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Gene: Sppl2b (signal peptide peptidase like 2B) Mus musculus
Symbol: Sppl2b
Name: signal peptide peptidase like 2B
Description: Predicted to have aspartic endopeptidase activity, intramembrane cleaving and protein homodimerization activity. Predicted to be involved in membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; and regulation of immune response. Predicted to localize to several cellular components, including the bounding membrane of organelle; cytoskeleton; and integral component of endoplasmic reticulum membrane. Is expressed in embryo. Orthologous to human SPPL2B (signal peptide peptidase like 2B); INTERACTS WITH ethanol; tetrachloroethene; 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3110056O03Rik; AW550292; PSL1; signal peptide peptidase-like 2B; SPP-like 2B
Homo sapiens (human) : SPPL2B (signal peptide peptidase like 2B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sppl2b (signal peptide peptidase-like 2B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sppl2b (signal peptide peptidase like 2B)
Pan paniscus (bonobo/pygmy chimpanzee) : SPPL2B (signal peptide peptidase like 2B)
Canis lupus familiaris (dog) : SPPL2B (signal peptide peptidase like 2B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sppl2b (signal peptide peptidase like 2B)
Sus scrofa (pig) : SPPL2B (signal peptide peptidase like 2B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381080,855,242 - 80,868,708 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371080,318,020 - 80,331,453 (+)NCBIGRCm37mm9NCBIm37
MGSCv361080,258,386 - 80,271,834 (+)NCBImm8
Celera1081,874,073 - 81,887,506 (+)NCBICelera
Cytogenetic Map10 C1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Sppl2b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1318398
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.