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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:lasalocid
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Accession:CHEBI:92181 term browser browse the term
Definition:A polyether antibiotic used for prevention and treatment of coccidiosis in poultry.
Synonyms:exact_synonym: (1S,9S)-1,5:6,9-dianhydro-9-[(3R,5S,6S,7R)-9-(2-carboxy-3-hydroxy-4-methylphenyl)-6-hydroxy-5,7-dimethyl-4-oxononan-3-yl]-3,4,7,8-tetradeoxy-6-ethyl-2-C-ethyl-1,8-dimethyl-D-galacto-nonitol
 related_synonym: 6-[(3R,4S,5S,7R)-7-{(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-3-methyltetrahydrofuran-2-yl}-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methylbenzoic acid;   Formula=C34H54O8;   InChI=1S/C34H54O8/c1-9-25(31-21(6)18-34(11-3,42-31)26-16-17-33(40,10-2)23(8)41-26)30(37)22(7)28(35)19(4)12-14-24-15-13-20(5)29(36)27(24)32(38)39/h13,15,19,21-23,25-26,28,31,35-36,40H,9-12,14,16-18H2,1-8H3,(H,38,39)/t19-,21+,22+,23+,25+,26-,28+,31+,33-,34+/m1/s1;   InChIKey=BBMULGJBVDDDNI-OWKLGTHSSA-N;   Ro 2-2985;   SMILES=[H][C@@]1(O[C@@](CC)(C[C@@H]1C)[C@@]1([H])CC[C@](O)(CC)[C@H](C)O1)[C@@H](CC)C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCC1=C(C(O)=O)C(O)=C(C)C=C1;   X 537A;   antibiotic X 537A;   ionophore X 537A;   lasalocid A;   lasalocide;   lasalocido;   lasalocidum
 xref: CAS:25999-31-9;   DrugBank:DB11423;   KEGG:D04671;   LINCS:LSM-2214;   LIPID_MAPS_instance:LMPK09000002
 xref_mesh: MESH:D007832
 xref: PDBeChem:LSD;   PMCID:PMC6663702;   PMID:1705820;   PMID:25364932;   PMID:25535803;   PMID:25556006;   PMID:26054429;   PMID:26812337;   PMID:27580396;   PMID:28178613;   PMID:28470877;   PMID:28956164;   PMID:30191481;   PMID:30973080;   PMID:31864181;   PMID:31906353;   PMID:32069059;   PMID:32228806;   PMID:32625606;   PMID:32738374;   PMID:32774509;   Wikipedia:Lasalocid
 cyclic_relationship: is_conjugate_acid_of CHEBI:156364


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lasalocid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapt microtubule-associated protein tau decreases expression ISO Lasalocid results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19784
      biological role 19782
        biophysical role 13830
          membrane transport modulator 13667
            ionophore 1259
              lasalocid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19810
      composite particle 19810
        hadron 19810
          baryon 19810
            nucleon 19810
              atomic nucleus 19810
                atom 19810
                  main group element atom 19755
                    p-block element atom 19755
                      carbon group element atom 19698
                        carbon atom 19693
                          organic molecular entity 19693
                            organic group 18902
                              organic divalent group 18884
                                organodiyl group 18884
                                  carbonyl group 18850
                                    carbonyl compound 18850
                                      carboxylic acid 18564
                                        aromatic carboxylic acid 11831
                                          benzoic acids 11806
                                            benzoic acid 4373
                                              hydroxybenzoic acid 3784
                                                monohydroxybenzoic acid 1483
                                                  lasalocid 1
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