Pip (prolactin induced protein) - Rat Genome Database

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Gene: Pip (prolactin induced protein) Mus musculus
Analyze
Symbol: Pip
Name: prolactin induced protein
RGD ID: 737423
MGI Page MGI
Description: Predicted to enable IgG binding activity; aspartic-type endopeptidase activity; and identical protein binding activity. Acts upstream of or within regulation of immune system process. Located in apical plasma membrane and extracellular region. Is expressed in several structures, including exocrine system and female reproductive system. Orthologous to human PIP (prolactin induced protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 14 kDa submandibular gland protein; GCDFP-1; GCDFP-15; GP17; gross cystic disease fluid protein 15; mSM; mSMGP; prolactin-induced protein; prolactin-inducible protein homolog; SMGP
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39641,824,483 - 41,828,999 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl641,824,469 - 41,828,999 (+)EnsemblGRCm39 Ensembl
GRCm38641,847,549 - 41,852,065 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl641,847,535 - 41,852,065 (+)EnsemblGRCm38mm10GRCm38
MGSCv37641,797,548 - 41,802,061 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36641,777,161 - 41,781,671 (+)NCBIMGSCv36mm8
Celera641,800,116 - 41,804,629 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.05NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
sinusitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
2. MGDs mouse GO annotations MGD data from the GO Consortium
3. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
4. Mouse MP Annotation Import Pipeline RGD automated import pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Identification of two rodent genes encoding homologues to seminal vesicle autoantigen: a gene family including the gene for prolactin-inducible protein. Yoshida M, etal., Biochem Biophys Res Commun 2001 Feb 16;281(1):94-100.
Additional References at PubMed
PMID:6546617   PMID:7925123   PMID:9801465   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12890565   PMID:14697523   PMID:15489334   PMID:15851553  
PMID:16141072   PMID:16141073   PMID:16602821   PMID:18696337   PMID:19832805   PMID:20052012   PMID:21677750   PMID:21873635   PMID:25594453   PMID:26751783   PMID:27602994   PMID:29536339  
PMID:31447246   PMID:34379992   PMID:38355793  


