PDE2A (phosphodiesterase 2A) - Rat Genome Database

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Gene: PDE2A (phosphodiesterase 2A) Sus scrofa
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Symbol: PDE2A
Name: phosphodiesterase 2A
RGD ID: 14279402
Description: ENCODES a protein that exhibits 3',5'-cyclic-AMP phosphodiesterase activity (ortholog); 3',5'-cyclic-GMP phosphodiesterase activity (ortholog); cGMP binding (ortholog); INVOLVED IN aorta development (ortholog); cAMP-mediated signaling (ortholog); cardiac septum development (ortholog); PARTICIPATES IN protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Breast Neoplasms (ortholog); cardiomyopathy (ortholog); FOUND IN axon (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: cGMP-dependent 3',5'-cyclic phosphodiesterase; phosphodiesterase 2A, cGMP-stimulated
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,136,644 - 7,227,964 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,136,637 - 7,227,966 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,896,906 - 7,988,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA)
aorta development  (ISO)
cAMP-mediated signaling  (IBA,IEA,ISS)
cardiac septum development  (ISO)
cellular response to 2,3,7,8-tetrachlorodibenzodioxine  (IEA)
cellular response to cAMP  (IEA)
cellular response to cGMP  (IEA,ISS)
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISS)
cellular response to lipopolysaccharide  (ISO)
cellular response to macrophage colony-stimulating factor stimulus  (IEA,ISS)
cellular response to mechanical stimulus  (ISS)
cellular response to transforming growth factor beta stimulus  (IEA)
cellular response to xenobiotic stimulus  (ISO)
cGMP catabolic process  (IBA,IEA,ISS)
cGMP-mediated signaling  (IBA,IEA,ISS)
coronary vasculature development  (ISO)
establishment of endothelial barrier  (ISS)
heart development  (ISO)
heart valve development  (ISO)
monocyte differentiation  (ISO)
negative regulation of cAMP-mediated signaling  (IBA,IEA,ISO,ISS)
negative regulation of cell death  (ISO)
negative regulation of cGMP-mediated signaling  (IBA)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISS)
negative regulation of vascular permeability  (IEA,ISS)
positive regulation of gene expression  (IBA)
positive regulation of inflammatory response  (ISS)
positive regulation of vascular permeability  (IEA,ISS)
regulation of cAMP-mediated signaling  (ISS)
regulation of cGMP-mediated signaling  (IEA)
regulation of mitochondrion organization  (IBA)
regulation of nitric oxide mediated signal transduction  (ISO)
response to hydrogen sulfide  (ISO)
signal transduction  (IBA,IEA)
ventricular septum development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712  


