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ONTOLOGY REPORT - ANNOTATIONS

Term:mediator complex
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Accession:GO:0016592 term browser browse the term
Definition:A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
Synonyms:exact_synonym: L mediator complex;   Srb-mediator complex
 narrow_synonym: TRAP complex
 related_synonym: CDK8-containing TRAP/mediator complex
 alt_id: GO:0000119
 xref: Wikipedia:Mediator_(coactivator)


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mediator complex term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bclaf3 BCLAF1 and THRAP3 family member 3 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr  X:35,257,228...35,328,883
Ensembl chr  X:35,263,576...35,328,816 		JBrowse link
G Ccnc cyclin C part_of IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:15340084)		 Ensembl
GO_Central
RGD		 PMID:15340084 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584 		JBrowse link
G Cdk8 cyclin-dependent kinase 8 part_of ISO (PMID:14638676), (PMID:30905399)
(PMID:15340084)		 RGD PMID:14638676 PMID:15340084 PMID:30905399 NCBI chr12:8,737,198...8,805,026
Ensembl chr12:8,737,262...8,804,177 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:30,882,484...30,914,018
Ensembl chr10:30,882,606...30,909,137 		JBrowse link
G LOC103694537 mediator of RNA polymerase II transcription subunit 14-like part_of IEA GO_REF:0000104 UniProt GO_REF:0000104
G Med1 mediator complex subunit 1 part_of ISS
ISO
IBA		 GO_REF:0000024
(PMID:10198638), (PMID:12037571), (PMID:14638676), (PMID:17641689)
GO_REF:0000033
(PMID:12093747), (PMID:15340084)		 UniProt
RGD
GO_Central		 PMID:10198638 PMID:12037571 PMID:12093747 PMID:14638676 PMID:15340084 More... GO_REF:0000024 GO_REF:0000033 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299 		JBrowse link
G Med10 mediator complex subunit 10 part_of IBA
ISO		 GO_REF:0000033
(PMID:15340084)		 GO_Central
RGD		 PMID:15340084 GO_REF:0000033 NCBI chr 1:33,470,064...33,481,698
Ensembl chr 1:33,470,066...33,475,767 		JBrowse link
G Med11 mediator complex subunit 11 part_of ISO
IBA		 (PMID:14638676)
GO_REF:0000033		 RGD
GO_Central		 PMID:14638676 GO_REF:0000033 NCBI chr10:55,164,322...55,165,940
Ensembl chr10:55,164,326...55,166,533 		JBrowse link
G Med12 mediator complex subunit 12 part_of ISO
IBA		 (PMID:10198638), (PMID:12037571)
GO_REF:0000033
(PMID:15340084)		 RGD
GO_Central		 PMID:10198638 PMID:12037571 PMID:15340084 GO_REF:0000033 NCBI chr  X:66,404,807...66,427,775
Ensembl chr  X:66,404,760...66,428,387 		JBrowse link
G Med12l mediator complex subunit 12L part_of IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 2:143,253,048...143,576,507
Ensembl chr 2:143,252,139...143,573,741 		JBrowse link
G Med13 mediator complex subunit 13 part_of ISO
IBA		 (PMID:10198638), (PMID:12037571)
GO_REF:0000033
(PMID:15340084)		 RGD
GO_Central		 PMID:10198638 PMID:12037571 PMID:15340084 GO_REF:0000033 NCBI chr10:71,086,978...71,176,535
Ensembl chr10:71,090,516...71,177,242 		JBrowse link
G Med13l mediator complex subunit 13L part_of ISO (PMID:12093747) RGD PMID:12093747 NCBI chr12:37,807,596...38,004,886
Ensembl chr12:37,808,285...38,004,473 		JBrowse link
