Lrrk2 (leucine rich repeat kinase 2) - Rat Genome Database

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Pathways
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Gene: Lrrk2 (leucine rich repeat kinase 2) Ictidomys tridecemlineatus
Analyze
Symbol: Lrrk2
Name: leucine rich repeat kinase 2
RGD ID: 12596687
Description: ENCODES a protein that exhibits actin binding (inferred); ATP binding (inferred); beta-catenin destruction complex binding (inferred); INVOLVED IN cellular response to organic cyclic compound (ortholog); Golgi organization (ortholog); negative regulation of neuron projection development (ortholog); PARTICIPATES IN Parkinson's disease pathway; ASSOCIATED WITH Alzheimer's disease 3 (ortholog); amyotrophic lateral sclerosis (ortholog); cancer (ortholog); FOUND IN axon (ortholog); dendrite (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeat serine/threonine-protein kinase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494573,794,012 - 73,929,347 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936607626,991 - 761,123 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936607628,469 - 761,117 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcium-mediated signaling  (IEA)
cell communication  (IEA)
cell differentiation  (IEA)
cellular response to dopamine  (IEA)
cellular response to manganese ion  (IEA)
cellular response to organic cyclic compound  (ISO)
cellular response to oxidative stress  (IEA)
cellular response to reactive oxygen species  (IEA)
cellular response to starvation  (IEA)
determination of adult lifespan  (IEA)
endocytosis  (IEA)
endoplasmic reticulum organization  (IEA)
excitatory postsynaptic potential  (IEA)
exploration behavior  (IEA)
Golgi organization  (IEA,ISO)
GTP metabolic process  (IEA)
intracellular distribution of mitochondria  (IEA)
intracellular signal transduction  (IEA)
JNK cascade  (IEA)
locomotory exploration behavior  (IEA)
lysosome organization  (IEA)
MAPK cascade  (IEA)
mitochondrion localization  (IEA)
mitochondrion organization  (IEA)
negative regulation of autophagosome assembly  (IEA)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IEA)
negative regulation of excitatory postsynaptic potential  (IEA)
negative regulation of macroautophagy  (IEA)
negative regulation of neuron projection development  (ISO)
negative regulation of Notch signaling pathway  (ISO)
negative regulation of protein phosphorylation  (IEA)
negative regulation of protein processing  (IEA)
negative regulation of protein targeting to mitochondrion  (IEA)
neuromuscular junction development  (IEA)
neuron differentiation  (ISO)
neuron projection arborization  (ISO)
neuron projection morphogenesis  (IEA)
olfactory bulb development  (IEA)
positive regulation of autophagy  (IEA)
positive regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of dopamine receptor signaling pathway  (IEA)
positive regulation of microglial cell activation  (ISO)
positive regulation of nitric-oxide synthase biosynthetic process  (ISO)
positive regulation of programmed cell death  (IEA)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA)
positive regulation of protein autoubiquitination  (IEA)
positive regulation of protein phosphorylation  (IEA)
positive regulation of protein ubiquitination  (IEA)
positive regulation of synaptic vesicle endocytosis  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
protein import into nucleus  (IEA,ISO)
protein localization  (IEA)
protein localization to endoplasmic reticulum exit site  (IEA)
regulation of autophagy  (IEA)
regulation of branching morphogenesis of a nerve  (IEA)
regulation of CAMKK-AMPK signaling cascade  (IEA)
regulation of canonical Wnt signaling pathway  (IEA)
regulation of dendritic spine morphogenesis  (IEA)
regulation of dopamine receptor signaling pathway  (IEA)
regulation of ER to Golgi vesicle-mediated transport  (IEA)
regulation of gene expression  (IEA,ISO)
regulation of kidney size  (IEA)
regulation of locomotion  (IEA)
regulation of lysosomal lumen pH  (IEA)
regulation of membrane potential  (IEA)
regulation of mitochondrial depolarization  (IEA)
regulation of neuroblast proliferation  (IEA)
regulation of neuron maturation  (IEA)
regulation of protein kinase A signaling  (IEA)
regulation of protein stability  (IEA)
regulation of reactive oxygen species metabolic process  (IEA)
regulation of retrograde transport, endosome to Golgi  (IEA)
regulation of signal transduction  (IEA)
regulation of synaptic transmission, glutamatergic  (IEA)
regulation of synaptic vesicle endocytosis  (IEA)
regulation of synaptic vesicle exocytosis  (IEA)
regulation of synaptic vesicle transport  (IEA)
response to oxidative stress  (IEA)
Rho protein signal transduction  (IEA)
spermatogenesis  (ISO)
striatum development  (ISO)
tangential migration from the subventricular zone to the olfactory bulb  (IEA)
Wnt signalosome assembly  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Lrrk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494573,794,012 - 73,929,347 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936607626,991 - 761,123 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936607628,469 - 761,117 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381240,224,997 - 40,369,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1240,196,744 - 40,369,285 (+)EnsemblGRCh38hg38GRCh38