Genomics

Comparative Map Data
PDE2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl97,136,644 - 7,227,964 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.197,136,637 - 7,227,966 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.297,896,906 - 7,988,379 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PDE2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1172,576,141 - 72,674,591 (-)EnsemblGRCh38hg38GRCh38
GRCh381172,576,141 - 72,674,422 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371172,287,185 - 72,385,466 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361171,964,833 - 72,063,060 (-)NCBINCBI36hg18NCBI36
Build 341171,964,833 - 72,063,060NCBI
Celera1169,589,446 - 69,690,059 (-)NCBI
Cytogenetic Map11q13.4NCBI
HuRef1168,580,047 - 68,680,751 (-)NCBIHuRef
CHM1_11172,170,508 - 72,268,807 (-)NCBICHM1_1
Pde2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397101,070,898 - 101,162,036 (+)NCBIGRCm39mm39
GRCm39 Ensembl7101,060,093 - 101,162,026 (+)Ensembl
GRCm39 Ensembl7101,070,898 - 101,162,034 (+)Ensembl
GRCm387101,421,691 - 101,512,829 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,410,886 - 101,512,819 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl7101,421,691 - 101,512,827 (+)EnsemblGRCm38mm10GRCm38
MGSCv377108,570,212 - 108,661,341 (+)NCBIGRCm37mm9NCBIm37
MGSCv367101,295,530 - 101,386,636 (+)NCBImm8
Celera7101,780,588 - 101,872,064 (+)NCBICelera
Cytogenetic Map7E2NCBI
Pde2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21155,823,590 - 155,915,434 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1155,813,180 - 155,915,434 (+)Ensembl
Rnor_6.01166,534,643 - 166,626,158 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1166,534,643 - 166,626,158 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01172,724,783 - 172,816,723 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41158,921,607 - 159,013,829 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11159,030,774 - 159,092,846 (+)NCBI
Celera1153,905,701 - 153,995,649 (+)NCBICelera
Cytogenetic Map1q32NCBI
Pde2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541418,735,822 - 18,827,236 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541418,765,591 - 18,826,717 (+)NCBIChiLan1.0ChiLan1.0
PDE2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11170,875,552 - 70,975,322 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1170,875,552 - 70,975,322 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01167,653,335 - 67,753,450 (-)NCBIMhudiblu_PPA_v0panPan3
PDE2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12125,542,030 - 25,635,661 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2125,542,268 - 25,635,660 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2125,314,283 - 25,406,213 (+)NCBI
ROS_Cfam_1.02125,751,755 - 25,844,665 (+)NCBI
UMICH_Zoey_3.12125,544,034 - 25,636,601 (+)NCBI
UNSW_CanFamBas_1.02125,747,386 - 25,839,981 (+)NCBI
UU_Cfam_GSD_1.02125,660,737 - 25,753,526 (+)NCBI
Pde2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494760,256,724 - 60,344,873 (-)NCBI
SpeTri2.0NW_0049364981,856,256 - 1,944,405 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PDE2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1163,812,877 - 63,912,602 (-)NCBI
ChlSab1.1 Ensembl163,812,840 - 63,880,492 (-)Ensembl
Vero_WHO_p1.0NW_02366604361,969,532 - 62,070,196 (+)NCBI
Pde2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248174,269,422 - 4,367,576 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 9
Low 10 4 3 5 2 13 2 3 1
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000016167   ⟹   ENSSSCP00000015734
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl97,136,644 - 7,227,964 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000031538   ⟹   ENSSSCP00000025730
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl97,136,644 - 7,227,964 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000065606   ⟹   ENSSSCP00000050215
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl97,136,644 - 7,192,018 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000066369   ⟹   ENSSSCP00000047136
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl97,136,648 - 7,201,792 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000082229   ⟹   ENSSSCP00000070178
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl97,136,644 - 7,201,771 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000090718   ⟹   ENSSSCP00000061354
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl97,136,646 - 7,164,746 (-)Ensembl
RefSeq Acc Id: XM_003482557   ⟹   XP_003482605
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.197,136,637 - 7,227,966 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005653692   ⟹   XP_005653749
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.197,136,637 - 7,202,137 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013999446   ⟹   XP_013854900
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.197,136,637 - 7,192,033 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013999451   ⟹   XP_013854905
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.197,136,637 - 7,227,966 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021102284   ⟹   XP_020957943
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.197,136,637 - 7,220,590 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021102285   ⟹   XP_020957944
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.197,136,637 - 7,220,742 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_003482605   ⟸   XM_003482557
- Peptide Label: isoform X3
- UniProtKB: I3LNQ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013854905   ⟸   XM_013999451
- Peptide Label: isoform X6
- UniProtKB: F1SUV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020957944   ⟸   XM_021102285
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_020957943   ⟸   XM_021102284
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_005653749   ⟸   XM_005653692
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013854900   ⟸   XM_013999446
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSSSCP00000015734   ⟸   ENSSSCT00000016167
RefSeq Acc Id: ENSSSCP00000050215   ⟸   ENSSSCT00000065606
RefSeq Acc Id: ENSSSCP00000061354   ⟸   ENSSSCT00000090718
RefSeq Acc Id: ENSSSCP00000025730   ⟸   ENSSSCT00000031538
RefSeq Acc Id: ENSSSCP00000047136   ⟸   ENSSSCT00000066369
RefSeq Acc Id: ENSSSCP00000070178   ⟸   ENSSSCT00000082229
Protein Domains
PDEase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000029388 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070020338 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000015734 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000025730 UniProtKB/TrEMBL
  ENSSSCP00000047136 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000050215 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000061354 UniProtKB/TrEMBL
  ENSSSCP00000070178 UniProtKB/TrEMBL
  ENSSSCP00070034432 UniProtKB/TrEMBL
  ENSSSCP00070034449 UniProtKB/TrEMBL
  ENSSSCP00070034486 UniProtKB/TrEMBL
  ENSSSCP00070034492 UniProtKB/TrEMBL
  ENSSSCP00070034502 UniProtKB/TrEMBL
  ENSSSCP00070034521 UniProtKB/TrEMBL
  ENSSSCP00070034543 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000016167 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000031538 UniProtKB/TrEMBL
  ENSSSCT00000065606 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000066369 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000082229 UniProtKB/TrEMBL
  ENSSSCT00000090718 UniProtKB/TrEMBL
  ENSSSCT00070041026 UniProtKB/TrEMBL
  ENSSSCT00070041042 UniProtKB/TrEMBL
  ENSSSCT00070041086 UniProtKB/TrEMBL
  ENSSSCT00070041092 UniProtKB/TrEMBL
  ENSSSCT00070041102 UniProtKB/TrEMBL
  ENSSSCT00070041123 UniProtKB/TrEMBL
  ENSSSCT00070041145 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1300.10 UniProtKB/TrEMBL
  3.30.450.40 UniProtKB/TrEMBL
InterPro GAF UniProtKB/TrEMBL
  GAF-like_dom_sf UniProtKB/TrEMBL
  HD/PDEase_dom UniProtKB/TrEMBL
  PDEase UniProtKB/TrEMBL
  PDEase_catalytic_dom UniProtKB/TrEMBL
  PDEase_catalytic_dom_sf UniProtKB/TrEMBL
  PDEase_CS UniProtKB/TrEMBL
NCBI Gene PDE2A ENTREZGENE
Pfam GAF UniProtKB/TrEMBL
  GAF_2 UniProtKB/TrEMBL
  PDEase_I UniProtKB/TrEMBL
PRINTS PDIESTERASE1 UniProtKB/TrEMBL
PROSITE PDEASE_I_1 UniProtKB/TrEMBL
  PDEASE_I_2 UniProtKB/TrEMBL
SMART GAF UniProtKB/TrEMBL
  HDc UniProtKB/TrEMBL
UniProt A0A287ASR1_PIG UniProtKB/TrEMBL
  A0A287B1D3_PIG UniProtKB/TrEMBL
  A0A4X1UWB2_PIG UniProtKB/TrEMBL
  A0A4X1UWH3_PIG UniProtKB/TrEMBL
  A0A4X1UWK4_PIG UniProtKB/TrEMBL
  A0A4X1UYP9_PIG UniProtKB/TrEMBL
  A0A4X1UYT7_PIG UniProtKB/TrEMBL
  A0A4X1UYU1_PIG UniProtKB/TrEMBL
  A0A4X1V1K2_PIG UniProtKB/TrEMBL
  A0A5G2QBD0_PIG UniProtKB/TrEMBL
  A0A5G2QZ68_PIG UniProtKB/TrEMBL
  F1SUV3 ENTREZGENE, UniProtKB/TrEMBL
  I3LNQ5 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:91251 ENTREZGENE