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ONTOLOGY REPORT - ANNOTATIONS

Term:aspartic-type endopeptidase activity
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Accession:GO:0004190 term browser browse the term
Definition:Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
Synonyms:exact_synonym: aspartic endopeptidase activity
 narrow_synonym: aspartate protease activity;   aspartic protease activity;   aspartyl protease activity;   carboxyl protease activity
 xref: EC:3.4.23;   reactome:R-HSA-157353 "NEXT1 is cleaved to produce NICD1";   reactome:R-HSA-157640 "NEXT2 is cleaved to produce NICD2";   reactome:R-HSA-2022403 "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)";   reactome:R-HSA-2022412 "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)";   reactome:R-HSA-2065357 "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)";   reactome:R-HSA-2220988 "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants";   reactome:R-HSA-373705 "Caspase cleavage of DCC";   reactome:R-HSA-9013361 "NEXT3 is cleaved to produce NICD3";   reactome:R-HSA-9017817 "Gamma-secretase cleaves YBX1:NOTCH3";   reactome:R-HSA-9604294 "Gamma-secretase cleaves NOTCH4"


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aspartic-type endopeptidase activity term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Asprv1 aspartic peptidase, retroviral-like 1 enables IDA
ISO		 (MGI:3694389|PMID:16837463) UniProt
MGI		 PMID:16837463 GO_REF:0000119 MGI:3694389 MGI:4834177 NCBI chr 6:86,605,216...86,606,692
Ensembl chr 6:86,605,146...86,606,692 		JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 enables IMP
IDA
ISO		 (MGI:6316502|PMID:29325091)
(PMID:25592972)		 UniProt
MGI		 PMID:25592972 PMID:29325091 GO_REF:0000119 MGI:4834177 MGI:6316502 NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697 		JBrowse link
G Bace2 beta-site APP-cleaving enzyme 2 enables ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:97,157,928...97,244,136
Ensembl chr16:97,157,942...97,244,136 		JBrowse link
G Casp3 caspase 3 enables IDA (PMID:15231831), (PMID:23727203) MGI PMID:15231831 PMID:23727203 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 enables IDA (MGI:7327228|PMID:35705808), (PMID:15231831) MGI PMID:15231831 PMID:35705808 MGI:7327228 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Cntnap5a contactin associated protein-like 5A enables IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 1:115,612,467...116,515,053
Ensembl chr 1:115,612,486...116,515,053 		JBrowse link
G Ctsd cathepsin D enables IDA
IBA		 (PMID:19293336) MGI
GO_Central		 PMID:19293336 GO_REF:0000033 NCBI chr 7:141,929,647...141,941,564
Ensembl chr 7:141,929,648...141,941,775 		JBrowse link
G Ctse cathepsin E enables IDA
ISO
IBA		 (MGI:87708|PMID:9180269) UniProt
MGI
GO_Central		 PMID:9180269 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 MGI:87708 NCBI chr 1:131,566,052...131,603,245
Ensembl chr 1:131,566,044...131,603,243 		JBrowse link
G Cym chymosin enables IBA GO_Central GO_REF:0000033 NCBI chr 3:107,118,611...107,129,048
Ensembl chr 3:107,118,609...107,129,048 		JBrowse link
G Ddi1 DNA-damage inducible 1 enables IEA UniProt GO_REF:0000002 GO_REF:0000043 MGI:1354194 MGI:2152098 NCBI chr 9:6,265,028...6,266,547
Ensembl chr 9:6,262,733...6,269,846 		JBrowse link
G Ddi2 DNA-damage inducible protein 2 enables ISS
ISO		 (MGI:6316441|PMID:27528193) UniProt
MGI		 PMID:27528193 GO_REF:0000119 MGI:4834177 MGI:6316441 NCBI chr 4:141,410,874...141,450,730
Ensembl chr 4:141,404,860...141,450,730 		JBrowse link
G Napsa napsin A aspartic peptidase enables IBA GO_Central GO_REF:0000033 NCBI chr 7:44,221,869...44,236,270
Ensembl chr 7:44,221,804...44,236,286 		JBrowse link
G Nrip2 nuclear receptor interacting protein 2 enables IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 6:128,374,780...128,386,747
Ensembl chr 6:128,376,259...128,393,390 		JBrowse link
G Nrip3 nuclear receptor interacting protein 3 enables IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr 7:109,357,263...109,380,752
Ensembl chr 7:109,357,262...109,381,232 		JBrowse link
G Pga5 pepsinogen 5, group I enables IDA
