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ONTOLOGY REPORT - ANNOTATIONS

Term:microglial cell activation
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Accession:GO:0001774 term browser browse the term
Definition:The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.

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microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ager advanced glycosylation end-product specific receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,418,342...1,422,005
Ensembl chrNW_004936727:1,418,799...1,422,147 		JBrowse link
G App amyloid beta precursor protein involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936640:1,549,977...1,787,436
Ensembl chrNW_004936640:1,550,167...1,787,286 		JBrowse link
G C1qa complement C1q A chain involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936474:8,007,953...8,010,591
Ensembl chrNW_004936474:8,008,534...8,010,191 		JBrowse link
G C5ar1 complement C5a receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936664:1,026,216...1,033,438
Ensembl chrNW_004936664:1,032,304...1,033,374 		JBrowse link
G Clu clusterin involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936675:499,745...513,515
Ensembl chrNW_004936675:499,199...513,836 		JBrowse link
G Csf1r colony stimulating factor 1 receptor ISO RGD PMID:33841088 RGD:151665762 NCBI chrNW_004936504:4,898,947...4,927,195
Ensembl chrNW_004936504:4,898,945...4,928,923 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in ISO PMID:11870871 RGD
ARUK-UCL		 PMID:11870871 PMID:20018408 RGD:4892001 RGD:9491804 NCBI chrNW_004936475:9,443,851...9,454,715
Ensembl chrNW_004936475:9,443,733...9,455,062 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:24447880 RGD:9491776 NCBI chrNW_004936473:28,508,726...28,535,640
Ensembl chrNW_004936473:28,510,523...28,535,627 		JBrowse link
G Ifng interferon gamma involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Ifngr1 interferon gamma receptor 1 involved_in ISO (MGI:3697769|PMID:17255335) ARUK-UCL PMID:17255335 MGI:3697769 NCBI chrNW_004936560:4,519,858...4,545,763
Ensembl chrNW_004936560:4,519,474...4,545,796 		JBrowse link
G Ifngr2 interferon gamma receptor 2 involved_in ISO PMID:27094552 ARUK-UCL PMID:27094552 RGD:14397550 NCBI chrNW_004936500:8,881,921...8,937,355
Ensembl chrNW_004936500:8,882,435...8,901,281 		JBrowse link
G Il13 interleukin 13 ISO RGD PMID:19752235 RGD:8549634 NCBI chrNW_004936647:2,529,933...2,532,503
Ensembl chrNW_004936647:2,530,491...2,532,373 		JBrowse link
G Itgam integrin subunit alpha M involved_in ISO (MGI:3814938|PMID:18981141) ARUK-UCL PMID:18981141 MGI:3814938 NCBI chrNW_004936543:8,460,526...8,508,524
Ensembl chrNW_004936543:8,461,307...8,508,524 		JBrowse link
G Jak2 Janus kinase 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936503:111,722...243,627
Ensembl chrNW_004936503:110,963...241,867 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit acts_upstream_of_or_within ISO (PMID:15233917) MGI PMID:15233917 NCBI chrNW_004936522:3,034,364...3,037,632
Ensembl chrNW_004936522:3,035,346...3,036,350 		JBrowse link
G Kcnj8 potassium inwardly rectifying channel subfamily J member 8 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:29540778) Ensembl
MGI		 PMID:29540778 GO_REF:0000107 NCBI chrNW_004936548:5,125,583...5,132,490
Ensembl chrNW_004936548:5,125,555...5,133,078 		JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:26607664) Ensembl
MGI		 PMID:26607664 GO_REF:0000107 NCBI chrNW_004936490:17,305,033...17,312,167
Ensembl chrNW_004936490:17,304,586...17,314,521 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase ISO RGD PMID:28528966 RGD:13781879 NCBI chrNW_004936479:17,682,070...17,716,713
Ensembl chrNW_004936479:17,682,201...17,716,661 		JBrowse link
