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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lasalocid
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Accession:CHEBI:92181 term browser browse the term
Definition:A polyether antibiotic used for prevention and treatment of coccidiosis in poultry.
Synonyms:exact_synonym: (1S,9S)-1,5:6,9-dianhydro-9-[(3R,5S,6S,7R)-9-(2-carboxy-3-hydroxy-4-methylphenyl)-6-hydroxy-5,7-dimethyl-4-oxononan-3-yl]-3,4,7,8-tetradeoxy-6-ethyl-2-C-ethyl-1,8-dimethyl-D-galacto-nonitol
 related_synonym: 6-[(3R,4S,5S,7R)-7-{(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-3-methyltetrahydrofuran-2-yl}-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methylbenzoic acid;   Formula=C34H54O8;   InChI=1S/C34H54O8/c1-9-25(31-21(6)18-34(11-3,42-31)26-16-17-33(40,10-2)23(8)41-26)30(37)22(7)28(35)19(4)12-14-24-15-13-20(5)29(36)27(24)32(38)39/h13,15,19,21-23,25-26,28,31,35-36,40H,9-12,14,16-18H2,1-8H3,(H,38,39)/t19-,21+,22+,23+,25+,26-,28+,31+,33-,34+/m1/s1;   InChIKey=BBMULGJBVDDDNI-OWKLGTHSSA-N;   Ro 2-2985;   SMILES=[H][C@@]1(O[C@@](CC)(C[C@@H]1C)[C@@]1([H])CC[C@](O)(CC)[C@H](C)O1)[C@@H](CC)C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCC1=C(C(O)=O)C(O)=C(C)C=C1;   X 537A;   antibiotic X 537A;   ionophore X 537A;   lasalocid A;   lasalocide;   lasalocido;   lasalocidum
 xref: CAS:25999-31-9;   DrugBank:DB11423;   KEGG:D04671;   LINCS:LSM-2214;   LIPID_MAPS_instance:LMPK09000002
 xref_mesh: MESH:D007832
 xref: PDBeChem:LSD;   PMCID:PMC6663702;   PMID:1705820;   PMID:25364932;   PMID:25535803;   PMID:25556006;   PMID:26054429;   PMID:26812337;   PMID:27580396;   PMID:28178613;   PMID:28470877;   PMID:28956164;   PMID:30191481;   PMID:30973080;   PMID:31864181;   PMID:31906353;   PMID:32069059;   PMID:32228806;   PMID:32625606;   PMID:32738374;   PMID:32774509;   Wikipedia:Lasalocid
 cyclic_relationship: is_conjugate_acid_of CHEBI:156364



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lasalocid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta increases expression ISO Lasalocid results in increased expression of ACTB protein CTD PMID:37788135 NCBI chr12:11,663,112...11,666,697
Ensembl chr12:11,663,109...11,672,877
JBrowse link
G Anxa1 annexin A1 increases expression ISO Lasalocid results in increased expression of ANXA1 protein CTD PMID:37788135 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa2 annexin A2 increases expression ISO Lasalocid results in increased expression of ANXA2 protein CTD PMID:37788135 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Dsp desmoplakin increases expression ISO Lasalocid results in increased expression of DSP protein CTD PMID:37788135 NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800
JBrowse link
G Hnrnpa1 heterogeneous nuclear ribonucleoprotein A1 increases expression ISO Lasalocid results in increased expression of HNRNPA1 protein CTD PMID:37788135 NCBI chr 7:134,375,318...134,381,610
Ensembl chr 7:134,375,150...134,381,609
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 increases expression ISO Lasalocid results in increased expression of HNRNPA2B1 protein CTD PMID:37788135 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO Lasalocid results in increased expression of HSPB1 protein CTD PMID:37788135 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Ivl involucrin increases expression ISO Lasalocid results in increased expression of IVL protein CTD PMID:37788135 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
JBrowse link
G Jup junction plakoglobin increases expression ISO Lasalocid results in increased expression of JUP protein CTD PMID:37788135 NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057
JBrowse link
G Krt5 keratin 5 increases expression ISO Lasalocid results in increased expression of KRT5 protein CTD PMID:37788135 NCBI chr 7:132,846,132...132,851,861
Ensembl chr 7:132,846,136...132,851,850
JBrowse link
G Mapt microtubule-associated protein tau decreases expression ISO Lasalocid results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Pkp1 plakophilin 1 increases expression ISO Lasalocid results in increased expression of PKP1 protein CTD PMID:37788135 NCBI chr13:47,309,607...47,357,432
Ensembl chr13:47,309,614...47,357,465
JBrowse link
G Ppl periplakin increases expression ISO Lasalocid results in increased expression of PPL protein CTD PMID:37788135 NCBI chr10:10,450,919...10,496,575
Ensembl chr10:10,450,919...10,496,575
JBrowse link
G S100a10 S100 calcium binding protein A10 increases expression ISO Lasalocid results in increased expression of S100A10 protein CTD PMID:37788135 NCBI chr 2:179,221,012...179,229,659
Ensembl chr 2:179,220,887...179,229,661
JBrowse link
G S100a11 S100 calcium binding protein A11 increases expression ISO Lasalocid results in increased expression of S100A11 protein CTD PMID:37788135 NCBI chr 2:179,191,688...179,197,098
Ensembl chr 2:179,191,715...179,197,044
JBrowse link
G S100a16 S100 calcium binding protein A16 increases expression ISO Lasalocid results in increased expression of S100A16 protein CTD PMID:37788135 NCBI chr 2:176,016,405...176,022,117
Ensembl chr 2:176,016,268...176,022,117
JBrowse link
G Serpinb2 serpin family B member 2 increases expression ISO Lasalocid results in increased expression of SERPINB2 protein CTD PMID:37788135 NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
JBrowse link
G Sprr1a small proline-rich protein 1A increases expression ISO Lasalocid results in increased expression of SPRR1A protein CTD PMID:37788135 NCBI chr 2:178,055,096...178,057,012
Ensembl chr 2:178,055,096...178,057,063
JBrowse link
G Sprr1b small proline-rich protein 1B increases expression ISO Lasalocid results in increased expression of SPRR1B protein CTD PMID:37788135 NCBI chr 2:178,008,844...178,010,742
Ensembl chr 2:178,009,130...178,009,567
JBrowse link
G Sprr2d small proline-rich protein 2D increases expression ISO Lasalocid results in increased expression of SPRR2D protein CTD PMID:37788135 NCBI chr 2:177,870,082...177,870,679
Ensembl chr 2:177,870,434...177,870,679
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        biophysical role 14069
          membrane transport modulator 13910
            ionophore 1287
              lasalocid 20
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        aromatic carboxylic acid 12279
                                          benzoic acids 12254
                                            benzoic acid 5331
                                              hydroxybenzoic acid 4798
                                                monohydroxybenzoic acid 2614
                                                  lasalocid 20
paths to the root