Genomics

Comparative Map Data
Pip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39641,824,483 - 41,828,999 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl641,824,469 - 41,828,999 (+)EnsemblGRCm39 Ensembl
GRCm38641,847,549 - 41,852,065 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl641,847,535 - 41,852,065 (+)EnsemblGRCm38mm10GRCm38
MGSCv37641,797,548 - 41,802,061 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36641,777,161 - 41,781,671 (+)NCBIMGSCv36mm8
Celera641,800,116 - 41,804,629 (+)NCBICelera
Cytogenetic Map6B2.1NCBI
cM Map620.05NCBI
PIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387143,132,077 - 143,139,739 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7143,132,077 - 143,139,739 (+)EnsemblGRCh38hg38GRCh38
GRCh377142,829,170 - 142,836,832 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,539,296 - 142,546,956 (+)NCBINCBI36Build 36hg18NCBI36
Build 347142,346,010 - 142,353,671NCBI
Celera7137,666,037 - 137,673,689 (+)NCBICelera
Cytogenetic Map7q34NCBI
HuRef7137,167,318 - 137,174,970 (+)NCBIHuRef
CHM1_17142,766,052 - 142,773,688 (+)NCBICHM1_1
T2T-CHM13v2.07144,487,494 - 144,495,160 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27142,231,068 - 142,238,728 (+)NCBI
Pip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8471,754,265 - 71,758,559 (+)NCBIGRCr8
mRatBN7.2470,787,627 - 70,791,921 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl470,787,627 - 70,791,921 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx475,705,167 - 75,709,461 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0471,618,416 - 71,622,710 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0470,044,294 - 70,048,604 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0471,320,859 - 71,325,153 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl471,320,859 - 71,325,153 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04136,110,485 - 136,114,779 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4469,633,474 - 69,637,768 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1469,909,603 - 69,913,898 (+)NCBI
Celera465,738,147 - 65,742,441 (+)NCBICelera
Cytogenetic Map4q24NCBI
PIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26179,984,853 - 179,992,474 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1731,995,110 - 32,002,731 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07135,127,479 - 135,135,117 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17147,618,291 - 147,625,936 (+)NCBIpanpan1.1PanPan1.1panPan2
PIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1166,491,424 - 6,498,175 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl166,491,424 - 6,498,133 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha167,479,446 - 7,486,201 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0166,344,252 - 6,351,022 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1166,303,071 - 6,309,839 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0166,143,590 - 6,150,363 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0166,219,083 - 6,225,860 (-)NCBIUU_Cfam_GSD_1.0
Pip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511812,358,839 - 12,363,416 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936527540,008 - 544,586 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936527540,051 - 544,586 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1187,110,528 - 7,117,274 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2187,440,016 - 7,446,732 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121112,015,420 - 112,024,133 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21112,016,135 - 112,024,030 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660728,744,946 - 8,753,431 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Pip
177 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:45
Interacting mature miRNAs:45
Transcripts:ENSMUST00000075351
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142271Egq8_mearly growth QTL 8 (mouse)Not determined450382396633110Mouse
4140989Spqq2_msperm quality QTL 2 (mouse)Not determined1771159851711719Mouse
26884441Sklq3_mskull length QTL 3, 5 week (mouse)6760000080576983Mouse
1357520Axtq2_manxiety QTL 2 (mouse)Not determined6450382348703611Mouse
10043869Cia6a_mcollagen induced arthritis QTL 6a (mouse)Not determined61211797146118069Mouse
11252142Mom12_mModifier of Min 12 (mouse)63387226167872400Mouse
1301850Fglu_mfasting glucose (mouse)Not determined61771159851711719Mouse
4141749Obrq2_mobesity resistance QTL 2 (mouse)Not determined1275122146751333Mouse
1300959Lxw2_mlupus BXSB x NZW 2 (mouse)Not determined63387226167872400Mouse
1300767Aliq4_macute lung injury QTL 4 (mouse)Not determined63627333270273435Mouse
1301724Pcd4ts1_mp-glycoprotein positive CD4 T cell subset 1 (mouse)Not determined61771159851711719Mouse
4142126W3q3_mweight 3 weeks QTL 3 (mouse)Not determined450382396633110Mouse
14746995Manh60_mmandible shape 60 (mouse)63720266271202662Mouse
10412107Desp4_mdespair 4 (mouse)Not determined62004983054049830Mouse
1357442Dbts1_mdiabetes 1 (mouse)Not determined61823414773364675Mouse
4141094Hrtr1_mheart rate 1 (mouse)Not determined3674146370741463Mouse
4141988Obrq3_mobesity resistance QTL 3 (mouse)Not determined2829099362291115Mouse
11353841Bmiq3_mbody mass index QTL 3 (mouse)6450382348703611Mouse
1301326Trbv4c2_mT cell receptor beta variable 4 (mouse)Not determined64086823071356155Mouse
11353840Bmiq2_mbody mass index QTL 2 (mouse)6450382345291115Mouse
1558984Cplaq9_mcircadian period of locomotor activity 9 (mouse)Not determined63864656092584431Mouse
1300556Cia6_mcollagen induced arthritis QTL 6 (mouse)Not determined6446488487403016Mouse
26884414Bzwq12_mbi-zygomatic width QTL 12, 16 week (mouse)63400000139076998Mouse
25440480Moaq2_mmodifier of alien QTL 2 (mouse)63050001117476961Mouse
4142361W10q11_mweight 10 weeks QTL 11 (mouse)Not determined450382396633110Mouse
4142232W6q4_mweight 6 weeks QTL 4 (mouse)Not determined450382396633110Mouse
12904940Edlmmq5_mextensor digitorum longus muscle mass QTL 5 (mouse)61961634653616346Mouse
4141782Mrdq5_mmodifier of retinal degeneration QTL 5 (mouse)Not determined3282758578215957Mouse
10412213Sxbq2_mSGC/Knj cross B6 QTL 2 (mouse)Not determined61991268571299759Mouse
12904943Tammq4_mtibialis anterior muscle mass QTL 4 (mouse)61961634653616346Mouse
12880424V25Dq4_mvitamin D inactive form serum level QTL 4 (mouse)64157698575576985Mouse
12880425V25Dq5_mvitamin D inactive form serum level QTL 5 (mouse)63267698066676980Mouse
1302051Sluc7_msusceptibility to lung cancer 7 (mouse)Not determined6929707443297168Mouse
4141454Obrq4_mobesity resistance QTL 4 (mouse)Not determined3170349965703611Mouse
14700690Ccs6_mcolon cancer susceptibility 6 (mouse)62377693457776934Mouse
1357539Bsbob3_mBSB obesity 3 (mouse)Not determined63644845670448576Mouse
27226726Tibmd7_mtibia midshaft diameter 7, 16 week (mouse)61769999953476985Mouse
12904952Gmmq4_mgastrocnemius muscle mass QTL 4 (mouse)61961634653616346Mouse
1301998Bts2_mbladder tumor susceptibility 2 (mouse)Not determined61275122146751333Mouse
1357481Aaj2_manxiety in A/J 2 (mouse)Not determined6450382348703611Mouse
13208564Bmiq7_mbody mass index QTL 7 (mouse)62499999979976983Mouse

