKZ8 ENTREZGENE, UniProtKB/TrEMBL
  K7GSR7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:96737 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-03-04 HTR2C  5-hydroxytryptamine receptor 2C  HTR2C  5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled  Symbol and/or name change 5135510 APPROVED