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Gene: Med22 (mediator complex subunit 22) Rattus norvegicus

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Symbol:

Med22

Name:

mediator complex subunit 22

RGD ID:

1564893

Description:

Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Orthologous to human MED22 (mediator complex subunit 22); PARTICIPATES IN RNA polymerase II transcription pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; gentamycin.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC100911917; LOC499762; mediator of RNA polymerase II transcription subunit 22; mediator of RNA polymerase II transcription subunit 22-like; RGD1564893; similar to surfeit 5 isoform b; Surf5; surfeit 5; surfeit locus protein 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MED22 (mediator complex subunit 22)	RGD	RGD
Mus musculus (house mouse):	Med22 (mediator complex subunit 22)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Med22 (mediator complex subunit 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MED22 (mediator complex subunit 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MED22 (mediator complex subunit 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Med22 (mediator complex subunit 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MED22 (mediator complex subunit 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MED22 (mediator complex subunit 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Med22 (mediator complex subunit 22)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MED22 (mediator complex subunit 22)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Med22 (mediator complex subunit 22)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	med22 (mediator complex subunit 22)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	mdt-22	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32971	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	MED22	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	med22	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	30,631,829 - 30,636,911 (-)	NCBI		GRCr8
mRatBN7.2	3	10,233,754 - 10,238,836 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	10,233,754 - 10,238,836 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	13,293,774 - 13,298,837 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	21,879,175 - 21,884,238 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	20,134,476 - 20,139,539 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	5,453,678 - 5,458,760 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	5,453,614 - 5,458,782 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	3	4,861,753 - 4,866,833 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	10,815,588 - 10,820,670 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	5,802,594 - 5,807,676 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	5,031,784 - 5,036,866 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

developmental and epileptic encephalopathy 14 (ISO)

Ehlers-Danlos syndrome classic type 1 (ISO)

Leigh disease (ISO)

primary coenzyme Q10 deficiency 7 (ISO)

Rafiq syndrome (ISO)

tuberous sclerosis 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

acrolein (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

doxorubicin (ISO)

folic acid (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

leflunomide (ISO)

nickel sulfate (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorohexanesulfonic acid (ISO)

pirinixic acid (ISO)

pyrimidifen (ISO)

testosterone (ISO)

trichloroethene (EXP)

triphenyl phosphate (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

core mediator complex (ISO)

mediator complex (IBA,ISO)

nucleus (ISO)

Molecular Function

protein binding (ISO)

transcription coregulator activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase II transcription pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:14638676	PMID:15489334

Genomics

Comparative Map Data

Med22
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	30,631,829 - 30,636,911 (-)	NCBI		GRCr8
mRatBN7.2	3	10,233,754 - 10,238,836 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	10,233,754 - 10,238,836 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	13,293,774 - 13,298,837 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	21,879,175 - 21,884,238 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	20,134,476 - 20,139,539 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	5,453,678 - 5,458,760 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	5,453,614 - 5,458,782 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	3	4,861,753 - 4,866,833 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	10,815,588 - 10,820,670 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	5,802,594 - 5,807,676 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	3	5,031,784 - 5,036,866 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

MED22
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	133,338,312 - 133,348,131 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	133,338,312 - 133,348,131 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	136,205,149 - 136,214,986 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	135,197,565 - 135,204,793 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	9	106,758,235 - 106,765,458 (-)	NCBI		Celera
Cytogenetic Map	9	q34.2	NCBI
HuRef	9	105,707,690 - 105,714,932 (-)	NCBI		HuRef
CHM1_1	9	136,357,935 - 136,365,175 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	145,552,239 - 145,562,071 (-)	NCBI		T2T-CHM13v2.0

Med22
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	26,795,279 - 26,800,654 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	26,795,274 - 26,800,689 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	26,905,267 - 26,910,642 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	26,905,262 - 26,910,677 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	26,760,787 - 26,766,162 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	26,727,276 - 26,732,651 (-)	NCBI		MGSCv36	mm8
Celera	2	26,615,012 - 26,620,387 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	19.09	NCBI

Med22
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	2,697,585 - 2,704,748 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	2,697,812 - 2,704,748 (-)	NCBI	ChiLan1.0	ChiLan1.0

MED22
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	6,005,303 - 6,012,470 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	6,007,636 - 6,014,806 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	104,464,103 - 104,471,294 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	133,074,826 - 133,082,071 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	133,074,826 - 133,082,071 (-)	Ensembl	panpan1.1		panPan2