GRCh371240,618,799 - 40,763,087 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361238,905,081 - 39,049,354 (+)NCBINCBI36Build 36hg18NCBI36
Celera1239,422,059 - 39,566,110 (+)NCBICelera
Cytogenetic Map12q12NCBI
HuRef1237,646,624 - 37,790,676 (+)NCBIHuRef
CHM1_11240,584,126 - 40,728,194 (+)NCBICHM1_1
T2T-CHM13v2.01240,177,355 - 40,321,422 (+)NCBIT2T-CHM13v2.0
Lrrk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391591,556,994 - 91,700,327 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1591,557,378 - 91,700,323 (+)EnsemblGRCm39 Ensembl
GRCm381591,672,791 - 91,816,124 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1591,673,175 - 91,816,120 (+)EnsemblGRCm38mm10GRCm38
MGSCv371591,503,655 - 91,646,555 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361591,501,048 - 91,643,302 (+)NCBIMGSCv36mm8
Celera1593,785,543 - 93,930,186 (+)NCBICelera
Cytogenetic Map15E3NCBI
cM Map1546.07NCBI
Lrrk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87124,706,246 - 124,867,234 (+)NCBIGRCr8
mRatBN7.27122,826,696 - 122,987,711 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7122,826,696 - 122,987,703 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7124,609,699 - 124,765,717 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07126,835,567 - 126,991,586 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07126,763,694 - 126,919,689 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07132,857,311 - 133,018,549 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7132,857,628 - 133,018,584 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07132,531,591 - 132,694,226 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47130,105,902 - 130,267,747 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera7119,264,946 - 119,423,875 (+)NCBICelera
Cytogenetic Map7q35NCBI
Lrrk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495550581,796 - 216,923 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495550584,324 - 216,923 (-)NCBIChiLan1.0ChiLan1.0
LRRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21053,787,599 - 53,931,814 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11253,783,370 - 53,928,117 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01248,343,621 - 48,488,337 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11249,205,930 - 49,350,462 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1249,205,930 - 49,350,462 (-)Ensemblpanpan1.1panPan2
LRRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12713,282,824 - 13,420,917 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2713,283,756 - 13,420,870 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2733,032,944 - 33,171,543 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02713,454,479 - 13,594,189 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2713,454,985 - 13,594,935 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12713,240,908 - 13,387,064 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02713,302,124 - 13,442,060 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02733,159,660 - 33,299,460 (+)NCBIUU_Cfam_GSD_1.0
LRRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl571,800,225 - 71,945,828 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1571,800,337 - 71,945,828 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2574,510,979 - 74,653,410 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRRK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11136,490,775 - 36,634,215 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1136,492,011 - 36,634,216 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037210,139,337 - 210,285,872 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624778108,761 - 279,230 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624778106,594 - 279,325 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000000540   ⟹   ENSSTOP00000000487
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936607626,991 - 761,123 (-)Ensembl
RefSeq Acc Id: XM_040281846   ⟹   XP_040137780
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494573,794,012 - 73,929,347 (-)NCBI
Protein Sequences
Protein RefSeqs XP_040137780 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000000487.3
GenBank Protein KAG3292158 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: XP_040137780   ⟸   XM_040281846
- UniProtKB: I3LWV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSSTOP00000000487   ⟸   ENSSTOT00000000540
Protein Domains
Protein kinase   Roc


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000000527 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000000540.3 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
  ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  COR UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  ROC_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene Lrrk2 ENTREZGENE
PANTHER LEUCINE RICH REPEAT KINASE 2 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE DDB_G0278509-RELATED UniProtKB/TrEMBL
Pfam COR UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Roc UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  RAB UniProtKB/TrEMBL
  ROC UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  RAB UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF50978 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt I3LWV1 ENTREZGENE, UniProtKB/TrEMBL