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ONTOLOGY REPORT - ANNOTATIONS

Term:MyD88-dependent toll-like receptor signaling pathway
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Accession:GO:0002755 term browser browse the term
Definition:A toll-like receptor signaling pathway in which the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.
Synonyms:exact_synonym: MyD88-dependent TLR signaling pathway;   MyD88-dependent toll-like receptor signalling pathway


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MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgb1 high mobility group box 1 involved_in ISO (PMID:14660645) RGD PMID:14660645 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 involved_in ISO (PMID:16148103) RGD PMID:16148103 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor involved_in
acts_upstream_of_or_within		 IEA
ISO		 GO_REF:0000002
MGI:1346060|MGI:2385681 (PMID:12719478), (PMID:12872135), (PMID:14764662)		 InterPro
RGD		 PMID:12719478 PMID:12872135 PMID:14764662 GO_REF:0000002 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Reg3g regenerating family member 3 gamma involved_in ISS
ISO		 GO_REF:0000024
(PMID:17635956)		 UniProt
RGD		 PMID:17635956 GO_REF:0000024 NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723 		JBrowse link
G Tlr2 toll-like receptor 2 acts_upstream_of_or_within ISO MGI:108005 (PMID:12719478) RGD PMID:12719478 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 involved_in IEA
ISO
IBA		 GO_REF:0000107
UniProtKB:Q9EPW9 (PMID:20037584)
GO_REF:0000033		 Ensembl
RGD
GO_Central		 PMID:20037584 GO_REF:0000033 GO_REF:0000107 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tlr6 toll-like receptor 6 involved_in ISO (PMID:20037584)
UniProtKB:Q9QUK6 (PMID:20037584)		 RGD PMID:20037584 NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685 		JBrowse link
G Tlr9 toll-like receptor 9 involved_in ISO UniProtKB:P22366 (PMID:18820679) RGD PMID:18820679 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796 		JBrowse link
G Tnip1 TNFAIP3 interacting protein 1 involved_in ISO (PMID:22011580) RGD PMID:22011580 NCBI chr10:39,037,048...39,084,328
Ensembl chr10:39,037,058...39,077,625 		JBrowse link
MyD88-dependent toll-like receptor 4 signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lrrfip2 LRR binding FLII interacting protein 2 acts_upstream_of_or_within ISO (PMID:19265123) RGD PMID:19265123 NCBI chr 8:111,091,453...111,193,947
Ensembl chr 8:111,091,503...111,193,255 		JBrowse link
negative regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd300a Cd300a molecule involved_in ISO (PMID:22043923) RGD PMID:22043923 NCBI chr10:99,929,801...99,942,674
Ensembl chr10:99,929,801...99,942,674 		JBrowse link
G Cd300lf Cd300 molecule-like family member F involved_in ISS
ISO		 GO_REF:0000024
(PMID:22043923)		 UniProt
RGD		 PMID:22043923 GO_REF:0000024 NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041 		JBrowse link
regulation of MyD88-dependent toll-like receptor signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Irf1 interferon regulatory factor 1 involved_in ISS
ISO		 GO_REF:0000024
(PMID:17018642)		 UniProt
RGD		 PMID:17018642 GO_REF:0000024 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166 		JBrowse link
G Irf7 interferon regulatory factor 7 involved_in ISO (PMID:15800576) RGD PMID:15800576 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20069
    immune system process 3008
      activation of immune response 576
        activation of innate immune response 314
          innate immune response-activating signaling pathway 287
            pattern recognition receptor signaling pathway 276
              toll-like receptor signaling pathway 78
                MyD88-dependent toll-like receptor signaling pathway 14
                  MyD88-dependent toll-like receptor 2 signaling pathway 0
                  MyD88-dependent toll-like receptor 4 signaling pathway 1
                  negative regulation of MyD88-dependent toll-like receptor signaling pathway 2
                  positive regulation of MyD88-dependent toll-like receptor signaling pathway 0
                  regulation of MyD88-dependent toll-like receptor signaling pathway + 4
Path 2
Term Annotations click to browse term
  biological_process 20069
    response to stimulus 10793
      response to biotic stimulus 1917
        response to external biotic stimulus 1870
          response to other organism 1866
            defense response to other organism 1320
              defense response to symbiont 1100
                innate immune response 1014
                  regulation of innate immune response 480
                    positive regulation of innate immune response 386
                      activation of innate immune response 314
                        innate immune response-activating signaling pathway 287
                          pattern recognition receptor signaling pathway 276
                            toll-like receptor signaling pathway 78
                              MyD88-dependent toll-like receptor signaling pathway 14
                                MyD88-dependent toll-like receptor 2 signaling pathway 0
                                MyD88-dependent toll-like receptor 4 signaling pathway 1
                                negative regulation of MyD88-dependent toll-like receptor signaling pathway 2
                                positive regulation of MyD88-dependent toll-like receptor signaling pathway 0
                                regulation of MyD88-dependent toll-like receptor signaling pathway + 4
paths to the root