MED22
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	49,777,374 - 49,783,501 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	49,058,862 - 49,065,030 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	50,651,412 - 50,657,573 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	50,651,433 - 50,657,489 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	49,413,881 - 49,420,042 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	49,755,313 - 49,761,486 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	49,833,322 - 49,839,492 (-)	NCBI		UU_Cfam_GSD_1.0

Med22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	199,833,410 - 199,839,412 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	3,535,640 - 3,542,338 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	3,535,646 - 3,541,643 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MED22
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	272,955,473 - 272,961,596 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	272,956,119 - 272,961,618 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MED22
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	4,787,771 - 4,794,942 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	4,789,061 - 4,795,011 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	192,001 - 199,225 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Med22
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	1,805,806 - 1,811,532 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	1,805,806 - 1,811,514 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Med22
39 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	138
Count of miRNA genes:	93
Interacting mature miRNAs:	105
Transcripts:	ENSRNOT00000006720, ENSRNOT00000066193
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	8658162	27494778	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	8227194	47233430	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	8227194	33703538	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	8658162	27494778	Rat
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat

Markers in Region

AW212655

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	10,234,035 - 10,234,169 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	4,862,035 - 4,862,168	NCBI	Rnor6.0
Rnor_6.0	3	5,453,960 - 5,454,093	NCBI	Rnor6.0
Rnor_5.0	3	10,217,232 - 10,217,365	UniSTS	Rnor5.0
Rnor_5.0	3	10,815,870 - 10,816,003	UniSTS	Rnor5.0
RGSC_v3.4	3	5,802,876 - 5,803,009	UniSTS	RGSC3.4
Celera	3	5,032,066 - 5,032,199	UniSTS
Cytogenetic Map	3	p12	UniSTS

RH130861

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	10,235,070 - 10,235,269 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	4,863,070 - 4,863,268	NCBI	Rnor6.0
Rnor_6.0	3	5,454,995 - 5,455,193	NCBI	Rnor6.0
Rnor_5.0	3	10,218,267 - 10,218,465	UniSTS	Rnor5.0
Rnor_5.0	3	10,816,905 - 10,817,103	UniSTS	Rnor5.0
RGSC_v3.4	3	5,803,911 - 5,804,109	UniSTS	RGSC3.4
Celera	3	5,033,101 - 5,033,299	UniSTS
Cytogenetic Map	3	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001077679	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC126134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC127519	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000006720 ⟹ ENSRNOP00000006720

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	10,233,754 - 10,238,836 (-)	Ensembl
Rnor_6.0 Ensembl	3	4,861,753 - 4,866,833 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000066193 ⟹ ENSRNOP00000062301

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	5,453,614 - 5,458,782 (-)	Ensembl

RefSeq Acc Id:

NM_001077679 ⟹ NP_001071147

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	30,631,829 - 30,636,911 (-)	NCBI
mRatBN7.2	3	10,233,754 - 10,238,836 (-)	NCBI
Rnor_6.0	3	5,453,678 - 5,458,760 (-)	NCBI
Rnor_5.0	3	10,815,588 - 10,820,670 (-)	NCBI
RGSC_v3.4	3	5,802,594 - 5,807,676 (-)	RGD
Celera	3	5,031,784 - 5,036,866 (-)	RGD

Sequence:

