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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:thyroid gland follicular carcinoma
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Accession:DOID:3962 term browser browse the term
Definition:A differentiated thyroid gland carcinoma that has_material_basis_in follicular cells. (DO)
Synonyms:exact_synonym: Follicular Adenocarcinomas;   Follicular Thyroid Carcinomas;   follicular adenocarcinoma;   follicular adenocarcinoma, well differentiated;   follicular carcinoma;   follicular carcinoma of the thyroid gland;   follicular thyroid carcinoma;   thyroid adenocarcinoma
 narrow_synonym: poorly differentiated follicular thyroid carcinoma
 primary_id: MESH:D018263
 xref: EFO:0000501;   EFO:1002016;   NCI:C132275;   NCI:C8054
For additional species annotation, visit the Alliance of Genome Resources.


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thyroid gland follicular carcinoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras KRAS proto-oncogene, GTPase ISO CTD Direct Evidence: marker/mechanism CTD PMID:27440272 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Prkar1a protein kinase cAMP-dependent type I regulatory subunit alpha ISS OMIM:188470 MouseDO NCBI chr10:94,621,042...94,639,534
Ensembl chr10:94,620,039...94,639,041 		JBrowse link
G Pten phosphatase and tensin homolog ISS OMIM:188470 MouseDO NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Thrb thyroid hormone receptor beta ISO
ISS		 CTD Direct Evidence: marker/mechanism
OMIM:188470		 CTD
MouseDO		 PMID:27440272 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
thyroid gland Hurthle cell carcinoma term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cbx7 chromobox 7 ISO protein:decreased expression:thyroid Human) RGD PMID:25759796 RGD:11352710 NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973 		JBrowse link
G Ndufa13 NADH:ubiquinone oxidoreductase subunit A13 ISO ClinVar Annotator: match by term: Hurthle cell carcinoma of the thyroid
CTD Direct Evidence: marker/mechanism		 OMIM
ClinVar
CTD		 PMID:15841082 PMID:25741868 NCBI chr16:19,526,633...19,533,567
Ensembl chr16:19,526,565...19,535,726 		JBrowse link
G Psmb9 proteasome 20S subunit beta 9 ISO RGD PMID:19924240 RGD:6483332 NCBI chr20:4,667,044...4,672,512
Ensembl chr20:4,666,046...4,672,512 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18976
    disease of cellular proliferation 7746
      cancer 5576
        cell type cancer 3837
          carcinoma 3278
            adenocarcinoma 1713
              thyroid gland adenocarcinoma 69
                differentiated thyroid gland carcinoma 69
                  thyroid gland follicular carcinoma 7
                    papillary follicular thyroid adenocarcinoma 0
                    thyroid gland Hurthle cell carcinoma 3
                    trabecular follicular adenocarcinoma 0
Path 2
Term Annotations click to browse term
  disease 18976
    disease of cellular proliferation 7746
      cancer 5576
        organ system cancer 5333
          endocrine gland cancer 2451
            thyroid cancer 101
              thyroid gland carcinoma 90
                thyroid gland adenocarcinoma 69
                  differentiated thyroid gland carcinoma 69
                    thyroid gland follicular carcinoma 7
                      papillary follicular thyroid adenocarcinoma 0
                      thyroid gland Hurthle cell carcinoma 3
                      trabecular follicular adenocarcinoma 0
paths to the root