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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:hepatocellular adenoma
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Accession:DOID:0050868 term browser browse the term
Definition:A liver benign neoplasm that is located_in liver cells and that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures. (DO)
Synonyms:exact_synonym: Benign Hepatoma;   benign hepatomas;   hepatocellular adenomas;   liver cell adenoma;   liver cell adenomas
 primary_id: MESH:D018248
 xref: EFO:0000762


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hepatocellular adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2M alpha-2-macroglobulin ISO
EXP		 mRNA,protein:increased expression:liver:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:15509519 PMID:15509519 RGD:1358261 NCBI chr12:9,067,708...9,116,229
Ensembl chr12:9,067,664...9,116,229 		JBrowse link
G CARM1 coactivator associated arginine methyltransferase 1 ISO mRNA,protein:increased expression:liver: RGD PMID:23912631 RGD:9586718 NCBI chr19:10,871,553...10,923,075
Ensembl chr19:10,871,553...10,923,075 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B EXP CTD Direct Evidence: marker/mechanism CTD PMID:17620307 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CTNNB1 catenin beta 1 EXP CTD Direct Evidence: marker/mechanism CTD PMID:21147764 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 treatment ISO RGD PMID:23543859 RGD:14700918 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G HNF1A HNF1 homeobox A susceptibility
exacerbates		 IAGP DNA:loss of heterozygosity, mutations:multiple
DNA:mutation: (human)
DNA:frameshift mutation, non-sense mutation:cds:R229X, G55fsX57 (human)		 RGD PMID:12355088 PMID:17663417 PMID:14598263 RGD:14700683, RGD:150530291, RGD:14700774 NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512 		JBrowse link
G HP haptoglobin ISO RGD PMID:10569800 RGD:1626391 NCBI chr16:72,054,505...72,061,055
Ensembl chr16:72,054,505...72,061,055 		JBrowse link
G HRAS HRas proto-oncogene, GTPase EXP CTD Direct Evidence: marker/mechanism CTD PMID:8200073 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,321 		JBrowse link
G KRAS KRAS proto-oncogene, GTPase induced ISO aflatoxin B1 induced:DNA:transversion,transition mutations:cds: RGD PMID:8446626 RGD:11568697 NCBI chr12:25,205,246...25,250,929
Ensembl chr12:25,205,246...25,250,936 		JBrowse link
G MAP3K8 mitogen-activated protein kinase kinase kinase 8 ameliorates ISO RGD PMID:26560698 RGD:11342977 NCBI chr10:30,434,021...30,461,833
Ensembl chr10:30,434,021...30,461,833 		JBrowse link
G MKI67 marker of proliferation Ki-67 EXP CTD Direct Evidence: marker/mechanism CTD PMID:31939706 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423 		JBrowse link
G NR1H4 nuclear receptor subfamily 1 group H member 4 ISO RGD PMID:17183066 RGD:14696794 NCBI chr12:100,473,866...100,564,414
Ensembl chr12:100,473,708...100,564,414 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 EXP CTD Direct Evidence: marker/mechanism CTD PMID:25656644 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G PTEN phosphatase and tensin homolog ISO
EXP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:27022031 PMID:15199412 RGD:1302555 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930 		JBrowse link
G PTPN11 protein tyrosine phosphatase non-receptor type 11 ISS MouseDO NCBI chr12:112,418,947...112,509,918
Ensembl chr12:112,418,351...112,509,918 		JBrowse link
G TMEM70 transmembrane protein 70 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27914986 NCBI chr 8:73,976,195...73,982,783
Ensembl chr 8:73,972,437...73,982,783 		JBrowse link
G UBE2E2 ubiquitin conjugating enzyme E2 E2 EXP CTD Direct Evidence: marker/mechanism CTD PMID:27914986 NCBI chr 3:23,203,098...23,591,925
Ensembl chr 3:23,203,020...23,591,794 		JBrowse link
familial hepatic adenoma term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HNF1A HNF1 homeobox A IAGP
EXP		 CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: LIVER CELL ADENOMAS, FAMILIAL
ClinVar Annotator: match by term: Hepatic adenomas, familial		 OMIM
CTD
ClinVar		 PMID:8866553 PMID:8945470 PMID:9032114 PMID:9045858 PMID:9075818 More... NCBI chr12:120,978,543...121,002,512
Ensembl chr12:120,978,543...121,002,512 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 110354
    disease of cellular proliferation 24235
      benign neoplasm 3980
        cell type benign neoplasm 3241
          adenoma 1026
            hepatocellular adenoma 17
              familial hepatic adenoma 1
Path 2
Term Annotations click to browse term
  disease 110354
    disease of cellular proliferation 24235
      Neoplasms by Site 22863
        Digestive System Neoplasms 5324
          Gastrointestinal Neoplasms 4947
            gastrointestinal system benign neoplasm 409
              hepatobiliary benign neoplasm 204
                liver benign neoplasm 44
                  hepatocellular adenoma 17
                    familial hepatic adenoma 1
paths to the root