G Med14 mediator complex subunit 14 part_of ISO
IBA		 (PMID:10198638), (PMID:12037571)
GO_REF:0000033
(PMID:15340084)		 RGD
GO_Central		 PMID:10198638 PMID:12037571 PMID:15340084 GO_REF:0000033 NCBI chr  X:10,036,749...10,127,910
Ensembl chr  X:10,036,805...10,126,240 		JBrowse link
G Med16 mediator complex subunit 16 part_of ISO
IBA		 (PMID:10198638)
GO_REF:0000033
(PMID:12093747), (PMID:15340084)		 RGD
GO_Central		 PMID:10198638 PMID:12093747 PMID:15340084 GO_REF:0000033 NCBI chr 7:9,798,641...9,811,172
Ensembl chr 7:9,798,668...9,811,172 		JBrowse link
G Med17 mediator complex subunit 17 part_of ISO
IBA		 (PMID:10198638), (PMID:12037571), (PMID:14638676)
GO_REF:0000033
(PMID:15340084)		 RGD
GO_Central		 PMID:10198638 PMID:12037571 PMID:14638676 PMID:15340084 GO_REF:0000033 NCBI chr 8:12,101,594...12,120,592
Ensembl chr 8:12,101,594...12,120,592 		JBrowse link
G Med18 mediator complex subunit 18 part_of ISO (PMID:14638676) RGD PMID:14638676 NCBI chr 5:144,663,316...144,668,652
Ensembl chr 5:144,663,252...144,668,635 		JBrowse link
G Med19 mediator complex subunit 19 part_of IBA
ISO		 GO_REF:0000033
(PMID:14638676)		 GO_Central
RGD		 PMID:14638676 GO_REF:0000033 NCBI chr 3:69,762,138...69,772,661
Ensembl chr 3:69,762,166...69,772,036 		JBrowse link
G Med20 mediator complex subunit 20 part_of IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:15340084)		 Ensembl
GO_Central
RGD		 PMID:15340084 GO_REF:0000033 GO_REF:0000107 NCBI chr 9:13,370,146...13,382,756
Ensembl chr 9:13,370,146...13,382,476 		JBrowse link
G Med21 mediator complex subunit 21 part_of ISO
IBA		 (PMID:12037571)
GO_REF:0000033
(PMID:12093747), (PMID:15340084)		 RGD
GO_Central		 PMID:12037571 PMID:12093747 PMID:15340084 GO_REF:0000033 NCBI chr 4:179,560,509...179,583,811
Ensembl chr 4:179,560,579...179,567,548 		JBrowse link
G Med22 mediator complex subunit 22 part_of ISO
IBA		 (PMID:14638676)
GO_REF:0000033		 RGD
GO_Central		 PMID:14638676 GO_REF:0000033 NCBI chr 3:10,233,754...10,238,836
Ensembl chr 3:10,233,754...10,238,836 		JBrowse link
G Med23 mediator complex subunit 23 part_of IEA
IBA
ISO		 GO_REF:0000107
GO_REF:0000033
(PMID:15340084)		 Ensembl
GO_Central
RGD		 PMID:15340084 GO_REF:0000033 GO_REF:0000107 NCBI chr 1:20,490,315...20,558,461
Ensembl chr 1:20,490,315...20,537,463 		JBrowse link
G Med24 mediator complex subunit 24 part_of IEA
IBA
ISO		 GO_REF:0000002
GO_REF:0000033
(PMID:12093747), (PMID:15340084)		 InterPro
GO_Central
RGD		 PMID:12093747 PMID:15340084 GO_REF:0000002 GO_REF:0000033 NCBI chr10:83,664,609...83,702,315
Ensembl chr10:83,664,609...83,690,123 		JBrowse link
G Med25 mediator complex subunit 25 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 1:95,359,961...95,375,827
Ensembl chr 1:95,360,284...95,375,877 		JBrowse link
G Med26 mediator complex subunit 26 part_of ISO
IBA		 (PMID:15989967)
GO_REF:0000033		 RGD
GO_Central		 PMID:15989967 GO_REF:0000033 NCBI chr16:17,299,722...17,350,168
Ensembl chr16:17,299,722...17,349,543 		JBrowse link
G Med27 mediator complex subunit 27 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr 3:12,629,593...12,803,340
Ensembl chr 3:12,629,603...12,803,339 		JBrowse link
