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Ontology Browser
Term:
Parent Terms Term With Siblings Child Terms
aspartic-type endopeptidase activity +   
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
cysteine-type endopeptidase activity +   
glutamic-type endopeptidase activity 
metalloendopeptidase activity +   
oligopeptidase activity  
peptidoglycan endopeptidase activity +  
serine-type endopeptidase activity  
threonine-type endopeptidase activity  

Synonyms
Exact Synonyms: aspartic endopeptidase activity
Narrow Synonyms: aspartate protease activity ;   aspartic protease activity ;   aspartyl protease activity ;   carboxyl protease activity
Xrefs: EC:3.4.23 ;   reactome:R-HSA-157353 "NEXT1 is cleaved to produce NICD1" ;   reactome:R-HSA-157640 "NEXT2 is cleaved to produce NICD2" ;   reactome:R-HSA-2022403 "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)" ;   reactome:R-HSA-2022412 "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)" ;   reactome:R-HSA-2065357 "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)" ;   reactome:R-HSA-2220988 "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants" ;   reactome:R-HSA-373705 "Caspase cleavage of DCC" ;   reactome:R-HSA-9013361 "NEXT3 is cleaved to produce NICD3" ;   reactome:R-HSA-9017817 "Gamma-secretase cleaves YBX1:NOTCH3" ;   reactome:R-HSA-9604294 "Gamma-secretase cleaves NOTCH4"
Definition Sources: ISBN:0198506732

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