Leg Ulcer - Ontology Report - Rat Genome Database

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RGD DISEASE ONTOLOGY - ANNOTATIONS

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RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.

Term:	Leg Ulcer	go back to main search page
Accession:	DOID:9001347	browse the term
Definition:	Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
Synonyms:	exact_synonym:	Leg Ulcers
	primary_id:	MESH:D007871

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Rat (25) Mouse (25) Human (25) Chinchilla (19) Bonobo (21) Dog (23) Squirrel (20) Pig (22) Green Monkey (21) Naked Mole-rat (20) All
Genes (22)

Leg Ulcer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

fibroblast growth factor receptor 2

associated with chronic venous insufficiency;DNA:SNP:3' utr: (human)

NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425

Diabetic Foot

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

protein:decreased expression:plasma

NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,685...124,646,646

G

advanced glycosylation end-product specific receptor

associated with Diabetes Mellitus, Type 2;protein:decreased expression:blood

NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162

G

C-reactive protein, pentraxin-related

disease_progression

protein:increased expression:blood:

NCBI chr 4:90,793,361...90,801,020
Ensembl chr 4:90,793,350...90,805,218

G

gap junction protein alpha 1

protein:increased expression:dermis

NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156

G

hypoxia inducible factor 1 subunit alpha

mRNA,protein:decreased expression:blood serum, foot (human)

NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845

G

insulin like growth factor 1

protein:decreased expression:fibroblast of dermis,stratum basale of epidermis:

NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033

G

interleukin 15

associated with Diabetes Mellitus, Non-Insulin-Dependent;protein:decreased expression:dermis, endothelial cell

NCBI chr 8:85,666,963...85,740,980
Ensembl chr 8:85,667,321...85,678,461

G

integrin subunit alpha M

protein:increased expression:pes (human)

NCBI chr 3:17,216,719...17,272,134
Ensembl chr 3:17,204,610...17,273,613

G

mannose binding lectin 2

protein:increased expression:serum:

NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083

G

microRNA mir-17

NCBI chr11:60,734,656...60,734,732
Ensembl chr11:60,734,656...60,734,732

G

matrix metallopeptidase 9

severity

NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788

G

notch receptor 1

protein:increased expression:skin, epidermis:

G

plasminogen activator, tissue type

NCBI chr17:11,195,599...11,223,821
Ensembl chr17:11,195,602...11,224,032

G

pentraxin 3

protein:decreased expression:plasma (human)

NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569

G

toll like receptor 4

susceptibility

DNA:SNPs,haplotype: :rs4986790,rs4986791,rs10759931,rs1927911(human);

NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970

Foot Ulcer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 10

associated with Diabetes Mellitus

NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948

Varicose Ulcer

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1

no_association

DNA:polymorphism:(TA) dinucleotide repeat

NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363

G

estrogen receptor 2

DNA:polymorphism:intron:(CA) dinucleotide repeat (human)
DNA:SNPs:promoter, exon

PMID:16153823 PMID:18070128

RGD:1626508 RGD:8553061

NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565

G

homeostatic iron regulator

susceptibility
onset

associated with Chronic Venous Disease;DNA:missense mutation:cds:p.C282Y (human)
associated with Chronic Venous Disease;DNA:missense mutation:cds:p.H63D (human)

PMID:16102632 PMID:16678024

RGD:1582685 RGD:8694379

NCBI chr 7:20,758,604...20,767,004
Ensembl chr 7:20,758,741...20,767,000

G

leptin receptor

mRNA:decreased expression:skin

NCBI chr 6:146,802,297...146,896,152
Ensembl chr 6:146,801,954...146,895,995

G

mannose binding lectin 2

protein:decreased expression:serum:

NCBI chr14:97,103,926...97,107,635
Ensembl chr14:97,102,823...97,108,083

G

microRNA mir-21

miRNA:increased expression:skin:

NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358

Term paths to the root

Path 1
Term	Annotations
disease	15275
sensory system disease	6529
skin disease	3713
chronic ulcer of skin	41
ulcer of lower limbs	22
Leg Ulcer	22
Familial Leg Ulcers of Juvenile Onset	0
Foot Ulcer +	16
Varicose Ulcer	6
Path 2
Term	Annotations
disease	15275
Pathological Conditions, Signs and Symptoms	11809
Signs and Symptoms	9748
Neurologic Manifestations	9430
sensory system disease	6529
skin disease	3713
chronic ulcer of skin	41
ulcer of lower limbs	22
Leg Ulcer	22
Familial Leg Ulcers of Juvenile Onset	0
Foot Ulcer +	16
Varicose Ulcer	6

paths to the root