IBA		 (PMID:11566730) MGI
GO_Central		 PMID:11566730 GO_REF:0000033 NCBI chr19:10,646,321...10,655,435
Ensembl chr19:10,646,320...10,655,435 		JBrowse link
G Pgc progastricsin (pepsinogen C) enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr17:48,037,767...48,045,403
Ensembl chr17:48,037,767...48,045,407 		JBrowse link
G Pip prolactin induced protein enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 6:41,824,483...41,828,999
Ensembl chr 6:41,824,469...41,828,999 		JBrowse link
G Psen1 presenilin 1 enables IMP (PMID:12684521) MGI PMID:12684521 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Ren1 renin 1 structural enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 1:133,278,412...133,288,058
Ensembl chr 1:133,278,248...133,288,063 		JBrowse link
G Ren2 renin 2 tandem duplication of Ren1 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177
G Sppl2c signal peptide peptidase 2C enables IDA (PMID:30733280) UniProt PMID:30733280 NCBI chr11:104,077,153...104,081,992
Ensembl chr11:104,077,153...104,081,989 		JBrowse link
G Sva seminal vesicle antigen enables IBA GO_Central GO_REF:0000033 NCBI chr 6:42,015,328...42,019,785
Ensembl chr 6:42,015,328...42,019,785 		JBrowse link
G Sval1 seminal vesicle antigen-like 1 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:41,928,562...41,933,032
Ensembl chr 6:41,928,564...41,933,032 		JBrowse link
G Sval2 seminal vesicle antigen-like 2 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:41,837,241...41,841,347
Ensembl chr 6:41,829,923...41,841,347 		JBrowse link
G Sval3 seminal vesicle antigen-like 3 enables IBA GO_Central GO_REF:0000033 NCBI chr 6:41,945,074...41,950,024
Ensembl chr 6:41,945,074...41,950,024 		JBrowse link
aspartic endopeptidase activity, intramembrane cleaving term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G H13 histocompatibility 13 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:152,511,292...152,550,590
Ensembl chr 2:152,511,381...152,550,590 		JBrowse link
G Ncstn nicastrin contributes_to IGI (PMID:16371134) MGI PMID:16371134 NCBI chr 1:171,893,580...171,910,356
Ensembl chr 1:171,893,580...171,910,362 		JBrowse link
G Psen1 presenilin 1 enables
contributes_to		 ISO
IGI
IBA
IMP		 (PMID:16371134)
(PMID:21206757)		 MGI
GO_Central		 PMID:16371134 PMID:21206757 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr12:83,734,926...83,781,869
Ensembl chr12:83,734,926...83,781,973 		JBrowse link
G Psen2 presenilin 2 enables IGI
IBA
IMP		 (PMID:21206757)
(PMID:12684521)		 MGI
GO_Central		 PMID:12684521 PMID:21206757 GO_REF:0000033 NCBI chr 1:180,054,569...180,091,030
Ensembl chr 1:180,054,569...180,091,003 		JBrowse link
G Sppl2a signal peptide peptidase like 2A enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:126,732,311...126,775,706
Ensembl chr 2:126,732,311...126,775,155 		JBrowse link
G Sppl2b signal peptide peptidase like 2B NOT|enables ISO
IBA		 (PMID:16873890) UniProt
GO_Central		 PMID:16873890 GO_REF:0000033 NCBI chr10:80,691,067...80,704,542
Ensembl chr10:80,691,109...80,704,542 		JBrowse link
G Sppl2c signal peptide peptidase 2C enables IDA
IBA		 (MGI:6281843|PMID:30733280), (MGI:7332329|PMID:35960805), (MGI:7387163|PMID:30733281) UniProt
GO_Central		 PMID:30733280 PMID:30733281 PMID:35960805 GO_REF:0000033 MGI:6281843 MGI:7332329 MGI:7387163 NCBI chr11:104,077,153...104,081,992
Ensembl chr11:104,077,153...104,081,989 		JBrowse link
G Sppl3 signal peptide peptidase 3 enables ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 5:115,149,204...115,236,849
Ensembl chr 5:115,149,196...115,236,849 		JBrowse link
Term paths to the root
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Term Annotations click to browse term
  molecular_function 28831
    catalytic activity 5721
      hydrolase activity 2454
        peptidase activity 656
          endopeptidase activity 444
            aspartic-type endopeptidase activity 31
              aspartic endopeptidase activity, intramembrane cleaving 8
              aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process 0
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