Markers in Region
BE630354  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38641,851,915 - 41,851,999UniSTSGRCm38
MGSCv37641,801,914 - 41,801,998UniSTSGRCm37
Celera641,804,482 - 41,804,566UniSTS
Cytogenetic Map6B2UniSTS
cM Map620.5UniSTS
Whitehead/MRC_RH6323.96UniSTS
26.MMHAP59FRA11.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38641,848,783 - 41,848,967UniSTSGRCm38
MGSCv37641,798,782 - 41,798,966UniSTSGRCm37
Celera641,801,350 - 41,801,534UniSTS
Cytogenetic Map6B2UniSTS
cM Map620.5UniSTS
Whitehead_YAC6 UniSTS
Pip  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map6B2UniSTS
cM Map620.5UniSTS


Sequence


Ensembl Acc Id: ENSMUST00000075351   ⟹   ENSMUSP00000074818
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl641,824,469 - 41,828,999 (+)Ensembl
GRCm38.p6 Ensembl641,847,535 - 41,852,065 (+)Ensembl
Ensembl Acc Id: ENSMUST00000203244   ⟹   ENSMUSP00000144995
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl641,824,502 - 41,828,891 (+)Ensembl
GRCm38.p6 Ensembl641,847,568 - 41,851,957 (+)Ensembl
Ensembl Acc Id: ENSMUST00000204575   ⟹   ENSMUSP00000144926
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl641,824,519 - 41,828,518 (+)Ensembl
GRCm38.p6 Ensembl641,847,585 - 41,851,584 (+)Ensembl
RefSeq Acc Id: NM_008843   ⟹   NP_032869
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39641,824,483 - 41,828,999 (+)NCBI
GRCm38641,847,549 - 41,852,065 (+)NCBI
MGSCv37641,797,548 - 41,802,061 (+)RGD
Celera641,800,116 - 41,804,629 (+)RGD
cM Map6 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_032869   ⟸   NM_008843
- Peptide Label: precursor
- UniProtKB: Q8K127 (UniProtKB/Swiss-Prot),   Q64013 (UniProtKB/Swiss-Prot),   Q9QUG8 (UniProtKB/Swiss-Prot),   P02816 (UniProtKB/Swiss-Prot),   Q3UU48 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000144995   ⟸   ENSMUST00000203244
Ensembl Acc Id: ENSMUSP00000144926   ⟸   ENSMUST00000204575
Ensembl Acc Id: ENSMUSP00000074818   ⟸   ENSMUST00000075351

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02816-F1-model_v2 AlphaFold P02816 1-146 view protein structure

Promoters
RGD ID:6889520
Promoter ID:EPDNEW_M8211
Type:multiple initiation site
Name:Pip_1
Description:Mus musculus prolactin induced protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38641,847,549 - 41,847,609EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:102696 AgrOrtholog
Ensembl Genes ENSMUSG00000058499 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000075351 ENTREZGENE
  ENSMUST00000075351.10 UniProtKB/Swiss-Prot
  ENSMUST00000203244.2 UniProtKB/TrEMBL
  ENSMUST00000204575.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18716 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:102696 ENTREZGENE
NCBI Gene 18716 ENTREZGENE
PANTHER PROLACTIN-INDUCIBLE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SVA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pip PhenoGen
PIRSF PIP-GCDFP-15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0N4SV27_MOUSE UniProtKB/TrEMBL
  A0A0N4SV85_MOUSE UniProtKB/TrEMBL
  P02816 ENTREZGENE, UniProtKB/Swiss-Prot
  Q3UU48 ENTREZGENE, UniProtKB/TrEMBL
  Q64013 ENTREZGENE
  Q8K127 ENTREZGENE
  Q8VCY2_MOUSE UniProtKB/TrEMBL
  Q9QUG8 ENTREZGENE
UniProt Secondary Q64013 UniProtKB/Swiss-Prot
  Q8K127 UniProtKB/Swiss-Prot
  Q9QUG8 UniProtKB/Swiss-Prot