G P2ry1 purinergic receptor P2Y1 NOT|involved_in ISO PMID:11245682 ARUK-UCL PMID:11245682 RGD:13673788 NCBI chrNW_004936519:865,756...872,466
Ensembl chrNW_004936519:866,208...872,393 		JBrowse link
G P2ry2 purinergic receptor P2Y2 NOT|involved_in ISO PMID:11245682 ARUK-UCL PMID:11245682 RGD:13673788 NCBI chrNW_004936498:2,432,436...2,444,495
Ensembl chrNW_004936498:2,432,448...2,444,354 		JBrowse link
G Snca synuclein alpha involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:17035541) Ensembl
MGI		 PMID:17035541 GO_REF:0000107 NCBI chrNW_004936685:2,077,017...2,175,298
Ensembl chrNW_004936685:2,076,651...2,175,338 		JBrowse link
G Tlr1 toll like receptor 1 ISO RGD PMID:16973131 RGD:1643119 NCBI chrNW_004936482:6,582,430...6,591,128
Ensembl chrNW_004936482:6,582,584...6,584,971 		JBrowse link
G Tlr2 toll like receptor 2 ISO RGD PMID:16973131 RGD:1643119 NCBI chrNW_004936576:522,234...531,660
Ensembl chrNW_004936576:527,434...529,788 		JBrowse link
G Tlr3 toll like receptor 3 ISO RGD PMID:16973131 RGD:1643119 NCBI chrNW_004936554:3,370,766...3,388,125
Ensembl chrNW_004936554:3,369,469...3,385,907 		JBrowse link
G Tlr4 toll like receptor 4 ISO RGD PMID:16973131 RGD:1643119 NCBI chrNW_004936487:6,519,140...6,532,018
Ensembl chrNW_004936487:6,518,441...6,533,095 		JBrowse link
G Tlr6 toll like receptor 6 ISO RGD PMID:16973131 RGD:1643119 NCBI chrNW_004936482:6,607,723...6,610,161
Ensembl chrNW_004936482:6,607,753...6,610,143 		JBrowse link
G Tnf tumor necrosis factor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936727:1,936,066...1,937,766
Ensembl chrNW_004936727:1,936,066...1,937,766 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
G Trpv1 transient receptor potential cation channel subfamily V member 1 ISO RGD PMID:19385063 RGD:2316194 NCBI chrNW_004936677:277,304...326,907
Ensembl chrNW_004936677:276,994...327,025 		JBrowse link
microglial cell activation involved in immune response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cx3cr1 C-X3-C motif chemokine receptor 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936473:28,508,726...28,535,640
Ensembl chrNW_004936473:28,510,523...28,535,627 		JBrowse link
G Grn granulin precursor involved_in ISO (MGI:4421471|PMID:20026663) UniProt PMID:20026663 MGI:4421471 NCBI chrNW_004936541:793,548...800,271
Ensembl chrNW_004936541:793,523...800,217 		JBrowse link
G Il33 interleukin 33 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936539:763,755...791,461
Ensembl chrNW_004936539:623,248...791,470 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
G Tyrobp transmembrane immune signaling adaptor TYROBP involved_in IEA TreeGrafter GO_REF:0000118 NCBI chrNW_004936570:457,993...460,735
Ensembl chrNW_004936570:458,054...460,579 		JBrowse link
negative regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cst7 cystatin F involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:28251676) Ensembl
MGI
TreeGrafter		 PMID:28251676 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936620:853,533...870,609
Ensembl chrNW_004936620:853,439...870,812 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in ISO PMID:19627440 ARUK-UCL PMID:19627440 RGD:13673772 NCBI chrNW_004936475:9,443,851...9,454,715
Ensembl chrNW_004936475:9,443,733...9,455,062 		JBrowse link
G Grn granulin precursor involved_in ISO (MGI:5440302|PMID:23041626) UniProt PMID:23041626 MGI:5440302 NCBI chrNW_004936541:793,548...800,271
Ensembl chrNW_004936541:793,523...800,217 		JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936659:1,259,405...1,300,545
Ensembl chrNW_004936659:1,259,369...1,302,294 		JBrowse link
G Nr1d1 nuclear receptor subfamily 1 group D member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936490:15,206,194...15,213,858
