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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lasalocid
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Accession:CHEBI:92181 term browser browse the term
Definition:A polyether antibiotic used for prevention and treatment of coccidiosis in poultry.
Synonyms:exact_synonym: (1S,9S)-1,5:6,9-dianhydro-9-[(3R,5S,6S,7R)-9-(2-carboxy-3-hydroxy-4-methylphenyl)-6-hydroxy-5,7-dimethyl-4-oxononan-3-yl]-3,4,7,8-tetradeoxy-6-ethyl-2-C-ethyl-1,8-dimethyl-D-galacto-nonitol
 related_synonym: 6-[(3R,4S,5S,7R)-7-{(2S,3S,5S)-5-ethyl-5-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-3-methyltetrahydrofuran-2-yl}-4-hydroxy-3,5-dimethyl-6-oxononyl]-2-hydroxy-3-methylbenzoic acid;   Formula=C34H54O8;   InChI=1S/C34H54O8/c1-9-25(31-21(6)18-34(11-3,42-31)26-16-17-33(40,10-2)23(8)41-26)30(37)22(7)28(35)19(4)12-14-24-15-13-20(5)29(36)27(24)32(38)39/h13,15,19,21-23,25-26,28,31,35-36,40H,9-12,14,16-18H2,1-8H3,(H,38,39)/t19-,21+,22+,23+,25+,26-,28+,31+,33-,34+/m1/s1;   InChIKey=BBMULGJBVDDDNI-OWKLGTHSSA-N;   Ro 2-2985;   SMILES=[H][C@@]1(O[C@@](CC)(C[C@@H]1C)[C@@]1([H])CC[C@](O)(CC)[C@H](C)O1)[C@@H](CC)C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCC1=C(C(O)=O)C(O)=C(C)C=C1;   X 537A;   antibiotic X 537A;   ionophore X 537A;   lasalocid A;   lasalocide;   lasalocido;   lasalocidum
 xref: CAS:25999-31-9;   DrugBank:DB11423;   KEGG:D04671;   LINCS:LSM-2214;   LIPID_MAPS_instance:LMPK09000002
 xref_mesh: MESH:D007832
 xref: PDBeChem:LSD;   PMCID:PMC6663702;   PMID:1705820;   PMID:25364932;   PMID:25535803;   PMID:25556006;   PMID:26054429;   PMID:26812337;   PMID:27580396;   PMID:28178613;   PMID:28470877;   PMID:28956164;   PMID:30191481;   PMID:30973080;   PMID:31864181;   PMID:31906353;   PMID:32069059;   PMID:32228806;   PMID:32625606;   PMID:32738374;   PMID:32774509;   Wikipedia:Lasalocid
 cyclic_relationship: is_conjugate_acid_of CHEBI:156364



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lasalocid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapt microtubule-associated protein tau decreases expression ISO Lasalocid results in decreased expression of MAPT protein CTD PMID:16930453 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    role 20042
      biological role 20011
        biophysical role 13235
          membrane transport modulator 13045
            ionophore 1218
              lasalocid 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  main group element atom 19960
                    p-block element atom 19990
                      carbon group element atom 19916
                        carbon atom 19909
                          organic molecular entity 19909
                            organic group 18988
                              organic divalent group 18950
                                organodiyl group 18974
                                  carbonyl group 18903
                                    carbonyl compound 18925
                                      carboxylic acid 18597
                                        aromatic carboxylic acid 11811
                                          benzoic acids 11786
                                            benzoic acid 4327
                                              hydroxybenzoic acid 3736
                                                monohydroxybenzoic acid 1460
                                                  lasalocid 1
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