show sequence

CTCCGAGACGCGACGGAGGCGCGAGAGGGGAACGAGAGCCTCGTGAAGGAGTGGGCCCTTTGTT
TCTTCGCGGGAAGGGCCTGCTGCCGGGCGTGTGTTCGTGGACGGACCTGTTGTAGCGGAAACCT
TAGTCCCCAGCCCTGCGTACTCGGTTCACGTCGGACCGGACTGTGTCTCTCACCCCGGGCCCGC
CATGGCCCAGCAGAGAGCCCTGCCCCAGAGCAAAGAGACGCTACTGCAGTCATATAACAAGCGG
CTCAAAGACGACATCAAGTCCATCATGGACAACTTCACCGAGATCATCAAAACGGCCAAGATTG
AGGATGAGACGCAGGTGTCGAGGGCTACTCAGGGCGAACAGGACAACTACGAGATGCACGTTCG
AGCTGCCAACATTGTCCGGGCTGGTGAGTCGCTGATGAAGCTGGTATCTGATCTCAAGCAGTTT
CTGATCCTCAATGACTTCCCATCTGTGAATGAAGCCATTGACCAGCGTAACCAGCAGCTTCGAG
CCCTGCAGGAGGAGTGTGACCGCAAGCTCATCACCCTGCGGGATGAGGTCTCCATTGACCTGTA
TGAGCTGGAGGAGGAGTACTACTCGTCCAGCTCAAGTCTCTGCGAAGCTAATGACCTGCCTCTA
TGTGAAGCTTACTGGAGGCTGGACCTCGACACAGATTCTGCTGATGGCCTCTCAGCCCCTCTTC
TGGCGTCCCCGGAGACTGGTGCTGGTCCCTTGCAGTCTGCAGCCCCTGTCCACTCCCATGGTGG
TGGCCCTGGCCCTACAGAACACACCTGAGCTTCTTGGGGTGCTGTCTCAGGGTAGCCTTCCCGA
GGGCCCTAGTTTATCAGAAAGGAAGTCCTGTGGATACCCACCACAGCCTAGCTTTTTTCAGTCT
TAGCTCCCTTGGGGACTTTGGATCAGGAGCCACTGTAGCCTTAGGAACCTGGCCAGGCCAGGGC
CAGTTCCCTGTGATAGTTGGGGAATGCTGTTCAGTTATTTACAGGCAGGTGGCTACCTTCCTGA
CTGCGGGTGGAGGTTTGTCCCATTGAAGACCTTGCATAGGGAGGGTGACTGCTGATAGGAAGAC
AGCCTCAGCTTGTTTAGAATTGTGAGGTATTCAGTGGACCTTAGTCCAGTCACCCATCCTTAGG
CTCAGGTTCTATACAGAGCCCTGTCCACTGCCTGGGGCCTGGAGCATAGAAGTCTGCCACAGCT
GACAGTCCAAGAAGGTTGTGTGAATGGCAGCTAGCGCGCCGGGGCATCTTCCTGGATTCTCCAC
CATTTTCTTCTGCTACTTTTGTGATGAGACCATTGAATAAAAGATCAGCTTTCAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAA

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Protein Sequences


Protein RefSeqs	NP_001071147	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A0JPN6	(Get FASTA)	NCBI Sequence Viewer
	AAI27520	(Get FASTA)	NCBI Sequence Viewer
	EDL93463	(Get FASTA)	NCBI Sequence Viewer
	EDL93464	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000006720.3

RefSeq Acc Id:

NP_001071147 ⟸ NM_001077679

- UniProtKB:

A0JPN6 (UniProtKB/Swiss-Prot), A6JTI3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVR
AANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRALQEECDRKLITLRDEVSIDLY
ELEEEYYSSSSSLCEANDLPLCEAYWRLDLDTDSADGLSAPLLASPETGAGPLQSAAPVHSHGG
GPGPTEHT

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Ensembl Acc Id:

ENSRNOP00000062301 ⟸ ENSRNOT00000066193

Ensembl Acc Id:

ENSRNOP00000006720 ⟸ ENSRNOT00000006720

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0JPN6-F1-model_v2	AlphaFold	A0JPN6	1-200	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691916

Promoter ID:

EPDNEW_R2441

Type:

multiple initiation site

Name:

Med22_1

Description:

mediator complex subunit 22

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	5,458,763 - 5,458,823	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564893	AgrOrtholog
BioCyc Gene	G2FUF-50330	BioCyc
Ensembl Genes	ENSRNOG00000005059	Ensembl, UniProtKB/Swiss-Prot
	ENSRNOG00000049749	Ensembl
Ensembl Transcript	ENSRNOT00000006720.5	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7104131	IMAGE-MGC_LOAD
InterPro	Med22	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:499762	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:156735	IMAGE-MGC_LOAD
NCBI Gene	499762	ENTREZGENE
PANTHER	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22	UniProtKB/Swiss-Prot
	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22	UniProtKB/TrEMBL
	MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22	UniProtKB/TrEMBL
	PTHR12434	UniProtKB/Swiss-Prot
Pfam	Med22	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Med22	PhenoGen
RatGTEx	ENSRNOG00000005059	RatGTEx
	ENSRNOG00000049749	RatGTEx
UniProt	A0JPN6	ENTREZGENE
	A6JTI3	ENTREZGENE, UniProtKB/TrEMBL
	MED22_RAT	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Med22	mediator complex subunit 22	LOC100911917	mediator of RNA polymerase II transcription subunit 22-like	Data merged from RGD:6489628	737654	PROVISIONAL
2012-07-05	LOC100911917	mediator of RNA polymerase II transcription subunit 22-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-06	Med22	mediator complex subunit 22	RGD1564893_predicted	similar to surfeit 5 isoform b (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-07	RGD1564893_predicted	similar to surfeit 5 isoform b (predicted)	LOC499762	similar to surfeit 5 isoform b	Symbol and Name status set to approved	1299863	APPROVED
2006-02-09	LOC499762	similar to surfeit 5 isoform b			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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