Ensembl chrNW_004936490:15,206,191...15,213,867 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma involved_in ISO (MGI:6270781|PMID:30412727) ARUK-UCL PMID:30412727 MGI:6270781 NCBI chrNW_004936602:1,230,907...1,368,588
Ensembl chrNW_004936602:1,230,907...1,304,743 		JBrowse link
G Syt11 synaptotagmin 11 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936580:5,123,196...5,142,976
Ensembl chrNW_004936580:5,129,865...5,142,885 		JBrowse link
G Tafa3 TAFA chemokine like family member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25595455) Ensembl
MGI
TreeGrafter		 PMID:25595455 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936690:1,273,255...1,281,362
Ensembl chrNW_004936690:1,274,868...1,284,991 		JBrowse link
positive regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsc cathepsin C acts_upstream_of_or_within ISO (PMID:28251676) MGI PMID:28251676 NCBI chrNW_004936736:1,201,343...1,240,311 JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ISO RGD PMID:21750563 RGD:329955444 NCBI chrNW_004936706:940,585...952,484 JBrowse link
G Lrrk2 leucine rich repeat kinase 2 ISO RGD PMID:22302802 RGD:13462052 NCBI chrNW_004936607:628,469...761,117
Ensembl chrNW_004936607:626,991...761,123 		JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in
acts_upstream_of		 IEA
ISO		 (MGI:6201889|PMID:25049354) Ensembl
ARUK-UCL		 PMID:25049354 GO_REF:0000107 MGI:6201889 NCBI chrNW_004936551:5,228,950...5,238,948
Ensembl chrNW_004936551:5,228,950...5,238,948 		JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936582:877,241...908,697
Ensembl chrNW_004936582:877,474...913,770 		JBrowse link
G Tafa3 TAFA chemokine like family member 3 involved_in
acts_upstream_of_or_within		 IEA
ISO		 (PMID:25595455) Ensembl
TreeGrafter
MGI		 PMID:25595455 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936690:1,273,255...1,281,362
Ensembl chrNW_004936690:1,274,868...1,284,991 		JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IEA Ensembl
TreeGrafter		 GO_REF:0000107 GO_REF:0000118 NCBI chrNW_004936476:18,659,725...18,665,406
Ensembl chrNW_004936476:18,659,815...18,663,940 		JBrowse link
G Ttbk1 tau tubulin kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936476:16,686,513...16,725,750
Ensembl chrNW_004936476:16,689,305...16,725,708 		JBrowse link
regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase ISO RGD PMID:28007901 RGD:12879399 NCBI chrNW_004936551:359,134...534,672
Ensembl chrNW_004936551:359,362...532,211 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 ISO rat gene in mouse model RGD PMID:17473852 RGD:5688754 NCBI chrNW_004936647:2,087,650...2,133,343
Ensembl chrNW_004936647:2,087,604...2,133,355 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in IEA Ensembl GO_REF:0000107 NCBI chrNW_004936594:1,482,830...1,489,337
Ensembl chrNW_004936594:1,486,111...1,489,188 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15975
    cellular process 15059
      cell activation 1063
        glial cell activation 58
          microglial cell activation 47
            microglial cell activation involved in immune response 5
            negative regulation of microglial cell activation 8
            positive regulation of microglial cell activation 8
            regulation of microglial cell activation + 18
Path 2
Term Annotations click to browse term
  biological_process 15975
    response to stimulus 8553
      response to stress 3659
        defense response 1494
          inflammatory response 703
            neuroinflammatory response 81
              glial cell activation 58
                microglial cell activation 47
                  microglial cell activation involved in immune response 5
                  negative regulation of microglial cell activation 8
                  positive regulation of microglial cell activation 8
                  regulation of microglial cell activation + 18
paths to the root