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ONTOLOGY REPORT - ANNOTATIONS


Term:neuroinflammatory response
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Accession:GO:0150076 term browser browse the term
Definition:The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents.
Synonyms:exact_synonym: nerve tissue inflammatory response;   nervous tissue inflammatory response;   neural tissue inflammatory response



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neuroinflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcy1 adenylate cyclase 1 involved_in ISO (MGI:3621665|PMID:12441059) RGD PMID:12441059 MGI:3621665 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
JBrowse link
G Adcy8 adenylate cyclase 8 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:3621665|PMID:12441059)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:12441059 GO_REF:0000024 GO_REF:0000107 MGI:3621665 NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911
JBrowse link
G Ifng interferon gamma involved_in IDA PMID:27235345 ARUK-UCL PMID:27235345 RGD:14401572 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il4 interleukin 4 involved_in IDA PMID:27235345 ARUK-UCL PMID:27235345 RGD:14401572 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Psen2 presenilin 2 acts_upstream_of_or_within ISO MGI:1202717 (MGI:4888047|PMID:21206757) RGD PMID:21206757 MGI:4888047 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6193432|PMID:29859094) RGD PMID:29859094 MGI:6193432 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Ulk4 unc-51 like kinase 4 acts_upstream_of_or_within ISO MGI:4362969 (MGI:6098946|PMID:29034508) RGD PMID:29034508 MGI:6098946 NCBI chr 8:120,670,879...120,966,026
Ensembl chr 8:120,670,866...120,966,924
JBrowse link
negative regulation of astrocyte activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ldlr low density lipoprotein receptor involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (MGI:4415751|PMID:20005821)
Ensembl
RGD
PMID:20005821 GO_REF:0000107 MGI:4415751 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in IEA
ISO
ISS
GO_REF:0000107
(MGI:6283959|PMID:30792350)
GO_REF:0000024
Ensembl
RGD
UniProt
PMID:30792350 GO_REF:0000024 GO_REF:0000107 MGI:6283959 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6152919|PMID:29407460) RGD PMID:29407460 MGI:6152919 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
negative regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cst7 cystatin F involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
MGI:5910746 (MGI:5904382|PMID:28251676)
RGD PMID:28251676 PMID:21873635 MGI:5904382, RGD:13792537 NCBI chr 3:139,396,830...139,405,557
Ensembl chr 3:139,396,850...139,405,557
JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 involved_in IDA PMID:19627440 ARUK-UCL PMID:19627440 RGD:13673772 NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833
JBrowse link
G Grn granulin precursor involved_in ISS
ISO
GO_REF:0000024
(MGI:5440302|PMID:23041626)
UniProt
RGD
PMID:23041626 GO_REF:0000024 MGI:5440302 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
JBrowse link
G Ldlr low density lipoprotein receptor involved_in IEA
ISO
GO_REF:0000107
UniProtKB:P05067|UniProtKB:P49768 (MGI:4415751|PMID:20005821)
Ensembl
RGD
PMID:20005821 GO_REF:0000107 MGI:4415751 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in ISS
ISO
IEA
GO_REF:0000024
(MGI:6283959|PMID:30792350)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:30792350 GO_REF:0000024 GO_REF:0000107 MGI:6283959 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO RNAcentral:URS000024A59E_10090 (MGI:6270781|PMID:30412727) RGD PMID:30412727 MGI:6270781 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Syt11 synaptotagmin 11 involved_in ISS
ISO
GO_REF:0000024
(MGI:5913303|PMID:28686317)
UniProt
RGD
PMID:28686317 GO_REF:0000024 MGI:5913303 NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964
JBrowse link
G Tafa3 TAFA chemokine like family member 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5621218|PMID:25595455)
RGD PMID:25595455 PMID:21873635 MGI:5621218, RGD:13792537 NCBI chr 2:192,264,153...192,280,356
Ensembl chr 2:192,267,093...192,274,019
JBrowse link
negative regulation of neuroinflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd200 Cd200 molecule involved_in IGI
ISO
PMID:18164423
(MGI:1927692|PMID:11099416)
RGD PMID:11099416 PMID:18164423 MGI:1927692, RGD:13792521 NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648
JBrowse link
G Cd200r1 CD200 receptor 1 involved_in IGI PMID:18164423 ARUK-UCL PMID:18164423 RGD:13792521 NCBI chr11:55,886,937...55,921,217
Ensembl chr11:55,887,717...55,921,285
JBrowse link
G Igf1 insulin-like growth factor 1 involved_in ISO
IEA
RNAcentral:URS000034B6F5_9606 (PMID:27277332)
GO_REF:0000107
RGD
Ensembl
PMID:27277332 GO_REF:0000107 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:6283959|PMID:30792350)
UniProt
RGD
PMID:30792350 GO_REF:0000024 MGI:6283959 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma involved_in ISO RNAcentral:URS000024A59E_10090 (MGI:6270781|PMID:30412727) RGD PMID:30412727 MGI:6270781 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in IBA
ISO
PMID:21873635
(MGI:5775216|PMID:27147664)
RGD PMID:27147664 PMID:21873635 MGI:5775216, RGD:13792537 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6152919|PMID:29407460), (MGI:6695687|PMID:31900229), (MGI:6695864|PMID:31134514)