G Med28 mediator complex subunit 28 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr14:65,594,785...65,603,583
Ensembl chr14:65,594,647...65,603,583 		JBrowse link
G Med29 mediator complex subunit 29 part_of ISO
IBA		 (PMID:14638676)
GO_REF:0000033		 RGD
GO_Central		 PMID:14638676 GO_REF:0000033 NCBI chr 1:83,677,961...83,683,365
Ensembl chr 1:83,677,961...83,683,365 		JBrowse link
G Med30 mediator complex subunit 30 part_of ISO
IBA		 (PMID:10198638)
GO_REF:0000033
(PMID:15340084)		 RGD
GO_Central		 PMID:10198638 PMID:15340084 GO_REF:0000033 NCBI chr 7:84,004,735...84,026,474
Ensembl chr 7:84,004,722...84,026,595 		JBrowse link
G Med31 mediator complex subunit 31 part_of IBA GO_REF:0000033 GO_Central GO_REF:0000033 NCBI chr10:56,836,944...56,840,326
Ensembl chr10:56,836,944...56,840,326 		JBrowse link
G Med4 mediator complex subunit 4 part_of ISO
IEA		 (PMID:10882111), (PMID:14638676)
GO_REF:0000002
GO_REF:0000107
(PMID:15340084)		 RGD
InterPro
Ensembl		 PMID:10882111 PMID:14638676 PMID:15340084 GO_REF:0000002 GO_REF:0000107 NCBI chr15:48,696,542...48,706,818
Ensembl chr15:48,696,511...48,706,820 		JBrowse link
G Med6 mediator complex subunit 6 part_of ISO
IBA		 (PMID:12037571), (PMID:14638676), (PMID:17641689)
GO_REF:0000033
(PMID:15340084)		 RGD
GO_Central		 PMID:12037571 PMID:14638676 PMID:15340084 PMID:17641689 GO_REF:0000033 NCBI chr 6:101,270,410...101,283,929
Ensembl chr 6:101,270,410...101,283,876 		JBrowse link
G Med7 mediator complex subunit 7 part_of IBA
ISO		 GO_REF:0000033
(PMID:15340084)		 GO_Central
RGD		 PMID:15340084 GO_REF:0000033 NCBI chr10:30,842,330...30,857,873
Ensembl chr10:30,842,292...30,859,220 		JBrowse link
G Med8 mediator complex subunit 8 part_of ISO (PMID:14638676) RGD PMID:14638676 NCBI chr 5:131,948,632...131,949,516
Ensembl chr 5:131,943,982...131,950,305 		JBrowse link
G Med9 mediator complex subunit 9 part_of IBA
ISO		 GO_REF:0000033
(PMID:14638676)		 GO_Central
RGD		 PMID:14638676 GO_REF:0000033 NCBI chr10:44,750,667...44,765,464
Ensembl chr10:44,750,698...44,765,464 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 is_active_in ISO (PMID:32727915) RGD PMID:32727915 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta part_of ISO
IEA		 (PMID:11854298)
GO_REF:0000107		 RGD
Ensembl		 PMID:11854298 GO_REF:0000107 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Thrap3 thyroid hormone receptor associated protein 3 part_of ISO
IBA		 (PMID:10198638), (PMID:12037571)
GO_REF:0000033
(PMID:12093747), (PMID:15340084)		 RGD
GO_Central		 PMID:10198638 PMID:12037571 PMID:12093747 PMID:15340084 GO_REF:0000033 NCBI chr 5:138,445,284...138,487,544
Ensembl chr 5:138,445,295...138,487,477 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  cellular_component 20624
    protein-containing complex 6602
      nuclear protein-containing complex 1276
        mediator complex 37
Path 2
Term Annotations click to browse term
  cellular_component 20624
    cellular anatomical entity 20386
      organelle 13799
        membrane-bounded organelle 12396
          intracellular membrane-bounded organelle 11845
            nucleus 7395
              nuclear protein-containing complex 1276
                mediator complex 37
paths to the root