(PMID:32514138)
RGD PMID:29407460 PMID:31134514 PMID:31900229 PMID:32514138 MGI:6152919 MGI:6695687 MGI:6695864 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
positive regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctsc cathepsin C acts_upstream_of_or_within ISO (MGI:5904382|PMID:28251676) RGD PMID:28251676 MGI:5904382 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Lrrk2 leucine-rich repeat kinase 2 IMP RGD PMID:22302802 RGD:13462052 NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703
JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in IEA
ISO
GO_REF:0000107
(MGI:6201889|PMID:25049354)
Ensembl
RGD
PMID:25049354 GO_REF:0000107 MGI:6201889 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Stap1 signal transducing adaptor family member 1 involved_in ISO (MGI:3831067|PMID:19100238) RGD PMID:19100238 MGI:3831067 NCBI chr14:21,950,466...21,981,395
Ensembl chr14:21,952,496...21,981,245
JBrowse link
G Tafa3 TAFA chemokine like family member 3 involved_in
acts_upstream_of_or_within
IBA
ISO
PMID:21873635
(MGI:5621218|PMID:25595455)
RGD PMID:25595455 PMID:21873635 MGI:5621218, RGD:13792537 NCBI chr 2:192,264,153...192,280,356
Ensembl chr 2:192,267,093...192,274,019
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in IBA
ISO
PMID:21873635
(MGI:5606096|PMID:24990881), (MGI:6284411|PMID:29752066), (MGI:6304666|PMID:25631124), (MGI:6313424|PMID:30617257), (MGI:6391511|PMID:31370707)
(PMID:24990881)
RGD PMID:24990881 PMID:25631124 PMID:29752066 PMID:30617257 PMID:31370707 More... MGI:5606096 MGI:6284411 MGI:6304666 MGI:6313424 MGI:6391511, RGD:13792537 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
G Ttbk1 tau tubulin kinase 1 involved_in ISO (PMID:19118186) RGD PMID:19118186 NCBI chr 9:14,493,166...14,538,372
Ensembl chr 9:14,493,389...14,535,774
JBrowse link
positive regulation of neuroinflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp8 matrix metallopeptidase 8 involved_in IMP
ISO
PMID:25049354
(MGI:6201889|PMID:25049354)
RGD PMID:25049354 PMID:25049354 MGI:6201889, RGD:13792525 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator involved_in ISS
ISO
GO_REF:0000024
(MGI:4418805|PMID:16374777)
UniProt
RGD
PMID:16374777 GO_REF:0000024 MGI:4418805 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Plcg2 phospholipase C, gamma 2 involved_in ISO
IEA
(PMID:32514138)
GO_REF:0000107
RGD
Ensembl
PMID:32514138 GO_REF:0000107 NCBI chr19:45,547,416...45,683,930
Ensembl chr19:45,547,416...45,683,930
JBrowse link
G Trem2 triggering receptor expressed on myeloid cells 2 involved_in ISO (MGI:6304666|PMID:25631124) RGD PMID:25631124 MGI:6304666 NCBI chr 9:12,647,605...12,654,190
Ensembl chr 9:12,647,259...12,654,170
JBrowse link
reactive gliosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgb1 integrin subunit beta 1 involved_in
acts_upstream_of_or_within_negative_effect
IEA
ISO
GO_REF:0000107
(MGI:5629870|PMID:25716834)
Ensembl
RGD
PMID:25716834 GO_REF:0000107 MGI:5629870 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Myo5a myosin VA IMP RGD PMID:22639889 RGD:42722007 NCBI chr 8:75,811,985...75,980,049
Ensembl chr 8:75,812,412...75,975,918
JBrowse link
regulation of microglial cell activation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase IMP RGD PMID:28007901 RGD:12879399 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
ISO
GO_REF:0000024
(MGI:6158194|PMID:29662056)
UniProt
RGD
PMID:29662056 GO_REF:0000024 MGI:6158194 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
regulation of neuroinflammatory response term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd200 Cd200 molecule involved_in IGI PMID:10981966 ARUK-UCL PMID:10981966 RGD:61663 NCBI chr11:55,410,166...55,437,527
Ensembl chr11:55,410,196...55,501,648
JBrowse link
G Cd200r1 CD200 receptor 1 involved_in IGI PMID:10981966 ARUK-UCL PMID:10981966 RGD:61663 NCBI chr11:55,886,937...55,921,217
Ensembl chr11:55,887,717...55,921,285
JBrowse link
G Cd200r1l CD200 receptor 1-like involved_in IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:55,842,632...55,860,914
Ensembl chr11:55,842,634...55,885,680
JBrowse link
G Dagla diacylglycerol lipase, alpha involved_in ISS
ISO
GO_REF:0000024
(MGI:5755189|PMID:26779719)
UniProt
RGD
PMID:26779719 GO_REF:0000024 MGI:5755189 NCBI chr 1:206,890,635...206,947,332
Ensembl chr 1:206,890,638...206,947,232
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 involved_in ISS
ISO
GO_REF:0000024
(MGI:6158194|PMID:29662056)
UniProt
RGD
PMID:29662056 GO_REF:0000024 MGI:6158194 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISS
ISO
IMP
GO_REF:0000024
(MGI:6158194|PMID:29662056)
PMID:28284343
UniProt
RGD
PMID:29662056 PMID:28284343 GO_REF:0000024 MGI:6158194, RGD:14397556 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B involved_in ISO UniProtKB:Q9Z0D9 (MGI:5888814|PMID:28052249) RGD PMID:28052249 MGI:5888814 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19812
    response to stimulus 10543
      response to stress 4137
        defense response 1730
          inflammatory response 765
            neuroinflammatory response 33
              glial cell activation 0
              negative regulation of neuroinflammatory response + 13
              positive regulation of neuroinflammatory response + 9
              reactive gliosis 2
              regulation of neuroinflammatory response + 25
paths to the root